6 Reasons to Include Actiful® in Your Energy Supplement

Top 6 Reasons to Include Actiful® in Your Energy Supplement

Top 6 Reasons to Include Actiful® in Your Energy Supplement

November 1st, 2021

As energy-boosting dietary supplements are gaining popularity amongst consumers, the need for clinically-proven health ingredients is growing accordingly. If you are a formulator looking to craft an effective product targeting energy & vitality, you may be overwhelmed by the many ingredients available out there. Can’t make your mind up? In this article, we explore the top 6 reasons to include Actiful® in your product.

6 Reasons to Include Actiful® in Your Energy Supplement

The growing interest in energy-boosting supplements.

In today’s hectic world, more than ever, people suffer from tiredness and lack of energy. Many consumers indeed tackle physical and mental stress with the help of dietary supplements, which help them with avoiding the fatigue feeling, doing more sport and being more socially active.

The interest in nutritional solutions for an extra energy kick is increasingly gaining popularity. In fact, according to the recent CRN consumer survey on dietary supplements, improving energy levels is among the top 5 reasons for consuming such products (28%, a 7% increase yearly), showing how people are relying on supplements to get through the day.

What is Actiful®?

Actiful® is a patent-protected orange and pomegranate complex specifically designed to enhance energy and vitality, affecting short-term and long-term energy systems and improving mood.

This all-natural ingredient is standardized for highly bioavailable hesperidin, an important polyphenol found in sweet orange (Citrus Sinensis).

BioActor developed Actiful® and, together with Maastricht University, researched the ingredient and confirmed its health benefits in multiple randomized, double-blind placebo-controlled clinical trials.

Including Actiful® in your formulation: top 6 reasons

If you are thinking of including Actiful® in your formulation, you must know the following:


1. It has been clinically tested in both young and senior subjects.
When the common goal is being more active, Actiful® is the ideal ingredient for both young and senior subjects.

The efficacy of Actiful® was first demonstrated in a 4-week randomized, placebo-controlled, double-blind clinical study conducted with young subjects. The results show that immediate and sustained energy improved significantly for the supplementation group compared to placebo.

In another clinical trial, the objective was to measure the effect of Actiful® on energy and mental wellness in seniors. As expected, anaerobic power significantly improved in the supplementation group.

Interestingly, also the WHO Quality of Life scores on mental wellness significantly increased in the Actiful® group, compared to the placebo.


2. It boosts the NO levels, thereby improving the blood flow.
The active flavonoids in sweet orange, the major component of Actiful®, were found to activate the phosphorylation of Endothelial Nitric Oxide Synthase (eNOS). eNOS is the key enzyme for Nitric Oxide (NO) synthesis. Consequently, NO increases, having a beneficial effect on the endothelium by promoting vasodilation and increasing blood flow.

As a direct consequence of the improved blood flow, oxygen and nutrients are more efficiently transported to the body districts where required.

Pomegranate further augments the production of NO as it is an excellent donor of highly bioavailable nitrate.


3. It works directly at the mitochondrial level.
Experiments in myotubes showed that Hesperitin, the active flavanone derived from the metabolization of Actiful®, enhances ATP production at the mitochondrial level.

By quenching the reactive oxygen species (ROS) and reducing proton leakage between the intermembrane space and the mitochondrial matrix, Hesperitin is able to improve the proton gradient required for the ADP-ATP phosphorylation cycle.

This process results in a better “respiration capacity” of the mitochondria, leading to more ATP production, the fuel for our muscle.


4. It acts on the body as well as on the mind.
Mood is a crucial aspect of every individual’s well-being. Stress, anxiety, focus and happiness are all factors that affect our psychophysical wellness.

It was demonstrated that the supplementation with Actiful® not only positively affects the energy level, but it may also affect the mood.

As it is clear that body and mind work in tandem, Actiful® can be considered the perfect vitality enhancer!


5. High bioavailability is proven.
Bioavailability is an important aspect to consider in nutraceuticals, as it is a key indicator of absorption and directly influences the bio-activity of specific molecules.

Actiful® was developed with this concept in mind, and a human and in vitro study demonstrated that the active ingredient starts to be taken up by the body within minutes.

Furthermore, the active metabolites remain available for several hours after consumptions. Hence, Actiful® offers excellent potential for a significant immediate energy boost, maintained over time after consumption.


6. It is patent-protected.
Actiful® is an innovative and patent-protected ingredient. BioActor is a pioneer in researching the positive effect of citrus flavonoids on energy metabolism.

This further adds value and makes Actiful® even more unique. Why? Because you won’t find imitations in the marketplace.

If you are interested in learning more about Energy & Vitality – Trends, Clinical Research and Innovation, you should check out our webinar on this topic. Click here to register!

6 ingredients for brain health

6 Best Ingredients For Brain Health

6 Best Ingredients For Brain Health

September 1st, 2021

If you are looking to include in your diet compounds to nourish your brain, you came to the right place; In this article, we explore six interesting ingredients that may improve your brain health

6 ingredients for brain health

What is a healthy brain?

The brain. This massive network of firing neurons is the center of each decision we make on a daily basis and in life. It consumes up to 20% of our total oxygen each day, while only accounting for 2% of our total body weight – underlining its importance [1]. Alongside oxygen, it also requires plenty of nutrients to keep processes running at all times, both when awake or sleeping.

A well-known nutritious diet that packs a variety of nutrients is the Mediterranean diet – often described as a diet that supports a well-functioning brain. This is due to the wide variation of key nutrient-providing foods such as seafood, fruits and vegetables, olives and olive oil, nuts, beans and wine.

Supplementing your diet for optimal brain health

As healthy as a diet can be, every diet can still be supplemented with supplements, and more specifically dedicated ingredients. Although the Italians consume the Mediterranean diet, they also consume a lot of supplements: the Italian supplements market remains by far and large the biggest in Europe. Yet, also for individuals living in other parts of the world, with different food options, supplements can be a useful asset to optimize their diet.

In this article we take a deep dive into 6 of the best ingredients that you should be looking for on the label of supplements, that can aid you in sustaining a healthy brain:

1. Berry Anthocyanins
Anthocyanins are a group of compounds that belong to the flavonoid family. They are renowned for giving fruits and vegetables their vibrant dark blue/purple colours. Blueberries, raspberries and acai berries contain high amounts of anthocyanins but are all dwarfed by Aronia berries (also known as chokeberries), which contain by far and large the highest amounts of anthocyanins.

Anthocyanins exhibit their biological effects mainly through their strong antioxidant activity. By increasing perfusion to the brain and also improving neurotransmitter levels, anthocyanins aid in improving cognitive functions, notably executive & working memory, psychomotor speed, and attention [2,3].

Read more about the health benefits of Aronia berries


2. Phosphatidylserine
Phosphatidylserine (PS) is a phospholipid that forms the inner side of the cell membrane – a fatty layer that makes up the layer of human cells. As a supplement, PS or intermediates like citicoline are widely available and found in multiple products on the market.

Orally consumed PS is absorbed efficiently by the human intestinal system and crosses the blood-brain barrier. PS is the main phospholipid in the brain and is involved in the protection of nerve cells and aids in relaying information from one neuronal cell to the other. These key functions of PS lead to roles for this compound in a multitude of cognitive functions, amongst others: long-term memory, concentration, problem solving and locomotor functions [4].


3. Choline
Choline is an essential nutrient that acts as a precursor to phospholipids (Phosphatidylcholine), acetylcholine (neurotransmitter) and betaine (involved in amino acid metabolism). Choline levels may be low in lactating and pregnant women, older and younger individuals [5], so adequate choline intake for these populations is advised.

Dietary choline intake correlates with cognitive function and choline-containing compounds have been linked with a reduction in vascular dementia [6]. Of course, choline levels need to remain optimal to have sufficient building blocks for acetylcholine, the chief neurotransmitter for relaying information from one neuron to the other.


4. Resveratrol
Resveratrol is a polyphenol predominantly found in grapes, and as a result, in wine. It has been linked to the promotion of health by exerting neuroprotective, anti-inflammatory and beneficial cardiovascular effects.

When we look at the cognitive benefits that resveratrol brings for a healthy brain, it improves blood flow in the frontal cortex; providing this decision-making area with more nutrients and oxygen. Resveratrol protects the brain from reactive oxygen species (ROS), which are formed as a by-product of the high energy and oxygen consumption of neurons. It scavenges the free radicals, protecting against damage to neurons and associated tissues [7].


5. Docosahexaenoic Acid
Abbreviated as DHA, this compound is a long-chain highly unsaturated omega-3 fatty acid. DHA is found predominantly in fish, krill and algae, but also widely available in supplement formats as fish oil, krill oil or algae oil. All of these sources also often contain the complementary eicosapentaenoic acid (EPA).

DHA affects key neurological processes like neurotransmitter release, gene expression, signal transduction and differentiation of neurons. Especially the frontal lobes, which are responsible for executive functions like attention, planning and problem solving, are sensitive to DHA levels. Keeping DHA levels in check is key to cognitive performance, with researchers indicating that dietary DHA intake is required to maintain sufficient brain DHA levels [8].


6. Ginkgo Biloba
Ginkgo biloba extracts (GBE) come from the dried leaves of the Ginkgo biloba tree. Chinese, Japanese and Korean cultures have used extracts from this tree in their traditional medicines. GBEs have been linked to improving cognitive function and decelerating cognitive decline. This is due to their strong antioxidative activities, ability to improve neurotransmitter levels and neuroprotection potential.

GBEs have been used to treat dementia, with significant efficacy being demonstrated at high daily doses of >240mg. Yet, also for healthy people, GBEs might be a useful ingredient for enhancing blood flow to the brain combined with an anti-oxidant effect [9].

Boost Coffee

The health benefits of Aronia Berry: why should you consume this superfruit?

The health benefits of Aronia Berry: why should you consume this superfruit?

September 1st, 2021

Aronia berries are small dark fruits that are becoming increasingly popular amongst health-conscious consumers. Current research suggests that due to their excellent content in micronutrients and antioxidant properties, these berries may provide important health benefits on immune health, cardiovascular function, brain health as well as exhibiting anti-diabetic function.

Boost Coffee

What is Aronia berry?

Aronia berries, are little dark fruits, belonging to the Rosaceae Family. Aronia is native to easter and North America but it is also commonly found in the Baltic region of Europe where it was introduced in the first half of the 20th century.

The reason why these berries are also called “Chokeberries” is that when consumed fresh off the shrub, they make your mouth tickle due to their incredibly strong tart taste and mouth-drying effect.

Though many people have never heard about them, Aronia berries are becoming increasingly popular among health-conscious consumers and are considered a real superfruit.

What are the health benefits of Aronia berries?

To answer this question we need to first take a step back in the past where, traditionally, Aronia was used by the North American Forest Potawatomi tribe as a cold remedy.

They called these fruits “nîki’mînûn” and used them to make a traditional tea. The reason why Aronia berry was found to be so effective in treating common cold symptoms is probably linked to their extremely powerful antioxidant capacity.

Nowadays, it is well-known that antioxidants in Aronia outperform any other fruits, even elderberries, blueberries, and raspberries.

Aronia berries contain high levels of vitamin C, but the real claim to fame is their high level of polyphenols, anthocyanins and proanthocyanins [1]. These are types of antioxidants that help to fight the damages caused by free radicals in the body, and it is these antioxidants where Aronia berries can have their greatest impact on our health and wellbeing.

Aronia Antioxidant

In fact, Aronia is considered a real superfruit due to its high level of antioxidant phytonutrients that can be beneficial in many ways.

Research around Aronia berries have focused on several health benefit areas, and there is evidence to suggest that these fruits may have the potential to:


  • Strengthen the immune system [2].
  • Improves cardiovascular function [3].
  • Improve brain health [4].
  • Help against metabolic syndrome [5].
  • Prevent urinary tract infections [6].

Nutritional Facts

Aronia berries are low-calories fruits, full of important micro-nutrients accountable for their numerous health benefits.

100 g of Aronia berries provide the following nutrients [7]:

  • Calories: 47.0 (197 Kj)
  • Carbs: 9.6 g
  • Fat: 0.5g
  • Protein: 1.4g
  • Fiber: 5.3g
  • Vitamin A: 350 IU (7% DV)
  • Vitamin C: 21 mg (35% DV)
  • Vitamin K: 13.6 mcg (17% DV)
  • Manganese: 0.6 mg (32% DV)

Moreover, researchers have identified a total of 7 different anthocyanins in Aronia berries. These include phytocompounds such as cyanidin-3-O-glucoside, an important molecule that has been reported to exhibit anti-inflammatory, anticarcinogenic and antimutagenic activities, while also enhancing spatial memory, cognition and psychomotor control.

How to get more Aronia berries in your diet

Unfortunately, it is not easy to commonly find fresh Aronia berries on the shelf at the grocery store.

However, there are many alternatives. Especially in specialised stores or online it is possible to buy Aronia in form of frozen or dried fruits, tea, jams, juice and wines.

Another effective way to include Aronia in your diet can be through the use of dietary supplements. This can be a great way to ensure you are getting the most out of the health benefits of Aronia berries.