Why are you more easily fatigued as you get older?
Why are you more easily fatigued as you get older?
Feeling tired all the time? Sleeping or resting is not doing the trick? You might be experiencing more than just regular tiredness – it could be fatigue. As we get older, our energy stores tend to drain more easily, which can contribute to fatigue. Fatigue is a common concern as we age, and it can have a significant impact on our overall well-being. In this article, we’ll explore fatigue in later life, its possible causes, and simple steps you can take to combat it.
What is fatigue?
As we age, it’s common to notice that our energy levels deplete more easily. We may find ourselves wanting to do the things we used to, but realizing we have less energy to perform these things. This change in energy levels can be attributed to fatigue.
Fatigue is defined as a state of tiredness or exhaustion that comprises a multifaceted combination of mental and physical elements. A crucial aspect of fatigue is that is not solved by simply resting more [1].
Contributing factors to fatigue at later age
One of the potential causes of fatigue at a later age is a loss of function in the mitochondria. Mitochondria are the “powerhouses” of the cell, and they produce energy in the form of adenosine triphosphate (ATP) to sustain all processes in the body.
Loss in function of mitochondria occurs naturally as a result of aging, specifically increased levels of oxidative damage by reactive oxygen species (ROS) cause a decrease in the ability of mitochondria to produce ATP efficiently [2].
Another common cause of fatigue at a later age may be related to the cardiovascular system since aging induces a functional and structural decline in the cardiovascular system [3]. Although the mechanisms are unclear at this moment, it is likely that increased arterial stiffness and reduced cardiac output are related to causing fatigue [4].
Other factors contributing to fatigue at a later age could be:
Hormonal changes: Experiencing hormonal changes as we age is a common symptom. In women, menopause causes decreased production of estrogen and progesterone. These hormonal fluctuations may lead to feeling fatigued [5].
Lack of physical activity: We might become more sedentary as we age, due to several factors. However, this may lead to, for example, mood disturbances, poorer sleep quality, or even changes in your metabolism.
Nutrient deficiencies: As we age, nutrient absorption and intake can be affected by various factors, such as the use of medication, changes in dietary patterns, and changes in gastrointestinal health [6].
Boosting your energy level
Unfortunately, aging is a process that cannot be reversed, so preventing fatigue is not avoidable. However, don’t despair! There are a number of easy lifestyle habits that can help: exercise regularly, participate in social activities you enjoy, and eat a well-balanced diet [6].
A well-balanced diet can be optimized by the implementation of supplements into your diet. Supplements can be a valuable addition to your diet since they address potential nutritional deficiencies and support your overall health and well-being.
Which nutrients help to beat fatigue?
Nutritional deficiencies often contribute to feelings of fatigue, so ensuring adequate nutrient levels is essential. Here are some key nutrients that can help in overcoming fatigue [7,8]:
1. Iron: This vital mineral supports oxygen supply to the muscles and plays a crucial role in energy production. It is also an important part in the structure of the enzymes responsible for ATP production.
2. Magnesium: Another important mineral involved in energy production, magnesium activates ATP synthase, an enzyme responsible for synthesizing ATP. It also serves various functions related to energy production, muscle function, bone health, and protein synthesis.
3. Vitamin C: This essential nutrient aids in fighting fatigue by enhancing iron absorption and safeguarding red blood cells from oxidative stress. By promoting improved oxygen supply to the muscles, vitamin C contributes to combating fatigue.
4. B vitamins: B vitamins play a multifaceted role in energy production. They are integral to the metabolism of macronutrients and also support the production of red blood cells, indirectly contributing to oxygen supply.
5. Bioflavonoids: These polyphenolic compounds offer numerous health benefits, like improved blood flow and increased mitochondrial efficiency. Actiful®, a substance rich in the bioflavonoid hesperidin, is particularly a good option to consider.
3. Actiful®: A natural ingredient for more energy
Actiful® is an orange & pomegranate complex, containing a high amount of micronized hesperidin. The ingredient is developed to boost vitality and optimize energy levels.
A proprietary clinical trial by BioActor showed that Actiful® provides immediate and sustained energy. It does so by improving blood flow to active muscles and optimizing the respiration capacity of mitochondria, in turn increasing ATP production [9].
Actiful®’s positive effect on blood flow is linked to vasodilative capacities of the active metabolites. Micronized hesperidin promotes vasodilation by stimulating the production of nitric oxide [10]. Nitric oxide relaxes the blood vessels, thereby enlarging their diameter and allowing the passage of a greater amount of nutrient-rich blood and oxygen.
As a bonus, Actiful® positively affects mental well-being. In our proprietary clinical trial, we showed a significant improvement in concentration, thinking, memory, and learning [11]. These aspects are vital for overall well-being and quality of life.
Overall, Actiful® is a safe, healthy, and natural ingredient which is perfect to be incorporated into energy-providing supplements.
New publication of clinical data: Actiful® reduces Methylglyoxal, an important marker for healthy aging
New publication of clinical data: Actiful® reduces Methylglyoxal, an important marker for healthy ageing
Press release
A randomized double blinded crossover study performed by Maastricht University, showed the potential of Actiful® as a dietary modulator against advanced glycation end-products (AGEs). AGEs are associated with various age-related chronic diseases. After a 4-week period of Actiful® consumption in healthy elderly subjects, plasma levels of methylglyoxal (MGO) decreased significantly by 9.8% (p = 0.042). These new clinical results highlight Actiful®’s potential to mitigate age-related diseases like diabetes, vascular dysfunction and neurodegeneration.
Actiful®: an energy-boosting ingredient developed by BioActor
Actiful® is a clinically validated blend of Citrus sinensis (sweet orange) and Punica granatum (pomegranate) extracts. These plants are abundant in bioactive polyphenolic components, mainly flavonoids (1, 2) . Actiful® has a dual mode of action: by increasing synthesis of nitric oxide and by improving ATP production through an increased mitochondrial respiration efficiency (3). In the first clinical study, Actiful® demonstrated to improve energy, mood and antioxidant status in healthy elderly individuals. Actiful® is used globally by leading supplement brands in a vast array of products supporting an active lifestyle and healthy aging.
The study: A Citrus and Pomegranate Complex Reduces Methylglyoxal in Healthy Elderly Subjects: Secondary Analysis of a Double-Blind Randomized Cross-Over Clinical Trial
Introduction
This study (4) was published in the International Jouranl of Molecular Sciences . It focuses on the evaluation of additional biomarkers and the effect of Actiful® in reducing the concentrations of reactive α-dicarbonyl compounds (specifically methylglyoxal, glyoxal, and 3-deoxyglucosone) in the blood of healthy elderly participants. These α-dicarbonyls are known to contribute to the formation of advanced glycation end-products (AGEs), which are associated with various chronic diseases, including diabetes and cardiovascular diseases (5).
Methods
Thirty-six healthy elderly subjects were recruited for this double-blind, randomized crossover clinical trial. They received either 700 mg of Actiful® in capsules, or a placebo for four weeks, with a 4-week washout period in between.
Blood samples were collected during the test day to measure α-Dicarbonyls in plasma. This was achieved via ultra-performance liquid chromatography tandem mass spectrometry.
Results
A significant reduction in plasma methylglyoxal concentrations was observed during a 4-week supplementation period. This reduction suggests a potential benefit in terms of reducing the formation of harmful AGEs, which could be attributed to the antioxidant properties of the active compounds in the supplement. The observed reduction in methylglyoxal was around 9.8%, which could be of clinical relevance in preventing or managing age-related conditions related to AGEs formation, like cardiovascular related diseases, diabetes and neurodegeneration. This confirms the importance of exploring promising nutraceuticals like Actiful® as potential healthy ageing strategies to mitigate the impact of reactive α-dicarbonyl compounds on health.
Conclusion
This study demonstrates the great potential of Actiful® for playing a role in healthy ageing. This is indicated by the significant reduction in AGEs, specifically MGO, found in the present study.
About BioActor
BioActor, based in Maastricht, Netherlands is part of the Solabia Group and has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. We focus on the development of innovative activities that address active living and healthy ageing. Our goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.
Feel free to contact via info@bioactor.com for more information on the possibilities Actiful® has to offer. Further information can also be found on: https://actiful.eu and https://bioactor.com/products/actiful
5 reasons to use Bonolive® in your women’s health product
5 reasons to use Bonolive® in your women’s health product
Bonolive® is an extract based on olive polyphenols that contains a high amount of oleuropein, a potent phytonutrient found primarily in olive trees. Numerous studies have demonstrated the beneficial properties of Bonolive®, including mitigation of potential risks associated with menopause. In this blog, we will explore some of the scientific evidence supporting the health benefits of olive polyphenols and why you should use it in your women’s health product.
Bonolive®: Mediterranean support for women’s health
Bonolive® is a natural compound sourced from olive leaves. It’s standardized to contain high levels of olive polyphenols, specifically Oleuropein.
Developed by BioActor, its primary aim is to support women’s health during the post-menopausal phase (1). This period often introduces various health challenges, such as decreased bone density, joint discomfort, and a heightened risk of cardiovascular problems.
Numerous clinical studies consistently highlight the positive effects of supplementing with Bonolive® (1 , 2 , 3). These studies have revealed that Bonolive® plays a role in enhancing bone strength, reducing joint discomfort, balancing lipid profiles, and easing specific menopause-related symptoms.
Consequently, it contributes to lowering the risk of developing conditions like osteoporosis (brittle bones) and heart issues as time progresses.
Oleuropein: the hero compound of Bonolive®
Olive oil holds a pivotal role in the Mediterranean diet (4). The primary polyphenols in olive oil are Oleuropein and its metabolite hydroxytyrosol. These polyphenols have been extensively studied and recognized for their preventive benefits against various disorders.
Researchers have unraveled their mechanisms, showing promise in reducing risks of breast cancer, ovarian cancer, postmenopausal osteoporosis, and other health issues.
Bonolive® is standardized to contain Oleuropein. Because of this, Bonolive® is a perfect match for adding to dietary supplements and functional beverages made to support women’s health during menopause.
5 reasons to use Bonolive® in your women’s health product
1. Bonolive® improves bone health and reduces joint discomfort
Bonolive® has demonstrated its positive influence on bone and joint health (1). An investigation centered on post-menopausal women with reduced bone mass unveiled a notable surge in a foundational protein that serves as the framework for generating new bone. Moreover, an improvement in bone mineral density was seen.
In a recent six-month study involving 124 participants aged 55 and above, the efficacy of Bonolive® came to light. It brought relief to joint discomfort linked to activities like walking, bending, and knee movement (2).
Consequently, a daily dosage of 250 mg of Bonolive® proves sufficient to deliver advantageous outcomes for both bone and joint well-being.
2. Bonolive® reduces menopause related symptoms
BioActor undertook a consumer study aimed at assessing the benefits of Bonolive® among post-menopausal women. This investigation unveiled the favorable influence of Bonolive® on alleviating menopause-related symptoms in this demographic.
The study focused on women who had already gone through menopause, aiming to see how Bonolive® affected their reported symptoms. For 28 days, participants took Bonolive® regularly. After just 14 days, they felt better in terms of bloating, anxiety, mood swings, energy levels, and skin health. This improvement continued even after the full 28 days of using Bonolive®.
This reinforces the potential of Bonolive® in enhancing the well-being of post-menopausal women.
3. Bonolive® has favorable effects on lipid control
Clinical research has shown the favorable impacts of Bonolive® in managing the blood lipid profile among post-menopausal women (1). Notably, supplementation with 250mg of Bonolive® over a 12-month period led to significant improvements. Specifically, a significant reduction in LDL-cholesterol, total cholesterol, and triglycerides was observed.
4. Bonolive® has a superior bioavailability
Another study aimed to assess the bioavailability of Bonolive®. Interestingly, a more substantial increase in the levels of metabolites in the blood of post-menopausal women was observed compared to women who hadn’t gone through menopause yet. This suggests that post-menopausal women experienced higher absorption of Bonolive®.
Additionally, the study revealed that Bonolive® possesses antioxidant effects, as evidenced by its ability to reduce levels of a substance called MDA, which is a marker of oxidative stress.
5. Bonolive® is a sustainable solution
Olive trees hold the distinction of being among the oldest cultivated trees globally. However, the surge in olive oil production has taken a toll on the environment (5).
The primary waste generated during olive growth is the pruned leaves of the olive trees. Yet, these leaves contain valuable compounds of which oleuropein is one. This is why Bonolive® is made from the freshly cut olive leaves, meaning it is a clean, sustainable and natural ingredient for a women’s health product.
Bonolive®: A key ingredient for women’s health
Studies have found that Bonolive® can help women stay healthy after menopause. Using Bonolive® as an olive polyphenol extract can bring big benefits to women’s health products. Bonolive® can be used in many different products and has lots of advantages. It’s a great ingredient to promote a healthier lifestyle and improve women’s well-being.
Curious to read about the clinical studies on Bonolive® in more detail? Download our white paper below!
Baltic Brainfuel: Discover the health and sustainability behind the Nero Eggert variety of Aronia berries
Baltic Brainfuel: Discover the health and sustainability behind the Nero Eggert variety of Aronia berries
Discover the world of Aronia berries, where health and sustainability intertwine in the extraordinary Nero Eggert variety. With its exceptional nutritional profile and eco-conscious characteristics, this superfruit is a beacon of wellness for both individuals and the planet. Learn more about the reasons Aronia berries are superfruits and about the ever more special Nero Eggert variety.
Aronia berries: Sustainable health-enhancers
Aronia berries are small dark fruits that are becoming increasingly popular amongst health-conscious consumers as they have excellent content in micronutrients and strong antioxidant properties. Moreover, they have many health benefits.
Apart from providing numerous health benefits, Aronia berries are also interesting from an environmental perspective, thanks to some unique characteristics of this plant.
This is particularly true for the variety called Nero Eggert, selected by BioActor to produce the active ingredient for brain health, namely Brainberry®.
Join us, while we dive into the reasons why Aronia berries are considered superfruit and why the Nero Eggert variety is especially great.
We visited Mr. Eggert, who spent more than 30 years on creating the Nero Eggert variety. Watch the video below:
Aronia Berries: Reason they are excellent for health and sustainability reasons
1. Full of nutrients and anthocyanins:
Aronia berries are more than just berries – they’re nutritional powerhouses. Packed with vital vitamins, minerals, and dietary fibers, these berries contribute significantly to your overall well-being. However, their true power lies in their antioxidant content, particularly the anthocyanins. These antioxidants play a pivotal role in combating oxidative stress and supporting cellular health.
2. Multifaceted health benefits:
Aronia berries have diverse health benefits. From bolstering cardiovascular health to enhancing cognitive function, these berries offer a holistic approach to health.
3. Embracing sustainability:
What truly sets Aronia berries apart is their minimal impact on the environment. Unlike resource-intensive crops, Aronia plants thrive on modest water consumption and natural pest resistance, making them a responsible and sustainable choice for environmentally-conscious consumers.
Nero Eggert variety: What sets it apart from other Aronia berries?
1. Sustainable harvesting methods:
Meet the Nero Eggert Aronia variety – a game-changer in sustainable agriculture. With unique low-reaching branches, this breed helps with harvesting practices. Not only does it yield more fruit per land area, but it also provides reduced land usage, striking a balance between productivity and ecological responsibility.
2. Flourishing amidst harsh climates:
Witness nature’s resilience through the Nero Eggert variety. Flourishing even in freezing temperatures as low as minus 20 degrees Celsius, these berries naturally rejuvenate during harsh winters, eliminating the need for chemical interventions. This adaptation showcases the variety’s capacity to coexist harmoniously with the environment.
3. Abundant in anthocyanins:
The Nero Eggert variety’s high anthocyanin content is a testament to its ability to thrive under stress. The challenging climate it thrives in stimulates the production of these antioxidants, making every berry a valuable source of natural health support.
4. Bee-friendly:
Beyond its health and sustainability attributes, the Nero Eggert Aronia berry plays a vital role in the ecosystem. Its extended flowering period provides nourishment for bees during their lifecycle, promoting biodiversity and exemplifying the variety’s contribution to preserving nature’s balance.
Nero Eggert Aronia Berries: A blend of health and sustainability
The Nero Eggert Aronia berry seamlessly intertwines health benefits and sustainable practices. For this reason, we have chosen this unique fruit as the base for our Brainberry® extract, which has been clinically validated to boost your cognitive performance.
Feel free to contact BioActor via info@bioactor.com and visit www.brainberry.eu and www.bioactor.com to learn more about Brainberry® or click here to learn everything you need to know about Brainberry® and brain health.
WEBINAR - Women's Health
WEBINAR – Women’s Health
Women’s health market, clinical data and product concepts with Bonolive® to address post-menopausal-related risks
More than ever, nutrition and supplementation are recognized to be effective strategies to address women’s health. Join us in our next webinar to learn more about the market for women’s health supplements, clinical evidence supporting Bonolive®, and product formulations to target post-menopausal-related risks. The webinar will take place on September 26th at 9AM PDT | 12PM EDT | 6PM CEST.
The Women’s Health market is a very dynamic one. Join our webinar to explore evolving trends, address needs across ages, and uncover recent developments. Experts will discuss key factors shaping women’s health, providing insights for global advancement.
Menopause is an important women’s health topic. It brings unique challenges due to hormonal changes. From short-term concerns like hot flashes to long-term risks like cardiovascular issues and bone loss, nutrition and supplementation are crucial for support.
Discover Bonolive® and how BioActor’s olive polyphenol-based ingredient enhances women’s health in our upcoming webinar.
When?
September 26th, 2023 at 9AM PDT | 12PM EDT | 6PM CEST
Meet the Speakers:
What are you going to learn during this webinar?
Women’s Health Market & Trends
Presentation by Marit Veenstra – Operations Manager & Brand Strategist, who is going to talk about the present state of the Women’s Health market, the key considerations for women belonging to various age groups, and the trends within the market.
Duration: 10 minutes
Clinical Research
Presentation by Maria Imperatrice – Clinical researcher, who will introduce the science behind Bonolive® and the clinical trials showing the positive effect of Bonolive® on cardiovascular health, bone health and mobility.
Duration: 15 minutes
Formulating with Bonolive®
Presentation by Valeria Mastromartino – Account Manager, who will dive into Bonolive® mode of action, a new consumer study on its effect and product formulation examples risks related to women’s health.
Duration: 15 minutes
Q&A session
Duration: 10 minutes
BIOACTOR and PIXIENCE start collaboration on validation of skin imaging technology in nutrition studies
BIOACTOR and PIXIENCE start collaboration on validation of skin imaging technology in nutrition studies
Press release
BIOACTOR and PIXIENCE announce the start of a collaboration to test and validate an innovative skin imaging and testing technology in the context of a clinical study with a nutritional bioactive.
BIOACTOR and PIXIENCE announce the start of a collaboration to test and validate an innovative skin imaging and testing technology in the context of a clinical study with a nutritional bioactive.
PIXIENCE has developed an innovative skin image capturing device (C-Cube) and image analysis software (QuickScale) for the evaluation of several skin parameters, including the evaluation of 3D images.
BIOACTOR has expertise in the clinical validation of health effects of natural compounds and is now setting-up a clinical testing platform around nutritional actives for skin health.
PIXIENCE is developing the C-Cube Clinical Edition and BIOACTOR will carry-out beta testing of the Clinical Edition in a new clinical study on an oral nutritional product. PIXIENCE will provide technical assistance to BIOACTOR for the skin image analysis in this new clinical study.
Sebastien Mangeruca, CEO of PIXIENCE comments:
“We have initially developed our C-Cube and QuickScale suite of technologies for the evaluation of topical cosmetic products. BIOACTOR’s experience in running clinical studies for nutrition and its active programme around nutrition and skin health, makes them an ideal partner for testing and validating of our C-Cube Clinical Edition for nutrition studies”.
Hans van der Saag, CEO of BIOACTOR comments:
“BIOACTOR is delighted to work with PIXIENCE, as PIXIENCE has developed a best in class skin imaging and analysis technology that will allow us to further improve our skin health for nutrition platform. BIOACTOR wants to bring clinically backed innovation to the nutrition industry. BIOACTOR tests all of its products in scientifically robust human intervention studies, working with partners like PIXIENCE and the Department of Health and Nutrition of Maastricht University.”
About BIOACTOR
BIOACTOR, based in Maastricht, Netherlands, is a product development company that develops and supplies proprietary bioactive formulations to the health and sports nutrition industry. All BIOACTOR’s products are clinically tested, doping-free and from natural origin. The main focus areas are: gut microbiome, brain health, energy & vitality and skin health.
For more information, please contact:
BioActor
Hans van der Saag, CEO
Email: hans.vandersaag@bioactor.com
Pixience
Sébastien Mangeruca, CEO
Email: Sebastien.mangeruca@pixience.com
www.pixience.com
How a healthy microbiome boosts your immune system
Unlocking the power of your gut: how a healthy microbiome boosts your immune system
Did you know that your immune system’s performance is intricately tied to the health of your gut microbiome? In this article, we delve into the fascinating connection between your gut microbiome and immune system. Discover the key role of the gut microbiome in immune function and learn about the dietary components that can nurture a diverse and thriving gut ecosystem.
A symbiotic relationship: gut microbiome and immune system harmony
The human body is a bustling ecosystem housing trillions of microorganisms, collectively known as the microbiome. Among these, the gut microbiome stands out as a vibrant community of bacteria, viruses, fungi, and parasites (1).
This intricate network collaborates to maintain a balanced blend of beneficial microorganisms, protecting us from potential invaders.
Recent advancements have illuminated the gut microbiome’s dynamic involvement in our well-being, extending beyond passive existence.
This intricate web of microorganisms actively influences various bodily functions, including bolstering the development and efficacy of the immune system. Our immune system, in turn, maintains a delicate equilibrium, defending against pathogens while avoiding autoimmune responses (2).
Microbiome’s immune-boosting strategies
Short-Chain Fatty Acids (SCFAs)
At the heart of the gut microbiota’s influence on immunity lies the production of Short-Chain Fatty Acids (SCFAs) through dietary fiber fermentation in the large intestine (3).
These SCFAs, such as acetate, propionate, and butyrate, play a pivotal role in maintaining gut balance and modulating immune responses. They orchestrate immune cell functions, like regulatory T cells and antigen-presenting cells, and stimulate cytokine and chemokine production, bolstering immunity.
Furthermore, SCFAs can directly quell pathogenic activity by suppressing virulence-related genes, curbing potential threats.
Fortifying the barricade: tight junctions
The gut’s tight junctions act as gatekeepers, upholding the integrity of the intestinal barrier (4). Inflammation or infections can disrupt these barriers, allowing undesirable substances to escape into the bloodstream, triggering immune responses (5, 6).
SCFAs step in as allies here, contributing to the assembly of robust tight junctions within intestinal cell walls. This reinforcement prevents the escape of harmful toxins from the gut, bolstering the gut wall’s ability to shield against infections (5).
When this symbiotic relationship thrives, the immune system guards us against infections. However, an unbalanced microbiota composition might trigger inflammation, autoimmune disorders, and chronic diseases (1, 5).
Strategies to help the gut ecosystem flourish
A diverse and balanced gut microbiome is universally recognized as vital for our health (7). Research highlights that such diversity empowers immune responses against infections while reducing autoimmune responses. Conversely, a low-diversity microbiome is linked to chronic inflammation and an elevated risk of colorectal cancer.
To nurture a flourishing and diverse gut microbiome, prioritizing a balanced diet and healthy lifestyle is very important.
Choose for a spectrum of fruits, vegetables, whole grains, and lean protein sources. These foods, rich in fiber, prebiotics, and nutrients, provide nourishment for beneficial gut bacteria.
1. Fiber: the gut’s aid for immunity
Fiber’s role in gut health is crucial, as it bolsters microbiome diversity. A diet rich in fiber, found in fruits, vegetables, and whole grains, enhances gut bacteria abundance and diversity. This, in turn, augments immune function, reducing chronic disease risks (8).
2. Prebiotics: fuel for beneficial bacteria
Prebiotics, a specific type of fiber, serve as sustenance for our beneficial gut inhabitants. Foods like onions, garlic, leeks, asparagus, bananas, and whole grains are brimming with prebiotics, nurturing a thriving microbial community.
3. Water: hydration and gut motility
Staying hydrated is crucial for optimal gut function. Drinking plenty of water helps maintain proper gut motility and prevents constipation. Adequate hydration supports the movement of food through the digestive tract, allowing beneficial bacteria to thrive and contribute to a healthier gut.
4. Probiotics and postbiotics: allies for immunity
Fermented foods like yogurt, kefir, sauerkraut, and kimchi harbor probiotics—live bacteria conferring health benefits. Additionally, postbiotics, metabolic by-products or components produced during fermentation, like SCFAs, amplify the benefits. Consuming these products directly ingests these components, bolstering health.
5. Synbiotics: Uniting Prebiotics and Probiotics
Synbiotics, the blend of prebiotics and probiotics, synergistically promote gut health. Examples include yogurt with inulin or fructooligosaccharides (FOS), and kefir with galactooligosaccharides (GOS).
6. Reducing stress levels
Besides diet-related strategies, there are other ways to help your gut stay healthy. Stress can negatively impact the gut-brain axis and disrupt gut health. Practicing stress-reduction techniques like meditation or deep breathing can have a positive impact on both your mental well-being and gut health.
Cultivate your gut for immune resilience
In summary, the gut microbiome profoundly impacts the immune system’s effectiveness. A thriving and varied gut ecosystem fortifies us against infections and chronic ailments, while an imbalanced one heightens vulnerability. By embracing a well-rounded diet full of fiber, prebiotics, and fermented foods, we can nurture our gut microbiome, bolstering overall health.
MEET US - Vitafoods Asia 2023
Visit us at Vitafoods Asia 2023
We are happy to announce that BioActor will participate in Vitafoods Asia 2023, the trade show that offers the opportunity to find out the latest trends in the field of dietary supplements, raw materials, and food and to network with other professionals from around the world. Visit us at Booth C41.
Meet us at Booth C41
If you’re looking for natural ingredients with verified clinical support to elevate your product development according to consumer needs, make sure to visit our booth! Our nutraceutical solutions guarantee success based on three fundamental principles: clinical efficacy, innovation, and high quality.
Vitafoods Asia 2023 offers an incredible opportunity to participate in discussions concerning our recently completed clinical trials, consumer studies, and collaborative endeavors!
New Clinical Data
Pass by our booth to learn about our recent trials on MicrobiomeX® for gut health, Brainberry® for cognitive performance or Actiful® for mitigating risk caused by harmful AGEs linked to chronic diseases.
Other than clinical data, we are happy to discuss the outcomes of our recent consumer research that delved into the effects of Bonolive® on postmenopausal symptoms.
New Collaboration
Vitafoods Asia also offers us a chance to chat about out new collaboration with PIXIENCE to test and validate an innovative skin imaging and testing technology in the context of a clinical study with a nutritional bioactive.
Solabia Nutrition
At Vitafoods Asia, we will be present under the flag of Solabia Nutrition, also showcasing our microalgae offering from our sister company Algatech. This includes their Astaxanthin and whole algae ingredients.
Book a meeting!
Exploring the significance of nutrients for mitochondrial health
Enhancing mitochondrial health: exploring the significance of nutrients
Discover the influence of nutrients on your mitochondrial health. Dive into our blog to learn how magnesium, hesperidin, vitamin C, omega-3s, and more can enhance your mitochondrial health and boost your overall vitality.
Nutrients to support mitochondrial health
Maintaining the optimal performance of our mitochondria is pivotal for our overall well-being. These microscopic organelles act as cellular powerhouses, generating a significant portion of the energy necessary for our cells to function at their best.
Beyond energy production, they also regulate metabolic processes and uphold a delicate balance of nutrients within our cells
Dysfunctional mitochondria can result in notable symptoms like fatigue and muscle weakness. In more serious instances, they have been linked to critical health conditions such as cardiovascular ailments and neurodegenerative diseases.
Consequently, prioritizing the health of our mitochondria is not only essential for general vitality but also plays a preventive role against potential illnesses.
Within this article, we will take a look at specific nutrients that actively contribute to the maintenance and augmentation of mitochondrial health.
Magnesium and mitochondrial vitality
Magnesium plays a vital role in ensuring the well-being of our mitochondria. It serves as a crucial facilitator for enzymes responsible for energy production, while also exhibiting antioxidant properties.
This antioxidative function of magnesium is particularly significant, shielding mitochondria from potential harm induced by harmful molecules. Additionally, magnesium takes on the responsibility of regulating calcium levels within mitochondria, a pivotal function in averting any potential malfunctioning (1).
Sustaining an appropriate intake of magnesium is essential to uphold the health of mitochondria and prevent any disruptions in their functioning. Incorporating magnesium-rich foods into our diet, such as nuts, seeds, whole grains, and leafy green vegetables, provides a natural source of this essential mineral. Additionally, it’s a possible addition for an energy supplement.
Hesperidin: a citrus boost for mitochondria
Hesperidin, a natural compound present in citrus fruits like oranges, lemons, and grapefruits, offers significant potential in maintaining robust mitochondrial health.
By boosting the expression of genes linked to energy production, hesperidin enhances mitochondrial functionality. This augmentation translates to increased energy production within the mitochondria, resulting in elevated energy levels and reduced fatigue (2).
Moreover, hesperidin boasts anti-inflammatory attributes that play a role in curbing inflammation throughout the body. As inflammation can contribute to mitochondrial disturbances, mitigating this inflammation becomes a supportive measure for preserving mitochondrial well-being.
Vitamin C to boost mitochondrial health
Vitamin C holds a crucial role in maintaining the well-being of our mitochondria. Serving as one of the body’s most potent antioxidants, vitamin C offers safeguarding prowess against detrimental molecules known as free radicals, shielding our mitochondria from harm (3).
Free radicals possess the capacity to impair mitochondria, diminishing their capacity to generate energy. However, vitamin C effectively counters these radicals, preventing their damaging effects.
Therefore, ensuring your diet includes a good dose of vitamin C becomes a noteworthy strategy to keep healthy mitochondria.
Omega-3s: helpful for energy
Omega-3 fatty acids are a type of healthy fat found in foods like fatty fish, nuts, and seeds. They play a crucial role in promoting the health of our mitochondria.
These fatty acids are boosters for mitochondria: they help these powerhouses extract more energy from the same amount of nutrients, which means less fatigue and more energy (4). Omega-3s also shield mitochondria from damage caused by harmful molecules. They also improve the mitochondria’s ability to transport nutrients in and out efficiently.
Omega-3 fatty acids also bring anti-inflammatory capabilities, which is good for our overall well-being. Including foods rich in omega-3s in our diet is a smart move to support your mitochondria, boost energy production, and keep inflammation in check.
B-vitamins and their ability to support mitochondrial well-being
B vitamins, including B1, B2, B3, B5, and B7, are fundamental contributors to the maintenance of optimal mitochondrial health. These vitamins play a pivotal role in facilitating energy production within mitochondria by participating in the breakdown of carbohydrates, fats, and proteins.
The main reason for this is that B vitamins can act as co-enzymes and precursors of co-enzymes that help in the breakdown of these nutrients. This is key for mitochondrial health. Inadequate intake of these B vitamins can lead to compromised mitochondrial function, resulting in sensations of fatigue, weakness, and muscular discomfort (5).
Sustaining an adequate dietary supply of B vitamins is imperative to sustain the functional integrity of mitochondria and facilitate efficient energy synthesis.
Intake of nutrients to support mitochondrial health
In summary, looking after the health of our mitochondria is vital for our general well-being. A range of nutrients, such as hesperidin, magnesium, B-vitamins, omega-3 fatty acids, and vitamin C, play key roles in supporting mitochondrial function. They not only help diminish oxidative stress and inflammation but also enhance exercise performance.
By incorporating these essential nutrients in your diet, we can effectively boost our mitochondrial health and ensure our body’s energy production functions at its best.
Discover YAMAMOTO’s Success Story
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New publication: Naxus® consumption supports weight management through reduction of actual calorie intake in an ad libitum meal
New publication: Naxus® consumption supports weight management through reduction of actual calorie intake in an ad libitum meal
Press release
This randomized controlled crossover study showed Naxus®’ potential for appetite control and weight management. In a 21-day trial with healthy adult males, it was reported that consumption of a blend of Naxus® and inulin showed significantly lower calorie intake in an ad libitum meal (838 kcal vs. 1023 kcal) while reporting no changes in appetite. The blend was also shown to increase faecal SCFA concentrations. These results highlight Naxus®’s potential to transform appetite regulation.
Naxus®: clinically validated and developed by BioActor
Naxus® is a clinically validated arabinoxylan extract developed by BioActor, derived from wheat endosperm. It has been extensively studied and shown to have beneficial effects on microbiota composition, glycaemic control, and immune system function.
Naxus® promotes the growth of beneficial bacteria, production of Short Chain Fatty Acids (SCFA) and improves glycaemic control by inducing GPR43 signaling which leads to reduced glucose peaks and improved insulin sensitivity (1, 2). It also strengthens the immune system through various mechanisms (3, 4, 5). It is a well-researched ingredient with significant potential for enhancing overall health and well-being.
The study: Chronic consumption of a blend of inulin and Naxus® reduces energy intake in an ad libitum meal but does not influence perceptions of appetite and satiety
Introduction
Two dominant bacterial strains account for more than 90% of the total bacterial gut community: Bacteroidetes and Firmicutes (6). They are widely believed to have important effects on the maintenance of normal intestinal homeostasis. Stressors associated with modern lifestyles (e.g. low fibre diet) can chronically change the bacterial gut composition and lead to the increase of more virulent microbes that adversely affect the health of the host.
Gut microbiota break down fibre from our diet and produce SCFAs such as propionate, acetate, and butyrate as a result. These metabolites lead to activation of a pathway that is linked to appetite reduction.
Specifically, propionate and acetate bind to a receptor called GPR43, which is found in cells lining our stomach and intestines (7). Activation of GPR43 leads to a cascade of signals eventually triggering the production of GLP-1 and PYY, two hormones involved in inducing satiety.
Naxus has previously been shown to increase propionate levels and GLP-1 production (8). In this current study, it was investigated whether a blend of Naxus® and inulin would positively affect satiety and energy intake.
Methods
In this cross-over study, the authors investigated the effect of inulin + Naxus® on 20 healthy adult males aged between 22 and 55 with no evidence of metabolic or cardiovascular disease.
Each participant took part in both control and intervention conditions, each lasting 21 days. Both the treatment and control groups had to drink two sachets of dry powder dissolved in 150 ml of water daily for 21 days. Therefore, the participants consumed the intervention (or the control) sachet for 21 days following a 14-day period washout, and afterwards the control (or the intervention) sachet for an additional 21 days. The intervention sachet contained 2 g of Naxus® and 2 g inulin, whereas the control sachet contained 4 g of maltodextrin.
After a 14-day wash-out period, participants switched to the other drink for another 21 days. The study comprised 4 visits to assess the participants’ perceived satiety and appetite, the energy intake in an ad libitum meal, faecal SCFA concentration, and the faecal microbiota composition.
Results
Appetite control and calorie intake
The study found that the mean energy intake in an ad libitum meal were significantly lower during the treatment period (838 kcal) compared to the control period (1023 kcal) (p<0.05).
Surprisingly, no changes in self-reported appetite were found. This difference between self-reported appetite and actual calorie intake is common in studies involving prebiotics, which is why measuring actual food intake provides a more objective measure.
Microbial composition
Significant changes in the microbial composition of fecal samples were noted, showing noteworthy increases in the abundance of Bifidobacteria (p = 0.035), Lactobacilli (p = 0.061), and Propionibacteria (p = 0.02).
Short-chain fatty acids
Moreover, these changes were accompanied by an elevation in the concentration of short-chain fatty acids (SCFAs), which are known to be associated with gut health. More specifically, an increase of acetate in the faeces sample was reported after 21 days (p=0.02). Acetate has the ability to independently influence appetite, which may explain why the participants consumed fewer calories during a single meal.
The hypothesized increase in propionate levels in the faeces sample was only minimal and not statistically significant (p=0.07). However, it is important to note that faecal propionate concentration alone does not reflect the absorption by the body. Additionally, the signals of propionate in the liver and bloodstream, which were not measured in this study, could potentially have a more significant impact on appetite regulation.
Triple effect
Overall, the results show that the chronic consumption of a blend of inulin and Naxus® leads to a reduction in energy intake, an increase in faecal SCFA concentrations, and an increase in beneficial gut bacteria.
Conclusion
This research indicates that a combination of inulin and Naxus® has positive effects on gut health and confirms existing data that Naxus® positively influences appetite control.
This publication also emphasizes the importance of new studies focusing on the effect of Naxus® on enhancing and tailoring nutritional products to promote satiety and help weight management.
About BioActor
BioActor, based in Maastricht, Netherlands is part of the Solabia Group and has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. We focus on the development of innovative activities that address active living and healthy ageing. Our goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.
Feel free to contact via info@bioactor.com for more information on the possibilities Naxus® has to offer. Further information can also be found on: www.naxus.nl or www.bioactor.com/products/naxus.
