hydration sports drinks

How to stay hydrated and increase physical performance?

How to stay hydrated and increase physical performance?

Maastricht, 16th February 2024

Hydration is the key to optimal physical activity. Our bodies work constantly to maintain an internal fluids balance. Effectively managing water loss is crucial for sustaining the body’s health and physical performance. In this blog we explore hydration and sports drinks. How can we stay hydrated and enhance performance?

hydration sports drinks

What is water balance?

When engaging in physical activity, body temperature rises due to increased muscle activity. In response, the body produces sweat to cool down. This process helps regulate body temperature as water and mineral salts evaporate from the skin.

Indeed, water loss during physical activity is a desirable natural process. Its rate varies based on factors such as the intensity and duration of the activity, environmental conditions, and individual differences. On average, an hour of moderate physical activity can cause a person to lose around 0.5 to 1 litre of water (1, 2). Maintaining the water balance in the body is essential to avoid dehydration and optimize overall physical performance.


How to maintain a healthy water balance and prevent dehydration?

Dehydration can impact performance of any exercise longer than 15s (3) by affecting endurance, strength, cognitive function, and delaying recovery. Therefore, maintaining a healthy water balance is crucial. Sport drinks are a great choice to solve this issue as they provide plenty of water and supply the electrolytes needed to maintain the body water balance (4).


The role of electrolytes

Electrolytes are essential minerals that play a crucial role in maintaining proper hydration and overall bodily function. When we sweat during physical activity or in hot environments, we lose electrolytes along with water. These electrolytes include sodium, potassium, chloride, calcium, and magnesium. Electrolytes help regulate the balance of fluids within the body. Sodium, for example, helps the body retain water, while potassium works to balance sodium levels and regulate fluid distribution within cells (5).

Sports drinks with electrolytes

Depending on their electrolyte concentration, sport drinks can be classified as isotonic, hypertonic, and hypotonic. Each of them serves different purposes. The choice of which type of drink to use depends on individual needs and the type and duration of physical activity.

Hypotonic drinks contain a lower concentration of sugars and electrolytes that the one the body has. Hypotonic drinks are ideal for quick hydration for low duration sports (6).

Isotonic drinks have a concentration of sugars and electrolytes that tries to mimic the body’s concentration and are typically used for electrolytes and water replenishment. They are ideal for endurance events longer than 40 minutes (7).

Lastly, hypertonic drinks contain a higher concentration of electrolytes and sugars than the body does (8). This high dose of electrolytes and sugar is particular useful for long duration sports and is ideal for glycogen stores and fluids replenishment (9).


How to improve your standard sports drink beyond electrolytes?

Several beneficial ingredients can be added to a sports drink to enhance its functionality and provide additional benefits to athletes and individuals engaging in physical activity. Here are some examples:

Carbohydrates: Carbohydrates are a primary source of energy for muscles during exercise. Fast absorbed ones like glucose, fructose and maltodextrin are a perfect fit for a sports drink to provide a readily available fuel source (10). On the other hand, adding slow digestible carbohydrates such as isomaltulose or arabinoxylans is also a good strategy to sustain endurance and performance during prolonged activity.

Polyphenols: polyphenols from sources like citrus extracts and Aronia berries can help improve performance by increasing focus, force and endurance.

Caffeine: Caffeine is a stimulant that can enhance mental alertness, focus, and endurance performance. Including caffeine in a sports drink can provide an extra boost of energy and improve exercise performance, particularly during intense workouts or endurance activities.

Vitamins and Minerals: Adding vitamins and minerals such as vitamin C, vitamin E, B-vitamins, and zinc can support overall health, immune function, and recovery from exercise-induced oxidative stress.

Amino Acids: Branched-chain amino acids (BCAAs) such as leucine, isoleucine, and valine may aid in muscle recovery, reduce muscle soreness, and support muscle protein synthesis. Other amino acids like glutamine may help maintain immune function and gut health during intense training.

Adaptogens: Adaptogenic herbs like rhodiola, ginseng, or ashwagandha may help improve resilience to stress, enhance endurance, and support recovery from intense exercise.


Preventing dehydration is crucial for physical performance and subsequent recovery. Choosing the right sports drink with the best quality ingredients according to individual needs is the best strategy to keep hydrated and boost performance.

New Approved Health Claim for Watts'Up®

WATTS’UP® receives an additional approved health claim from Health Canada

Maastricht, 14th February 2024


Health Canada has issued a new Product Licence for WATTS’UP® and has approved the use of an additional health claim: “Helps to improve average power output during high intensity exercise in moderately trained individuals.

power strength wattsup bioactor solabia

WATTS’UP®, a customized flavonoid extract from sweet orange, has been tested in 2 double-blind placebo-controlled studies. The latest study was conducted in moderately trained men and women and showed a significant improvement in exercise performance with a significant increase in peak force and average 30 seconds power output.

Health Canada has issued a new Product Licence for WATTS’UP® with an enlarged scope. Pursuant to this Product Licence, WATTS’UP® is recommended to be used as “Athletic support” or “Workout/Exercise supplement.”

The following specific claims have been allowed by Health Canada: “Helps to improve average power output during high intensity exercise in moderately trained individuals” ; “Helps improve physical performance during exercise in trained male athletes”; and “Provides antioxidants that help cells to fight against the oxidative effect of free radicals and that helps protect cells and reduce oxidative damage and cell damage caused by free radicals”

The Journal of the International Scoiety of Sports Nutrition has published the results of the latest clinical study with WATTS’UP®. WATTS’UP® is a patent-protected citrus extract with enhanced bioavailability. It was tested in moderately trained athletes (both men and women) and showed a significant increase in power output during the Wingate anaerobic exercise test.

WATTS’UP® can be found on the market in multiple products in the USA, Europe, and Asia. It can be applied in various finished dosage forms, including powders, effervescent tablets, capsules, RTD sachets and beverages.

Feel free to contact us via info@bioactor.com for more information on the possibilities WATTS’UP® has to offer.

Further information can be found on: www.wattsup.eu


About Solabia – BioActor

BioActor, a Solabia Nutrition company, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive formulations with clinical studies. The company focuses on the development of innovative bioactives that address healthy living and ageing. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

For further information, see www.bioactor.com

WEBINAR: Women's Health with Bonolive®

WEBINAR: Women’s Health

With Bonolive®

Are you interested in a women’s health ingredient backed-up by science? At this webinar, we will present Bonolive® and the benefits of adding it to your formulation. Find out more about the science behind Bonolive® its formulation possibilities. Dive into the world of women’s health with our exclusive webinar in Spanish . Register here!


Why attend?


The awareness about women’s health and especially menopause support is growing. As consumer demand is increasing in this area, brands should be satisfying the need for science-based and clean-produced ingredients. At this webinar, we set the focus on Bonolive®, our premium women’s health ingredient. Deepen your knowledge about the science behind this olive leaf extract as well as the benefits it offers. Find out the opportunities of formulation and product formats available. 

bonolive webinar speakers

Presentation by Marit

10 minutes

EU Market Insights: Explore the latest trends, expected growth, and consumer preferences in the EU women’s health market, with a specific focus on Spain. 


Presentation by Valeria

10 minutes 

The Science behind Bonolive®: Discover the clinical data behind Bonolive® and understand the advantages it has to offer for menopausal women.


Presentation by Tony

10 minutes

Sales and Formulation possibilities of Bonolive®: Learn about the origin and benefits of formulating with Bonolive®.


supplement to slow down aging

Actiful®: a key ingredient for healthy aging

Actiful®: a key ingredient for healthy aging

Maastricht, 29th January 2024

Are you looking for an impactful science-based ingredient to add to your energy and vitality supplement? Well, look no further as the research-based evidence is expanded on the key role of Actiful® in supporting energy production, improving mental wellness, and reducing oxidative stress.

supplement to slow down aging

How can we slow down the aging process?

Aging is a complex process (1) characterized by a gradual decline in physiological function and an increased susceptibility to various diseases. It encompasses a range of biological, psychological, and social changes that occur over time. At the cellular level, aging involves factors such as mitochondrial dysfunction and accumulation of damage from oxidative stress. These processes contribute to a decline in the efficiency of cellular repair and maintenance mechanisms.


Factors impacting the aging process

Additionally, genetic and environmental factors play significant roles in influencing the rate of aging. While aging is a natural and inevitable part of life, lifestyle choices, such as diet, exercise, and stress management, can impact the rate at which the aging process unfolds. Continuous research is taking place to study aging and better understand potential interventions to promote healthy aging and longevity (2).


A combination of diet and supplementation

Slowing down the aging process involves adopting a holistic approach that addresses various aspects of one’s lifestyle. A balanced and nutritious diet rich in antioxidants, vitamins, and minerals is crucial for maintaining cellular health and preventing oxidative stress. Regular exercise, adequate sleep and stress management can positively impact both mental and physical health (3). Avoiding harmful habits such as smoking and excessive alcohol consumption is also vital, as they accelerate the aging process.


Combining these lifestyle factors and taking appropriate supplements can create a foundation for a healthier and more vibrant aging experience. Adding supplements to the diet can be beneficial for healthy aging, as they can help address specific nutrient deficiencies and support overall well-being. They are often recommended for digestive health, immune support or cell function optimization. (4, 5)

mitochondria health and energy and healthy aging

Actiful®: clinically proven ingredient for healthy aging

Actiful® is a patent-protected plant-based ingredient for improved energy production, mental wellness and mitochondria support. It is standardized for hesperidin which is a key polyphenol extracted from sweet oranges (Citrus sinensis). Actiful® also contain pomegranate (Punica granatum), known to be rich in nitrate and useful for NO production, leading to vasodilation. Previous clinical data has already shown the beneficial properties that the combination of these polyphenols has in terms of enhanced physical performance (6, 7), mental health support (7), improved energy production by the mitochondria (8) and improved blood flow (9).

Recent clinical data further underlines the benefits that Actiful® brings to the table. The combination of hesperedin and pomegranate in a 350mg supplement capsule was provided to healthy seniors for 4 weeks in a randomised, blinded, placebo-controlled manner. In the end of the intervention period, the concentration of methylglyoxal (MGO) in the blood decreased by ≈ 10% (10). This is a statistically significant and clinically relevant result as MGO accumulation in cells leads to cellular disfunction and shorter cell life. Clearly, you would like to stimulate MGO scavenging, if you are targeting healthy aging. 


The role of Actiful® in supporting the mitochondria

The mechanism of action of the polyphenols present in Actiful® is quite complex and apparently linked with benefits and protection for our mitochondria, the so called ‘powerhouse’ of the cells. Hesperidin and pomegranate are known for their antioxidant properties (11, 12), which contributes to the direct MGO scavenging. They also reduce oxidative stress which leads to support of the natural body’s detoxification mechanisms. All of the above mentioned benefits are directly linked with the potential of Actiful® to protect the mitochondria and support its function via the reduction of MGO, observed in the latest clinical data of Actiful® (10).


The potential of Actiful® for the supplements market

The latest data allows Actiful® to expand its market possibilities. It can be an active ingredient in vitality supplements for mid-aged adults and active seniors as well as in energy drinks and sports drinks. Actiful® can be marketed for its beneficial effects on vitality, mental wellbeing, energy production and mitochondria support.

brainberry algasense science

WEBINAR: Watch on demand

Webinar Watch on Demand: Maintain your Brain!

With Brainberry® and AlgaSense®

Are you looking for a brain health ingredient backed-up by science? We presented two ingredients fitting into the current trends. Find out more about the science behind Brainberry® and AlgaSense® and their formulation possibilities. Dive into the world of brain health and cognitive wellness with our exclusive webinar . Watch on demand here.


Why should you watch?


The world of cognitive wellness and brain health is growing as more and more people become aware of their importance. At this webinar, we set the focus on Brainberry® and AlgaSense®, our premium brain health ingredients. Deepen your knowledge about the science behind Aronia Nero Eggert berries and whole algae as well as the benefits they offer. Find out the opportunities of formulation and product formats available. 

brainberry and algasense webinar speakers

Presentation by Marit

10 minutes

US Market Insights: Explore the latest trends, expected growth, and consumer preferences in the US brain supplements market.


Presentation by Joris

10 minutes 

The Science and Formulation possibilities of Brainberry®: Uncover the scientific data behind Brainberry® and understand its impact on brain health.


Presentation by Thomas

10 minutes

The Science and Formulation possibilities of AlgaSense®: Learn about the diverse formulation possibilities of AlgaSense® and its benefits for mood support and stress management.


oleuropein skin health bonolive

How can oleuropein improve skin health?

How can oleuropein improve skin health?

Maastricht, 16th January 2024

Who doesn’t desire youthful looks and optimal skin health? Unfortunately, the aging process tends to impact our skin negatively. Wouldn’t it be great if we could slow down this natural process and improve skin health? This article delves into the beneficial impact of oleuropein on preserving skin health.

oleuropein skin health bonolive

Why is skin health important?

The skin, our body’s largest organ, acts as the primary barrier between the external environment and our internal world. Beyond its role in protecting against pathogens, toxins, and physical injuries, maintaining skin health is crucial to reduce the risk of infections and diseases (1).


Additionally, the skin plays a vital role in regulating body temperature and preventing dehydration, contributing significantly to the overall balance and well-being of the body through the process of homeostasis (2).


How does aging affect skin health? 

As we age, the importance of maintaining healthy skin becomes even more apparent. The skin undergoes changes, caused by a combination of genetic and environmental factors. Sun and wind exposure, air pollution, climate conditions, chemical exposure, stress, smoking and alcohol consumption contribute to alterations in the appearance and function of the skin (3).


Primarily, visible signs of aging manifest as wrinkles and fine lines. Collagen breakdown and a reduction in elastin fibers results in decreased skin elasticity and firmness. Additionally, aging causes thinning of the skin. The upper layers, the epidermis and dermis, become less thick and lose density, increasing the risk of injury and making blood vessels more visible on the skin surface (4).


Maintaining healthy skin becomes paramount to tackle the aging factors, ultimately improving the quality of life as one ages (5). For example, skin dryness and irritation are natural consequences of the decreased oil production with age (6, 7). To remedy this situation, nutritional supplements containing omega-3, collagen or oleuropein are showing some promise. Therefore, supporting skin health from within is a trend, currently popular for investigation among the scientific community.


What is oleuropein?

Oleuropein, a natural polyphenol, is abundant in olives, olive leaves and olive oil, giving them a distinctive bitter taste, especially in extra virgin olive oil (8). It is renowned for its antioxidant and anti-inflammatory properties, making it a subject of interest in various studies focused on skin health (8, 9, 10). It holds promise to support the skin’s natural oil production and tackle dryness and irritation.

oleuropein benefits skin

The beneficial effect of oleuropein on skin health

As the skin undergoes the natural aging process, one of the prominent challenges it faces is an escalation in oxidative stress within skin cells. Oxidative stress is characterized by an imbalance between free radicals and the body’s ability to neutralize them. Free radicals are highly reactive molecules that can damage cellular structures including proteins, lipids, and DNA, which contributes significantly to skin damage. By effectively neutralizing free radicals, oleuropein helps to reduce oxidative stress in skin cells and preserves the integrity of cellular structures and functions (9).


Furthermore, aging is often accompanied by an increased tendency towards inflammation in skin cells, a phenomenon linked to the emergence of various skin conditions. Oleuropein is suggested to have anti-inflammatory properties. It targets the pathways involved in the inflammatory process, helping to reduce the overall inflammatory burden. By doing so, oleuropein not only addresses the symptoms but also acts preventatively and it’s anti-inflammatory ability emerges as a valuable asset in promoting overall skin wellness and resilience (9).


How to use Oleuropein as a supplement? 

Olive leaf extract comprises of 25-40% oleuropein (11). Achieving the clinically studied dose of 100mg oleuropein per day through regular diet alone poses a challenge. Consequently, oleuropein supplementation is the practical consideration. Taking a daily supplement can help you reach the recommended clinical dose and have positive results.

Typical application formats include soft gels, capsules, tablets and powders. Oleuropein is stable and can be combined with collagen, magnesium, selenium and vitamins B, D, E & K.

Oleuropein’s dual action as an antioxidant and anti-inflammatory agent positions it as a valuable component in skincare, offering protective measures against oxidative stress and inflammation associated with the aging process (12, 13, 14)

eye strain stop

How do you relieve eye strain

How do you relieve eye strain?

Maastricht, 15th December 2023

Tingling sensation in your eyes and headaches? Struggling to keep your eyes open? Eye strain is a common condition caused by intense focusing of the eyes during a task, such as during prolonged exposure to digital devices. This condition has become increasingly common since COVID-19, a period during which our reliance on phones and laptops has grown significantly. In this article, we will explore what eye strain is and provide practical steps to help prevent it.

eye strain stop

What is eye strain? Causes and symptoms

Also known as Asthenopia, eye strain is linked to physical fatigue of the eye. It occurs when your eyes get tired from intense focus, such as while driving, reading for hours or staring at a screen.

Several distinct causes can lead to eye strain. But nowadays, most of the oxidative stress leading to eye fatigue is caused by prolonged exposure to screens as the radiated blue light can induce photoreceptor damage (1, 2, 3). Common symptoms are:

  • Irritated or dry eyes
  • Blurring of vision
  • Headaches or sensibility to light
  • Body pain, neck or shoulder pain.

Fortunately, there are several ways to reduce eye strain.

Practical tips to prevent eye strain

Whether in the form of energy drinks or supplements, consumption of caffeine seems to be the first option for people who want to avoid fatigue.

While caffeine can indeed make you feel more awake and energetic, it’s essential to be aware that its consumption can also lead to adverse effects, including heightened stress, anxiety, or tachycardia (4). It is advisable to reduce caffeine consumption and to explore these alternatives:


Adapted equipment

To enhance your comfort, ensure you properly adjust screen settings like brightness and contrast on your digital devices. 60 to 70% contrast and brightness are usually recommended for reduced eye strain. The use of anti-blue light glasses or anti-blue light filters for screens is also recommended (5).


Yoga ocular exercises
Practicing eye yoga is a good way of providing effective relief for your eyes and minimize eye fatigue symptoms by increasing the efficiency of extraocular muscles (6). Here is a simple exercise: sweep your eyes from left to right and then up and down, always going as far as you can. Do this exercise for a couple of minutes twice a day.


Artificial tears
Using non-prescription artificial tears keeps your eyes moisturised and relieves eye irritation and dry eyes. If the symptoms of eye strain are causing major discomfort, see your eye doctor before getting any medication.


Eye health supplements to relieve eye strain
Nutritional supplements rich in antioxidants can promote healthy visual function (7). We will explore a few options to consider in the next section.

Ingredients for maintaining eye health


1.Zinc is a crucial mineral with various vital functions in our body. One of the important nutritional effects of zinc is slowing the progression of age-related macular degeneration (8), Оne of the leading causes of visual disability worldwide. Studies have demonstrated that zinc supplementation, when combined with other antioxidants, can suppress retinal degeneration.


2. Vitamin B1, also known as thiamine, is essential for maintaining proper nerve function and overall eye health. Thiamine is responsible for transmitting visual information from the eyes to the brain. While there is limited direct evidence directly linking vitamin B1 to alleviating eye strain, its general benefits for nerve function may indirectly contribute to reducing eye discomfort (9). Adequate thiamine levels may help optimize nerve function, potentially reducing the likelihood or severity of eye strain (10).


3. Astaxanthin is a powerful carotenoid. It exerts its antioxidant properties in the ciliary muscle which controls focus in the eyes. Eye strain is usually present if this muscle is overworked by staring at a screen all day long. Astaxanthin works directly to relax the ciliary muscle and therefore reduce eye strain.


4. Anthocyanins are known to improve blood flow and concentration. Commonly present in red, blue, or purple fruits and vegetables, they contain a specific anthocyanin, Cyanidin-3-O-galactoside. This is also the main active ingredient of Brainberry®, the Aronia Melanocarpa extract researched and developed by BioActor. Clinical studies have validated this ingredient’s efficacy in improving focus and hand-eye coordination.

2023 Recap & Plans for 2024

2023 Recap & Plans for 2024

December 5th, 2023

As 2023 is coming to an end, we take a moment to reflect on our work and achievements of the year. 

Our dedicated team actively participated in 17 international events, contributed to academia by publishing four scientific papers in international peer-reviewed journals, and initiated two promising research collaborations.

In addition, our team had regular monthly business trips and numerous productive client meetings. These accomplishments stand as a testament to our collective efforts and dedication to our work, providing high quality, science-based nutrition solutions.

solabia bioactor 2023

With gratitude, we reflect upon the accomplishments of 2023 and we are looking forward to what lies ahead in 2024.

Here we share a brief glimpse into what the upcoming year holds:

  • 6-7 March: Nutraceuticals Europe, Barcelona
  • 14-16 May: VitaFoods Europe, Geneva
  • 18-20 September: VitaFoods Asia, Bangkok
  • 30-31 October: SupplySide West, Las Vegas


Get in touch!

    heart health and food and cordiart

    What are the best ingredients for heart health?

    What are the best ingredients for heart health?

    Maastricht, 5th December 2023

    Cardiovascular health is vital for longevity. Lifestyle factors, including regular exercise and a heart-healthy diet, are crucial for maintaining cardiovascular well-being. Omega-3 fatty acids, soluble fibers, vitamins, and polyphenols in the diet play key roles in regulating blood pressure and cholesterol levels. Find out more about keeping your heart healthy.

    ingredients to improve heart health

    The cardiovascular system

    Maintaining cardiovascular health is essential for a long and active life (1). The cardiovascular system consists of the heart, arteries and veins in the human body.

    There are two important blood transportation systems: the pulmonary circulation and the systemic circulation. The pulmonary circulation transports deoxygenated blood to the lungs, to allow the exchange of carbon dioxide for oxygen by the lungs. The second system is the systemic circulation, which transports nutrient- and oxygen rich blood to all organs and cells (2). Therefore, both systems contribute to delivery of oxygen blood to tissues from head to toe. This is essential because every single cell in the human body needs oxygen and nutrients to maintain energy production.

    How can nutrition impact cardiovascular health?

    There are several factors that can influence the well-being of cardiovascular health. Stress is a major player in changing blood flow. It can temporarily increase blood pressure and heart rate. Over time, chronic stress can lead to persistent high blood pressure, inflammation, and the buildup of fatty deposits in the arteries, a condition known as atherosclerosis. (3)


    On the other hand, regular exercise and physical activity help improve heart and blood vessel function, lower blood pressure, reduce cholesterol levels, and maintain a healthy weight.


    Another factor that impacts cardiovascular health, is diet. A “heart-healthy” diet is low in saturated fats, cholesterol, salt, and added sugars, and high in fruits, vegetables and whole grains. Food directly impacts the health condition of your heart. If you choose the right foods, you can help to keep your heart in good shape. (4).


    These heart-healthy foods help to reduce inflammation, lower blood pressure, and maintain healthy blood vessels. Here are a few great options:


    Healthy fats, found in olive oil, avocados, and fatty fish like salmon, are integral to cardiovascular health. They promote optimal cholesterol profiles and reduce the risk of blood clots.

    Legumes like beans, chickpeas and lentils, aid in lowering cholesterol levels and blood pressure. The health effects of this food are typically attributed to the high content of fiber, nutrients, and active plant compounds (5).

    Fruits that contain high levels of polyphenols – a complex group of secondary plant metabolites. There is growing evidence that suggests that polyphenols could be relevant compounds for improving heart health. Notably, certain varieties of citrus fruit are known for their high levels of antioxidants, which play a role against oxidative stress (6, 7).

    cordiart heart health ingredients

    Key ingredients for heart health

    Some people are limited in choosing their food, because of limited availability, so they may not be able to consume a diet rich in abovementioned foods. Supplementation could be a feasible alternative to consume the crucial compounds from those foods for supporting cardiovascular health. Therefore, we will now have a deeper look into the effective compounds, which can be easily supplemented:


    Omega-3 fatty acids are an example of healthy fats. They can be found in a lot of retail channels, pharmacies or online, predominantly in soft gels. They reduce the amount of triglycerides and improve cholesterol levels by lowering LDL cholesterol and increase the good HDL cholesterol. Moreover, omega-3 regulate blood pressure and have anti-inflammatory properties.

    Soluble fibers, normally found in fruits, legumes, vegetables and grains. They bind to cholesterol and remove it from the body. In this way, cholesterol levels can be reduced (8). Examples of soluble fibers to look for in terms of supplementation are psyllium, pectin and wheat dextrin.

    Vitamins can help to improve heart health. For example, there is high-quality research showing that Vitamin B9 supplementation can reduce the risk of stroke and cardiovascular disease (9). Moreover, Vitamin K2 serves an important role in cardiovascular health through regulation of calcium homeostasis. It can lead to a reduction in arterial stiffness (10).

    Citrus flavonoids are a group of polyphenols that are, unsurprisingly, found in citrus fruits. Flavonones are a subclass of flavonoids that are linked to an improvement in heart health. Specifically, hesperidin (hesperitin-7-O-rutinoside), offers several health advantages due to its anti-inflammatory and antioxidant properties, potentially playing a role in cardiovascular health (11). Some studies suggest that hesperidin may help lowering blood pressure and improving blood vessel function, which can be beneficial for heart health (12).


    BioActor has developed Cordiart®, a proprietary sweet orange extract that is high in the rutinoside hesperidin. Cordiart® has the potential to support heart health by improving blood vessel function, reducing inflammation, and helping to manage high blood pressure. It can also assist in lowering LDL cholesterol levels. The beneficial effects of Cordiart® on endothelial function are clinically proven (13, 14).

    Solabia BioACtor Quadram Institute

    BioActor & Quadram Institute announce collaboration

    Solabia-BioActor announces the start of a collaboration with The Quadram Institute to assess the bioavailability and kinetics of Brainberry®

    Maastricht/Norwich, 29th November  2023

    Solabia-BioActor announces the start of a collaboration with The Quadram Institute to assess the bioavailability and kinetics of Brainberry®, Solabia-BioActor’s proprietary Aronia melanocarpa extract.

    Solabia BioActor Quadram Institute

    Solabia-BioActor has expertise and experience in developing innovative active ingredients, extracted from plants (botanicals) with great potential to support human health in terms of cognitive support, healthy aging and gut health enhancement.


    The Quadram Institute is a premier research organization, based at the Norwich Research Park in the United Kingdom. It is home to researchers and clinicians that work together to develop world-class health, microbiome and food science. 


    Solabia-BioActor’s Senior Scientist Sanne Ahles takes the lead on this collaboration together with Dr. Paul Kroon, a principal investigator at The Quadram Institute. Dr. Kroon is the leader of the Polyphenols and Health Group and his research focuses on understanding the mechanisms by which dietary polyphenols are absorbed and exert health benefits.


    The objective of this project is to study the bioavailability and kinetics of Brainberry®, a proprietary aronia melanocarpa extract, in human volunteers. BioActor will carry-out the human intervention study and the Quadram Institute will identify and quantify a broad range of metabolites in a variety of samples obtained in the study.

    Sanne Ahles, Senior Scientist at Solabia-BioActor comments:

    “The bioavailability of Brainberry® has not been researched until this point. This collaboration with the Quadram Institute will allow us to broaden our knowledge regarding the anthocyanin metabolism and shed light on any possible differences between its steady-state bioavailability in young and older adults.”

    About Solabia-BioActor

    Solabia-BioActor, based in Maastricht, Netherlands, is a product development company that develops and supplies proprietary bioactive formulations to the health and sports nutrition industry. All Solabia-BioActor’s products are clinically tested, doping-free and from natural origin. The main focus areas are: gut microbiome, brain health, energy & vitality and skin health.