man-training

The effects of Hesperidin on exercise performance - New publication from BioActor in collaboration with Maastricht University

The effects of Hesperidin on exercise performance – New publication from BioActor in collaboration with Maastricht University

Maastricht, The Netherlands, July 22nd, 2022

Press release
The review recently published in Nutrients was conducted by BioActor in collaboration with Maastricht University and examined the potential mechanisms through which hesperidin can improve exercise performance.

man-training

A review on hesperidin and exercise performance

Nutrients, a leading peer-reviewed scientific journal of human nutrition, has recently published a review about hesperidin’s effect on exercise performance. The research was conducted by M. Imperatrice, a clinical researcher at BioActor, in collaboration with the Maastricht University’s Department of Human Biology.

 

This review collects the results of randomized controlled trials (RTCs), animal studies, and in vitro studies providing more evidence on how hesperidin, a flavanone abundantly present in citrus fruits, could lead to enhancement in exercise performance.

 

According to the review’s results, hesperidin is able to improve endothelial function (via increased NO availability), inhibit ROS production, decrease production and plasma levels of pro-inflammatory markers, and improve anaerobic exercise outcomes (e.g. power, speed, energy).

 

We are really proud to share the results collected in our review about the potential mechanisms linking hesperidin to enhanced anaerobic performance, namely improved endothelial function, reduced exercise-induced oxidative stress, and inflammation. For elite and recreational athletes, hesperidin could be a promising food supplement to optimize the oxygen and nutrient supplies of the muscles, stimulate muscle contraction, and enhance muscle recovery between training sessions. The ergogenic effects that hesperidin can bring to the spectrum of improved exercise performance are promising and should be investigated further. With our “Actiful 2” ongoing Clinical Study, we are going to deepen this knowledge by investigating both the effects of hesperidin supplementation on endurance exercise and on changes in intramuscular markers via skeletal muscle biopsies.” said M. Imperatrice.

 

BioActor’s interest in hesperidin has resulted in the development of two active ingredients. The first ingredient branded under the name WATTS’UP® and targeting sports performance has already been tested in two randomized placebo-controlled clinical trials, one with highly trained athletes and one with moderately trained subjects. The second ingredient goes under the name Actiful® and targets energy and vitality. This ingredient has already been tested in randomized placebo-controlled clinical trials, in elderly subjects, showing physical and mental benefits.

 

About BioActor

BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.

Feel free to contact BioActor via info@bioactor.com for more information on the possibilities WATTS’UP® and Actiful® have to offer.
Further information can be found on: www.wattsup.eu, www.actiful.eu and www.bioactor.com


Environmental-benefits-of-Aronia

Top 5 environmental benefits of Aronia Melanocarpa (Nero Eggert variety)

Top 5 environmental benefits of Aronia Melanocarpa (Nero Eggert variety)

July 12th, 2022

Sustainability is a hot topic as issues such as food security, pollution, and climate change have become major concerns. Nowadays, more and more consumers have a better understanding and pay attention to the sustainability aspect of products they buy and consume. In this article, we’ll explain 5 key environmental benefits of Aronia melanocarpa.

Environmental-benefits-of-Aronia

Over the last years, there has been an increased awareness around sustainability, as issues such as food security, pollution, and climate change have become major concerns. As more and more consumers have a better understanding and care more about sustainability, they also tend to pay attention to which products they buy and consume.

Aronia berries are small dark fruits that are becoming increasingly popular amongst health-conscious consumers as they have excellent content in micronutrients and strong antioxidant properties.

Research around these berries suggests that they provide important health benefits to immune health, cardiovascular function, brain health, and anti-diabetic function.

Read more about the health benefits of Aronia berries

Apart from providing numerous health benefits, Aronia berries are also interesting from an environmental perspective, thanks to some unique characteristics of this plant.

This is particularly true for the variety called Nero Eggert, selected by BioActor to produce the active ingredient for brain health, namely Brainberry®.

Let’s find out why Aronia is considered a super berry not only for the health of consumers but also for the planet.

1. Aronia keeps the bees healthy and happy.

Many scientists have asserted that bees are not only one of the most important pollinators for food crops, but also for the existence of humanity. For that reason, it is critical to find ways that will ensure bees’ happiness.

Aronia melanocarpa is a plant with an incredibly extended flowering time, meaning that bees are provided with enough sugars and protein from the nectar and pollen. That lasts around two weeks more compared to other fruits, and in most cases, this is enough for their healthy growth and reproduction.

 

2. It’s naturally organic.

When thinking about sustainability, often the best route to take is the organic route, which involves far fewer pesticides added to the soil. This not only keeps the food natural, but also protects the soil from becoming overloaded with unnatural substances, which is essential for the long-term viability of any patch of farmland.

In Aronia melanocarpa plants, pests occur only rarely and in small quantities. In fact, Aronia is considered a strong and very resistant plant, and growers don’t need to use chemicals to control the growth when cultivating it.

 

3. Lower water consumption.

Another sustainable indicator in plantations is the usage of water that is required for growth. Much effort has been made to reduce the water footprint in agriculture, where 80% accounts for crop production. Thanks to its strong rooting system, Aronia plants can grow with very little water, even in poor soils.

Additionally, mature shrubs are resistant to weather anomalies. For example, it is resistant to frost, drought, as well as excess rainfall. This makes possible the cultivation of Aronia plants where it is difficult to grow other plants.

For example, the Aronia berries used to produce Brainberry® are cultivated on the icy plains of the Baltic region of Europe, where in winter is extremely cold.

 

4. Less land and higher yield.

As mentioned above, BioActor selected a unique variety of Aronia named Nero Eggert. What sets this variety apart from the rest is the ability of the plant to grow its branches in width rather than in height.

The main advantages of this characteristic are a higher yield, which means obtaining more fruits (and consuming less land), and more flowers to keep the bees happy!

Furthermore, the branches of these plants are more resistant and harder to break off, further reducing the possibility of contacting pests and diseases.

 

5. Reduced food loss.

It is estimated that global food production must increase by 60% by 2050 to meet the demands of the growing world population. Yet, more than one-third of the food produced today is lost or wasted.

While food waste means food that is wasted at the retail or consumer level, food loss refers to the decrease in edible food mass at the production, post-harvest, and processing stages of the food chain.

Aronia berries are durable fruits. This is important because it facilitates the storage and transport to processing facilities with minimal to no loss.

Bottom Line

In conclusion, the environmental benefits of Aronia combined with its health effects on consumers make it a super berry. BioActor focuses on developing innovative plant-based ingredients that target healthy living and aging.

Feel free to contact BioActor via info@bioactor.com and visit www.brainberry.eu and www.bioactor.com to learn more about Brainberry®.


Women's-Health-Webinar

WEBINAR - Women's Health

WEBINAR – Women’s Health

Product concepts with Bonolive® to address post-menopausal-related risks

July 11th 2022

More than ever, nutrition and supplementation are recognized to be effective strategies to address concerns associated with metabolic changes during menopause. Join us in our next webinar to learn more about the clinical evidence supporting Bonolive®, and product formulations to target post-menopausal-related risks.

The menopause journey is part of every woman’s life. For some, menopause can be more challenging than for others. With the hormonal changes occurring during this critical period, menopausal women will experience new health challenges.

From short-term complaints, such as hot flashes, mood changes and insomnia, to associated long-term risks such as cardiovascular, bone loss and joint discomfort; nutrition and supplementation are recognised to play an essential role in supporting women during menopause.

Join us in our next webinar and discover the clinical evidence supporting Bonolive® and how BioActor’s olive polyphenol-based ingredient can be integrated into effective menopausal management products.

When?

28th July 2022 at 16:00h CET

WATCH ON DEMAND

Meet the Speakers:

Meet the speakers

What are you going to learn during this webinar?

Clinical Research

How does menopause affect women’s health and how can Bonolive® help? Presentation by Maria Imperatrice – Clinical researcher, who will introduce the science behind Bonolive® and the clinical trials showing the positive effect of Bonolive® on cardiovascular health, bone health and mobility.
Duration: 15 minutes

The Women’s Health trends & consumer insights

How to address post-menopausal risks with Bonolive®? Presentation by Damian van der Broeck – Account manager, who will dive into the customer insights, Bonolive® mode of action and product formulation examples targeting post-menopausal-related risks.
Duration: 15 minutes

Q&A session

Duration: 10 minutes

WATCH ON DEMAND

Why-is-bone-health-important-and-how-does-it-work-(functions-bone-metabolism-and-influencing-factors)

Why is bone health important and how does it work? (functions, bone metabolism and influencing factors)

Why is bone health important and how does it work? (functions, bone metabolism and influencing factors)

July 4th, 2022

Our bones play various key functions for our bodies, and it is therefore important to maintain their health. To do so, it is essential to understand how our bones work and what factors affect bone health. Bone metabolism is a lifelong occurring process where bone tissue is turned over from mature to new bone tissue. This process keeps your bones healthy and their health is influenced by several aspects, such as age, gender, family history and several risk factors such as tobacco use, physical inactivity and diet.

Why-is-bone-health-important-and-how-does-it-work-(functions-bone-metabolism-and-influencing-factors)

Bone health, menopause, and dietary supplements

Menopause is the permanent cessation of menstruation naturally occurring in females at an average age of 51 [1].

Importantly, menopause leads to a decrease in estrogen levels and consequently increases bone loss. Estrogen is a hormone responsible for menstruation and known to have protective effects on bone loss and reduce inflammation.

Bone tissue in women is generally thinner than in men, and bone density has been reported to markedly decrease after menopause (post-menopause). Women can lose up to 20% of their bone density in just 5-7 years due to these hormonal shifts and experience increased joint pain [2].

The rise in the use of dietary supplements, especially by post-menopausal women, who are at risk of bone loss, is growing tremendously as advances in research are made, and the benefits of multiple natural ingredients are proven [3].

How does bone metabolism work?

Bone metabolism, also known as bone remodelling, is a lifelong occurring process where bone tissue is turned over from mature to new bone tissue. Bone resorption is the process where mature bone tissue is removed by osteoclasts and ossification is the formation of new bone tissue executed by osteoblasts [4]. These processes are responsible for replacing and reshaping bone following injuries such as fractures, but also micro-damage occurring during normal activity.

In the early stages of life, nearly 100% of the skeleton is replaced, due to the bones needing to develop, lengthen and grow. While in adults, bone remodelling proceeds at about 10% yearly [5].

For as long as bone growth is greater than bone breakdown, adults are able to maintain healthy bones. Many living cells within bone originate from the same mesenchymal stem cell. These mesenchymal stem cells can differentiate into the various cell types present in bone, such as osteoblasts (bone-building cells), adipocytes (fat cells) and chondrocytes (cartilage) [6].

However, due to stress, inflammation and ageing, this differentiation shifts towards producing more fat cells and fewer osteoblasts, resulting in more brittle and fatty bones [7]. Usually, bone mass starts to decline at the age of 40 as bone loss overtakes the speed of bone growth [8].

Fortunately, there are factors at play that we have control over to mitigate this bone loss.

What are the factors influencing bone health?

Although both our genes and the environment influence bone health, there is only one we have control over. Our genes, for example, determine whether signalling errors occur and lead to birth defects, while the extrinsic factors, such as lifestyle and diet, are crucial for optimising and maintaining bone health. Bone loss, also referred to as osteoporosis, affects people of all different ages and backgrounds. However, other intrinsic factors that are out of our control include:

Age: naturally as we grow older, our bone mass and strength decreases. This is mainly due to decreased osteoblast activity and an increase in osteoblast apoptosis, while inflammation increases [9,10].

Gender: osteoporosis is four times more common in women than men [11].

Body frame size: people with small body frames tend to have a higher risk of bone loss as they have less bone mass to draw from as they age.

Family history: having a parent or sibling with osteoporosis puts you at greater risk..

 

Fortunately, however, we do have the ability to modify extrinsic factors such as physical activity, diet choices and lifestyle choices. Here is how they can disturb bone health:

Tobacco use: smoking contributes to weak bones by disturbing the balance of bone turnover negatively.

Physical inactivity: just like muscles, bones gets stronger by exercising them. Resistance exercise and weight-bearing exercise help with this.

Alcohol use: alcohol interferes with the calcium balance and affects the production of hormones, linking chronic alcohol intake to an increase in bone fractures and falls.

Diet: foods high in calcium, and vitamin D such as dairy products and green leafy vegetables should be consumed in sufficient quantities to support the maintenance of bone health [12]. Additionally, polyphenols such as oleuropein can help mitigate bone loss, especially with age, through their anti-oxidative effects reducing inflammation [13].

If you want to know more about the crucial nutrients for bone health, click here and read our article on the 8 best ingredients.


Basketball player

New Open Label Study: Brainberry® shows cognitive and performance benefits in professional basketball players.

New open-label study: Brainberry® shows cognitive and performance benefits in professional basketball players.

Maastricht, The Netherlands, July 1st, 2022

Press release
BioActor recruited 35 professional Greek male and female basketball players to assess their cognitive and basketball-specific skills after an acute and one-week intake of Brainberry®. Notably, cognitive performance linked to focus, reaction time and hand-eye coordination improved acutely and following a one-week intake. Also, basketball-specific skills like shooting, rebounding and dribbling improved significantly, underlining the ability of Brainberry® to benefit sports performance.

Basketball player

Open-label study in professional basketball players

According to the F.I.B.A. (Fédération Internationale de Basketball), more than 450 million people play basketball worldwide, and about 70.000 of them are professionals. In the US, basketball is one of the most followed sports, and according to Statista, the National Basketball Association (NBA) generates about $6 to $8 billion in revenue per season.

Especially at the top level, nutritional strategies to improve cognition are key to succeeding in this sport. A professional basketball player needs to combine cognitive and physical skills and react to different situations during the game. Moreover, since players need to communicate with each other and their coach while performing, the cognitive load involved in this sport is massive.

Brainberry® is a nootropic ingredient developed by BioActor to help consumers improve their brain fitness in a natural and safe way. More specifically, Brainberry® is an Aronia berry extract from the Baltics, standardized for high levels of cyanidin-3-O-galactoside.

BioActor already conducted 2 double-blind placebo-controlled clinical studies which demonstrated cognitive benefits in middle-aged healthy individuals and in young healthy individuals.

Moreover, in a previous open-label study, Brainberry® improved cognitive performance of amateur gamers. The study revealed that gamers can benefit from the consumption of Brainberry® and improve their gaming skills such as eye-hand coordination and focus.

In follow up to these studies, BioActor now completed another open-label study on 35 professional basketball players in Greece, who consumed 65 mg of Brainberry® for seven days. Basketball is characterized by highly intermittent actions with changes in movement type every 1-2 seconds. Particularly at the highest level, the combination of gross and fine motor skills along with cognitive functions and psychomotor control is key to success. Female and male professional basketball players were selected from teams that participate in the first Greek basketball league.

The objective of the study was to investigate the effect of a daily intake of a capsule containing 65mg of Brainberry® on overall cognitive and basketball-specific skills.

The study results

During the three time points, Baseline (Time 0), Acute (Time 1) and 7 days (Time 2), the participants had to fill out a questionnaire with specific questions aiming at assessing cognitive skills, basketball-specific skills, mood, and sleep quality. At Time 0, the participants did not consume Brainberry®, in order to generate a baseline measurement for their self-reported skills during a basketball session.

The results show that the basketball players who participated in the study experienced a significant improvement (P < 0.05) from day one, in terms of cognitive: focus, reaction time and eye-hand coordination; and basketball-specific skills: shooting, rebounding, and dribbling. At the same time, no significant differences were found in their speed and quality of sleep was not affected.

Results-of-Brainberry-in-basketball-players

*Sig (P < 0.05) baseline vs acute; **Sig (P < 0.05) baseline vs after 7 days and ***Sig (P < 0.05) acute vs 7 days

 

With this additional study, which highlights the ability to enhance cognitive and basketball-specific skills, Brainberry® taps into the sports nutrition segment, where already some sports nutrition brands have adopted the ingredient and formulated products targeting brain fitness for athletes.

Vasiliki Louka, a professional basketball player that belongs to the women’s national Greek team stated:

“Brainberry® surprised me in a good way. This month was really tiring and stressful, especially for the athletes competing for the national team. I felt more focused during my training and considering that Brainberry® contains only natural ingredients, it makes it an interesting choice.”

Furthermore, the participants reported that one of the advantages of Brainberry®, compared to the most common caffeine-based supplements that they have been using, is that Brainberry® did not affect their quality of sleep and, at the same time, helped them decrease their stress level.

 

About BioActor

BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.

Feel free to contact BioActor via info@bioactor.com for more information on the possibilities Brainberry® has to offer.
Further information can be found on: www.brainberry.eu and www.bioactor.com