supplement to slow down aging

Actiful®: a key ingredient for healthy aging

Actiful®: a key ingredient for healthy aging

Maastricht, 29th January 2024

Are you looking for an impactful science-based ingredient to add to your energy and vitality supplement? Well, look no further as the research-based evidence is expanded on the key role of Actiful® in supporting energy production, improving mental wellness, and reducing oxidative stress.

supplement to slow down aging

How can we slow down the aging process?

Aging is a complex process (1) characterized by a gradual decline in physiological function and an increased susceptibility to various diseases. It encompasses a range of biological, psychological, and social changes that occur over time. At the cellular level, aging involves factors such as mitochondrial dysfunction and accumulation of damage from oxidative stress. These processes contribute to a decline in the efficiency of cellular repair and maintenance mechanisms.

 

Factors impacting the aging process

Additionally, genetic and environmental factors play significant roles in influencing the rate of aging. While aging is a natural and inevitable part of life, lifestyle choices, such as diet, exercise, and stress management, can impact the rate at which the aging process unfolds. Continuous research is taking place to study aging and better understand potential interventions to promote healthy aging and longevity (2).

 

A combination of diet and supplementation

Slowing down the aging process involves adopting a holistic approach that addresses various aspects of one’s lifestyle. A balanced and nutritious diet rich in antioxidants, vitamins, and minerals is crucial for maintaining cellular health and preventing oxidative stress. Regular exercise, adequate sleep and stress management can positively impact both mental and physical health (3). Avoiding harmful habits such as smoking and excessive alcohol consumption is also vital, as they accelerate the aging process.

 

Combining these lifestyle factors and taking appropriate supplements can create a foundation for a healthier and more vibrant aging experience. Adding supplements to the diet can be beneficial for healthy aging, as they can help address specific nutrient deficiencies and support overall well-being. They are often recommended for digestive health, immune support or cell function optimization. (4, 5)

mitochondria health and energy and healthy aging

Actiful®: clinically proven ingredient for healthy aging

Actiful® is a patent-protected plant-based ingredient for improved energy production, mental wellness and mitochondria support. It is standardized for hesperidin which is a key polyphenol extracted from sweet oranges (Citrus sinensis). Actiful® also contain pomegranate (Punica granatum), known to be rich in nitrate and useful for NO production, leading to vasodilation. Previous clinical data has already shown the beneficial properties that the combination of these polyphenols has in terms of enhanced physical performance (6, 7), mental health support (7), improved energy production by the mitochondria (8) and improved blood flow (9).

Recent clinical data further underlines the benefits that Actiful® brings to the table. The combination of hesperedin and pomegranate in a 350mg supplement capsule was provided to healthy seniors for 4 weeks in a randomised, blinded, placebo-controlled manner. In the end of the intervention period, the concentration of methylglyoxal (MGO) in the blood decreased by ≈ 10% (10). This is a statistically significant and clinically relevant result as MGO accumulation in cells leads to cellular disfunction and shorter cell life. Clearly, you would like to stimulate MGO scavenging, if you are targeting healthy aging. 

 

The role of Actiful® in supporting the mitochondria

The mechanism of action of the polyphenols present in Actiful® is quite complex and apparently linked with benefits and protection for our mitochondria, the so called ‘powerhouse’ of the cells. Hesperidin and pomegranate are known for their antioxidant properties (11, 12), which contributes to the direct MGO scavenging. They also reduce oxidative stress which leads to support of the natural body’s detoxification mechanisms. All of the above mentioned benefits are directly linked with the potential of Actiful® to protect the mitochondria and support its function via the reduction of MGO, observed in the latest clinical data of Actiful® (10).

 

The potential of Actiful® for the supplements market

The latest data allows Actiful® to expand its market possibilities. It can be an active ingredient in vitality supplements for mid-aged adults and active seniors as well as in energy drinks and sports drinks. Actiful® can be marketed for its beneficial effects on vitality, mental wellbeing, energy production and mitochondria support.


MEET US - November 2023

Meet us in November 2023 at different events across Europe!

November 10th, 2023

The Solabia-BioActor team will be out and in about again in November 2023. Below you will find where you can meet our team in person at multiple international events!

14th European Nutrition Conference FENS in Belgrade, Serbia

14-17 November 2023

Our clinical researcher Sanne Ahles will present at the 14th European Nutrition Conference, at the Sava Center in Belgrade. Her presentation on how Aronia melanocarpa extract (Brainberry®) supplementation could improve cognitive performance will take place on 15 November in Room 9 from 13:30 till 15:00.

In-Vitality, Milan, Italy

22-23 November 2023

Valeria Mastromartino, Account Manager Italy, will be present at In-Vitality in Milan. This is a B2B exhibition and conference for health ingredients, supplements and functional foods in Italy, the biggest European market for supplements. Feel free to reach out to Valeria to arrange a meeting!

Food Ingredients Europe, Frankfurt, Germany

28-30 November, 2023

Hans van der Saag, CEO, and Joris Kretzers, Commercial Director, will visit FI Europe in Frankfurt. FI Europe is a great opportunity to observe market trends in the European markets, and meet with valued customers and business partners. Reach out to either Hans or Joris to arrange a quick get-together in Frankfurt!

Book a meeting!



    men health

    Top 5 ingredients for men's health

    Top 5 ingredients for men’s health

    October 30th, 2023

    Incorporating health ingredients into daily routines helps to support men’s well-being and health. We will provide you with evidence-based recommendations on five key ingredients supporting men’s health and sexual function, including fenugreek seed extract, zinc, B vitamins, pomegranate extract, and hesperidin.

    men health

    In today’s fast-paced world, prioritizing our health and well-being is becoming more and more important, also for men. As the increasing expectations and pressures of our lives continue to evolve, it is important for men to develop a proactive approach to maintain their physical, mental, and sexual health.

    Health ingredients are designed to meet men’s health needs, ensuring that they stay healthy and full of energy. In this article, we will provide evidence-based recommendations on five key ingredients supporting men’s health and sexual function.

    Fenugreek seed extract

    As men age, they experience a decrease in testosterone levels. This phenomenon is also known as andropause. Testosterone plays a role in many aspects of health, including sexual function, muscle and bone mass, energy levels, and metabolism. One of the ingredients that may help to combat the problems related to andropause is fenugreek seed extract . Fenugreek (Trigonella foenum-graecum) is a very interesting herb with many potential health benefits.

    A study performed on 120 healthy men showed that a 12-week supplementation of fenugreek seed extract (600 mg/day) increased testosterone levels and improved sexual function, compared to placebo [1]. Also, supplementation of fenugreek seed extract in healthy male athletes resulted in increased fat-free mass, lean body mass, and elevated testosterone levels compared to placebo [2]. These findings suggest that fenugreek seed extract is a promising ingredient for men’s health, especially in terms of increasing testosterone levels and improving sexual function.

    Zinc

    Zinc is an essential mineral, which means that it is not produced by the body itself. It plays an important role in many physiological functions, such as supporting the immune system and healing damaged cells. Zinc is a critical mineral for men’s health as even a small deficiency can impact the immune system, cardiovascular health, reproductive function, and fertility [3].

    Sufficient intake of zinc contributes to normal fertility and sexual function in males. Low levels of zinc are related to low levels of testosterone. Besides, it is also important for the normal functioning of the immune system, and the maintenance of bone health [4].

    Therefore, we can state that zinc is an important mineral that can help men improve their sexual health and energy levels and maintain a healthy immune system.

    B Vitamins

    B vitamins play a vital role in the human body. They are involved in many important functions. For example, they are crucial for energy production, oxygen support, and bone health.

    The vitamin B complex consists of a total of eight B vitamins, with several of them having beneficial effects on men’s health, for example:

    Vitamin B12: Adequate levels of vitamin B12 are important for the production of red blood cells, which are responsible for oxygen transport. Also, studies showed that vitamin B12 is important for bone health [5, 6].

    Vitamin B9: Vitamin B9, also known as folate, is not only an important vitamin for women but also for men. Research has shown that folate contributes to the reduction of fatigue, which is a common complaint nowadays [7].

    Vitamin B6: Vitamin B6 plays a vital role in energy and vitality. Intake of this vitamin contributes to normal energy metabolism. Studies also showed that it leads to a decrease in fatigue and tiredness [8].

    Vitamin B5: Pantothenic acid, also known as vitamin B5 is an essential vitamin, which plays a vital role in various functions in the body. It is mainly known for its important role in the metabolism of food, leading to energy production [9].

    All in all, B vitamins are important for energy production. Increased energy levels lead to improved stamina and sexual performance.

    Pomegranate extract

    Pomegranate (Punicagranatum L.) is a fruit that contains lots of healthy phytochemical compounds, such as polyphenols, flavonoids, and nitrates [10]. These phytochemicals have many antioxidant and anti-inflammatory qualities beneficial for men’s health [11].

    The polyphenols within pomegranate fruit are the main bioactive compounds responsible for the various health benefits attributed to this extract. The peel of the pomegranate contains the highest amounts of polyphenols. Two of the primary polyphenols in the peel are ellagitannins (punicalagin and punicalin) and ellagic acid [12].

    Studies showed that pomegranate extracts are associated with the treatment and prevention of many diseases and disorders in men , such as cardiovascular diseases, infertility, and erectile dysfunction [13, 14, 15]. For example, pomegranate has a positive effect on blood flow, key for erectile function and sexual performance [16].

    Hesperidin 

    Hesperidin is a bioflavonoid found in citrus fruits, abundant in sweet oranges (Citrus sinensis). After ingestion, hesperidin is converted to hesperetin by the microbiome. Hesperetin is considered the active metabolite of hesperidin and has been shown to have several beneficial health effects for men.

    One of the health effects of hesperidin is that it has antioxidant activity, through neutralizing Reactive Oxygen Species (ROS) [17]. This may eventually lead to enhanced overall well-being and an increase in energy when you need it most. This antioxidant activity also has a positive effect on fertility in men, since free radicals (ROS) decrease sperm motility and increase DNA damage [18].

    Additionally, hesperidin is known for its positive effect on blood flow. The active ingredient achieves this by increasing the availability of nitric oxide [19]. Eventually, this leads to an improved supply of nutrients and oxygen during physical and sexual activity, and to an improved erectile function.

    Actiful®: An ingredient containing hesperidin and punicalagin

    Actiful® is a natural orange and pomegranate complex and is standardized for highly bioavailable hesperidin and punicalagin: the primary polyphenols present in sweet orange (Citrus sinensis) and pomegranate peel (Punica granatum).

    The health benefits of this ingredient have been scientifically validated and confirmed through multiple randomized double-blind controlled trials. It is clinically proven that Actiful® results in enhanced physical performance in men [20, 21].

    Actiful® not only influences physical performance. It also boosts energy levels by targeting the mitochondria within the cells [22]. Additionally, Actiful® has been demonstrated to positively impact mental health [19].

    Lastly, it has been shown that Actiful® positively affects blood flow [21], by increasing the availability of nitric oxide. Hereby it promotes improved erectile function in men, leading to longer-lasting erections.

    Overall, Actiful® stands as a promising and scientifically backed choice for men aiming to improve their physical performance, sexual function, and overall health.


    MEET US - Supply Side West 2023

    Meet us at Supply Side West in Las Vegas, 2023!

    September 29th, 2023

    The Solabia-BioActor team is looking forward to be a part of the premier event for nutraceutical ingredients, Supply Side West in Las Vegas. Mark your calendar for October 25th and 26th, and make sure to visit us at Booth #3544.

    Meet us in Las Vegas!

    As part of Solabia Nutrition, we are presenting our range of clean-label products, amongst which Brainberry®, MicrobiomeX® and Bonolive®. We invite you to drop by our booth and discover our eco-friendly and sustainable product range. All BioActor ingredients are not only patented but also supported by clinical research conducted at Maastricht University, in the Netherlands.

    Additionally, you can explore the active ingredients of Solabia Nutrition and Solabia-Algatech at our booth. We will be displaying a variety of ingredients, like our AstaPure® astaxanthin range, Arava, BioGlena® and BioEcolians®. And there is more!

    Latest publications with Actiful® and MicrobiomeX®

    We are also eager to share the latest publications with Actiful® and MicrobiomeX®.

    The latest publication on, Actiful®demonstrates its ability to support energy and vitality as well as its potential to protect and support the mitochondria.

    For MicrobiomeX®, the latest clinical data confirms its ability to support the gut microbiome and increase butyrate production in an elderly subject population.

    Join us at Booth #3544, and let’s explore the future of nutraceutical ingredients together!

    Book a meeting!



      Why are you more easily fatigued as you get older?

      Why are you more easily fatigued as you get older? 

      September 20th, 2023

      Feeling tired all the time? Sleeping or resting is not doing the trick? You might be experiencing more than just regular tiredness – it could be fatigue. As we get older, our energy stores tend to drain more easily, which can contribute to fatigue. Fatigue is a common concern as we age, and it can have a significant impact on our overall well-being. In this article, we’ll explore fatigue in later life, its possible causes, and simple steps you can take to combat it.  

      What is fatigue?

      As we age, it’s common to notice that our energy levels deplete more easily. We may find ourselves wanting to do the things we used to, but realizing we have less energy to perform these things. This change in energy levels can be attributed to fatigue.

      Fatigue is defined as a state of tiredness or exhaustion that comprises a multifaceted combination of mental and physical elements. A crucial aspect of fatigue is that is not solved by simply resting more [1].

      Contributing factors to fatigue at later age

      One of the potential causes of fatigue at a later age is a loss of function in the mitochondria. Mitochondria are the “powerhouses” of the cell, and they produce energy in the form of adenosine triphosphate (ATP) to sustain all processes in the body.

      Loss in function of mitochondria occurs naturally as a result of aging, specifically increased levels of oxidative damage by reactive oxygen species (ROS) cause a decrease in the ability of mitochondria to produce ATP efficiently [2].

      Another common cause of fatigue at a later age may be related to the cardiovascular system since aging induces a functional and structural decline in the cardiovascular system [3]. Although the mechanisms are unclear at this moment, it is likely that increased arterial stiffness and reduced cardiac output are related to causing fatigue [4].

      Other factors contributing to fatigue at a later age could be:

      Hormonal changes: Experiencing hormonal changes as we age is a common symptom. In women, menopause causes decreased production of estrogen and progesterone. These hormonal fluctuations may lead to feeling fatigued [5].

      Lack of physical activity: We might become more sedentary as we age, due to several factors. However, this may lead to, for example, mood disturbances, poorer sleep quality, or even changes in your metabolism.

      Nutrient deficiencies: As we age, nutrient absorption and intake can be affected by various factors, such as the use of medication, changes in dietary patterns, and changes in gastrointestinal health [6].

      Boosting your energy level

      Unfortunately, aging is a process that cannot be reversed, so preventing fatigue is not avoidable. However, don’t despair! There are a number of easy lifestyle habits that can help: exercise regularly, participate in social activities you enjoy, and eat a well-balanced diet [6].

      A well-balanced diet can be optimized by the implementation of supplements into your diet. Supplements can be a valuable addition to your diet since they address potential nutritional deficiencies and support your overall health and well-being.

      Which nutrients help to beat fatigue?

      Nutritional deficiencies often contribute to feelings of fatigue, so ensuring adequate nutrient levels is essential. Here are some key nutrients that can help in overcoming fatigue [7,8]:

      1. Iron: This vital mineral supports oxygen supply to the muscles and plays a crucial role in energy production. It is also an important part in the structure of the enzymes responsible for ATP production.

      2. Magnesium: Another important mineral involved in energy production, magnesium activates ATP synthase, an enzyme responsible for synthesizing ATP. It also serves various functions related to energy production, muscle function, bone health, and protein synthesis.

      3. Vitamin C: This essential nutrient aids in fighting fatigue by enhancing iron absorption and safeguarding red blood cells from oxidative stress. By promoting improved oxygen supply to the muscles, vitamin C contributes to combating fatigue.

      4. B vitamins: B vitamins play a multifaceted role in energy production. They are integral to the metabolism of macronutrients and also support the production of red blood cells, indirectly contributing to oxygen supply.

      5. Bioflavonoids: These polyphenolic compounds offer numerous health benefits, like improved blood flow and increased mitochondrial efficiency. Actiful®, a substance rich in the bioflavonoid hesperidin, is particularly a good option to consider.

      3. Actiful®: A natural ingredient for more energy

      Actiful® is an orange & pomegranate complex, containing a high amount of micronized hesperidin. The ingredient is developed to boost vitality and optimize energy levels.

      A proprietary clinical trial by BioActor showed that Actiful® provides immediate and sustained energy. It does so by improving blood flow to active muscles and optimizing the respiration capacity of mitochondria, in turn increasing ATP production [9].

      Actiful®’s positive effect on blood flow is linked to vasodilative capacities of the active metabolites. Micronized hesperidin promotes vasodilation by stimulating the production of nitric oxide [10]. Nitric oxide relaxes the blood vessels, thereby enlarging their diameter and allowing the passage of a greater amount of nutrient-rich blood and oxygen.

      As a bonus, Actiful® positively affects mental well-being. In our proprietary clinical trial, we showed a significant improvement in concentration, thinking, memory, and learning [11]. These aspects are vital for overall well-being and quality of life.

      Overall, Actiful® is a safe, healthy, and natural ingredient which is perfect to be incorporated into energy-providing supplements.


      Actiful: a sweet orange and pomegranate extract suitable for supplements

      New publication of clinical data: Actiful® reduces Methylglyoxal, an important marker for healthy aging

      New publication of clinical data: Actiful® reduces Methylglyoxal, an important marker for healthy ageing

      Maastricht, The Netherlands, 15th September  2023

      Press release

      A randomized double blinded crossover study performed by Maastricht University, showed the potential of Actiful® as a dietary modulator against advanced glycation end-products (AGEs). AGEs are associated with various age-related chronic diseases. After a 4-week period of Actiful® consumption in healthy elderly subjects, plasma levels of methylglyoxal (MGO) decreased significantly by 9.8% (p = 0.042). These new clinical results highlight Actiful®’s potential to mitigate age-related diseases like diabetes, vascular dysfunction and neurodegeneration. 

      Actiful: a sweet orange and pomegranate extract suitable for supplements

      Actiful®: an energy-boosting ingredient developed by BioActor

      Actiful® is a clinically validated blend of Citrus sinensis (sweet orange) and Punica granatum (pomegranate) extracts. These plants are abundant in bioactive polyphenolic components, mainly flavonoids (1, 2) . Actiful® has a dual mode of action: by increasing synthesis of nitric oxide and by improving ATP production through an increased mitochondrial respiration efficiency (3). In the first clinical study, Actiful® demonstrated to improve energy, mood and antioxidant status in healthy elderly individuals. Actiful® is used globally by leading supplement brands in a vast array of products supporting an active lifestyle and healthy aging.

      The study: A Citrus and Pomegranate Complex Reduces Methylglyoxal in Healthy Elderly Subjects: Secondary Analysis of a Double-Blind Randomized Cross-Over Clinical Trial

       

      Introduction

      This study (4) was published in the International Jouranl of Molecular Sciences . It focuses on the evaluation of additional biomarkers and the effect of Actiful® in reducing the concentrations of reactive α-dicarbonyl compounds (specifically methylglyoxal, glyoxal, and 3-deoxyglucosone) in the blood of healthy elderly participants. These α-dicarbonyls are known to contribute to the formation of advanced glycation end-products (AGEs), which are associated with various chronic diseases, including diabetes and cardiovascular diseases (5).

      Methods

      Thirty-six healthy elderly subjects were recruited for this double-blind, randomized crossover clinical trial. They received either 700 mg of Actiful® in capsules, or a placebo for four weeks, with a 4-week washout period in between.

      Blood samples were collected during the test day to measure α-Dicarbonyls in plasma. This was achieved via ultra-performance liquid chromatography tandem mass spectrometry.

      Results

      A significant reduction in plasma methylglyoxal concentrations was observed during a 4-week supplementation period. This reduction suggests a potential benefit in terms of reducing the formation of harmful AGEs, which could be attributed to the antioxidant properties of the active compounds in the supplement. The observed reduction in methylglyoxal was around 9.8%, which could be of clinical relevance in preventing or managing age-related conditions related to AGEs formation, like cardiovascular related diseases, diabetes and neurodegeneration. This confirms the importance of exploring promising nutraceuticals like Actiful® as potential healthy ageing strategies to mitigate the impact of reactive α-dicarbonyl compounds on health.

      Conclusion

      This study demonstrates the great potential of Actiful® for playing a role in healthy ageing. This is indicated by the significant reduction in AGEs, specifically MGO, found in the present study.

      Click here to read the complete publication

      About BioActor

      BioActor, based in Maastricht, Netherlands is part of the Solabia Group and has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. We focus on the development of innovative activities that address active living and healthy ageing. Our goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

      Feel free to contact via info@bioactor.com for more information on the possibilities Actiful® has to offer. Further information can also be found on: https://actiful.eu and https://bioactor.com/products/actiful


      Enhancing Mitochondrial Health Exploring the Significance of Nutrients

      Exploring the significance of nutrients for mitochondrial health

      Enhancing mitochondrial health: exploring the significance of nutrients

      August 8th, 2023

      Discover the influence of nutrients on your mitochondrial health. Dive into our blog to learn how magnesium, hesperidin, vitamin C, omega-3s, and more can enhance your mitochondrial health and boost your overall vitality.

      Enhancing Mitochondrial Health Exploring the Significance of Nutrients

      Nutrients to support mitochondrial health

      Maintaining the optimal performance of our mitochondria is pivotal for our overall well-being. These microscopic organelles act as cellular powerhouses, generating a significant portion of the energy necessary for our cells to function at their best.

      Beyond energy production, they also regulate metabolic processes and uphold a delicate balance of nutrients within our cells

      Dysfunctional mitochondria can result in notable symptoms like fatigue and muscle weakness. In more serious instances, they have been linked to critical health conditions such as cardiovascular ailments and neurodegenerative diseases.

      Consequently, prioritizing the health of our mitochondria is not only essential for general vitality but also plays a preventive role against potential illnesses.

      Within this article, we will take a look at specific nutrients that actively contribute to the maintenance and augmentation of mitochondrial health.

      Magnesium and mitochondrial vitality

      Magnesium plays a vital role in ensuring the well-being of our mitochondria. It serves as a crucial facilitator for enzymes responsible for energy production, while also exhibiting antioxidant properties.

      This antioxidative function of magnesium is particularly significant, shielding mitochondria from potential harm induced by harmful molecules. Additionally, magnesium takes on the responsibility of regulating calcium levels within mitochondria, a pivotal function in averting any potential malfunctioning (1).

      Sustaining an appropriate intake of magnesium is essential to uphold the health of mitochondria and prevent any disruptions in their functioning. Incorporating magnesium-rich foods into our diet, such as nuts, seeds, whole grains, and leafy green vegetables, provides a natural source of this essential mineral. Additionally, it’s a possible addition for an energy supplement.

      Hesperidin: a citrus boost for mitochondria

      Hesperidin, a natural compound present in citrus fruits like oranges, lemons, and grapefruits, offers significant potential in maintaining robust mitochondrial health.

      By boosting the expression of genes linked to energy production, hesperidin enhances mitochondrial functionality. This augmentation translates to increased energy production within the mitochondria, resulting in elevated energy levels and reduced fatigue (2).

      Moreover, hesperidin boasts anti-inflammatory attributes that play a role in curbing inflammation throughout the body. As inflammation can contribute to mitochondrial disturbances, mitigating this inflammation becomes a supportive measure for preserving mitochondrial well-being.

      Vitamin C to boost mitochondrial health

      Vitamin C holds a crucial role in maintaining the well-being of our mitochondria. Serving as one of the body’s most potent antioxidants, vitamin C offers safeguarding prowess against detrimental molecules known as free radicals, shielding our mitochondria from harm (3).

      Free radicals possess the capacity to impair mitochondria, diminishing their capacity to generate energy. However, vitamin C effectively counters these radicals, preventing their damaging effects.

      Therefore, ensuring your diet includes a good dose of vitamin C becomes a noteworthy strategy to keep healthy mitochondria.

      Omega-3s: helpful for energy

      Omega-3 fatty acids are a type of healthy fat found in foods like fatty fish, nuts, and seeds. They play a crucial role in promoting the health of our mitochondria.

      These fatty acids are boosters for mitochondria: they help these powerhouses extract more energy from the same amount of nutrients, which means less fatigue and more energy (4). Omega-3s also shield mitochondria from damage caused by harmful molecules. They also improve the mitochondria’s ability to transport nutrients in and out efficiently.

      Omega-3 fatty acids also bring anti-inflammatory capabilities, which is good for our overall well-being. Including foods rich in omega-3s in our diet is a smart move to support your mitochondria, boost energy production, and keep inflammation in check.

      B-vitamins and their ability to support mitochondrial well-being

      B vitamins, including B1, B2, B3, B5, and B7, are fundamental contributors to the maintenance of optimal mitochondrial health. These vitamins play a pivotal role in facilitating energy production within mitochondria by participating in the breakdown of carbohydrates, fats, and proteins.

      The main reason for this is that B vitamins can act as co-enzymes and precursors of co-enzymes that help in the breakdown of these nutrients. This is key for mitochondrial health. Inadequate intake of these B vitamins can lead to compromised mitochondrial function, resulting in sensations of fatigue, weakness, and muscular discomfort (5).

      Sustaining an adequate dietary supply of B vitamins is imperative to sustain the functional integrity of mitochondria and facilitate efficient energy synthesis.

      Intake of nutrients to support mitochondrial health

      In summary, looking after the health of our mitochondria is vital for our general well-being. A range of nutrients, such as hesperidin, magnesium, B-vitamins, omega-3 fatty acids, and vitamin C, play key roles in supporting mitochondrial function. They not only help diminish oxidative stress and inflammation but also enhance exercise performance.

      By incorporating these essential nutrients in your diet, we can effectively boost our mitochondrial health and ensure our body’s energy production functions at its best.

      Discover YAMAMOTO’s Success Story

      Learn how YAMAMOTO integrated WATTS’UP® into their products, driving remarkable success.

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      The importance of clinical research: An interview with BioActor's in-house scientists

      The importance of clinical research: An interview with BioActor’s in-house scientists

      Maastricht, The Netherlands, 29th June 2023

      Interview
      In the world of clinical research and scientific exploration, BioActor stands out as a leading company dedicated to the development of health ingredients. At the forefront of BioActor’s research and development (R&D) efforts are Sanne Ahles and Maria Imperatrice, two certified clinical research scientists who play vital roles in the BioActor’s R&D initiatives. In this interview, Sanne and Maria provide insights into their responsibilities, experiences, and the challenges they face in their pursuit of scientific advancement.

      Could you introduce yourself and your role within BioActor?

      Sanne: My name is Sanne Ahles and I am a clinical research scientist at BioActor. In addition, I am a PhD candidate at the Department of Nutrition and Movement Sciences at Maastricht University. I obtained my master’s degree in biomedical sciences after my internship at BioActor, after which I started working as a researcher.

      Within BioActor, I am responsible for the research regarding our product Brainberry®, mainly focused on cognitive performance and vascular function. Over the years, I have designed, performed, analyzed, and reported various clinical studies, as well as written a systematic literature review.

      Maria: My name is Maria Imperatrice and I also work as a clinical research scientist at BioActor. My research focus is Healthy Ageing and I’m currently performing two studies, Actiful2 and FEMMED, on two of our ingredients (Actiful® and Bonolive®) to evaluate their effect on exercise performance and postmenopausal symptoms, respectively.

      I obtained my Bachelor Degree in Biology and my Master in Human Nutrition at the University “Federico II Di Napoli” in Italy, and my second master’s degree in Human Movement Sciences, with a specialisation in Sport and Nutrition, at Maastricht University.

      At BioActor, we highly value clinical research because it plays a crucial role in providing evidence-based ingredients. What does clinical research entail and what do you like about it?

      Sanne: Clinical research entails many different processes. This includes idea formation and initial literature searches, finding collaborations, obtaining ethics approval, practical work, data analyses, writing reports and papers, and communicating our results at national and international conferences.

      Maria: A very interesting part for us is the ideation of the study. At BioActor we highly value innovation, which is why before starting a new clinical trial, we sit in brainstorming sessions with the R&D, marketing and sales teams to try to find white spaces in the current knowledge that can be of interest for the common public and different health domains. Once we find an interesting and never explored topic, the investigation can start.

      Could you briefly take us through the process of a clinical trial?

      Sanne: First, we initiate the idea formation process by brainstorming ideas that are relevant to customer questions or explore new areas of interest. Next, we perform literature searches to look for relevant papers, available data, and discover white space; topics that have not yet been researched.

      Then we reach out to a collaborator, usually a professor at a University, to work with on developing a protocol for ethics review.

      Maria: Once we obtain ethics approval, we dive into the practical phase of the clinical trial. This involves engaging with participants through visits where we collect data. This includes not only traditional data that we can extrapolate by collecting blood samples, but also performing tests to evaluate outcomes like reaction time, exercise capacity and mental flexibility.

      It’s an interactive and rewarding experience that brings our research to life and allows us to better understand how our ingredients contribute to improving human health and develop evidence-based solutions. Afterwards, we analyze the data, draw conclusions, and share our findings through peer-reviewed publications. It’s a cool journey from start to finish!

      Which of the above do you enjoy the most as a scientist?

      Sanne: I enjoy collaborating with other companies or academic institutes! It’s such an incredible opportunity for us to broaden our knowledge and take our research to the next level. The energy and creativity that come from working with diverse teams is truly great.

      Maria: The practical side of our work is always interesting! Collecting data means we get to perform visits with participants, and trust me, it’s never boring when you’re involved in a human study. The hands-on experience and the constant interaction with people make it such an exciting and fulfilling part of our job.

      What is the biggest challenge in designing a study?

      Sanne: In my opinion, the biggest challenge in designing a study is obtaining ethics approval, which is a rigorous and time-consuming process. We meticulously prepare documents explaining our research goals, methodology, and participant recruitment.

      The ethical committee thoroughly reviews these documents, granting final approval for each aspect of our research.

      Maria: I agree! Obtaining ethics approval is a significant challenge. However, this process is crucial for upholding ethical standards and protecting participant rights.

      It also adds credibility to our research, fostering trust and allowing our findings to have a greater impact. Despite the challenges, navigating the ethics approval process is vital for conducting valuable and ethically sound research.

      What is the best part of working at BioActor as a scientist?

      Sanne & Maria: Being a scientist at BioActor is truly rewarding due to the chance to collaborate with a dynamic and passionate team of international colleagues. Within BioActor, we also see other aspects of the company besides R&D.

      Our weekly company meetings allow us to really understand the bigger picture of the company and understand what each department entails. Consequently, we explore different facets of the company and gain valuable insights beyond our specific research and development focus.

      BioActor: Using clinical science as the key to innovative ingredients

      Sanne Ahles and Maria Imperatrice exemplify the passion and dedication that drive BioActor’s pursuit of finding new health effects of ingredients and advancing scientific innovation. From ideation to practical implementation, data analysis, and knowledge dissemination; they are pushing the boundaries of scientific knowledge and embracing the multidisciplinary nature of their work. Sanne and Maria contribute to BioActor’s mission of creating innovative and impactful solutions for a healthier life.


      making-a-gummy-supplement

      Why should you consider making a gummy supplement?

      Why should you consider making a gummy supplement?

      June 14th, 2023

      Gummy supplements are on the rise as people look for a convenient and tasty way to add essential nutrients to their diet. Gummies are a great alternative to capsules and pills for individuals looking for supplements that are not hard to swallow. In this article, we will discuss the advantages of gummy supplements over traditional supplement formats and the factors to consider when choosing a gummy as a supplement.

      making-a-gummy-supplement

      Tablets as dietary supplements

      Recently, there has been a rise in people’s interest in their well-being by using nutritional supplements. This has resulted in a 12% increase in the production of supplements in 2020.

      The most common forms of supplements are tablets and capsules, which are convenient, easy to use, and widely available.

      Tablets are a solid form of supplement that is typically round or long in shape and can range in size from small and easy to swallow to larger and more difficult to swallow.

      Tablets are made by compressing the active ingredients together with other inactive ingredients such as fillers, binders, and lubricants. These ingredients help to give the tablet its shape, size, and consistency and may also affect how the supplement is absorbed and used by the body.

      Capsulated supplements

      Capsules are another common form of supplement that is made by enclosing the active ingredients in a gelatin or vegetarian shell. Capsules can be filled with powders, liquids, or oils and come in a variety of sizes and shapes.

      Both tablets and capsules have advantages and disadvantages depending on the individual and their needs. Tablets are often preferred by people who prefer a solid form of supplement and are more affordable than capsules.

      However, what both forms of supplements have in common is that they are generally not liked for their taste. The demand for supplements that are nice to take is growing, which is why gummy supplements are on the rise.

      The rise of gummy supplements

      Gummies are a type of food supplement that provides essential nutrients that might be lacking in one’s regular diet. They are becoming increasingly popular in the food supplement industry due to their combination of health benefits and sweetness. Gummies are also a great option for individuals looking for vegan, gluten-free, or lactose-free products.

      Manufacturers of functional gummies use natural and organic raw materials in their production, making them more appealing to quality-conscious consumers. These gummies typically contain gelatin, corn starch, water, sugar, and added colorings.

      Gummies contain active ingredients such as vitamins, minerals, probiotics, antioxidants, and amino acids that can have positive effects on various aspects of health, including digestion, immune system function, cardiovascular health, and mental well-being.

      Why choose gummies over pills?

      Gummies are a versatile form of supplement that can be used for many different purposes. They can help prevent digestive, sleep, and skin problems, treat vitamin deficiencies, and boost the immune system.

      – Studies have shown that gummies are more effective than pills or tablets at delivering nutrients to the body. This is because the nutrients in gummies are dissolved in a liquid gelatin base, which makes them more easily absorbed by the body. As a result, gummies can be a more efficient way of supplying essential nutrients and provide a significant advantage over traditional supplement formats (1).

      Gummies are a convenient and tasty way to add vitamins and minerals to your diet. They’re becoming increasingly popular as a simple and easy way to supplement your diet with micronutrients, offering an enjoyable alternative to traditional supplements.

      – The soft and chewy textures of gummies make them a great option for people who struggle with swallowing pills or capsules.

      – Unlike traditional tablets or pills, gummies come in a variety of delicious flavors that can make taking supplements a more enjoyable experience. By taking vitamin gummies formulated with essential nutrients, individuals can avoid vitamin deficiencies and supplement their diet.

      – Incorporating gummies into your brand can help you stand out from traditional supplement companies and offer consumers a unique and enjoyable option for improving their health.

      Factors to consider when creating a gummy supplement

      Creating high-quality gummy supplements requires careful consideration of the ingredients used. Here are some key points to keep in mind:

      – Look for ingredient suppliers that provide options with minimal sugar content or natural sweeteners as alternatives. This ensures that the final gummy product aligns with consumer preferences for reduced sugar intake.

      – Prioritize sourcing pure and natural ingredients for your gummy supplements. Consider using natural sources for colors and flavors to enhance the appeal and marketability of the product.

      – Incorporate ingredients that offer a significant amount of dietary fiber per serving. Fiber not only adds nutritional value but also promotes digestive health and supports a strong immune system, making your gummies more appealing to health-conscious consumers.

      In conclusion, it is important to look for gummies with natural and pure ingredients, as well as sweeteners or with a minimal amount of sugar. Having these factors in mind, consumers can find gummies that not only taste good but also provide essential nutrients and health benefits.

      Creating a gummy supplement for focus and brain health

      BioActor’s Brainberry® is a great example of an ingredient that can be used in a gummy. It has a low daily dose of only 65mg and has been clinically validated for cognitive performance, focus and hand-eye coordination.

      It’s an extract from Aronia berries and if you want to find out more: Here’s everything you need to know about Brainberry® and brain health.

      Discover YAMAMOTO’s Success Story

      Learn how YAMAMOTO integrated WATTS’UP® into their products, driving remarkable success.

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      Ingredients-for-energy-supplements

      Top 5 reasons why Actiful® is a good ingredient for your energy supplement

      Top 5 reasons why Actiful® is a good addition to your energy supplement

      May 25th, 2023

      The need for healthy ingredients that have undergone extensive clinical testing is increasing as consumers become more interested in dietary supplements that improve energy. The abundance of ingredients available can feel overpowering for supplement formulators who aim to create a product that promotes energy and vitality. But don’t worry – in this article, we’ll cover the top five reasons why Actiful® is a good ingredient for your energy supplement.

      Ingredients-for-energy-supplements

      Finding ingredients for the rising demand in energy supplements

      Low energy levels and a lack of vitality are common complaints in today’s fast-paced world. Many consumers turn to dietary supplements to manage the daily mental and physical stressors they face. Energy-enhancing supplements aim to prevent fatigue, increase physical activity, and promote social engagement.

      With the growing demand for energy-enhancing products, it can be challenging to identify scientifically backed ingredients. To simplify the process, we’ve compiled the top 5 reasons why Actiful should be included in your energy supplement as an ingredient.

      Actiful®: A combination of sweet orange and pomegranate

      Actfiul® is a patent-protected, all-natural ingredient developed by BioActor; a pioneer in clinically substantiating the beneficial impact of citrus flavonoids on energy metabolism. Actiful® is standardized for hesperidin and punicalagin; the main polyphenols found in sweet orange (Citrus sinensis) and the peel of pomegranate (Punica granatum), respectively. Both compounds have been extensively studied for their potential health benefits.

      Top 5 reasons to use Actiful® as an ingredient for your energy supplement

      1. Enhanced physical performance in both young and old

      A double-blind randomized controlled trial conducted on physically fit young males revealed that Actiful® can increase absolute power output by 5% during a 10-minute cycling time-trial without requiring additional oxygen (1). This advantage was observed after just four weeks of daily supplementation with Actiful®.

      In addition, a recently published double-blind randomized controlled trial conducted on active seniors found that daily supplementation with Actiful® for four weeks significantly increased their handgrip strength (2). Handgrip strength is a crucial measure of physical fitness in the elderly as it is indicative of overall health and functional status in day-to-day life.

      Given that Actiful® has been clinically proven to enhance physical performance in both young and older individuals, it is an ideal ingredient to target a wide population.

      2. Mental health benefits

      Mental wellbeing plays a significant role in physical fitness, as the way one handles cognitive demanding tasks can affect how energized they feel.

      In addition to improved physical performance, the elderly subjects who supplemented with Actiful® also experienced psychological benefits. Compared to the placebo group, the Actiful® group demonstrated significant improvements in cognitive domains such as thinking, memory, learning, and concentration (2). These elements are essential for maintaining one’s quality of life and wellbeing.

      Given the critical connection between the mind and body in enhancing vitality, Actiful® is the ideal ingredient to target both.

      3. Mitochondria

      Boosting your energy can be done by targeting mitochondria, which are the powerhouses of the cell.

      A strategy to target the mitochondria is by implementing specific nutrients into your diet. Actiful® enhances energy levels via mitochondria as well. Experiments in muscle cells have demonstrated that Hesperetin, the active metabolite of Hesperidin, can improve energy production by directly targeting the mitochondria (3).

      This improvement in energy production has been observed to translate into improved running performance in mice. The mechanism behind this is that Actiful® improves the respiration capacity of the mitochondria.

      To produce energy, mitochondria require oxygen to form an electron gradient across the intermembrane, which mechanically produces ATP. When protons leak across the intermembrane, the gradient weakens, resulting in fewer ATP molecules being formed. By inhibiting proton leakage across the mitochondrial intermembrane, Actiful® enhances energy production directly.

      4. Antioxidant

      During physical activity, there is a heightened production of reactive oxygen species (ROS) due to the increased demand on mitochondria to produce energy. Excessive ROS can lead to damage to the mitochondria and other crucial structures of the cell, which can impair their functionality.

      Hesperidin has been demonstrated to not only scavenge ROS directly but also enhance the natural antioxidant systems present in cells (3). In addition, pomegranate has also been found to improve antioxidant status (4).
      As a result, Actiful®’s antioxidant capabilities may improve vitality by preserving the functionality of cells and tissues.

      5. NO improved bloodflow

      Nitric oxide (NO) is a critical component in regulating blood flow. NO relaxes the blood vessels, increasing their diameter, and allowing more oxygen and nutrient-rich blood to pass through.
      Endothelial cells that line the blood vessels produce more NO through the enzyme eNOS, which Hesperidin has been found to activate, promoting vasodilation (5).

      Furthermore, when oxygen is limited, dietary nitrate can raise NO levels. Pomegranate, which is high in Punicalagin, is a potent source of dietary nitrate that may improve blood flow and increase the efficiency of oxygen and nutrient delivery.

      Actiful®: the key ingredient of your energy supplement

      All in all, Actiful® is a natural and safe ingredient that has the ideal properties to be incorporated in energy supplements that aim to provide acute and sustained improvements in vitality!