Top 6 ingredients for cognition and eye health
Top 6 ingredients for cognition and eye health
All of our senses allow us to enjoy the world around us and vision is no exception. Cognition is essential to make something meaningful of all senses. As you can imagine, nutrition is crucial in maintaining healthy vision and cognition, since several nutrients are essential for the visual system. In this blog, we embark on a journey to discover these essential nutrients, and, as a bonus, discuss a few compounds that can actually enhance cognition and eye-health!
The connection between cognition and vision
Cognition is a broad term encompassing thinking, learning, memory, and attention; in other words, it refers to all the mental processes that occur in the brain (1). Vision functions as a key information provider to cognition. This relationship between the brain and eyes is crucial since vision can impact performance of cognitive tasks, positively or negatively. Deterioration of eye performance is actually linked to a reduction in cognitive activities like reading and socializing, notably leading to a poor cognitive state (2).
Challenges for a healthy vision
In our modern-day society, numerous factors present challenges to the well-being of both our vision and cognition. One essential challenge is the abundance of time spent behind screens. Digital eye strain is a condition that is attributed to prolonged and extended use of digital screens typically related to symptoms like blurry vision, headaches and dry eyes (3).
According to the American Optometric Association, workers and regular users of digital screen devices are especially at risk. Screen time of two or more hours without interruption, can already lead to aforementioned symptoms (4). More than 60% of the working population in the US report having symptoms related to too much screen time. Moreover, >70% of children and adolescents exceed the two hour screen time as well (5).
Given the extent of the challenges, it becomes imperative to adopt proactive measures to mitigate their effects and safeguard eye health, and cognition by extent. By addressing these factors head-on, we can not only slow down the development of age-related degenerative processes but also actively support the resilience and vitality of our eyes and cognitive functions.
Taking care of our eyes
How should we take care of our eyes? Let’s discuss a couple of easily adoptable measures:
Regular eye check-ups. It’s advisable to have a comprehensive eye examination every two years, regardless of wearing glasses or not (6). Optometrists may prescribe glasses with anti-reflective coatings to protect eyes from harmful blue light emitted by electronic devices.
Adopting eye-friendly behavior. The 20-20-20 rule is a simple and effective measure to reduce eye strain. It encompasses the idea to look at an object at least 20 feet (6 meters) away for 20 seconds, every 20 minutes (7). In order to make this a habit, you can opt to put a timer every 20 minutes when you are at work.
A diet rich in eye-healthy foods. Nutrition is a crucial modifiable factor with the potential for a huge effect on our daily life. There are sources that naturally contain compounds that help in maintaining a healthy vision and cognition. You can think of eggs, fatty fish, certain seeds, nuts and berries.
Eye health supplements. If you are limited by inconvenience or geographical access for food choice, it can be tricky to consume nutrients in recommended quantities through a regular diet. Therefore, adding nutritional supplements is a great additional strategy for reaching the required amount of nutrients in a safe and convenient manner.
The 6 best ingredients for cognition and eye health
When choosing to select supplements for supporting cognition and eye health, you consider a couple of relevant ingredients. Let’s check out the six to keep in mind:
Vitamin A is essential to protect the outer surface of the eye, known as the cornea. It also maintains the function of the retina, which allows us to differentiate colors and shades. Vitamin A can be obtained from yolks, liver and some vegetables like carrots (8). Supplementation is advised if the recommended daily dose cannot be reached via the diet – 900mcg for men and 700mcg for women.
Lutein is a yellow carotenoid pigment, found in the central retina. Its function is to protect against the harmful blue light (9), often emitted by electronic devises. Lutein supplementation may reduce the risk of developing harmful eye conditions. Common sources of lutein include green peas, parsley and kale as well as egg yolks. The daily dose of lutein supplements is between 5-20 mg.
Astaxanthin is a well-known anti-oxidant, often referred to as “the king of the caretonoids”, with health benefits in multiple areas, amongst which eye health. It improves ocular blood flow, enhancing oxygen distribution and waste clearance in the eyes (10). Astaxanthin can be obtained by eating salmon, shrimp and lobster. However, for supplementation purposes, there is a great alternative through microalgae sources, which is a natural and animal-friendly alternative. Supplementation daily dose varies between 4-12 mg (11).
Omega 3 fatty acids are a great strategy for overall health support, including the eyes. Omega-3s could reduce the risk of dry eyes and high eyes pressure (12). Food sources of omega 3 include salmon, herring and tuna. Additionally, supplements derived from fish, krill or microalgae are widely available. The daily dose for supplementation ranges from 500-600mg.
Vitamin E protects the retina from harmful oxidation. It’s crucial for optimal eye health and can be mostly obtained by eating seeds and nuts (13). Daily supplementation dose ranges between 5-12mg (14).
Aronia berry extract. Aronia berries are fruits with a high concentration of anthocyanins, specifically cyanidin-3-0-glycosides (14). These compounds are linked to benefits for cognition, focus, and eye health. BioActor’s proprietary Aronia berry extract, Brainberry®, has been demonstrated to improve focus, concentration and hand-eye coordination at a low daily dose of only 65 mg (15, 16).
Exploring the power of postbiotics: benefits and uses
Exploring the power of postbiotics: benefits and uses
Currently, probiotics and prebiotics are widely known for their favorable impact on gut health. More recently, the focus has expanded to include postbiotics, which encompass products or byproducts generated through microbial fermentation and are also acknowledged for their health advantages. Nevertheless, these postbiotics remain unfamiliar to most consumers. Dive into our new blog to find out more!
What are postbiotics?
Gut health is key to your overall well-being and there are many ways to support your gut health. Prebiotics and probiotics are well-known, but what about probiotics?
Postbiotics encompass a class of substances defined as “preparations containing non-living microorganisms or their components, which bring about positive health effects for the host.” In simpler terms, they refer to the byproducts or metabolic products that result from the fermentation processes of bacteria.
This category of postbiotics encompasses various kinds of compounds. Among them are short-chain fatty acids, known for their multiple health advantages, as well as fragments of microbial cells, functional proteins, extracellular polysaccharides, cell lysates, and teichoic acid.
In contrast to probiotics, postbiotics offer health benefits without requiring a live state. This characteristic contributes to their stability compared to the live bacteria they originate from. [1]
Why should I use postbiotics?
A question on your mind might be: why should you consider postbiotics when you’re already using pre- and probiotics?
It’s crucial to recognize that everyone’s gut microbiota composition differs. As a result, the way various components are processed can vary from person to person.
This means that the impact of probiotics and prebiotics on health can differ among individuals. A way to control for this is by consuming postbiotics. You are then directly taking the beneficial components, so differences in microbiota composition don’t have an effect in this case.
If you’re interested in learning more about prebiotics, you can refer to this article. Alternatively, if you’re already familiar with prebiotics, you might find this article on synbiotics to be of interest!
What are the advantages for health that postbiotics offer?
Research indicates that postbiotics can bring forth a range of health benefits, including:
Balancing the microbiota: Elements found in postbiotics, like butyrate, a type of short-chain fatty acid, prove advantageous for maintaining gut health. [2]
Influencing the immune system: Butyrate has the ability to trigger the generation of T cells within the intestinal tract, thereby aiding in the regulation of immune responses. Additional components, such as fragments of microbial cell walls, can enhance the production of cytokines—chemical messengers that mitigate inflammation and bolster immune reactions. [2,3]
Shaping metabolic processes: Short-chain fatty acids such as propionate play a role in enhancing insulin sensitivity and glucose tolerance. Simultaneously, butyrate spurs the generation of an antioxidant called glutathione. [1,2]
Assisting in weight loss: Short-chain fatty acids could contribute to weight loss by influencing eating behaviors. This is attributed to the release of hormones that induce a sense of fullness. [1]
Easing symptoms of irritable bowel syndrome (IBS): In a study involving 443 individuals with IBS, the administration of orally ingested, heat-inactivated Bifidobacterium bifidum, a postbiotic, notably alleviated IBS-related symptoms such as abdominal pain, discomfort, bloating, and irregular bowel habits. [4] Curious to read about the effect of pre- and probiotics on IBS symptoms? Read more here!
Potential additional advantages: Administering inactivated lactic acid bacteria orally might aid in eradicating Helicobacter pylori infection, addressing chronic unexplained diarrhea, and mitigating the adverse impacts of stress. [1]
How can I incorporate postbiotics into my diet effectively?
Postbiotics might not be as readily available as probiotics and prebiotics, but you can acquire them from health food stores or online retailers. They are generally regarded as safe and well-tolerated.
Given that postbiotics are a product of bacterial fermentation within your gut, you can enhance their production by consuming foods abundant in probiotics and prebiotics. Probiotic-rich options include fermented foods like yogurt, kefir, tempeh, and kombucha. For prebiotics, focus on incorporating high-fiber foods into your diet, such as vegetables and whole-grain products.
Top 5 ingredients for men's health
Top 5 ingredients for men’s health
Incorporating health ingredients into daily routines helps to support men’s well-being and health. We will provide you with evidence-based recommendations on five key ingredients supporting men’s health and sexual function, including fenugreek seed extract, zinc, B vitamins, pomegranate extract, and hesperidin.
In today’s fast-paced world, prioritizing our health and well-being is becoming more and more important, also for men. As the increasing expectations and pressures of our lives continue to evolve, it is important for men to develop a proactive approach to maintain their physical, mental, and sexual health.
Health ingredients are designed to meet men’s health needs, ensuring that they stay healthy and full of energy. In this article, we will provide evidence-based recommendations on five key ingredients supporting men’s health and sexual function.
Fenugreek seed extract
As men age, they experience a decrease in testosterone levels. This phenomenon is also known as andropause. Testosterone plays a role in many aspects of health, including sexual function, muscle and bone mass, energy levels, and metabolism. One of the ingredients that may help to combat the problems related to andropause is fenugreek seed extract . Fenugreek (Trigonella foenum-graecum) is a very interesting herb with many potential health benefits.
A study performed on 120 healthy men showed that a 12-week supplementation of fenugreek seed extract (600 mg/day) increased testosterone levels and improved sexual function, compared to placebo [1]. Also, supplementation of fenugreek seed extract in healthy male athletes resulted in increased fat-free mass, lean body mass, and elevated testosterone levels compared to placebo [2]. These findings suggest that fenugreek seed extract is a promising ingredient for men’s health, especially in terms of increasing testosterone levels and improving sexual function.
Zinc
Zinc is an essential mineral, which means that it is not produced by the body itself. It plays an important role in many physiological functions, such as supporting the immune system and healing damaged cells. Zinc is a critical mineral for men’s health as even a small deficiency can impact the immune system, cardiovascular health, reproductive function, and fertility [3].
Sufficient intake of zinc contributes to normal fertility and sexual function in males. Low levels of zinc are related to low levels of testosterone. Besides, it is also important for the normal functioning of the immune system, and the maintenance of bone health [4].
Therefore, we can state that zinc is an important mineral that can help men improve their sexual health and energy levels and maintain a healthy immune system.
B Vitamins
B vitamins play a vital role in the human body. They are involved in many important functions. For example, they are crucial for energy production, oxygen support, and bone health.
The vitamin B complex consists of a total of eight B vitamins, with several of them having beneficial effects on men’s health, for example:
– Vitamin B12: Adequate levels of vitamin B12 are important for the production of red blood cells, which are responsible for oxygen transport. Also, studies showed that vitamin B12 is important for bone health [5, 6].
– Vitamin B9: Vitamin B9, also known as folate, is not only an important vitamin for women but also for men. Research has shown that folate contributes to the reduction of fatigue, which is a common complaint nowadays [7].
– Vitamin B6: Vitamin B6 plays a vital role in energy and vitality. Intake of this vitamin contributes to normal energy metabolism. Studies also showed that it leads to a decrease in fatigue and tiredness [8].
– Vitamin B5: Pantothenic acid, also known as vitamin B5 is an essential vitamin, which plays a vital role in various functions in the body. It is mainly known for its important role in the metabolism of food, leading to energy production [9].
All in all, B vitamins are important for energy production. Increased energy levels lead to improved stamina and sexual performance.
Pomegranate extract
Pomegranate (Punicagranatum L.) is a fruit that contains lots of healthy phytochemical compounds, such as polyphenols, flavonoids, and nitrates [10]. These phytochemicals have many antioxidant and anti-inflammatory qualities beneficial for men’s health [11].
The polyphenols within pomegranate fruit are the main bioactive compounds responsible for the various health benefits attributed to this extract. The peel of the pomegranate contains the highest amounts of polyphenols. Two of the primary polyphenols in the peel are ellagitannins (punicalagin and punicalin) and ellagic acid [12].
Studies showed that pomegranate extracts are associated with the treatment and prevention of many diseases and disorders in men , such as cardiovascular diseases, infertility, and erectile dysfunction [13, 14, 15]. For example, pomegranate has a positive effect on blood flow, key for erectile function and sexual performance [16].
Hesperidin
Hesperidin is a bioflavonoid found in citrus fruits, abundant in sweet oranges (Citrus sinensis). After ingestion, hesperidin is converted to hesperetin by the microbiome. Hesperetin is considered the active metabolite of hesperidin and has been shown to have several beneficial health effects for men.
One of the health effects of hesperidin is that it has antioxidant activity, through neutralizing Reactive Oxygen Species (ROS) [17]. This may eventually lead to enhanced overall well-being and an increase in energy when you need it most. This antioxidant activity also has a positive effect on fertility in men, since free radicals (ROS) decrease sperm motility and increase DNA damage [18].
Additionally, hesperidin is known for its positive effect on blood flow. The active ingredient achieves this by increasing the availability of nitric oxide [19]. Eventually, this leads to an improved supply of nutrients and oxygen during physical and sexual activity, and to an improved erectile function.
Actiful®: An ingredient containing hesperidin and punicalagin
Actiful® is a natural orange and pomegranate complex and is standardized for highly bioavailable hesperidin and punicalagin: the primary polyphenols present in sweet orange (Citrus sinensis) and pomegranate peel (Punica granatum).
The health benefits of this ingredient have been scientifically validated and confirmed through multiple randomized double-blind controlled trials. It is clinically proven that Actiful® results in enhanced physical performance in men [20, 21].
Actiful® not only influences physical performance. It also boosts energy levels by targeting the mitochondria within the cells [22]. Additionally, Actiful® has been demonstrated to positively impact mental health [19].
Lastly, it has been shown that Actiful® positively affects blood flow [21], by increasing the availability of nitric oxide. Hereby it promotes improved erectile function in men, leading to longer-lasting erections.
Overall, Actiful® stands as a promising and scientifically backed choice for men aiming to improve their physical performance, sexual function, and overall health.
Everything you need to know about MicrobiomeX® and gut health
Everything you need to know about MicrobiomeX® and gut health
The gut microbiome plays a vital role in our digestive system, responsible for digesting nutrients while also serving as a central component of our gut wall and immune system. Maintaining a healthy microbiome profile is of utmost importance and ongoing research continues to shed light on its intricate functions. In this article, we introduce MicrobiomeX®, one of our sustainably sourced, plant-based active ingredients supported by clinical research. Explore the benefits of incorporating MicrobiomeX® into your formulation.
What is gut health and why is the gut microbiome important?
The gastrointestinal system is often referred to as the ‘gut’, including the stomach, intestines, and colon. Its primary function is to digest and absorb nutrients, essential for meeting our energy needs.
Within the gut approximately 200 billion species of bacteria reside, collectively known as the gut microbiome. Many of these microorganisms play a vital role in food digestion and are crucial for maintaining a healthy gut and overall well-being.
It’s important to recognize that the condition of the gut microbiome can significantly impact physical health, but also mental health. Well-established connections exist between the gut microbiome and various aspects such as the immune system, the gut wall, mental health, autoimmune diseases, sleep, skin health etc. (1). Numerous factors, including diet, age, and lifestyle, can influence the gut microbiome. Hence, it is clearly important to maintain and support a healthy gut microbiota through nutritious foods and supplements.
Tips for improving Gut Health
Enhancing gut health is possible through dietary and lifestyle choices. Certain foods are known for their positive impact on gut health, particularly fermented foods and fiber-rich options. By increasing their intake, we can reduce the risk of developing gut inflammation and metabolic diseases. Incorporating physical activity and using supplements, including prebiotics and probiotics, are additional strategies. Emerging products now focus on non-fermenting plant-based ingredients, such as prebiotics and citrus flavonoids.
Exploring Prebiotics, Probiotics and More
- Prebiotics: these non-digestible food ingredients offer health benefits by selectively stimulating the growth and activity of specific intestinal bacteria (2). Foods rich in prebiotics include onions, garlic, greens, cereals and bananas.
- Probiotics: Live microorganisms that benefit the host by reducing harmful bacteria and supporting the gut’s natural flora (3). Consider consuming fermented foods and probiotic supplements, such as yogurt, tempeh, kombucha, and kimchi, to promote good bacteria.
- Postbiotics: the byproducts of digestion (4). vitamins B and K, antimicrobial peptides, amino acids, and short-chain fatty acids, play a role in supporting good bacteria. Some postbiotics, like de-glycosylated ‘active’ flavonoids, are generated by specific beneficial bacteria and are also known as flavobiotics.
- Synbiotics: a powerful combination of probiotics and prebiotics (5). As mentioned above, prebiotics support the function of probiotics, working in synergy to optimize digestive health and bolster the immune system.
Understanding flavonoids
What are flavonoids? Flavonoids are natural substances found in plants, known for their diverse health benefits. They have become an indispensable part of the nutraceutical market, due to their ability to modulate key cellular enzymes and their antioxidative, anti-inflammatory, and anticarcinogenic properties.
Fortunately, sourcing flavonoids is sustainable. They are primarily extracted from immature fruits in an eco-friendly manner. For example, orange and grapefruit trees bloom annually, but not all blossoms can become full grown fruits. The trees undergo a natural selection process called ‘fruit drop,’ shedding immature fruits to conserve their resources.
What are the benefits of using immature fruits?
After the fruit drop, immature oranges and grapefruits are not suitable for raw consumption. Still, they are full of valuable nutrients. To harness these nutrients, the most practical approach is to process them into a powdered form, which can be easily incorporated into nutritional supplements.
Why do immature oranges and grapefruits matter?
These immature fruits are particularly rich in a nutrient of interest, hesperidin. By standardizing the extract from immature oranges for hesperidin content, we can create an eco-friendly and sustainable ingredient. As mentioned earlier, fruit drop is a natural occurrence, and these immature oranges become a byproduct that we can utilize. Similarly, another valuable ingredient, naringin, can be extracted from immature grapefruits.
What are hesperidin and naringin?
Hesperidin and naringin are flavonoids with numerous health benefits. What sets them apart is their unique ability to reach the colon intact, where they directly nourish the gut microbiome. This, in turn, leads to the production of short-chain fatty acids (6, 7), including the vital butyrate, the primary energy source for colon wall cells.
These flavonoids are abundantly found in citrus fruits like oranges, grapefruits, and lemons (8). The extraction of valuable flavonoids from such citrus fruits is a well-established practice. Extensive studies (9) confirm that a combination of hesperidin and naringin positively affects the gut microbiome composition by improving the short-chain fatty acids profile, mainly increasing butyrate content.
How can hesperidin and naringin improve gut health?
The unique chemical structure of hesperidin and naringin allows them to traverse the digestive system, arriving mostly intact in the colon. Here, the gut microbiota breaks them down into their active forms, hesperetin and naringenin, both highly bioavailable and transported to various tissues via the bloodstream.
Notably, hesperidin and naringin selectively nourish specific bacteria species, such as Bifidobacterium, Roseburia, and Lactobacilli (10). This promotes the growth of beneficial bacteria, reinforcing the gut’s defense against harmful pathogens. Additionally, these flavonoids play a pivotal role in supporting the immune system by inhibiting oxidative stress and gut inflammation.
In summary, the journey from immature fruits to powdered extracts of hesperidin and naringin offers an eco-friendly and sustainable way to enhance gut health and overall well-being, while also minimizing waste and maximizing the benefits of these valuable compounds.
What is MicrobiomeX®?
MicrobiomeX® is a potent blend of extracts derived from Citrus sinensis (immature oranges) and Citrus paradisi (grapefruit). It stands as a pioneering Flavobiotic®, designed to fortify the gut barrier and unlock the full potential of the gut microbiome. Remarkably, MicrobiomeX® is entirely plant-based and produced sustainably. It adheres to multiple dietary preferences, including vegan, halal, kosher, gluten-free, and hormone-free. Notably, MicrobiomeX® distinguishes itself by being non-fermenting, with its flavonoids activated through a microbiota-driven process known as de-glycosylation.
Extensive research conducted by BioActor, through pre-clinical and clinical trials, has illuminated the remarkable benefits of MicrobiomeX®. Consumption of MicrobiomeX® leads to an enhanced profile of short-chain fatty acids, with a specific increase in butyrate. Additionally, calprotectin levels decrease, signaling a reduction in gut inflammation.
Who can benefit from taking MicrobiomeX®?
MicrobiomeX® can be beneficial for everyone who wants to immprove their microbiome composition and strengthen their immunity. For a more targeted approach, this blend of sweet orange and pomegranate extracts could help the following groups:
MicrobiomeX® is a promising solution for individuals struggling with irritable bowel syndrome (IBS). Notably, MicrobiomeX®’ non-fermenting nature reduces the production of gas and intestinal discomfort. Additionally, it fosters the proliferation of Bifidobacterium, a beneficial bacteria associated with improved gastrointestinal symptoms in individuals with IBS.
Another demographic that can find MicrobiomeX® beneficial is athletes, particularly those engaged in endurance sports. Endurance athletes frequently experience gastrointestinal discomfort due to the extended and repetitive nature of activities like running or cycling. MicrobiomeX® offers a potential remedy by reducing gut permeability and bolstering the gut barrier.
What is our source of citrus flavonoids?
Nestled in the heart of Spain, at Finca la Gloria, lies a family-run orange plantation. Here, eco-friendly methods are employed to safeguard the trees, eschewing the use of pesticides. Every year, the orange trees burst with blooms. After the natural selection process known as ‘fruit drop,’ immature oranges fall from the trees. Fortunately, they are readily available for us to harvest and extract all benefits they can offer.
Learn more about MicrobiomeX®
If you are curious to know more about MicrobiomeX®, you can check out the product page of MicrobiomeX® or its website.
Why are you more easily fatigued as you get older?
Why are you more easily fatigued as you get older?
Feeling tired all the time? Sleeping or resting is not doing the trick? You might be experiencing more than just regular tiredness – it could be fatigue. As we get older, our energy stores tend to drain more easily, which can contribute to fatigue. Fatigue is a common concern as we age, and it can have a significant impact on our overall well-being. In this article, we’ll explore fatigue in later life, its possible causes, and simple steps you can take to combat it.
What is fatigue?
As we age, it’s common to notice that our energy levels deplete more easily. We may find ourselves wanting to do the things we used to, but realizing we have less energy to perform these things. This change in energy levels can be attributed to fatigue.
Fatigue is defined as a state of tiredness or exhaustion that comprises a multifaceted combination of mental and physical elements. A crucial aspect of fatigue is that is not solved by simply resting more [1].
Contributing factors to fatigue at later age
One of the potential causes of fatigue at a later age is a loss of function in the mitochondria. Mitochondria are the “powerhouses” of the cell, and they produce energy in the form of adenosine triphosphate (ATP) to sustain all processes in the body.
Loss in function of mitochondria occurs naturally as a result of aging, specifically increased levels of oxidative damage by reactive oxygen species (ROS) cause a decrease in the ability of mitochondria to produce ATP efficiently [2].
Another common cause of fatigue at a later age may be related to the cardiovascular system since aging induces a functional and structural decline in the cardiovascular system [3]. Although the mechanisms are unclear at this moment, it is likely that increased arterial stiffness and reduced cardiac output are related to causing fatigue [4].
Other factors contributing to fatigue at a later age could be:
Hormonal changes: Experiencing hormonal changes as we age is a common symptom. In women, menopause causes decreased production of estrogen and progesterone. These hormonal fluctuations may lead to feeling fatigued [5].
Lack of physical activity: We might become more sedentary as we age, due to several factors. However, this may lead to, for example, mood disturbances, poorer sleep quality, or even changes in your metabolism.
Nutrient deficiencies: As we age, nutrient absorption and intake can be affected by various factors, such as the use of medication, changes in dietary patterns, and changes in gastrointestinal health [6].
Boosting your energy level
Unfortunately, aging is a process that cannot be reversed, so preventing fatigue is not avoidable. However, don’t despair! There are a number of easy lifestyle habits that can help: exercise regularly, participate in social activities you enjoy, and eat a well-balanced diet [6].
A well-balanced diet can be optimized by the implementation of supplements into your diet. Supplements can be a valuable addition to your diet since they address potential nutritional deficiencies and support your overall health and well-being.
Which nutrients help to beat fatigue?
Nutritional deficiencies often contribute to feelings of fatigue, so ensuring adequate nutrient levels is essential. Here are some key nutrients that can help in overcoming fatigue [7,8]:
1. Iron: This vital mineral supports oxygen supply to the muscles and plays a crucial role in energy production. It is also an important part in the structure of the enzymes responsible for ATP production.
2. Magnesium: Another important mineral involved in energy production, magnesium activates ATP synthase, an enzyme responsible for synthesizing ATP. It also serves various functions related to energy production, muscle function, bone health, and protein synthesis.
3. Vitamin C: This essential nutrient aids in fighting fatigue by enhancing iron absorption and safeguarding red blood cells from oxidative stress. By promoting improved oxygen supply to the muscles, vitamin C contributes to combating fatigue.
4. B vitamins: B vitamins play a multifaceted role in energy production. They are integral to the metabolism of macronutrients and also support the production of red blood cells, indirectly contributing to oxygen supply.
5. Bioflavonoids: These polyphenolic compounds offer numerous health benefits, like improved blood flow and increased mitochondrial efficiency. Actiful®, a substance rich in the bioflavonoid hesperidin, is particularly a good option to consider.
3. Actiful®: A natural ingredient for more energy
Actiful® is an orange & pomegranate complex, containing a high amount of micronized hesperidin. The ingredient is developed to boost vitality and optimize energy levels.
A proprietary clinical trial by BioActor showed that Actiful® provides immediate and sustained energy. It does so by improving blood flow to active muscles and optimizing the respiration capacity of mitochondria, in turn increasing ATP production [9].
Actiful®’s positive effect on blood flow is linked to vasodilative capacities of the active metabolites. Micronized hesperidin promotes vasodilation by stimulating the production of nitric oxide [10]. Nitric oxide relaxes the blood vessels, thereby enlarging their diameter and allowing the passage of a greater amount of nutrient-rich blood and oxygen.
As a bonus, Actiful® positively affects mental well-being. In our proprietary clinical trial, we showed a significant improvement in concentration, thinking, memory, and learning [11]. These aspects are vital for overall well-being and quality of life.
Overall, Actiful® is a safe, healthy, and natural ingredient which is perfect to be incorporated into energy-providing supplements.
5 reasons to use Bonolive® in your women’s health product
5 reasons to use Bonolive® in your women’s health product
Bonolive® is an extract based on olive polyphenols that contains a high amount of oleuropein, a potent phytonutrient found primarily in olive trees. Numerous studies have demonstrated the beneficial properties of Bonolive®, including mitigation of potential risks associated with menopause. In this blog, we will explore some of the scientific evidence supporting the health benefits of olive polyphenols and why you should use it in your women’s health product.
Bonolive®: Mediterranean support for women’s health
Bonolive® is a natural compound sourced from olive leaves. It’s standardized to contain high levels of olive polyphenols, specifically Oleuropein.
Developed by BioActor, its primary aim is to support women’s health during the post-menopausal phase (1). This period often introduces various health challenges, such as decreased bone density, joint discomfort, and a heightened risk of cardiovascular problems.
Numerous clinical studies consistently highlight the positive effects of supplementing with Bonolive® (1 , 2 , 3). These studies have revealed that Bonolive® plays a role in enhancing bone strength, reducing joint discomfort, balancing lipid profiles, and easing specific menopause-related symptoms.
Consequently, it contributes to lowering the risk of developing conditions like osteoporosis (brittle bones) and heart issues as time progresses.
Oleuropein: the hero compound of Bonolive®
Olive oil holds a pivotal role in the Mediterranean diet (4). The primary polyphenols in olive oil are Oleuropein and its metabolite hydroxytyrosol. These polyphenols have been extensively studied and recognized for their preventive benefits against various disorders.
Researchers have unraveled their mechanisms, showing promise in reducing risks of breast cancer, ovarian cancer, postmenopausal osteoporosis, and other health issues.
Bonolive® is standardized to contain Oleuropein. Because of this, Bonolive® is a perfect match for adding to dietary supplements and functional beverages made to support women’s health during menopause.
5 reasons to use Bonolive® in your women’s health product
1. Bonolive® improves bone health and reduces joint discomfort
Bonolive® has demonstrated its positive influence on bone and joint health (1). An investigation centered on post-menopausal women with reduced bone mass unveiled a notable surge in a foundational protein that serves as the framework for generating new bone. Moreover, an improvement in bone mineral density was seen.
In a recent six-month study involving 124 participants aged 55 and above, the efficacy of Bonolive® came to light. It brought relief to joint discomfort linked to activities like walking, bending, and knee movement (2).
Consequently, a daily dosage of 250 mg of Bonolive® proves sufficient to deliver advantageous outcomes for both bone and joint well-being.
2. Bonolive® reduces menopause related symptoms
BioActor undertook a consumer study aimed at assessing the benefits of Bonolive® among post-menopausal women. This investigation unveiled the favorable influence of Bonolive® on alleviating menopause-related symptoms in this demographic.
The study focused on women who had already gone through menopause, aiming to see how Bonolive® affected their reported symptoms. For 28 days, participants took Bonolive® regularly. After just 14 days, they felt better in terms of bloating, anxiety, mood swings, energy levels, and skin health. This improvement continued even after the full 28 days of using Bonolive®.
This reinforces the potential of Bonolive® in enhancing the well-being of post-menopausal women.
3. Bonolive® has favorable effects on lipid control
Clinical research has shown the favorable impacts of Bonolive® in managing the blood lipid profile among post-menopausal women (1). Notably, supplementation with 250mg of Bonolive® over a 12-month period led to significant improvements. Specifically, a significant reduction in LDL-cholesterol, total cholesterol, and triglycerides was observed.
4. Bonolive® has a superior bioavailability
Another study aimed to assess the bioavailability of Bonolive®. Interestingly, a more substantial increase in the levels of metabolites in the blood of post-menopausal women was observed compared to women who hadn’t gone through menopause yet. This suggests that post-menopausal women experienced higher absorption of Bonolive®.
Additionally, the study revealed that Bonolive® possesses antioxidant effects, as evidenced by its ability to reduce levels of a substance called MDA, which is a marker of oxidative stress.
5. Bonolive® is a sustainable solution
Olive trees hold the distinction of being among the oldest cultivated trees globally. However, the surge in olive oil production has taken a toll on the environment (5).
The primary waste generated during olive growth is the pruned leaves of the olive trees. Yet, these leaves contain valuable compounds of which oleuropein is one. This is why Bonolive® is made from the freshly cut olive leaves, meaning it is a clean, sustainable and natural ingredient for a women’s health product.
Bonolive®: A key ingredient for women’s health
Studies have found that Bonolive® can help women stay healthy after menopause. Using Bonolive® as an olive polyphenol extract can bring big benefits to women’s health products. Bonolive® can be used in many different products and has lots of advantages. It’s a great ingredient to promote a healthier lifestyle and improve women’s well-being.
Curious to read about the clinical studies on Bonolive® in more detail? Download our white paper below!
Baltic Brainfuel: Discover the health and sustainability behind the Nero Eggert variety of Aronia berries
Baltic Brainfuel: Discover the health and sustainability behind the Nero Eggert variety of Aronia berries
Discover the world of Aronia berries, where health and sustainability intertwine in the extraordinary Nero Eggert variety. With its exceptional nutritional profile and eco-conscious characteristics, this superfruit is a beacon of wellness for both individuals and the planet. Learn more about the reasons Aronia berries are superfruits and about the ever more special Nero Eggert variety.
Aronia berries: Sustainable health-enhancers
Aronia berries are small dark fruits that are becoming increasingly popular amongst health-conscious consumers as they have excellent content in micronutrients and strong antioxidant properties. Moreover, they have many health benefits.
Apart from providing numerous health benefits, Aronia berries are also interesting from an environmental perspective, thanks to some unique characteristics of this plant.
This is particularly true for the variety called Nero Eggert, selected by BioActor to produce the active ingredient for brain health, namely Brainberry®.
Join us, while we dive into the reasons why Aronia berries are considered superfruit and why the Nero Eggert variety is especially great.
We visited Mr. Eggert, who spent more than 30 years on creating the Nero Eggert variety. Watch the video below:
Aronia Berries: Reason they are excellent for health and sustainability reasons
1. Full of nutrients and anthocyanins:
Aronia berries are more than just berries – they’re nutritional powerhouses. Packed with vital vitamins, minerals, and dietary fibers, these berries contribute significantly to your overall well-being. However, their true power lies in their antioxidant content, particularly the anthocyanins. These antioxidants play a pivotal role in combating oxidative stress and supporting cellular health.
2. Multifaceted health benefits:
Aronia berries have diverse health benefits. From bolstering cardiovascular health to enhancing cognitive function, these berries offer a holistic approach to health.
3. Embracing sustainability:
What truly sets Aronia berries apart is their minimal impact on the environment. Unlike resource-intensive crops, Aronia plants thrive on modest water consumption and natural pest resistance, making them a responsible and sustainable choice for environmentally-conscious consumers.
Nero Eggert variety: What sets it apart from other Aronia berries?
1. Sustainable harvesting methods:
Meet the Nero Eggert Aronia variety – a game-changer in sustainable agriculture. With unique low-reaching branches, this breed helps with harvesting practices. Not only does it yield more fruit per land area, but it also provides reduced land usage, striking a balance between productivity and ecological responsibility.
2. Flourishing amidst harsh climates:
Witness nature’s resilience through the Nero Eggert variety. Flourishing even in freezing temperatures as low as minus 20 degrees Celsius, these berries naturally rejuvenate during harsh winters, eliminating the need for chemical interventions. This adaptation showcases the variety’s capacity to coexist harmoniously with the environment.
3. Abundant in anthocyanins:
The Nero Eggert variety’s high anthocyanin content is a testament to its ability to thrive under stress. The challenging climate it thrives in stimulates the production of these antioxidants, making every berry a valuable source of natural health support.
4. Bee-friendly:
Beyond its health and sustainability attributes, the Nero Eggert Aronia berry plays a vital role in the ecosystem. Its extended flowering period provides nourishment for bees during their lifecycle, promoting biodiversity and exemplifying the variety’s contribution to preserving nature’s balance.
Nero Eggert Aronia Berries: A blend of health and sustainability
The Nero Eggert Aronia berry seamlessly intertwines health benefits and sustainable practices. For this reason, we have chosen this unique fruit as the base for our Brainberry® extract, which has been clinically validated to boost your cognitive performance.
Feel free to contact BioActor via info@bioactor.com and visit www.brainberry.eu and www.bioactor.com to learn more about Brainberry® or click here to learn everything you need to know about Brainberry® and brain health.
How a healthy microbiome boosts your immune system
Unlocking the power of your gut: how a healthy microbiome boosts your immune system
Did you know that your immune system’s performance is intricately tied to the health of your gut microbiome? In this article, we delve into the fascinating connection between your gut microbiome and immune system. Discover the key role of the gut microbiome in immune function and learn about the dietary components that can nurture a diverse and thriving gut ecosystem.
A symbiotic relationship: gut microbiome and immune system harmony
The human body is a bustling ecosystem housing trillions of microorganisms, collectively known as the microbiome. Among these, the gut microbiome stands out as a vibrant community of bacteria, viruses, fungi, and parasites (1).
This intricate network collaborates to maintain a balanced blend of beneficial microorganisms, protecting us from potential invaders.
Recent advancements have illuminated the gut microbiome’s dynamic involvement in our well-being, extending beyond passive existence.
This intricate web of microorganisms actively influences various bodily functions, including bolstering the development and efficacy of the immune system. Our immune system, in turn, maintains a delicate equilibrium, defending against pathogens while avoiding autoimmune responses (2).
Microbiome’s immune-boosting strategies
Short-Chain Fatty Acids (SCFAs)
At the heart of the gut microbiota’s influence on immunity lies the production of Short-Chain Fatty Acids (SCFAs) through dietary fiber fermentation in the large intestine (3).
These SCFAs, such as acetate, propionate, and butyrate, play a pivotal role in maintaining gut balance and modulating immune responses. They orchestrate immune cell functions, like regulatory T cells and antigen-presenting cells, and stimulate cytokine and chemokine production, bolstering immunity.
Furthermore, SCFAs can directly quell pathogenic activity by suppressing virulence-related genes, curbing potential threats.
Fortifying the barricade: tight junctions
The gut’s tight junctions act as gatekeepers, upholding the integrity of the intestinal barrier (4). Inflammation or infections can disrupt these barriers, allowing undesirable substances to escape into the bloodstream, triggering immune responses (5, 6).
SCFAs step in as allies here, contributing to the assembly of robust tight junctions within intestinal cell walls. This reinforcement prevents the escape of harmful toxins from the gut, bolstering the gut wall’s ability to shield against infections (5).
When this symbiotic relationship thrives, the immune system guards us against infections. However, an unbalanced microbiota composition might trigger inflammation, autoimmune disorders, and chronic diseases (1, 5).
Strategies to help the gut ecosystem flourish
A diverse and balanced gut microbiome is universally recognized as vital for our health (7). Research highlights that such diversity empowers immune responses against infections while reducing autoimmune responses. Conversely, a low-diversity microbiome is linked to chronic inflammation and an elevated risk of colorectal cancer.
To nurture a flourishing and diverse gut microbiome, prioritizing a balanced diet and healthy lifestyle is very important.
Choose for a spectrum of fruits, vegetables, whole grains, and lean protein sources. These foods, rich in fiber, prebiotics, and nutrients, provide nourishment for beneficial gut bacteria.
1. Fiber: the gut’s aid for immunity
Fiber’s role in gut health is crucial, as it bolsters microbiome diversity. A diet rich in fiber, found in fruits, vegetables, and whole grains, enhances gut bacteria abundance and diversity. This, in turn, augments immune function, reducing chronic disease risks (8).
2. Prebiotics: fuel for beneficial bacteria
Prebiotics, a specific type of fiber, serve as sustenance for our beneficial gut inhabitants. Foods like onions, garlic, leeks, asparagus, bananas, and whole grains are brimming with prebiotics, nurturing a thriving microbial community.
3. Water: hydration and gut motility
Staying hydrated is crucial for optimal gut function. Drinking plenty of water helps maintain proper gut motility and prevents constipation. Adequate hydration supports the movement of food through the digestive tract, allowing beneficial bacteria to thrive and contribute to a healthier gut.
4. Probiotics and postbiotics: allies for immunity
Fermented foods like yogurt, kefir, sauerkraut, and kimchi harbor probiotics—live bacteria conferring health benefits. Additionally, postbiotics, metabolic by-products or components produced during fermentation, like SCFAs, amplify the benefits. Consuming these products directly ingests these components, bolstering health.
5. Synbiotics: Uniting Prebiotics and Probiotics
Synbiotics, the blend of prebiotics and probiotics, synergistically promote gut health. Examples include yogurt with inulin or fructooligosaccharides (FOS), and kefir with galactooligosaccharides (GOS).
6. Reducing stress levels
Besides diet-related strategies, there are other ways to help your gut stay healthy. Stress can negatively impact the gut-brain axis and disrupt gut health. Practicing stress-reduction techniques like meditation or deep breathing can have a positive impact on both your mental well-being and gut health.
Cultivate your gut for immune resilience
In summary, the gut microbiome profoundly impacts the immune system’s effectiveness. A thriving and varied gut ecosystem fortifies us against infections and chronic ailments, while an imbalanced one heightens vulnerability. By embracing a well-rounded diet full of fiber, prebiotics, and fermented foods, we can nurture our gut microbiome, bolstering overall health.
Exploring the significance of nutrients for mitochondrial health
Enhancing mitochondrial health: exploring the significance of nutrients
Discover the influence of nutrients on your mitochondrial health. Dive into our blog to learn how magnesium, hesperidin, vitamin C, omega-3s, and more can enhance your mitochondrial health and boost your overall vitality.
Nutrients to support mitochondrial health
Maintaining the optimal performance of our mitochondria is pivotal for our overall well-being. These microscopic organelles act as cellular powerhouses, generating a significant portion of the energy necessary for our cells to function at their best.
Beyond energy production, they also regulate metabolic processes and uphold a delicate balance of nutrients within our cells
Dysfunctional mitochondria can result in notable symptoms like fatigue and muscle weakness. In more serious instances, they have been linked to critical health conditions such as cardiovascular ailments and neurodegenerative diseases.
Consequently, prioritizing the health of our mitochondria is not only essential for general vitality but also plays a preventive role against potential illnesses.
Within this article, we will take a look at specific nutrients that actively contribute to the maintenance and augmentation of mitochondrial health.
Magnesium and mitochondrial vitality
Magnesium plays a vital role in ensuring the well-being of our mitochondria. It serves as a crucial facilitator for enzymes responsible for energy production, while also exhibiting antioxidant properties.
This antioxidative function of magnesium is particularly significant, shielding mitochondria from potential harm induced by harmful molecules. Additionally, magnesium takes on the responsibility of regulating calcium levels within mitochondria, a pivotal function in averting any potential malfunctioning (1).
Sustaining an appropriate intake of magnesium is essential to uphold the health of mitochondria and prevent any disruptions in their functioning. Incorporating magnesium-rich foods into our diet, such as nuts, seeds, whole grains, and leafy green vegetables, provides a natural source of this essential mineral. Additionally, it’s a possible addition for an energy supplement.
Hesperidin: a citrus boost for mitochondria
Hesperidin, a natural compound present in citrus fruits like oranges, lemons, and grapefruits, offers significant potential in maintaining robust mitochondrial health.
By boosting the expression of genes linked to energy production, hesperidin enhances mitochondrial functionality. This augmentation translates to increased energy production within the mitochondria, resulting in elevated energy levels and reduced fatigue (2).
Moreover, hesperidin boasts anti-inflammatory attributes that play a role in curbing inflammation throughout the body. As inflammation can contribute to mitochondrial disturbances, mitigating this inflammation becomes a supportive measure for preserving mitochondrial well-being.
Vitamin C to boost mitochondrial health
Vitamin C holds a crucial role in maintaining the well-being of our mitochondria. Serving as one of the body’s most potent antioxidants, vitamin C offers safeguarding prowess against detrimental molecules known as free radicals, shielding our mitochondria from harm (3).
Free radicals possess the capacity to impair mitochondria, diminishing their capacity to generate energy. However, vitamin C effectively counters these radicals, preventing their damaging effects.
Therefore, ensuring your diet includes a good dose of vitamin C becomes a noteworthy strategy to keep healthy mitochondria.
Omega-3s: helpful for energy
Omega-3 fatty acids are a type of healthy fat found in foods like fatty fish, nuts, and seeds. They play a crucial role in promoting the health of our mitochondria.
These fatty acids are boosters for mitochondria: they help these powerhouses extract more energy from the same amount of nutrients, which means less fatigue and more energy (4). Omega-3s also shield mitochondria from damage caused by harmful molecules. They also improve the mitochondria’s ability to transport nutrients in and out efficiently.
Omega-3 fatty acids also bring anti-inflammatory capabilities, which is good for our overall well-being. Including foods rich in omega-3s in our diet is a smart move to support your mitochondria, boost energy production, and keep inflammation in check.
B-vitamins and their ability to support mitochondrial well-being
B vitamins, including B1, B2, B3, B5, and B7, are fundamental contributors to the maintenance of optimal mitochondrial health. These vitamins play a pivotal role in facilitating energy production within mitochondria by participating in the breakdown of carbohydrates, fats, and proteins.
The main reason for this is that B vitamins can act as co-enzymes and precursors of co-enzymes that help in the breakdown of these nutrients. This is key for mitochondrial health. Inadequate intake of these B vitamins can lead to compromised mitochondrial function, resulting in sensations of fatigue, weakness, and muscular discomfort (5).
Sustaining an adequate dietary supply of B vitamins is imperative to sustain the functional integrity of mitochondria and facilitate efficient energy synthesis.
Intake of nutrients to support mitochondrial health
In summary, looking after the health of our mitochondria is vital for our general well-being. A range of nutrients, such as hesperidin, magnesium, B-vitamins, omega-3 fatty acids, and vitamin C, play key roles in supporting mitochondrial function. They not only help diminish oxidative stress and inflammation but also enhance exercise performance.
By incorporating these essential nutrients in your diet, we can effectively boost our mitochondrial health and ensure our body’s energy production functions at its best.
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From tree to health support: uncovering the benefits of olives, olive leaf and olive oil
From tree to health: uncovering the benefits of olives, olive leaf and olive oil
Delve into the health benefits of the Mediterranean diet, centering on olives and extra virgin olive oil. Uncover the positive effects of oleuropein, particularly for women during and after menopause, providing natural support for overall well-being.
The Mediterranean diet has gained widespread recognition as one of the healthiest diets globally, known for its ability to prevent diseases like heart disease and cancer.
Key components of this diet include olives and extra virgin olive oil (EVOO), which are celebrated for their health benefits.
In this article, we will delve into the composition of olives and EVOO, exploring the various health benefits associated with their consumption. Moreover, we will focus on their potential advantages for women facing post-menopausal concerns, shedding light on the natural alternatives available to alleviate their symptoms.
Olives and extra virgin olive oil: Pillars of Mediterranean health
The Mediterranean diet revolves around plant-based foods, whole grains, nuts, herbs, and spices. It encourages moderate consumption of fish, seafood, and poultry, while red meat and sugar are consumed infrequently. The main source of added fat in this diet is EVOO, which stands out for its numerous health benefits (1).
Composition of extra virgin olive oil
EVOO is derived from freshly cold-pressed olives, the fruits of the olive tree (Olea europaea). This process ensures that the beneficial components of EVOO, known as biophenols, are preserved.
The primary fatty acids in EVOO are monounsaturates, particularly oleic acid, which constitutes 55-80% of the total fatty acid content. The remaining portion consists of small amounts of saturated and polyunsaturated fatty acids.
Beyond the fatty acids, EVOO contains various minor components such as antioxidants, including carotenoids, α-tocopherol, and phenol compounds. Among these phenols, the main ones found in EVOO are hydroxytyrosol, tyrosol, and oleuropein. Oleuropein, in particular, is present in olives, olive leaves, and olive oil, making oleuropein a key player in the health benefits associated with these products.
Oleuropein: a compound from olives and olive leaf with remarkable health benefits
Oleuropein, a compound with remarkable health benefits, has been extensively studied for its potential in preventing various disorders. As an antioxidant, it effectively combats harmful compounds in the body, reducing the risk of heart problems, cancer, osteoporosis, Alzheimer’s, and premenstrual syndrome, among others. Studies have demonstrated its ability to protect cells from oxidative damage, reducing the risk of chronic diseases and contributing to the prevention of inflammatory conditions (2, 3).
Furthermore, the cardiovascular benefits of oleuropein are noteworthy, as it supports heart health by reducing LDL (“bad”) cholesterol levels and lowering blood pressure. These effects, in combination with its antioxidant properties, contribute to the prevention of cardiovascular diseases such as atherosclerosis.
Interestingly, while oleuropein is present in olive oil and olives, you might be surprised to learn that olive leaves contain even higher levels of this beneficial compound. This makes olive leaves a great source for obtaining oleuropein and reaping its healthful advantages (4).
Women’s health: how can it benefit from olives?
Postmenopausal women often experience symptoms such as fatigue, anxiety, and mood swings. The global population of postmenopausal women has grown significantly, leading to increased research on natural alternatives to alleviate these symptoms (5).
Oleuropein’s ability to lower blood pressure may be beneficial for women with hypertension during menopause. High blood pressure is a common concern during this stage of life, and the consumption of EVOO as part of the Mediterranean diet could help manage this condition naturally (6).
Oleuropein’s antioxidant properties are also relevant to women’s health. Oxidative stress is a contributing factor to the development of various diseases, and antioxidants like oleuropein help counteract this stress, promoting overall well-being.
Recent studies have also shown that oleuropein has positive effects on bone health, which further enhances its impact on women’s health, especially during and after menopause.
Osteoporosis, a condition characterized by reduced bone density and an increased risk of fractures, is a significant concern for postmenopausal women due to hormonal changes and declining estrogen levels. The anti-inflammatory properties of oleuropein play a crucial role in reducing bone loss and inflammation, helping to maintain bone strength and integrity.
By including the Mediterranean diet with its oleuropein-rich olives and EVOO, women can potentially safeguard their bone health and mitigate the risks associated with osteoporosis, contributing to an overall improvement in their well-being during the post-menopausal stage.
Oleuropein and women’s health: the benefits of olives and olive leaf
The Mediterranean diet, which includes olives and extra virgin olive oil, offers many health benefits, thanks to oleuropein: a compound that helps prevent diseases and promotes overall well-being, especially in women post-menopause.
For those who may have limited olives or olive oil in their regular diet, supplements containing high levels of oleuropein might be beneficial. Bonolive®, an ingredient by BioActor, is high in its oleuropein content and has been extensively studied. To read more about these studies, download our white paper below.
