Actiful-physical-and-mental-benefits

Actiful® - New Publication Reveals Physical and Mental Health Benefits in Elderly

Actiful® – New Publication Reveals Physical and Mental Health Benefits in Elderly

Maastricht, The Netherlands, August 29th, 2022

Press release
A new randomized, double-blind, placebo-controlled clinical trial with Actiful® was recently published in the Journal of Nutrition, Health & Ageing. The study investigated whether Actiful® improves physical fitness and mental well-being in healthy elderly. Additionally, blood biomarkers for oxidative stress and endothelial function were measured. Key findings of the study were an improvement in handgrip strength, a measure of physical fitness, and psychological functioning facets, such as thinking, memory, learning, and concentration.

Actiful-physical-and-mental-benefits

The study

The new research, published in the Journal of Nutrition Health & Ageing, was conducted by researchers at Maastricht University led by Dr Freddy Troost in collaboration with BioActor, the developer and manufacturer of the branded ingredient, Actiful®.

Actiful® is a citrus flavonoid and pomegranate complex designed to boost vitality and support energy levels for an active lifestyle. The ingredient is standardised for its content in highly bioavailable 2S-hesperidin, an important citrus flavonoid which already showed in previous BioActor studies the efficacy in improving blood flow and sports performances in both highly trained and recreational athletes.

The new study investigated whether daily supplementation with 700mg of Actiful® would affect physical fitness and psychological functioning in a healthy elderly population.

As life expectancy increases rapidly, the elderly population is growing in numbers. Ageing is one of the main risk factors for a wide variety of diseases, such as cardiovascular disease, cognitive decline and reduced physical function. Therefore, strategies to support vitality in senior subjects are becoming increasingly relevant.

 

The methods

The study included 36 active seniors aged between 60-75 years old. The design of the clinical trial was a randomised, double-blind, placebo-controlled, crossover study. All participants received both treatments and placebo: four weeks of supplementation with Actiful® and four weeks of supplementation with the placebo, separated by a washout period of 4 to 8 weeks.

During the intervention, participants completed the WHOQOL-100 questionnaire, a list of 100 questions created by the World Health Organisation and validated to assess the quality of life. In addition, a senior fitness test and handgrip measurements were performed, which are validated measures of physical performance.

Furthermore, nitrate levels were measured as a marker of endothelial function. Nitrate is considered an important signalling molecule involved in endothelial function by inducing vasodilation, leading to improved blood flow.

Oxidative stress was also evaluated by determining malondialdehyde (MDA) plasma levels. Oxidative stress is an imbalance between free radicals and antioxidants in your body and can damage cells, proteins and DNA, contributing to ageing.

 

The results

The study results indicate that four weeks of daily Actiful® supplementation significantly improved handgrip strength in healthy elderly. Handgrip strength is an important measure of physical fitness associated with reduced all-cause mortality, as well as increased cognitive function, mobility, and functional status.

According to the researchers, a potential mechanism that might be associated with improving handgrip strength is improved mitochondrial function. In fact, the role of hesperetin – the main metabolite of Actiful®, in mitochondrial functioning, increased intracellular ATP production, and mitochondrial spare capacity was already observed in vitro.

“With age, the number and functionality of mitochondria decreases. Dysfunctional mitochondria have reduced the capacity for producing ATP – our muscles’ principal energy source. Therefore, the next step is to confirm the effect of Actiful® on mitochondrial biogenesis and functionality in humans in vivo”, the researchers commented.

In addition to the handgrip strength, also psychological function improved after the 4 weeks of supplementation with Actiful®.

Specifically, the researchers found a significantly higher score for the treatment group than the placebo in the thinking, memory, learning, and concentration facet. As the quality of life is an important factor in successful ageing, improved psychological functioning is deemed increasingly relevant.

MDA and NO3 were also analysed as a measure of oxidative stress and endothelial functions. After supplementation, plasma MDA decreased compared to the placebo, a sign of improved oxidative stress status.

Finally, higher production of NO3 was observed. NO3 is an important signalling molecule involved in endothelial function by causing vasodilation in smooth muscle cells and can contribute to improving blood flow and exercise capacity, as demonstrated in previous studies.

Overall, the study results suggest that Actiful® consumption results in improved physical performance and better quality of life, which are two crucial factors in successful ageing.

We are pleased with the results of this clinical trial, which includes improvements both in physical fitness and mental well-being, as well as improved oxidative stress markers. These results have piqued our interest regarding potential underlying mechanisms of action, which are currently being investigated in our new clinical trial.” Commented Sanne Ahles – clinical researcher at BioActor.

 

Opportunity for innovation

Actiful® has been developed to support vitality and energy levels contributing to healthy ageing. The active ingredient can already be found in various products on the market worldwide. Actiful® is easy to formulate, and it can be added to a wide variety of dietary supplements in several convenient formats, including gummies, effervescent tablets, capsules, ready-to-use sachets and drinks.

 

About BioActor

BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.

Feel free to contact BioActor via info@bioactor.com for more information on the possibilities that Actiful® has to offer.
Further information can be found on: www.actiful.eu and www.bioactor.com


man-training

The effects of Hesperidin on exercise performance - New publication from BioActor in collaboration with Maastricht University

The effects of Hesperidin on exercise performance – New publication from BioActor in collaboration with Maastricht University

Maastricht, The Netherlands, July 22nd, 2022

Press release
The review recently published in Nutrients was conducted by BioActor in collaboration with Maastricht University and examined the potential mechanisms through which hesperidin can improve exercise performance.

man-training

A review on hesperidin and exercise performance

Nutrients, a leading peer-reviewed scientific journal of human nutrition, has recently published a review about hesperidin’s effect on exercise performance. The research was conducted by M. Imperatrice, a clinical researcher at BioActor, in collaboration with the Maastricht University’s Department of Human Biology.

 

This review collects the results of randomized controlled trials (RTCs), animal studies, and in vitro studies providing more evidence on how hesperidin, a flavanone abundantly present in citrus fruits, could lead to enhancement in exercise performance.

 

According to the review’s results, hesperidin is able to improve endothelial function (via increased NO availability), inhibit ROS production, decrease production and plasma levels of pro-inflammatory markers, and improve anaerobic exercise outcomes (e.g. power, speed, energy).

 

We are really proud to share the results collected in our review about the potential mechanisms linking hesperidin to enhanced anaerobic performance, namely improved endothelial function, reduced exercise-induced oxidative stress, and inflammation. For elite and recreational athletes, hesperidin could be a promising food supplement to optimize the oxygen and nutrient supplies of the muscles, stimulate muscle contraction, and enhance muscle recovery between training sessions. The ergogenic effects that hesperidin can bring to the spectrum of improved exercise performance are promising and should be investigated further. With our “Actiful 2” ongoing Clinical Study, we are going to deepen this knowledge by investigating both the effects of hesperidin supplementation on endurance exercise and on changes in intramuscular markers via skeletal muscle biopsies.” said M. Imperatrice.

 

BioActor’s interest in hesperidin has resulted in the development of two active ingredients. The first ingredient branded under the name WATTS’UP® and targeting sports performance has already been tested in two randomized placebo-controlled clinical trials, one with highly trained athletes and one with moderately trained subjects. The second ingredient goes under the name Actiful® and targets energy and vitality. This ingredient has already been tested in randomized placebo-controlled clinical trials, in elderly subjects, showing physical and mental benefits.

 

About BioActor

BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.

Feel free to contact BioActor via info@bioactor.com for more information on the possibilities WATTS’UP® and Actiful® have to offer.
Further information can be found on: www.wattsup.eu, www.actiful.eu and www.bioactor.com


Basketball player

New Open Label Study: Brainberry® shows cognitive and performance benefits in professional basketball players.

New open-label study: Brainberry® shows cognitive and performance benefits in professional basketball players.

Maastricht, The Netherlands, July 1st, 2022

Press release
BioActor recruited 35 professional Greek male and female basketball players to assess their cognitive and basketball-specific skills after an acute and one-week intake of Brainberry®. Notably, cognitive performance linked to focus, reaction time and hand-eye coordination improved acutely and following a one-week intake. Also, basketball-specific skills like shooting, rebounding and dribbling improved significantly, underlining the ability of Brainberry® to benefit sports performance.

Basketball player

Open-label study in professional basketball players

According to the F.I.B.A. (Fédération Internationale de Basketball), more than 450 million people play basketball worldwide, and about 70.000 of them are professionals. In the US, basketball is one of the most followed sports, and according to Statista, the National Basketball Association (NBA) generates about $6 to $8 billion in revenue per season.

Especially at the top level, nutritional strategies to improve cognition are key to succeeding in this sport. A professional basketball player needs to combine cognitive and physical skills and react to different situations during the game. Moreover, since players need to communicate with each other and their coach while performing, the cognitive load involved in this sport is massive.

Brainberry® is a nootropic ingredient developed by BioActor to help consumers improve their brain fitness in a natural and safe way. More specifically, Brainberry® is an Aronia berry extract from the Baltics, standardized for high levels of cyanidin-3-O-galactoside.

BioActor already conducted 2 double-blind placebo-controlled clinical studies which demonstrated cognitive benefits in middle-aged healthy individuals and in young healthy individuals.

Moreover, in a previous open-label study, Brainberry® improved cognitive performance of amateur gamers. The study revealed that gamers can benefit from the consumption of Brainberry® and improve their gaming skills such as eye-hand coordination and focus.

In follow up to these studies, BioActor now completed another open-label study on 35 professional basketball players in Greece, who consumed 65 mg of Brainberry® for seven days. Basketball is characterized by highly intermittent actions with changes in movement type every 1-2 seconds. Particularly at the highest level, the combination of gross and fine motor skills along with cognitive functions and psychomotor control is key to success. Female and male professional basketball players were selected from teams that participate in the first Greek basketball league.

The objective of the study was to investigate the effect of a daily intake of a capsule containing 65mg of Brainberry® on overall cognitive and basketball-specific skills.

The study results

During the three time points, Baseline (Time 0), Acute (Time 1) and 7 days (Time 2), the participants had to fill out a questionnaire with specific questions aiming at assessing cognitive skills, basketball-specific skills, mood, and sleep quality. At Time 0, the participants did not consume Brainberry®, in order to generate a baseline measurement for their self-reported skills during a basketball session.

The results show that the basketball players who participated in the study experienced a significant improvement (P < 0.05) from day one, in terms of cognitive: focus, reaction time and eye-hand coordination; and basketball-specific skills: shooting, rebounding, and dribbling. At the same time, no significant differences were found in their speed and quality of sleep was not affected.

Results-of-Brainberry-in-basketball-players

*Sig (P < 0.05) baseline vs acute; **Sig (P < 0.05) baseline vs after 7 days and ***Sig (P < 0.05) acute vs 7 days

 

With this additional study, which highlights the ability to enhance cognitive and basketball-specific skills, Brainberry® taps into the sports nutrition segment, where already some sports nutrition brands have adopted the ingredient and formulated products targeting brain fitness for athletes.

Vasiliki Louka, a professional basketball player that belongs to the women’s national Greek team stated:

“Brainberry® surprised me in a good way. This month was really tiring and stressful, especially for the athletes competing for the national team. I felt more focused during my training and considering that Brainberry® contains only natural ingredients, it makes it an interesting choice.”

Furthermore, the participants reported that one of the advantages of Brainberry®, compared to the most common caffeine-based supplements that they have been using, is that Brainberry® did not affect their quality of sleep and, at the same time, helped them decrease their stress level.

 

About BioActor

BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.

Feel free to contact BioActor via info@bioactor.com for more information on the possibilities Brainberry® has to offer.
Further information can be found on: www.brainberry.eu and www.bioactor.com


prebiotics-and-probiotics

MEET US - BioActor Presenting MicrobiomeX® and Naxus® at the 15th Annual IPC conference

MEET US – BioActor Presenting MicrobiomeX® and Naxus® at the 15th Annual IPC conference

Maastricht, The Netherlands, June 16th, 2022

Press release
The 15th International Scientific Conference on Probiotics, Prebiotics, Gut Microbiota and Health – IPC2022 will be held during 27 – 30 June 2022 in Bratislava. BioActor is an active contributor and confirmed partner of this conference. Hans van der Saag (CEO) will present on our ingredient Naxus®, a prebiotic with metabolic and immune effects, and Yala Stevens (CSO) presents the clinical and mechanistic research on MicrobiomeX® in irritable bowel syndrome (IBS) patients and elderly subjects.

prebiotics-and-probiotics

BioActor Presenting MicrobiomeX® and Naxus® at the 15th Annual IPC conference

The 15th International Scientific Conference on Probiotics, Prebiotics, Gut Microbiota and Health – IPC2022 will be held during 27 – 30 June 2022 in Bratislava.

The IPC conference is the world’s biggest scientific conference that focuses solely on basic and applied research of probiotics, prebiotics, gut microbiota and health. More than 400 scientists from over more than 80 countries have attended the conference last season.

The scientific program will focus on current advances in the research, production and use of probiotics and prebiotics with particular focus on their role in maintaining health and preventing diseases. At IPC, leading scientists from industry and academia present current advances in understanding and influencing the interaction between gut microbiota and human health.

The conference enables the interactive exchange of state-of-the-art knowledge. It is focused on evidence-based benefits, health claims proven in scientific experiments and clinical trials.

BioActor is an active contributor and confirmed partner of this conference. Hans van der Saag (CEO) will present on our ingredient Naxus®, a prebiotic with metabolic and immune effects, and Yala Stevens (CSO) presents the clinical and mechanistic research on MicrobiomeX® in irritable bowel syndrome (IBS) patients and elderly subjects.

Naxus® presentation by Hans van der Saag (CEO)

Naxus® is a native arabinoxylan extract from the wheat endosperm. It is a powerful and well-tolerated prebiotic with metabolic and immune effects. Due to its complex branched structure, Naxus® is slowly and selectively fermented by multiple species of the microbiota, inducing a remarkable bifidogenic effect without causing gas formation and intestinal discomfort. It induces a remarkable microbiota shift and increased short-chain fatty acids production, with proven effects on immune health and glycemic control.

MicrobiomeX® presentation by Yala Stevens (CSO)

MicrobiomeX® is a natural extract from citrus fruit designed to beneficially modulate the microbiome composition in the gut. It’s a first-in-class Flavobiotic® that protects the gut barrier and directly leverages the gut microbiome’s potential. This results in enhanced immune health, as well as anti-inflammatory effects.

IBS is a functional gastrointestinal disorder with various symptoms including pain and discomfort in the abdomen. Also, elderly often develop imbalances in their gut microbiota and often experience discomfort.

Patients with IBS and elderly would benefit substantially from treatments that could relieve their symptoms and improve their gut health. The flavonoids in MicrobiomeX® have the potential to benefit individuals with gastrointestinal conditions because of its antioxidant and anti-inflammatory properties.

Business opportunities

The IPC conference is a great opportunity to reconnect with colleagues from all over the world and make new contacts. Hans van der Saag (CEO) and Yala Stevens (CSO) will be there to represent BioActor’s portfolio, with a focus on our gut health ingredients. Feel free to pass by at any time to chat about our innovative ingredients for gut health support!

We look forward to meeting you in Bratislava!

The IPC 2022 conference will take place from 27 to 30 June 2022.

Where: Hviezdoslavovo námestie 3, 811 02 Bratislava, Slovakia

About BioActor

BioActor, based in Maastricht, Netherlands, is a product development company that supplies proprietary bioactive formulations to the nutrition & healthcare industry. The company focuses on the development of innovative bioactives that address active living and healthy ageing. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

For further information, see www.bioactor.com or visit https://microbiomex.com/ or https://naxus.nl/


BioActor-showcasing-WATTS’UP-at-the-19th-Annual-ISSN-Conference

MEET US - BioActor showcasing WATTS’UP® at the 19th Annual ISSN Conference

MEET US – BioActor showcasing WATTS’UP® at the 19th Annual ISSN Conference

Maastricht, The Netherlands, June 3rd, 2022

Press release
The International Society of Sports Nutrition (ISSN) is organizing their 19th Annual Conference and Expo. BioActor is an active contributor to this conference and Yala Stevens, our chief scientific officer will present the clinical results on our ingredient WATTS’UP®.

BioActor-showcasing-WATTS’UP-at-the-19th-Annual-ISSN-Conference

BioActor showcasing WATTS’UP® at the 19th Annual ISSN Conference

The International Society of Sports Nutrition (ISSN) is the world’s leader in providing science-based sports nutrition and supplement information. This year they are organizing their 19th Annual Conference and Expo. Anyone interested in sports science/nutrition can attend!

The conference addresses a diverse audience such as researchers, students, dieticians, sports nutritionists, but also the athletes themselves. Therefore, the conference offers a platform to discuss various hot topics related to sports nutrition, such as sports supplements, elucidation of the physiological mechanisms behind nutraceutical interventions, as well as nutritional effects on performance.

The strength of the annual ISSN conference is that top researchers present on novel paradigms in sports nutrition. Besides, it is also an excellent opportunity to make new contacts and reconnect with colleagues from all over the world.

BioActor is an active contributor to this conference, since Yala Stevens, our chief scientific officer will present the clinical results on our ingredient WATTS’UP®. Title of the study: The effect of citrus flavonoid extract supplementation on anaerobic capacity in moderately trained athletes: a randomized controlled trial.

Original research paper presentation by Yala Stevens (CSO)

Previous studies have demonstrated that supplementation with flavonoids from citrus fruits may be an effective strategy to improve exercise performance in male athletes. Repeated intake of 500 mg of a specific citrus fruit extract improved aerobic exercise performance. Also, an increased absolute power output and a decreased oxygen consumption/power ratio were observed.

Yala will be presenting new insights on the beneficial effects of 400 mg and 500 mg citrus fruit extract (WATTS’UP®) supplementation on short-term high-intensity exercise performance. In this study, we used a WinGate protocol, the gold standard for testing high-intensity performance for 92 male and female participants.

Join us on Friday 17th of June at 10:10am for Yala’s presentation in the Westin Fort Lauderdale Beach Resort (Florida).

Business opportunities

BioActor will also be present with a small table top, together with the exclusive distributor for the US market, SEPPIC Inc. Jeremie Feuer (SEPPIC) and Joris Kretzers (BioActor) will be there to represent BioActor’s portfolio, with a specific focus on our sports nutrition ingredients. If you are looking for natural ingredients that benefit athlete’s performance, feel free to pass by at any time on Thursday or Friday for a chat!

We look forward to meeting you in Fort Lauderdale!

The ISSN conference and expo will take place from June, 16-18 2022.
Westin Fort Lauderdale Beach Resort, 321 North Fort Lauderdale Beach Blvd., Fort Lauderdale Florida USA 33304

About BioActor

BioActor, based in Maastricht, Netherlands, is a product development company that supplies proprietary bioactive formulations to the nutrition & healthcare industry. The company focuses on the development of innovative bioactives that address active living and healthy ageing. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

For further information, see www.bioactor.com or visit www.wattsup.eu


MicrobiomeX® nominated as finalist for 2022 NutraIngredients-USA ‘Ingredient of the Year’

MicrobiomeX® nominated as finalist for 2022 NutraIngredients-USA ‘Ingredient of the Year’

Maastricht, Netherlands, June 2nd, 2022

Press release
BioActor is delighted to share that MicrobiomeX® was nominated as a finalist for the 2022 NutraIngredients-USA ‘Ingredient of the Year’ in the category Prebiotic. NutraIngredients-USA Awards honour the best and brightest in ingredients, finished products, companies, people and initiatives in the nutrition and dietary supplements industry.

MicrobiomeX-is-a-finalist-for-the-NutraIngredients-Awards

Finalist for 2022 NutraIngredients-USA ‘Ingredient of the Year’

We are excited to announce that MicrobiomeX® was nominated as a finalist for the 2022 NutraIngredients-USA ‘Ingredient of the Year’ in the category Prebiotic.

The NutraIngredients brand has led the online news source in the nutrition industry for over 19 years, providing insights into the functional food and supplement market in North America, ranging from investments and innovation to ingredients, product formulation, regulation, consumer trends and more!

Specifically, NutraIngredients-USA Awards honour the best and brightest in ingredients, finished products, companies, people and initiatives in the nutrition and dietary supplements industry. With a focus on innovation, long-term market success and state-of-the-art research, it is an honour that MicrobiomeX® was nominated a finalist!

MicrobiomeX® is a first-in-class Flavobiotic® that has been clinically proven to improve the SCFA profile, lower gut inflammation and enhance immunity through its precision prebiotic effect. Beneficial changes in the microbiota are induced at a low dose of 250-500 mg, and MicrobiomeX® is stable with probiotics.

“Special thanks goes out to our US distributor SEPPIC with whom we collaborated to get there”, says Joris Kretzers, Sales Manager Western Europe & North America of BioActor. “We are very proud of this achievement and are looking forward to the winner announcement in July!”

About BioActor

BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.

Feel free to contact BioActor via info@bioactor.com for more information on the possibilities MicrobiomeX® has to offer.

Further information can be found on:  www.microbiomex.com and www.bioactor.com


BioActor-receives-ISO9001:2015-certification

BioActor receives ISO 9001:2015 certification

BioActor receives ISO 9001:2015 certification

Maastricht, Netherlands, May 19th, 2022

Press release
BioActor proudly announces to have been awarded the ISO 9001:2015 certification! ISO is one of the most rigorous and acclaimed internationally recognised standards, which ensures that BioActor’s products and services meet the needs of customers through an effective quality management system.

BioActor-receives-ISO9001:2015-certification

ISO 9001:2015

BioActor is dedicated to continuous improvements in its products and services and strives to surpass customer expectations, evidenced by the ISO 9001:2015 accreditation. In order to become ISO 9001:2015 compliant, the BioActor team, based in Maastricht – the Netherlands, underwent a comprehensive company-wide audit including a management system documentation review, pre-audit, initial assessment, and ultimately, clearance of the minor non-conformities.

The BioActor team were audited by Bureau Veritas and obtained their certificate in May 2022.

BioActor’s Quality Manager, Myrto Papageorgiou says:

“I’m proud of our team for how we worked together and proved that our main aspiration is to satisfy our customers by providing them with high-quality products and services. It gives me great pride to receive the ISO 9001:2015 certificate and it highlights our commitment to continually improve for our customers “

Find our certificate here.

About BioActor

BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.

Feel free to contact BioActor via info@bioactor.com for more information on our products.

Further information can be found on: www.bioactor.com


BioActor-starts-new-clinical-trial-on-Actiful

Started new clinical trial with Actiful®

Started new clinical trial with Actiful®

Maastricht, Netherlands, May 4th, 2022

Press release
BioActor has officially started a new clinical trial with Actiful® in healthy middle-aged adults. Actiful® is BioActor’s innovative citrus and pomegranate complex ingredient designed to enhance vitality and support an active lifestyle.

BioActor-starts-new-clinical-trial-on-Actiful

The new randomized double-blind placebo-controlled study

BioActor announced today that it has officially started the new intervention study on Actiful®.

Actiful® is an orange and pomegranate complex with demonstrated health benefits such as improving blood flow,  increasing energy levels, improving mitochondrial efficiency and boosting mental well-being.

This is the second clinical study that will be conducted with Actiful® and it will be performed in collaboration with Maastricht University at the research facilities in Maastricht and Venlo.

Duting this new double-blind placebo-controlled study, 52 healthy middle-aged (40-65 years) will take the supplements (or the placebo) for a duration of 12 weeks. The aim of this study is to assess the effects of Actiful® on physical fitness, vitality and quality of life.

The primary outcome (VO2max) will be estimated by use of the Ekblom-Bak submaximal test, a novel test performed on a cycle ergometer.

Additionally, a sub-group of participants will undergo a skeletal muscle biopsy to explore the effect of Actiful® on mitochondrial biogenesis and muscle repair.

As we age, we tend to have less energy and lose vitality. Functional foods and dietary supplements containing polyphenols are seen as an excellent strategy for long term sustained energy production. BioActor is addressing this need by developing a unique product- Actiful®. This product consists of all-natural ingredients from oranges and pomegranates.

“I’m really excited to be part of this project as the combined effect of hesperidin and punicalagin on enhanced performance has never been studied before”, says Maria Imperatrice, the study executive researcher in Maastricht. “We are very curious to explore their effect on human exercise and deepen the knowledge of the effect of polyphenols on mitochondrial biogenesis and muscle regeneration.”

About BioActor

BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.

Feel free to contact BioActor via info@bioactor.com for more information on the possibilities Actiful® has to offer.

Further information can be found on:  www.actiful.eu and www.bioactor.com


BioActor-is-participating-in-Vitafoods-2022-meet-us-Booth-F140

MEET US - Vitafoods Europe 2022

Visit us at Vitafoods Europe 2022

April 22nd, 2022

We are happy to announce that BioActor will participate in Vitafoods 2022, the trade show that offers the opportunity to find out the latest trends in the field of dietary supplements, raw materials, and food and to network with other professionals from around the world. Visit us at Booth F140.

BioActor-is-participating-in-Vitafoods-2022-meet-us-Booth-F140

Meet us at Booth F140

Our team can’t wait to meet you online from May 2nd to May 13th, and in Geneva from May 10th to 12th.

You are welcome to come over for a coffee at our booth F140 to discuss new business opportunities and get an idea of how our science-based ingredient can help you achieve your product development goals.

Amongst the most exciting news, our team will be happy to present the recently concluded randomized clinical trials on our gut health and brain fitness solutions, MicrobiomeX® and Brainberry®.

Don’t miss it, we are looking forward to seeing you there!

Book a meeting!



    New-in-vitro-co-culture-model-study-published-with-citrus-flavonoid-extract

    New in vitro co-culture model study published with citrus flavonoid extract MicrobiomeX®

    New in vitro co-culture model study published with citrus flavonoid extract MicrobiomeX®

    Maastricht, Netherlands, April 21st, 2022

    Press release
    British Journal of Nutrition has recently published a new in vitro co-culture model study with a citrus flavonoid extract MicrobiomeX® and its metabolites, hesperetin and naringenin. The novel publication suggests that these citrus flavonoids, as well as their metabolites, may reduce intestinal inflammation.

    New-in-vitro-co-culture-model-study-published-with-citrus-flavonoid-extract

    New in vitro co-culture model study published with citrus flavonoid extract MicrobiomeX®

    MicrobiomeX® is a first-in-class Flavobiotic® developed by BioActor, that combines active ingredients from Citrus sinensis and Citrus paradisi. MicrobiomeX® has already been studied and reported to have various beneficial effects on the gut and immunity. MicrobiomeX® consists of standardised citrus flavonoids, that form active metabolites, hesperetin and naringenin, in the gut after being deglycosylated by the gut microbiota.

    In the recently published in-vitro study, a validated co-culture system of Caco-2/THP-1 cells as model for intestinal inflammation and cytokine-induced barrier disruption was used to determine the effects of citrus flavonoids and their metabolites on intestinal inflammation.

    During the research, cells were treated with citrus flavonoids, their metabolites, or a vehicle control. Additionally, cells were incubated with lipopolysaccharide (LPS), which is known to induce inflammation and deterioration in epithelial integrity.

    The conclusion highlights that hesperetin and naringenin significantly reduced NF-kB activity, leading to a reduction in intestinal inflammation. Pro-inflammatory cytokines IL-8, TNF-α and IL-6 were also significantly reduced after hesperetin and naringenin administration.

    The mechanism behind this reduction in inflammation can be ascribed to partial inhibition of the NF-κB signalling pathway.

    “We are very happy with the results of this study, as we were able to show that both the citrus flavonoids themselves and their metabolites are able to reduce inflammation in the intestine”, says Yala Stevens, CSO of BioActor. “These new scientific insights on MicrobiomeX® will allow us to consolidate its applications to products targeting gut health and immune function”.

    About BioActor

    BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.

    Feel free to contact BioActor via info@bioactor.com for more information on the possibilities MicrobiomeX® has to offer.

    Further information can be found on:  www.microbiomex.com and www.bioactor.com