MEET US - Supply Side West 2023

Meet us at Supply Side West in Las Vegas, 2023!

September 29th, 2023

The Solabia-BioActor team is looking forward to be a part of the premier event for nutraceutical ingredients, Supply Side West in Las Vegas. Mark your calendar for October 25th and 26th, and make sure to visit us at Booth #3544.

Meet us in Las Vegas!

As part of Solabia Nutrition, we are presenting our range of clean-label products, amongst which Brainberry®, MicrobiomeX® and Bonolive®. We invite you to drop by our booth and discover our eco-friendly and sustainable product range. All BioActor ingredients are not only patented but also supported by clinical research conducted at Maastricht University, in the Netherlands.

Additionally, you can explore the active ingredients of Solabia Nutrition and Solabia-Algatech at our booth. We will be displaying a variety of ingredients, like our AstaPure® astaxanthin range, Arava, BioGlena® and BioEcolians®. And there is more!

Latest publications with Actiful® and MicrobiomeX®

We are also eager to share the latest publications with Actiful® and MicrobiomeX®.

The latest publication on, Actiful®demonstrates its ability to support energy and vitality as well as its potential to protect and support the mitochondria.

For MicrobiomeX®, the latest clinical data confirms its ability to support the gut microbiome and increase butyrate production in an elderly subject population.

Join us at Booth #3544, and let’s explore the future of nutraceutical ingredients together!

Book a meeting!



    gut health or butyrate or short chain fatty acids

    New clinical study: MicrobiomeX® improves microbiota composition and SCFA production

    New clinical study: MicrobiomeX® improves microbiota composition and SCFA production

    Maastricht, The Netherlands, 29th September  2023

    Press release

    New clinical and pre-clinical data from a study with MicrobiomeX® have been published in a peer-reviewed journal. It is a randomised, double-blind, placebo-controlled parallel study performed by scientists of Maastricht University, the department of Gastro-enterology of Maastricht University Medical Center and BioActor. It shows the potential of MicrobiomeX® to improve short-chain fatty acid (SCFA) profiles in the intestine. After 12 weeks of daily supplementation, there was a significant shift in the SCFA profile (p=0.022) towards butyrate. In addition, a reduction in faecal calprotectin levels was observed, a marker of gut inflammation. Interestingly, a new in-vitro study in the TIM2 model, where faecal samples from volunteers were tested, also showed a strong increase in butyrate production. These new clinical and pre-clinical results highlight MicrobiomeX®’s potential to support intestinal microbiota of subjects with features of metabolic syndrome.

    gut health or butyrate or short chain fatty acids

    MicrobiomeX®: an an active ingredient supporting the gut microbiome, developed by BioActor

    MicrobiomeX® is a clinically validated blend of Citrus sinensis (sweet orange) and Citrus paradisi (grapefruit) extracts. These fruits are naturally rich in flavonoids, known for their anti-inflammatory and antiviral properties (1, 2). MicrobiomeX® already showed promising potential to reduce markers of gut inflammation and increase SCFAs in previous in-vitro and ex-vivo studies conducted with this ingredient (3, 4). Supplement brands all over the world have adopted MicrobiomeX® in their formulations, typically positioned for improving gut microbiome balance and immune system regulation.

    The study: Citrus Extract High in Flavonoids Beneficially Alters Intestinal Metabolic Responses in Subjects with Features of Metabolic Syndrome

     

    Introduction

    This study (5) was published in the international journal “Foods”. The western diet and lifestyle may be the leading causes for the development of various metabolic disorders. An overlooked factor is the gut microbiota composition, which should be considered as a factor determining health status. A healthy gut is related to mental wellbeing and strong immunity. This study aimed to evaluate the benefits of MicrobiomeX® supplementation on the intestinal microbiome of subjects with metabolic disorder traits.

    Methods

    Fifty adult subjects with features of metabolic syndrome took part in the study. They ingested 500mg MicrobiomeX® or placebo daily for 12 weeks. Additionally, seven volunteers provided faecal samples that were introduced into a TIM-2 system for further analysis. The TIM-2 is a computer-controlled model in an anaerobic environment that replicates the appropriate conditions for microbial growth in the human colon and is able to measure microbiota composition and SCFA production.

    Results

    A significant shift in the SCFA profile towards more butyrate (p=0.022) was observed in the MicrobiomeX® group after the 12-week supplementation period. An increase in SCFA production was also found in the TIM-2 model, that was mainly due to an increased production of butyrate, acetate and valerate. Additionally, in the MicrobiomeX® group, a trend in calprotectin reduction was observed, which is a marker of gut inflammation. Both in vivo and in vitro data confirm the benefits of MicrobiomeX on gut health, specifically the increased butyrate production and improved SCFA profile. These findings are in line with previous in vitro results and show that MicrobiomeX® can beneficially modulate the gut microbiome.

    Conclusion

    This study demonstrates the great potential of MicrobiomeX® in playing a role in gut health modulation. This is indicated by the significant increase in SCFAs, mainly butyrate, and a reduction in calprotectin, as found in the present study. By adding MicrobiomeX® to your supplement, you can offer customers a science-based support for gut health. It is an alternative to common prebiotics and an ideal partner for synbiotic formulation targeting gut health and immunity.

    Click here to read the complete publication

    About BioActor

    BioActor, based in Maastricht, Netherlands is part of the Solabia Group and has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. We focus on the development of innovative activities that address active living and healthy ageing. Our goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

    Feel free to contact via info@bioactor.com for more information on the possibilities MicrobiomeXl® has to offer. Further information can also be found on: https://bioactor.com/products/microbiomex/ and https://microbiomex.com/


    Why are you more easily fatigued as you get older?

    Why are you more easily fatigued as you get older? 

    September 20th, 2023

    Feeling tired all the time? Sleeping or resting is not doing the trick? You might be experiencing more than just regular tiredness – it could be fatigue. As we get older, our energy stores tend to drain more easily, which can contribute to fatigue. Fatigue is a common concern as we age, and it can have a significant impact on our overall well-being. In this article, we’ll explore fatigue in later life, its possible causes, and simple steps you can take to combat it.  

    What is fatigue?

    As we age, it’s common to notice that our energy levels deplete more easily. We may find ourselves wanting to do the things we used to, but realizing we have less energy to perform these things. This change in energy levels can be attributed to fatigue.

    Fatigue is defined as a state of tiredness or exhaustion that comprises a multifaceted combination of mental and physical elements. A crucial aspect of fatigue is that is not solved by simply resting more [1].

    Contributing factors to fatigue at later age

    One of the potential causes of fatigue at a later age is a loss of function in the mitochondria. Mitochondria are the “powerhouses” of the cell, and they produce energy in the form of adenosine triphosphate (ATP) to sustain all processes in the body.

    Loss in function of mitochondria occurs naturally as a result of aging, specifically increased levels of oxidative damage by reactive oxygen species (ROS) cause a decrease in the ability of mitochondria to produce ATP efficiently [2].

    Another common cause of fatigue at a later age may be related to the cardiovascular system since aging induces a functional and structural decline in the cardiovascular system [3]. Although the mechanisms are unclear at this moment, it is likely that increased arterial stiffness and reduced cardiac output are related to causing fatigue [4].

    Other factors contributing to fatigue at a later age could be:

    Hormonal changes: Experiencing hormonal changes as we age is a common symptom. In women, menopause causes decreased production of estrogen and progesterone. These hormonal fluctuations may lead to feeling fatigued [5].

    Lack of physical activity: We might become more sedentary as we age, due to several factors. However, this may lead to, for example, mood disturbances, poorer sleep quality, or even changes in your metabolism.

    Nutrient deficiencies: As we age, nutrient absorption and intake can be affected by various factors, such as the use of medication, changes in dietary patterns, and changes in gastrointestinal health [6].

    Boosting your energy level

    Unfortunately, aging is a process that cannot be reversed, so preventing fatigue is not avoidable. However, don’t despair! There are a number of easy lifestyle habits that can help: exercise regularly, participate in social activities you enjoy, and eat a well-balanced diet [6].

    A well-balanced diet can be optimized by the implementation of supplements into your diet. Supplements can be a valuable addition to your diet since they address potential nutritional deficiencies and support your overall health and well-being.

    Which nutrients help to beat fatigue?

    Nutritional deficiencies often contribute to feelings of fatigue, so ensuring adequate nutrient levels is essential. Here are some key nutrients that can help in overcoming fatigue [7,8]:

    1. Iron: This vital mineral supports oxygen supply to the muscles and plays a crucial role in energy production. It is also an important part in the structure of the enzymes responsible for ATP production.

    2. Magnesium: Another important mineral involved in energy production, magnesium activates ATP synthase, an enzyme responsible for synthesizing ATP. It also serves various functions related to energy production, muscle function, bone health, and protein synthesis.

    3. Vitamin C: This essential nutrient aids in fighting fatigue by enhancing iron absorption and safeguarding red blood cells from oxidative stress. By promoting improved oxygen supply to the muscles, vitamin C contributes to combating fatigue.

    4. B vitamins: B vitamins play a multifaceted role in energy production. They are integral to the metabolism of macronutrients and also support the production of red blood cells, indirectly contributing to oxygen supply.

    5. Bioflavonoids: These polyphenolic compounds offer numerous health benefits, like improved blood flow and increased mitochondrial efficiency. Actiful®, a substance rich in the bioflavonoid hesperidin, is particularly a good option to consider.

    3. Actiful®: A natural ingredient for more energy

    Actiful® is an orange & pomegranate complex, containing a high amount of micronized hesperidin. The ingredient is developed to boost vitality and optimize energy levels.

    A proprietary clinical trial by BioActor showed that Actiful® provides immediate and sustained energy. It does so by improving blood flow to active muscles and optimizing the respiration capacity of mitochondria, in turn increasing ATP production [9].

    Actiful®’s positive effect on blood flow is linked to vasodilative capacities of the active metabolites. Micronized hesperidin promotes vasodilation by stimulating the production of nitric oxide [10]. Nitric oxide relaxes the blood vessels, thereby enlarging their diameter and allowing the passage of a greater amount of nutrient-rich blood and oxygen.

    As a bonus, Actiful® positively affects mental well-being. In our proprietary clinical trial, we showed a significant improvement in concentration, thinking, memory, and learning [11]. These aspects are vital for overall well-being and quality of life.

    Overall, Actiful® is a safe, healthy, and natural ingredient which is perfect to be incorporated into energy-providing supplements.


    Actiful: a sweet orange and pomegranate extract suitable for supplements

    New publication of clinical data: Actiful® reduces Methylglyoxal, an important marker for healthy aging

    New publication of clinical data: Actiful® reduces Methylglyoxal, an important marker for healthy ageing

    Maastricht, The Netherlands, 15th September  2023

    Press release

    A randomized double blinded crossover study performed by Maastricht University, showed the potential of Actiful® as a dietary modulator against advanced glycation end-products (AGEs). AGEs are associated with various age-related chronic diseases. After a 4-week period of Actiful® consumption in healthy elderly subjects, plasma levels of methylglyoxal (MGO) decreased significantly by 9.8% (p = 0.042). These new clinical results highlight Actiful®’s potential to mitigate age-related diseases like diabetes, vascular dysfunction and neurodegeneration. 

    Actiful: a sweet orange and pomegranate extract suitable for supplements

    Actiful®: an energy-boosting ingredient developed by BioActor

    Actiful® is a clinically validated blend of Citrus sinensis (sweet orange) and Punica granatum (pomegranate) extracts. These plants are abundant in bioactive polyphenolic components, mainly flavonoids (1, 2) . Actiful® has a dual mode of action: by increasing synthesis of nitric oxide and by improving ATP production through an increased mitochondrial respiration efficiency (3). In the first clinical study, Actiful® demonstrated to improve energy, mood and antioxidant status in healthy elderly individuals. Actiful® is used globally by leading supplement brands in a vast array of products supporting an active lifestyle and healthy aging.

    The study: A Citrus and Pomegranate Complex Reduces Methylglyoxal in Healthy Elderly Subjects: Secondary Analysis of a Double-Blind Randomized Cross-Over Clinical Trial

     

    Introduction

    This study (4) was published in the International Jouranl of Molecular Sciences . It focuses on the evaluation of additional biomarkers and the effect of Actiful® in reducing the concentrations of reactive α-dicarbonyl compounds (specifically methylglyoxal, glyoxal, and 3-deoxyglucosone) in the blood of healthy elderly participants. These α-dicarbonyls are known to contribute to the formation of advanced glycation end-products (AGEs), which are associated with various chronic diseases, including diabetes and cardiovascular diseases (5).

    Methods

    Thirty-six healthy elderly subjects were recruited for this double-blind, randomized crossover clinical trial. They received either 700 mg of Actiful® in capsules, or a placebo for four weeks, with a 4-week washout period in between.

    Blood samples were collected during the test day to measure α-Dicarbonyls in plasma. This was achieved via ultra-performance liquid chromatography tandem mass spectrometry.

    Results

    A significant reduction in plasma methylglyoxal concentrations was observed during a 4-week supplementation period. This reduction suggests a potential benefit in terms of reducing the formation of harmful AGEs, which could be attributed to the antioxidant properties of the active compounds in the supplement. The observed reduction in methylglyoxal was around 9.8%, which could be of clinical relevance in preventing or managing age-related conditions related to AGEs formation, like cardiovascular related diseases, diabetes and neurodegeneration. This confirms the importance of exploring promising nutraceuticals like Actiful® as potential healthy ageing strategies to mitigate the impact of reactive α-dicarbonyl compounds on health.

    Conclusion

    This study demonstrates the great potential of Actiful® for playing a role in healthy ageing. This is indicated by the significant reduction in AGEs, specifically MGO, found in the present study.

    Click here to read the complete publication

    About BioActor

    BioActor, based in Maastricht, Netherlands is part of the Solabia Group and has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. We focus on the development of innovative activities that address active living and healthy ageing. Our goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

    Feel free to contact via info@bioactor.com for more information on the possibilities Actiful® has to offer. Further information can also be found on: https://actiful.eu and https://bioactor.com/products/actiful


    Bonolive for your women's health product

    5 reasons to use Bonolive® in your women’s health product

    5 reasons to use Bonolive® in your women’s health product

    September 5th, 2023

    Bonolive® is an extract based on olive polyphenols that contains a high amount of oleuropein, a potent phytonutrient found primarily in olive trees. Numerous studies have demonstrated the beneficial properties of Bonolive®, including mitigation of potential risks associated with menopause. In this blog, we will explore some of the scientific evidence supporting the health benefits of olive polyphenols and why you should use it in your women’s health product.

    Bonolive for your women's health product

    Bonolive®: Mediterranean support for women’s health

    Bonolive® is a natural compound sourced from olive leaves. It’s standardized to contain high levels of olive polyphenols, specifically Oleuropein.

    Developed by BioActor, its primary aim is to support women’s health during the post-menopausal phase (1). This period often introduces various health challenges, such as decreased bone density, joint discomfort, and a heightened risk of cardiovascular problems.

    Numerous clinical studies consistently highlight the positive effects of supplementing with Bonolive® (1 , 2 , 3). These studies have revealed that Bonolive® plays a role in enhancing bone strength, reducing joint discomfort, balancing lipid profiles, and easing specific menopause-related symptoms.

    Consequently, it contributes to lowering the risk of developing conditions like osteoporosis (brittle bones) and heart issues as time progresses.

    Oleuropein: the hero compound of Bonolive®

    Olive oil holds a pivotal role in the Mediterranean diet (4). The primary polyphenols in olive oil are Oleuropein and its metabolite hydroxytyrosol. These polyphenols have been extensively studied and recognized for their preventive benefits against various disorders.

    Researchers have unraveled their mechanisms, showing promise in reducing risks of breast cancer, ovarian cancer, postmenopausal osteoporosis, and other health issues.

    Bonolive® is standardized to contain Oleuropein. Because of this, Bonolive® is a perfect match for adding to dietary supplements and functional beverages made to support women’s health during menopause.

    5 reasons to use Bonolive® in your women’s health product

    1. Bonolive® improves bone health and reduces joint discomfort

    Bonolive® has demonstrated its positive influence on bone and joint health (1). An investigation centered on post-menopausal women with reduced bone mass unveiled a notable surge in a foundational protein that serves as the framework for generating new bone. Moreover, an improvement in bone mineral density was seen.

    In a recent six-month study involving 124 participants aged 55 and above, the efficacy of Bonolive® came to light. It brought relief to joint discomfort linked to activities like walking, bending, and knee movement (2).

    Consequently, a daily dosage of 250 mg of Bonolive® proves sufficient to deliver advantageous outcomes for both bone and joint well-being.

    2. Bonolive® reduces menopause related symptoms

    BioActor undertook a consumer study aimed at assessing the benefits of Bonolive® among post-menopausal women. This investigation unveiled the favorable influence of Bonolive® on alleviating menopause-related symptoms in this demographic.

    The study focused on women who had already gone through menopause, aiming to see how Bonolive® affected their reported symptoms. For 28 days, participants took Bonolive® regularly. After just 14 days, they felt better in terms of bloating, anxiety, mood swings, energy levels, and skin health. This improvement continued even after the full 28 days of using Bonolive®.

    This reinforces the potential of Bonolive® in enhancing the well-being of post-menopausal women.

    3. Bonolive® has favorable effects on lipid control

    Clinical research has shown the favorable impacts of Bonolive® in managing the blood lipid profile among post-menopausal women (1). Notably, supplementation with 250mg of Bonolive® over a 12-month period led to significant improvements. Specifically, a significant reduction in LDL-cholesterol, total cholesterol, and triglycerides was observed.

    4. Bonolive® has a superior bioavailability

    Another study aimed to assess the bioavailability of Bonolive®. Interestingly, a more substantial increase in the levels of metabolites in the blood of post-menopausal women was observed compared to women who hadn’t gone through menopause yet. This suggests that post-menopausal women experienced higher absorption of Bonolive®.

    Additionally, the study revealed that Bonolive® possesses antioxidant effects, as evidenced by its ability to reduce levels of a substance called MDA, which is a marker of oxidative stress.

    5. Bonolive® is a sustainable solution

    Olive trees hold the distinction of being among the oldest cultivated trees globally. However, the surge in olive oil production has taken a toll on the environment (5).

    The primary waste generated during olive growth is the pruned leaves of the olive trees. Yet, these leaves contain valuable compounds of which oleuropein is one. This is why Bonolive® is made from the freshly cut olive leaves, meaning it is a clean, sustainable and natural ingredient for a women’s health product.

    Bonolive®: A key ingredient for women’s health

    Studies have found that Bonolive® can help women stay healthy after menopause. Using Bonolive® as an olive polyphenol extract can bring big benefits to women’s health products. Bonolive® can be used in many different products and has lots of advantages. It’s a great ingredient to promote a healthier lifestyle and improve women’s well-being.

    Curious to read about the clinical studies on Bonolive® in more detail? Download our white paper below!