Solabia BioACtor Quadram Institute

BioActor & Quadram Institute announce collaboration

Solabia-BioActor announces the start of a collaboration with The Quadram Institute to assess the bioavailability and kinetics of Brainberry®

Maastricht/Norwich, 29th November  2023

Solabia-BioActor announces the start of a collaboration with The Quadram Institute to assess the bioavailability and kinetics of Brainberry®, Solabia-BioActor’s proprietary Aronia melanocarpa extract.

Solabia BioActor Quadram Institute

Solabia-BioActor has expertise and experience in developing innovative active ingredients, extracted from plants (botanicals) with great potential to support human health in terms of cognitive support, healthy aging and gut health enhancement.

 

The Quadram Institute is a premier research organization, based at the Norwich Research Park in the United Kingdom. It is home to researchers and clinicians that work together to develop world-class health, microbiome and food science. 

 

Solabia-BioActor’s Senior Scientist Sanne Ahles takes the lead on this collaboration together with Dr. Paul Kroon, a principal investigator at The Quadram Institute. Dr. Kroon is the leader of the Polyphenols and Health Group and his research focuses on understanding the mechanisms by which dietary polyphenols are absorbed and exert health benefits.

 

The objective of this project is to study the bioavailability and kinetics of Brainberry®, a proprietary aronia melanocarpa extract, in human volunteers. BioActor will carry-out the human intervention study and the Quadram Institute will identify and quantify a broad range of metabolites in a variety of samples obtained in the study.

Sanne Ahles, Senior Scientist at Solabia-BioActor comments:

“The bioavailability of Brainberry® has not been researched until this point. This collaboration with the Quadram Institute will allow us to broaden our knowledge regarding the anthocyanin metabolism and shed light on any possible differences between its steady-state bioavailability in young and older adults.”

About Solabia-BioActor

Solabia-BioActor, based in Maastricht, Netherlands, is a product development company that develops and supplies proprietary bioactive formulations to the health and sports nutrition industry. All Solabia-BioActor’s products are clinically tested, doping-free and from natural origin. The main focus areas are: gut microbiome, brain health, energy & vitality and skin health.


top 6 ingredients for cognition and eye health

Top 6 ingredients for cognition and eye health

Top 6 ingredients for cognition and eye health

November 22nd, 2023

All of our senses allow us to enjoy the world around us and vision is no exception. Cognition is essential to make something meaningful of all senses. As you can imagine, nutrition is crucial in maintaining healthy vision and cognition, since several nutrients are essential for the visual system. In this blog, we embark on a journey to discover these essential nutrients, and, as a bonus, discuss a few compounds that can actually enhance cognition and eye-health!

top 6 ingredients for cognition and eye health

The connection between cognition and vision

Cognition is a broad term encompassing thinking, learning, memory, and attention; in other words, it refers to all the mental processes that occur in the brain (1). Vision functions as a key information provider to cognition. This relationship between the brain and eyes is crucial since vision can impact performance of cognitive tasks, positively or negatively. Deterioration of eye performance is actually linked to a reduction in cognitive activities like reading and socializing, notably leading to a poor cognitive state (2).

 

Challenges for a healthy vision

In our modern-day society, numerous factors present challenges to the well-being of both our vision and cognition. One essential challenge is the abundance of time spent behind screens. Digital eye strain is a condition that is attributed to prolonged and extended use of digital screens typically related to symptoms like blurry vision, headaches and dry eyes (3).

 

According to the American Optometric Association, workers and regular users of digital screen devices are especially at risk. Screen time of two or more hours without interruption, can already lead to aforementioned symptoms (4). More than 60% of the working population in the US report having symptoms related to too much screen time. Moreover, >70% of children and adolescents exceed the two hour screen time as well (5).

 

Given the extent of the challenges, it becomes imperative to adopt proactive measures to mitigate their effects and safeguard eye health, and cognition by extent. By addressing these factors head-on, we can not only slow down the development of age-related degenerative processes but also actively support the resilience and vitality of our eyes and cognitive functions.

Taking care of our eyes

How should we take care of our eyes? Let’s discuss a couple of easily adoptable measures:

 

Regular eye check-ups. It’s advisable to have a comprehensive eye examination every two years, regardless of wearing glasses or not (6). Optometrists may prescribe glasses with anti-reflective coatings to protect eyes from harmful blue light emitted by electronic devices.

 

Adopting eye-friendly behavior. The 20-20-20 rule is a simple and effective measure to reduce eye strain. It encompasses the idea to look at an object at least 20 feet (6 meters) away for 20 seconds, every 20 minutes (7). In order to make this a habit, you can opt to put a timer every 20 minutes when you are at work.

 

A diet rich in eye-healthy foods. Nutrition is a crucial modifiable factor with the potential for a huge effect on our daily life. There are sources that naturally contain compounds that help in maintaining a healthy vision and cognition. You can think of eggs, fatty fish, certain seeds, nuts and berries.

 

Eye health supplements. If you are limited by inconvenience or geographical access for food choice, it can be tricky to consume nutrients in recommended quantities through a regular diet. Therefore, adding nutritional supplements is a great additional strategy for reaching the required amount of nutrients in a safe and convenient manner.

food for eye health

The 6 best ingredients for cognition and eye health

When choosing to select supplements for supporting cognition and eye health, you consider a couple of relevant ingredients. Let’s check out the six to keep in mind:

 

Vitamin A is essential to protect the outer surface of the eye, known as the cornea. It also maintains the function of the retina, which allows us to differentiate colors and shades. Vitamin A can be obtained from yolks, liver and some vegetables like carrots (8). Supplementation is advised if the recommended daily dose cannot be reached via the diet – 900mcg for men and 700mcg for women.

 

Lutein is a yellow carotenoid pigment, found in the central retina. Its function is to protect against the harmful blue light (9), often emitted by electronic devises. Lutein supplementation may reduce the risk of developing harmful eye conditions. Common sources of lutein include green peas, parsley and kale as well as egg yolks. The daily dose of lutein supplements is between 5-20 mg.

 

Astaxanthin is a well-known anti-oxidant, often referred to as “the king of the caretonoids”, with health benefits in multiple areas, amongst which eye health. It improves ocular blood flow, enhancing oxygen distribution and waste clearance in the eyes (10). Astaxanthin can be obtained by eating salmon, shrimp and lobster. However, for supplementation purposes, there is a great alternative through microalgae sources, which is a natural and animal-friendly alternative. Supplementation daily dose varies between 4-12 mg (11).

 

Omega 3 fatty acids are a great strategy for overall health support, including the eyes. Omega-3s could reduce the risk of dry eyes and high eyes pressure (12). Food sources of omega 3 include salmon, herring and tuna. Additionally, supplements derived from fish, krill or microalgae are widely available. The daily dose for supplementation ranges from 500-600mg.

 

Vitamin E protects the retina from harmful oxidation. It’s crucial for optimal eye health and can be mostly obtained by eating seeds and nuts (13). Daily supplementation dose ranges between 5-12mg (14).

 

Aronia berry extract. Aronia berries are fruits with a high concentration of anthocyanins, specifically cyanidin-3-0-glycosides (15). These compounds are linked to benefits for cognition, focus, and eye health. BioActor’s proprietary Aronia berry extract, Brainberry®, has been demonstrated to improve focus, concentration and hand-eye coordination at a low daily dose of only 65 mg (16, 17).


postbiotics

Exploring the power of postbiotics: benefits and uses

Exploring the power of postbiotics: benefits and uses

October 18th, 2023

Currently, probiotics and prebiotics are widely known for their favorable impact on gut health. More recently, the focus has expanded to include postbiotics, which encompass products or byproducts generated through microbial fermentation and are also acknowledged for their health advantages. Nevertheless, these postbiotics remain unfamiliar to most consumers. Dive into our new blog to find out more!

postbiotics

What are postbiotics?

Gut health is key to your overall well-being and there are many ways to support your gut health. Prebiotics and probiotics are well-known, but what about probiotics?

Postbiotics encompass a class of substances defined as “preparations containing non-living microorganisms or their components, which bring about positive health effects for the host.” In simpler terms, they refer to the byproducts or metabolic products that result from the fermentation processes of bacteria.

This category of postbiotics encompasses various kinds of compounds. Among them are short-chain fatty acids, known for their multiple health advantages, as well as fragments of microbial cells, functional proteins, extracellular polysaccharides, cell lysates, and teichoic acid.

In contrast to probiotics, postbiotics offer health benefits without requiring a live state. This characteristic contributes to their stability compared to the live bacteria they originate from. [1]

Why should I use postbiotics?

A question on your mind might be: why should you consider postbiotics when you’re already using pre- and probiotics?

It’s crucial to recognize that everyone’s gut microbiota composition differs. As a result, the way various components are processed can vary from person to person.

This means that the impact of probiotics and prebiotics on health can differ among individuals. A way to control for this is by consuming postbiotics. You are then directly taking the beneficial components, so differences in microbiota composition don’t have an effect in this case.

If you’re interested in learning more about prebiotics, you can refer to this article. Alternatively, if you’re already familiar with prebiotics, you might find this article on synbiotics to be of interest!

What are the advantages for health that postbiotics offer?

Research indicates that postbiotics can bring forth a range of health benefits, including:

Balancing the microbiota: Elements found in postbiotics, like butyrate, a type of short-chain fatty acid, prove advantageous for maintaining gut health. [2]

Influencing the immune system: Butyrate has the ability to trigger the generation of T cells within the intestinal tract, thereby aiding in the regulation of immune responses. Additional components, such as fragments of microbial cell walls, can enhance the production of cytokines—chemical messengers that mitigate inflammation and bolster immune reactions. [2,3]

Shaping metabolic processes: Short-chain fatty acids such as propionate play a role in enhancing insulin sensitivity and glucose tolerance. Simultaneously, butyrate spurs the generation of an antioxidant called glutathione. [1,2]

Assisting in weight loss: Short-chain fatty acids could contribute to weight loss by influencing eating behaviors. This is attributed to the release of hormones that induce a sense of fullness. [1]

Easing symptoms of irritable bowel syndrome (IBS): In a study involving 443 individuals with IBS, the administration of orally ingested, heat-inactivated Bifidobacterium bifidum, a postbiotic, notably alleviated IBS-related symptoms such as abdominal pain, discomfort, bloating, and irregular bowel habits. [4] Curious to read about the effect of pre- and probiotics on IBS symptoms? Read more here!

Potential additional advantages: Administering inactivated lactic acid bacteria orally might aid in eradicating Helicobacter pylori infection, addressing chronic unexplained diarrhea, and mitigating the adverse impacts of stress. [1]

How can I incorporate postbiotics into my diet effectively?

Postbiotics might not be as readily available as probiotics and prebiotics, but you can acquire them from health food stores or online retailers. They are generally regarded as safe and well-tolerated.

Given that postbiotics are a product of bacterial fermentation within your gut, you can enhance their production by consuming foods abundant in probiotics and prebiotics. Probiotic-rich options include fermented foods like yogurt, kefir, tempeh, and kombucha. For prebiotics, focus on incorporating high-fiber foods into your diet, such as vegetables and whole-grain products.


MEET US - November 2023

Meet us in November 2023 at different events across Europe!

November 10th, 2023

The Solabia-BioActor team will be out and in about again in November 2023. Below you will find where you can meet our team in person at multiple international events!

14th European Nutrition Conference FENS in Belgrade, Serbia

14-17 November 2023

Our clinical researcher Sanne Ahles will present at the 14th European Nutrition Conference, at the Sava Center in Belgrade. Her presentation on how Aronia melanocarpa extract (Brainberry®) supplementation could improve cognitive performance will take place on 15 November in Room 9 from 13:30 till 15:00.

In-Vitality, Milan, Italy

22-23 November 2023

Valeria Mastromartino, Account Manager Italy, will be present at In-Vitality in Milan. This is a B2B exhibition and conference for health ingredients, supplements and functional foods in Italy, the biggest European market for supplements. Feel free to reach out to Valeria to arrange a meeting!

Food Ingredients Europe, Frankfurt, Germany

28-30 November, 2023

Hans van der Saag, CEO, and Joris Kretzers, Commercial Director, will visit FI Europe in Frankfurt. FI Europe is a great opportunity to observe market trends in the European markets, and meet with valued customers and business partners. Reach out to either Hans or Joris to arrange a quick get-together in Frankfurt!

Book a meeting!



    WEBINAR (french)- Women's Health EU Market

    WEBINAR in french – Women’s Health EU market

    European Women’s health market, clinical data and product concepts with Bonolive® to support women during menopause.

    Webinar: 7th November 2023 – 15:00 CEWT

    More than ever, nutrition and supplementation are recognized to be effective strategies to address women’s health. Watch our latest webinar to learn more about the EU market for women’s health supplements, clinical evidence supporting Bonolive®, and product formulations. Watch now on demand!

    WATCH ON DEMAND

    The European Women’s Health market is growing. Join our webinar to explore evolving trends with a focus on France, address needs across ages, and uncover recent developments. Experts will discuss key factors shaping women’s health, providing insights for global advancement.

    Menopause is an important stage of every women’s life. It brings unique challenges due to hormonal changes. From short-term concerns like hot flashes to long-term risks like cardiovascular issues and bone loss , nutrition and supplementation are crucial for support.

    Discover Bonolive® and how BioActor’s olive polyphenol-based ingredient supports women during peri- and post-menopause!

    What are you going to learn during this webinar?

    European Women’s Health Market & Trends in France

    Presentation by Aurore de Monclin from the Healthy Marketing Team, who is going to talk about the present state of the European Women’s Health market, the key considerations for women belonging to various age groups, and the trends within the french market.
    Duration: 10 minutes

    Clinical Research

    Presentation provided by Maria Imperatrice – our in house clinical researcher, and presented by Billie Icheva – our Marketing Officer. You will be introduced to the science behind Bonolive® and the clinical trials showing the positive effect of Bonolive® on cardiovascular health, bone health and mobility.
    Duration: 10 minutes

    Formulating with Bonolive®

    Presentation by Tony Payet– Sales Manager Europe, who will dive into Bonolive® mode of action, a new consumer study on its effect and product formulation examples related to women’s health.
    Duration: 10 minutes

    Q&A session

    Duration:  5 minutes

    WATCH ON DEMAND

    Brainberry®: Winner of Ingredient Idol 2023

    Brainberry® is the Winner of Ingredient Idol 2023, Nootropics 

    Maastricht, The Netherlands, 2nd November  2023

    We are happy to announce that Brainberry® won the Ingredient Idol 2023 award in the Nootropics Category! The contest was organized by Informa Markets and held at SupplySide West on October 26, 2023 in Las Vegas.

    Ingredient Idol winner

    Out of all ingredients that were submitted for the competition in the Nootropics category, Brainberry® was selected as one of the three finalists that was invited to give a 3-min elevator pitch at the SupplySide West show in Las Vegas. Brainberry® was voted as Winner by the respected jury because of its unique clinically validated benefits on psychomotor control, better focus and mental flexibility.

    Judges were three experienced professionals in the field of health and nutrition:

    • David Foreman, also known as “The Herbal Pharmacist” is an established author, and currently on the  editorial advisory board for Nutritional Outlook and on the content advisory board for Vitafoods Europe, Vitafoods Asia and Vitafoods Insights.

     

    • Douglas Lynch, CEO of MarketWell Nutrition Inc., has three decades of experience in the clinical nutrition and wellness industries. He has an award-winning product background in sales and marketing of dietary supplements, medical foods, functional foods, cosmetics, animal nutrition, and proprietary actives.

     

    • Diana Morgan, VP of global regulatory and government affairs for Nutrabolt, makers of the famous C4 Energy, is the founder of What’s Up with Supps. She has numerous years of experience in the natural products industry, having worked for reputable brands in the US nutritional supplement industry.

    We are thankful to the jury and all visitors at SupplySide West for voting Brainberry® as the winner in the Nootropics category of Ingredient Idol 2023. Brainberry® was recognized for its advantages such as the low daily dose of 65mg, clinically backed benefits for improving focus and eye-hand coordination, and convenience of formulating in different product formats.

    We strongly believe in the importance of clinical research backing up all our ingredients in order to offer true innovation in the health ingredients market. Brainberry® is an extract from Aronia Melanocarpa, standardized for Cyanadin-3-O-glycosides (>25%) and, specifically cyanidin-3-O-galactoside (>15%). It is able to cross the blood-brain barrier and improve neuronal signaling and synaptic plasticity. It is positioned for brain and cognitive support suitable for students, workers, gamers and athletes.

    Consumer studies with acute and 7-days intake of 65mg Brainberry® among gamers and professional basketball players demonstrate improved eye-hand coordination, focus and reaction time, without negative impact on sleep or anxiety in self-reported questionnaires.

     

    To learn more about Brainberry®, visit www.brainberry.eu, to explore other clinically validated ingredients by Solabia-BioActor, click here.