New Publication in Nutrients shows beneficial effects of MicrobiomeX® in TIM-2 model

New Publication in Nutrients shows beneficial effects of MicrobiomeX® in TIM-2 model

Maastricht, The Netherlands, 17th November 2021

Press release
The effect of MicrobiomeX®, a natural citrus ingredient consisting of specific active flavonoids, was evaluated through in-vitro examination in the TIM-2 model. The study results, recently published in a peer-reviewed journal, showed that MicrobiomeX® can beneficially change the microbiota composition and Short-Chain Fatty Acids production of human volunteers.

In-Vitro Study on MicrobiomeX®

A recent in-vitro study in the TIM-2 dynamic model of the large intestine has shown that MicrobiomeX® has a profound effect on the microbiota composition, already after three days.

MicrobiomeX® is a natural Flavobiotics® from citrus fruits, designed to support gut & immune health by lowering gut inflammation and beneficially shifting the gut microbiome composition.

This innovative flavonoid-based ingredient has already shown in a first clinical trial to boost overall gut health by positively changing the short-chain fatty acid composition. In addition, lower faecal calprotectin levels (an important biomarker of gut inflammation) were found in the treatment group.

The outcome of the new in-vitro study, recently published in Nutrients, showed that the consumption of MicrobiomeX® led to a microbiota composition typical of a person following a healthy plant-based diet rich in fibre.

The study was conducted by the group of Professor Koen Venema, who is also the last author of the publication.

The purpose of the study was to find out whether low doses of MicrobiomeX® – 250mg and 350mg – would have a short term effect on the human gut microbiota and the production of short-chain fatty acids.

The study was carried out in the TIM-2 model with faecal samples from 7 human volunteers. These samples were either treated with two different doses of MicrobiomeX® or a control. Already after 48 hours, the first differences between the treatment and the control could be observed, which became significant after 72 hours.

Interestingly, a potent butyrate-producing class of bacteria – Roseburia spp – was significantly increased with both the 250mg and the 350mg doses, whereby the increases were clearly dose-dependent.

Click here to download the complete publication.

About BioActor

BioActor, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. The company focuses on the development of innovative activities that address active living and healthy ageing. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

Feel free to contact us for more information on the possibilities MicrobiomeX® has to offer.

Further information can also be found on: www.microbiomex.com


Brain imaging research

BioActor and UM establish a Public Private Partnership to study the benefits of Aronia on cognition

BioActor and UM establish a Public Private Partnership to study the benefits of Aronia on cognition

Maastricht, The Netherlands, September 22nd, 2021

Press release
BioActor already collaborates with Maastricht University in several areas, but this Private public partnership marks the start of an ambitious and comprehensive joint research programme, which will last three years, and aims to unravel possible mechanisms that make Aronia Melanocarpa such a powerful bioactive to improve brain fitness

Brain imaging research

The joint research programme will study the benefits of Aronia on cognition

BioActor and Maastricht University (“UM”) established a Public Private Partnership (“PPP”) to study the effects of Aronia Melanocarpa on brain fitness and cognition. This PPP received a competitive grant from Health Holland and will last for 3 years.

BioActor already collaborates with UM in several areas, but this PPP marks the start of an ambitious and comprehensive joint research programme to unravel possible mechanisms that make Aronia Melanocarpa such a powerful bioactive to improve brain fitness.

The PPP will be led by Dr. Peter Joris and Professor Jogchum Plat of UM’s Department of Nutrition and Movement Sciences. BioActor will make available a senior scientist, Sanne Ahles, who has already coordinated a previous clinical study with BioActor’s proprietary aronia extract Brainberry®.

The research programme will comprise a comprehensive clinical study, where besides cognitive parameters and blood biomarkers, brain scans will be made by Scannexus, specialist in Ultra High-Field MRI.

Dr. Peter Joris, Assistant Professor at UM comments:
“I’m very pleased with the establishment of this partnership with BioActor as it will allow us to explore mechanisms underlying beneficial effects of Aronia Melanocarpa on cognitive function, which may contribute to the prevention of cognitive impairment and ultimately dementia. Focus will be on brain insulin-sensitivity and vascular function assessed with brain MRI imaging in people at increased risk of cognitive impairment.”

Dr. Yala Stevens, Chief Scientific Officer of BioActor comments:
“This partnership with UM underscores our commitment to science and our passion for exploring research areas that have hitherto not been touched by others. That’s why we have decided to take a deep dive together with Dr. Peter Joris into the effects and mechanisms of aronia melanocarpa in the cognition and brain fitness space. I’m really curious what will come out of this research programme and excited to be able to share the results with the global nutrition science community.”

About BioActor:

BioActor is a life science company based on the Maastricht Health Campus and dedicated to research, develop and sell health ingredients addressing healthy ageing and active living. BioActor has a targeted portfolio of patented and branded health ingredients that are all based on food crops, clinically researched and produced in Europe.
For more info: www.bioactor.com

About Maastricht University:

The current project is performed at the Department of Nutrition and Movement Sciences within the School of Nutrition and Translational research in Medicine (NUTRIM), and will be integrated within an excellent scientific environment that offers facilities to perform state-of-the-art multi-disciplinary research, such as a unique Metabolic Research Unit (MRUM) and advanced MRI systems at Scannexus – an internationally focused brain MRI imaging center – facilities in Maastricht.


Arabinoxilan vaccine efficiency.j

Naxus® positive clinical results on its contribution towards an effective vaccination in elderly individuals

Naxus® positive clinical results on its contribution towards an effective vaccination in elderly individuals

Maastricht, The Netherlands, September 8th, 2021

Press release
The results of the recent clinical trial displayed the significant benefits of Naxus® towards the efficacy of vaccines . Naxus® led to a significant positive changes in parameters such as, cytokine production, microbiota composition, and fecal PH compared to other non-digestible polysaccharides.

Arabinoxilan vaccine efficiency.j

The Clinical Benefits of Naxus®

Immunosenescence is the process of deterioration of immune system functionality, mostly present in the elderly. Effective vaccination of the older adult is therefore a rising concern and a point to consider. BioActor has published the results of its recent clinical trial on Naxus®, an arabinoxylan extract from wheat endosperm on vaccination efficiency in Nutrients (Laue et al. 2021). Naxus® was compared to other non-digestible polysaccharides (NSPs): Wellmune®, Oatwell®, a beta-glucan from shiitake and exopolysaccharide preparation from L. Mucosae. NSPs are known for their promising effects on improving the immune response. From all investigated products, daily supplementation of Naxus® improved vaccination efficiency most effectively. Naxus® was further found to be safe, tolerable and feasible as a supplement.

The participants that completed the randomized, placebo-controlled, double-blind study were 231 of 239 subjects. Participants where split into six groups, each consuming a different non-digestible polysaccharide or control: Naxus®, Oatwell®, Wellmune®, a beta-glucan preparation from shiitake prepared according to a pre-specified procedure or an exopolysaccharide preparation from L. Mucosae for the duration of 5 weeks. The study showed significant beneficial changes in the Naxus® group compared to control in several parameters such as, cytokine production, microbiota composition and fecal pH.

Some of these beneficial changes could be linked with the significant increase in the abundance of Bifidobacterium in the gut that Naxus® demonstrated in the study. This increase is associated with a reduced infection, duration of influenza and severity of the common cold. Furthermore, an increase in IFN-γ was observed as a result of Naxus® consumption. IFN-y cytokines are produced by natural killer cells, which function as the first in line of defense against viral infections.

The researchers conclude that Naxus® is the most effective compound tested, compared to other NSPs, in this study to promote an adjuvant effect on the immune response to vaccination.
Although lack of understanding of the underlying mechanism, strong immunomodulatory are likely to explain the effect. Previous In-vitro work already demonstrated convincing links between the innate immune system and Naxus®. An enhanced vigilance of the immune system could therefore be the key to an explanation of the vaccination efficiency.

In conclusion, the findings in this study show a valuable contribution of Naxus® to our body, functioning as a prebiotic and enhancing protection against unwanted intruders!

BioActor’s Chief Scientific Officer, Yala Stevens says: “I am very happy with the publication of the vaccination trial, as it is the culmination of a great effort and collaboration involving multiple partners. These interesting results I believe are also very relevant and deserve to be shared within the scientific community and beyond.”

Naxus® can be applied in various finished dosage forms, including bars, granola, flapjacks, capsules, stick packs, scoopable powder.

About BioActor

BioActor, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. The company focuses on the development of innovative activities that address active living and healthy aging. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

Feel free to contact us via info@bioactor.com for more information on the possibilities Naxus® has to offer.
Further information can be found on: www.naxus.nl


Berries anthocyanins

The effects of berry anthocyanins on cognition - New publication

The effects of berry anthocyanins on cognitive performance – New publication from BioActor in collaboration with Maastricht University

Maastricht, The Netherlands, July 8th, 2021

Press release
The systematic review recently published in the International Journal of Molecular Sciences was conducted by BioActor in collaboration with Maastricht University and reviewed the effects of berry anthocyanins on cognitive performance.

Berries anthocyanins

Systematic review on berry anthocyanins and cognition

The International Journal of Molecular Sciences has recently published a systematic review about the Berry Anthocyanins’ effect on Cognitive Performance. The research was conducted by S. Ahles, clinical researcher at BioActor, in collaboration with the Maastricht University’s Department of Nutrition and Movement Sciences, School of Nutrition and Translational Research in Metabolism (NUTRIM).

This systematic review of randomized Placebo-Controlled Studies in Humans provides further evidence into the beneficial effects of berry anthocyanins on cognitive performance such as attention and psychomotor speed, executive function, and memory. Moreover, effects on vascular function and cardiometabolic risk markers were investigated.

Anthocyanins are a specific type of flavonoids abundantly found in various berries such as blueberry, black raspberry, and Aronia berry, to which these molecules confer the specific colours. These compounds offer a promising approach to improve cognitive performance and/or lower the risk of cognitive decline.

Ahles commented: “We are proud to report the achieved results providing evidence for the beneficial effects of berry anthocyanin on cognitive function. The observed health effects might be due to the anthocyanin-induced improvements in vascular function and blood pressure. Moreover, we found that the composition of the intervention product may play an important role as the bioactivity of anthocyanins is known to be dependent on their chemical structure. Future studies should focus on exploring a potential causal link between the beneficial effects on cognitive performance and improvement in vascular function and cardiometabolic risk markers.”

BioActor’s interest in berry anthocyanins has resulted in the development of the first-ever Aronia Berry extract targeting cognitive performance. The ingredient, branded under the name “Brainberry®”, was already tested in a randomized placebo-controlled clinical trial in healthy individuals and an observational study conducted with e-sports gamers, while a second RCT study, assessing its acute effect on cognition, is ongoing.

About BioActor

BioActor, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. The company focuses on the development of innovative activities that address active living and healthy aging. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

Feel free to contact us via info@bioactor.com for more information on the possibilities Brainberry® has to offer.
Further information can be found on: www.brainberry.eu


Gut microbiome

Partnership between BioActor and Wageningen University to integrate microbiota and immunity into a miniaturized assay

Partnership between BioActor and Wageningen University to integrate microbiota and immunity into a miniaturized assay

Maastricht, The Netherlands, June 28th, 2021

Press release
The intestine-on-a-chip model is a promising technology to revolutionize the currently used in vitro methods to better emulate the complex in vivo human intestinal physiology

Gut microbiome

The project

BioActor is thrilled to be an industrial partner of the INIMINI project, in partnership with Wageningen University & Research. The project “INIMINI-health: immune- and microbiota-competent intestine-on-a-chip to study health-promoting nutrition and drugs”, funded by Health Holland, aims to integrate microbiota and immunity into a miniaturized assay.

The intestine-on-a-chip model is a promising technology to revolutionize the currently used in vitro methods to better emulate the complex in vivo human intestinal physiology, providing an alternative for animal models in which species differences and ethical concerns are problematic. With this innovative tool, it will be possible to explore food interventions (and food-drug interactions) that can be used to prevent a compromised intestinal immune system and/or to treat the consequences.

The project consortium is a unique combination of knowledge partners (TO2 and academic institutes), six industry partners (Dutch and international) along the value chain, and the Dutch Maag Lever Darm Stichting (MLDS) as the key patient organization. BioActor will provide its knowledge on the physiological effects of flavonoids and arabinoxylans on the gut microbiota and the immune system.

This embodies the ‘quadruple helix’ approach that contributes to the overarching mission of “vital functioning citizens in a healthy economy”.

About BioActor
BioActor, based in Maastricht, Netherlands, is a life science company that develops and markets proprietary bioactives for the nutrition & healthcare industries. The company focuses on clinically validated innovative bioactives that address active living and healthy ageing. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer real health benefits to the consumer.

For further information, see www.bioactor.com


E-Sports athlete

New Open Label Study: BrainBerry® improves cognitive parameters in young, healthy e-gamers

New Open Label Study: BrainBerry® improves cognitive parameters in young, healthy e-gamers

Maastricht, The Netherlands, March 25th, 2021

Press release
Brainberry® was tested in amateur female and male gamers showing a significant improvement in relevant measures for gaming performance such as eye-hand coordination, focus, reaction time and energy.

E-Sports athlete

Open-label study in active gamers

According to Statista, there are currently over 2.4 billion gamers in the world, about one-third of the world’s entire population. Online gaming has definitively changed as it moved from being viewed as just a recreational activity to a proper industry. The annual revenue for gaming in 2017 has been estimated to cross over $100 billion and will climb to expected total revenue of $132 billion by 2021, even surpassing the movie industry revenue.

BioActor was the first to perform a clinical study that linked an Aronia Berry Extract (BrainBerry®) to cognitive performance (Ahles et al. Nutrients, 2020). This study showed a significant increase in eye-hand coordination for the group that consumed 65mg of BrainBerry®. Moreover, a significant post-hoc improvement was found for focus in the BrainBerry® group.

Recently, BioActor completed an open-label study in active gamers that consumed BrainBerry® for seven days. Acute (one time intake) and seven-day improvements in several cognitive performance measures were assessed via an online questionnaire. Twenty-one amateur female and male gamers participated in the trial (mean age 25.6 years of age). The participants were active gamers with an average of 2,5 hours of gaming per day. They were allowed to choose their own action-related game, provided they played the same game on all test days.

Study design

The study results

After acute intake, participants reported a significant improvement in relevant measures for gaming performance: eye-hand coordination, focus, reaction time and energy. Importantly, these improvements were sustained even after a seven-day intake. Moreover, we did not see any negative effect on sleep quality for the participants after seven-days intake.

Open label study result

In conclusion, BrainBerry® results in a significant improvement in eye-hand coordination, focus, reaction time and energy in amateur female and male gamers. BrainBerry® is a healthy, natural and effective ingredient to include in gamer (nootropic) supplements to aid performance. It also serves new consumer demands by providing similar benefits to caffeine, without the negative side effects like jitters, anxiety feelings or sleep deprivation. The current open-label study adds to previous positive effects of BrainBerry® on cognitive performance found in the placebo-controlled clinical study conducted by BioActor.

About BioActor

BioActor, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. The company focuses on the development of innovative activities that address active living and healthy aging. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

Feel free to contact us via info@bioactor.com for more information on the possibilities BrainBerry® has to offer.
Further information can be found on: www.brainberry.eu


wingate test aerobic performance

WATTS’UP® – New Study on Peak Force & Anaerobic Performance Published in Peer-reviewed Journal

WATTS’UP® – New Study on Peak Force & Anaerobic Performance Published in Peer-reviewed Journal

Maastricht, The Netherlands, January 11th, 2021

Press release
A new clinical study with WATTS’UP® on Peak Force and Anaerobic Performance was recently published in the Journal of the International Society of Sports Nutrition. WATTS’UP®, a customized flavonoid extract from sweet orange developed by BioActor, was tested in a double-blind, placebo-controlled study in trained male and female athletes and showed a significant peak force and anaerobic exercise performance improvement.

wingate test aerobic performance

The findings of the new publication

WATTS’UP®, a customized flavonoid extract from sweet orange with enhanced bioavailability, was tested in moderately trained male and female athletes and showed a significant increase in peak power output and anaerobic power during a Wingate Anaerobic Test.

The study was performed at the High-Performance Center of Topsport Limburg in collaboration with Dr. Freddy Troost (Maastricht University).

The purpose of the study, now available in the Journal of the International Society of Sports nutrition, was to assess whether supplementation of WATTS’UP® for 4 weeks improved anaerobic performance in trained male and female athletes.

Participants were given a daily dose of either 400 mg, 500 mg of WATTS’UP®or a placebo for 4 weeks. Exercise performance was tested by means of a 30 second Wingate Anaerobic Test on a WATT BIKE, the gold standard in research.

Peak Force during the first 5 seconds of the exercise significantly increased after 4 weeks of 400mg WATTS’UP® supplementation compared to the placebo, corresponding with a 7.5 % increase.

In addition, the average anaerobic power during the entire Wingate Test significantly increased in the 400mg WATTS’UP® group compared to placebo.

This study is the second RCT-study in trained athletes conclusively showing that WATTS’UP® contributes to exercise performance. WATTS’UP® has been specifically developed to contain a high concentration of the most active isomer hesperidin 2S and an earlier pharmacokinetics study showed that the product is more quickly absorbed.

WATTS’UP® can already be found on the market in several products in the USA and Europe. It can be applied in various finished dosage forms, including effervescent tablets, capsules, RTD sachets and beverages.

Feel free to contact BioActor via info@bioactor.com for more information on the possibilities WATTS’UP® has to offer.
Further information can be found on: www.wattsup.eu and www.bioactor.com

About BioActor
BioActor, based in Maastricht, Netherlands, is a product development company that supplies proprietary bioactive formulations to the nutrition & healthcare industry. The company focuses on the development of innovative bioactives that address active living and healthy ageing. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

For further information, see www.bioactor.com or visit www.wattsup.eu


BioActor and Biovital extend their partnership to include the distribution of BRAINBERRY® for the compounding pharmacy market in Brazil

BioActor and Biovital extend their partnership to include the distribution of BRAINBERRY® for the compounding pharmacy market in Brazil

Maastricht, The Netherlands, February 18th, 2020

Press release
Biovital Ltda. and BioActor B.V. entered into an agreement that appoints Biovital as exclusive distributor of BRAINBERRY®, BioActor’s proprietary brain fitness ingredient, for the compounding pharmacy market in Brazil.

INSERT HEADER

BioActor and Biovital signed a partnership agreement for the exclusive distribution of BRAINBERRY®, BioActor’s science-based brain fitness ingredient. Under this partnership agreement, Biovital is appointed as exclusive distributor of BRAINBERRY® for the compounding pharmacy market in Brazil. BioActor will actively support Biovital with scientific input, as well as formulation advice.

Biovital Ltda. is a dynamic Brazilian distribution company with high qualitative standards and ample know-how to import unique raw materials in Brazil. BioActor and Biovital are already successfully working together on the marketing of MICROBIOMEX® in Brazil. BioActor is delighted to extends its partnership with Biovital Ltda. to launch BRAINBERRY® in the rapidly growing compounding pharmacy market in Brazil.

BRAINBERRY®, is a unique Aronia berry extract with a high concentration of cyanidin 3 glycosides. BRAINBERRY® was tested in a placebo-controlled and double-blind study for effects on cognitive performance. The results show that BRAINBERRY® consumption leads to a significant improvement of eye-hand coordination.

BRAINBERRY® can already be found on the European market. The next step is to expand the footprint of BRAINBERRY® in the Americas, starting with the compounding pharmacy market in Brazil.

Are you a compounding pharmacy in Brazil interested in BRAINBERRY®?
Please feel free to reach out to Biovital via: maria.alice@biovital.ind.br

About Biovital Ltda.
Biovital is a Brazilian distributor of cosmetics, dermocosmetics, food and pharmaceutical raw ingredients to the compounding pharmacy market and to cosmetic, food and pharmaceutical industries. With a highly specialized team and complete laboratory, logistics and operational infrastructures, Biovital is able to provide assistance to consumers in all aspects for the development of products and innovative solutions.

For further information, see www.biovital.ind.br

About BioActor

BioActor, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. The company focuses on the development of innovative activities that address active living and healthy aging. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

Feel free to contact us via info@bioactor.com for more information on the possibilities BRAINBERRY® has to offer, feel free to contact us via info@bioactor.com


Active Pharmaceutica appointed as Exclusive Distributor of WATTS’UP® for the compounding pharmacy market in Brazil

Active Pharmaceutica appointed as Exclusive Distributor of WATTS’UP® for the compounding pharmacy market in Brazil

Maastricht, The Netherlands, October 3rd, 2019

Press release
Active Pharmaceutica Ltda. and BioActor B.V. entered into an Agreement that appoints Active Pharmaceutica as exclusive distributor of WATTS’UP®, BioActor’s proprietary sports performance ingredient, for the compounding pharmacy market in Brazil.

INSERT HEADER

BioActor and Active Pharmaceutica signed a partnership agreement for the exclusive distribution of WATTS’UP®, BioActor’s science-based sports performance ingredient. Under this partnership agreement, Active Pharmaceutica is appointed as exclusive distributor of WATTS’UP® for the compounding pharmacy market in Brazil. BioActor will actively support Active Pharmaceutica with scientific and formulation input.

Active Pharmaceutica Ltda. is a dynamic Brazilian distribution company with high qualitative standards and know-how to import unique raw materials in Brazil. BioActor is very pleased to start this new partnership with Active Pharmaceutica Ltda. to launch WATTS’UP® in the rapidly growing compound pharmacy market in Brazil.

WATTS’UP®, is a customized flavonoid extract from sweet orange, that can be formulated in a wide range of sports and exercise nutritional products. WATTS’UP® was tested in two placebo-controlled and double-blind studies. The results showed both an aerobic and anaerobic power increase in athletes. WATTS’UP® has a positive effect on the efficiency of the mitochondria and helps to increase ATP production.

The most recent clinical study also showed a significant effect of WATTS’UP® on peak power in a Wingate Test in moderately trained male and female participants. A low daily dose of 400-mg has shown to be sufficient to reach this beneficial effect.

WATTS’UP® can already be found on the market in the USA and Europe. The next step is to expand the footprint of WATTS’UP® in Latin America, starting from the compounding pharmacy market in Brazil.

To know more about WATTS’UP®, visit Active Pharmaceutica at Ação Magistral on the 25th and 26th October, 2019 – Porto Alegre/RS (Brazil)!

About Active Pharmaceutica Ltda.
Active Pharmaceutica, based in Santa Catarina, Brazil, is an importer and distributor of pharmaceutical products that supplies nutraceuticals, botanical extracts, probiotics, among other bioactives to Brazilian compounding pharmacies. The company strives to provide exceptional customer service through the commitment to quality, transparency, and integrity as well as offering innovative solutions to the pharmaceutical compounding market.

For further information, see www.activepharmaceutica.com.br

Are you a compounding pharmacy in Brazil interested in WATTS’UP®?

Please feel free to reach out Active Pharmaceutica at sac@activepharamaceutica.com.br

About BioActor

BioActor, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. The company focuses on the development of innovative activities that address active living and healthy aging. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

Feel free to contact us via info@bioactor.com for more information on the possibilities WATTS’UP® has to offer.
Further information can be found on: www.wattsup.eu


microbiomex systematic review

Clinical and pre-clinical data on MicrobiomeX® now published in a peer-reviewed journal

Clinical and pre-clinical data on MicrobiomeX® now published in a peer-reviewed journal

Maastricht, The Netherlands, July 11th, 2019

Press release
Nutrients, peer-reviewed journal of human nutrition, has published a systematic review on ‘flavobiotics’ – citrus flavonoids – and their effects on the microbiota and gastrointestinal health. The review includes original research data obtained with MicrobiomeX®. MicrobiomeX® is a natural citrus flavonoid complex designed to support gut and immune health, by lowering gut inflammation and beneficially shifting the gut microbiome composition.

microbiomex systematic review

The Systematic Review of MicrobiomeX®

Nutrients have published a systematic review on ‘flavobiotics’ – citrus flavonoids – and their effects on gastrointestinal health. The review includes original in-vitro and in-vivo data on MicrobiomeX®.

MicrobiomeX® is a first-in-class Flavobiotic® that protects the gut barrier and directly leverages the gut microbiome’s potential, enhancing the immune system. MicrobiomeX® is standardized for the two active citrus flavonoids: Hesperidin and Naringin.

The purpose of this systemic review article on citrus flavonoids and gut health was to provide a detailed overview of the intestinal metabolism of citrus flavonoids, their interaction with the gut microbiota composition, and their positive effect on the host barrier function and gut inflammation.

The review article also includes the outcomes of a 12-week randomized, parallel, double-blind, placebo-controlled study in which the effect of MicrobiomeX® on the gut microbiome composition, short-chain fatty acid production and gut inflammation was assessed. The study was conducted in a group of 50 healthy subjects with overweight, low background chronic gut inflammation and a somewhat disturbed microbiota.

The results showed
MicrobiomeX® anti-inflammatory activity as a result of a cross-talk between the active citrus flavonoids and the gut microbiome composition. Indeed, a significant increase in the butyrate proportion of total SCFA was measured, and an almost significant reduction in calprotectin levels are signs of the positive contribution of MicrobiomeX® to a balanced microbiome and host gut health.

MicrobiomeX® can already be found as a stand-alone ingredient or in combination with different probiotic strains, in several products worldwide. It can be applied in various finished dosage forms, including capsules, tablets, RTD sachets and beverages. MicrobiomeX® is the ideal candidate to bring cutting edge science from the microbiome revolution to nutritional formulas.

About BioActor

BioActor, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. The company focuses on the development of innovative activities that address active living and healthy ageing. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

Feel free to contact us for more information on the possibilities MicrobiomeX® has to offer.

Further information can also be found on: www.microbiomex.com