Why are you more easily fatigued as you get older?

Why are you more easily fatigued as you get older? 

September 20th, 2023

Feeling tired all the time? Sleeping or resting is not doing the trick? You might be experiencing more than just regular tiredness – it could be fatigue. As we get older, our energy stores tend to drain more easily, which can contribute to fatigue. Fatigue is a common concern as we age, and it can have a significant impact on our overall well-being. In this article, we’ll explore fatigue in later life, its possible causes, and simple steps you can take to combat it.  

What is fatigue?

As we age, it’s common to notice that our energy levels deplete more easily. We may find ourselves wanting to do the things we used to, but realizing we have less energy to perform these things. This change in energy levels can be attributed to fatigue.

Fatigue is defined as a state of tiredness or exhaustion that comprises a multifaceted combination of mental and physical elements. A crucial aspect of fatigue is that is not solved by simply resting more [1].

Contributing factors to fatigue at later age

One of the potential causes of fatigue at a later age is a loss of function in the mitochondria. Mitochondria are the “powerhouses” of the cell, and they produce energy in the form of adenosine triphosphate (ATP) to sustain all processes in the body.

Loss in function of mitochondria occurs naturally as a result of aging, specifically increased levels of oxidative damage by reactive oxygen species (ROS) cause a decrease in the ability of mitochondria to produce ATP efficiently [2].

Another common cause of fatigue at a later age may be related to the cardiovascular system since aging induces a functional and structural decline in the cardiovascular system [3]. Although the mechanisms are unclear at this moment, it is likely that increased arterial stiffness and reduced cardiac output are related to causing fatigue [4].

Other factors contributing to fatigue at a later age could be:

Hormonal changes: Experiencing hormonal changes as we age is a common symptom. In women, menopause causes decreased production of estrogen and progesterone. These hormonal fluctuations may lead to feeling fatigued [5].

Lack of physical activity: We might become more sedentary as we age, due to several factors. However, this may lead to, for example, mood disturbances, poorer sleep quality, or even changes in your metabolism.

Nutrient deficiencies: As we age, nutrient absorption and intake can be affected by various factors, such as the use of medication, changes in dietary patterns, and changes in gastrointestinal health [6].

Boosting your energy level

Unfortunately, aging is a process that cannot be reversed, so preventing fatigue is not avoidable. However, don’t despair! There are a number of easy lifestyle habits that can help: exercise regularly, participate in social activities you enjoy, and eat a well-balanced diet [6].

A well-balanced diet can be optimized by the implementation of supplements into your diet. Supplements can be a valuable addition to your diet since they address potential nutritional deficiencies and support your overall health and well-being.

Which nutrients help to beat fatigue?

Nutritional deficiencies often contribute to feelings of fatigue, so ensuring adequate nutrient levels is essential. Here are some key nutrients that can help in overcoming fatigue [7,8]:

1. Iron: This vital mineral supports oxygen supply to the muscles and plays a crucial role in energy production. It is also an important part in the structure of the enzymes responsible for ATP production.

2. Magnesium: Another important mineral involved in energy production, magnesium activates ATP synthase, an enzyme responsible for synthesizing ATP. It also serves various functions related to energy production, muscle function, bone health, and protein synthesis.

3. Vitamin C: This essential nutrient aids in fighting fatigue by enhancing iron absorption and safeguarding red blood cells from oxidative stress. By promoting improved oxygen supply to the muscles, vitamin C contributes to combating fatigue.

4. B vitamins: B vitamins play a multifaceted role in energy production. They are integral to the metabolism of macronutrients and also support the production of red blood cells, indirectly contributing to oxygen supply.

5. Bioflavonoids: These polyphenolic compounds offer numerous health benefits, like improved blood flow and increased mitochondrial efficiency. Actiful®, a substance rich in the bioflavonoid hesperidin, is particularly a good option to consider.

3. Actiful®: A natural ingredient for more energy

Actiful® is an orange & pomegranate complex, containing a high amount of micronized hesperidin. The ingredient is developed to boost vitality and optimize energy levels.

A proprietary clinical trial by BioActor showed that Actiful® provides immediate and sustained energy. It does so by improving blood flow to active muscles and optimizing the respiration capacity of mitochondria, in turn increasing ATP production [9].

Actiful®’s positive effect on blood flow is linked to vasodilative capacities of the active metabolites. Micronized hesperidin promotes vasodilation by stimulating the production of nitric oxide [10]. Nitric oxide relaxes the blood vessels, thereby enlarging their diameter and allowing the passage of a greater amount of nutrient-rich blood and oxygen.

As a bonus, Actiful® positively affects mental well-being. In our proprietary clinical trial, we showed a significant improvement in concentration, thinking, memory, and learning [11]. These aspects are vital for overall well-being and quality of life.

Overall, Actiful® is a safe, healthy, and natural ingredient which is perfect to be incorporated into energy-providing supplements.


Actiful: a sweet orange and pomegranate extract suitable for supplements

New publication of clinical data: Actiful® reduces Methylglyoxal, an important marker for healthy aging

New publication of clinical data: Actiful® reduces Methylglyoxal, an important marker for healthy ageing

Maastricht, The Netherlands, 15th September  2023

Press release

A randomized double blinded crossover study performed by Maastricht University, showed the potential of Actiful® as a dietary modulator against advanced glycation end-products (AGEs). AGEs are associated with various age-related chronic diseases. After a 4-week period of Actiful® consumption in healthy elderly subjects, plasma levels of methylglyoxal (MGO) decreased significantly by 9.8% (p = 0.042). These new clinical results highlight Actiful®’s potential to mitigate age-related diseases like diabetes, vascular dysfunction and neurodegeneration. 

Actiful: a sweet orange and pomegranate extract suitable for supplements

Actiful®: an energy-boosting ingredient developed by BioActor

Actiful® is a clinically validated blend of Citrus sinensis (sweet orange) and Punica granatum (pomegranate) extracts. These plants are abundant in bioactive polyphenolic components, mainly flavonoids (1, 2) . Actiful® has a dual mode of action: by increasing synthesis of nitric oxide and by improving ATP production through an increased mitochondrial respiration efficiency (3). In the first clinical study, Actiful® demonstrated to improve energy, mood and antioxidant status in healthy elderly individuals. Actiful® is used globally by leading supplement brands in a vast array of products supporting an active lifestyle and healthy aging.

The study: A Citrus and Pomegranate Complex Reduces Methylglyoxal in Healthy Elderly Subjects: Secondary Analysis of a Double-Blind Randomized Cross-Over Clinical Trial

 

Introduction

This study (4) was published in the International Jouranl of Molecular Sciences . It focuses on the evaluation of additional biomarkers and the effect of Actiful® in reducing the concentrations of reactive α-dicarbonyl compounds (specifically methylglyoxal, glyoxal, and 3-deoxyglucosone) in the blood of healthy elderly participants. These α-dicarbonyls are known to contribute to the formation of advanced glycation end-products (AGEs), which are associated with various chronic diseases, including diabetes and cardiovascular diseases (5).

Methods

Thirty-six healthy elderly subjects were recruited for this double-blind, randomized crossover clinical trial. They received either 700 mg of Actiful® in capsules, or a placebo for four weeks, with a 4-week washout period in between.

Blood samples were collected during the test day to measure α-Dicarbonyls in plasma. This was achieved via ultra-performance liquid chromatography tandem mass spectrometry.

Results

A significant reduction in plasma methylglyoxal concentrations was observed during a 4-week supplementation period. This reduction suggests a potential benefit in terms of reducing the formation of harmful AGEs, which could be attributed to the antioxidant properties of the active compounds in the supplement. The observed reduction in methylglyoxal was around 9.8%, which could be of clinical relevance in preventing or managing age-related conditions related to AGEs formation, like cardiovascular related diseases, diabetes and neurodegeneration. This confirms the importance of exploring promising nutraceuticals like Actiful® as potential healthy ageing strategies to mitigate the impact of reactive α-dicarbonyl compounds on health.

Conclusion

This study demonstrates the great potential of Actiful® for playing a role in healthy ageing. This is indicated by the significant reduction in AGEs, specifically MGO, found in the present study.

Click here to read the complete publication

About BioActor

BioActor, based in Maastricht, Netherlands is part of the Solabia Group and has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. We focus on the development of innovative activities that address active living and healthy ageing. Our goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

Feel free to contact via info@bioactor.com for more information on the possibilities Actiful® has to offer. Further information can also be found on: https://actiful.eu and https://bioactor.com/products/actiful


Enhancing Mitochondrial Health Exploring the Significance of Nutrients

Exploring the significance of nutrients for mitochondrial health

Enhancing mitochondrial health: exploring the significance of nutrients

August 8th, 2023

Discover the influence of nutrients on your mitochondrial health. Dive into our blog to learn how magnesium, hesperidin, vitamin C, omega-3s, and more can enhance your mitochondrial health and boost your overall vitality.

Enhancing Mitochondrial Health Exploring the Significance of Nutrients

Nutrients to support mitochondrial health

Maintaining the optimal performance of our mitochondria is pivotal for our overall well-being. These microscopic organelles act as cellular powerhouses, generating a significant portion of the energy necessary for our cells to function at their best.

Beyond energy production, they also regulate metabolic processes and uphold a delicate balance of nutrients within our cells

Dysfunctional mitochondria can result in notable symptoms like fatigue and muscle weakness. In more serious instances, they have been linked to critical health conditions such as cardiovascular ailments and neurodegenerative diseases.

Consequently, prioritizing the health of our mitochondria is not only essential for general vitality but also plays a preventive role against potential illnesses.

Within this article, we will take a look at specific nutrients that actively contribute to the maintenance and augmentation of mitochondrial health.

Magnesium and mitochondrial vitality

Magnesium plays a vital role in ensuring the well-being of our mitochondria. It serves as a crucial facilitator for enzymes responsible for energy production, while also exhibiting antioxidant properties.

This antioxidative function of magnesium is particularly significant, shielding mitochondria from potential harm induced by harmful molecules. Additionally, magnesium takes on the responsibility of regulating calcium levels within mitochondria, a pivotal function in averting any potential malfunctioning (1).

Sustaining an appropriate intake of magnesium is essential to uphold the health of mitochondria and prevent any disruptions in their functioning. Incorporating magnesium-rich foods into our diet, such as nuts, seeds, whole grains, and leafy green vegetables, provides a natural source of this essential mineral. Additionally, it’s a possible addition for an energy supplement.

Hesperidin: a citrus boost for mitochondria

Hesperidin, a natural compound present in citrus fruits like oranges, lemons, and grapefruits, offers significant potential in maintaining robust mitochondrial health.

By boosting the expression of genes linked to energy production, hesperidin enhances mitochondrial functionality. This augmentation translates to increased energy production within the mitochondria, resulting in elevated energy levels and reduced fatigue (2).

Moreover, hesperidin boasts anti-inflammatory attributes that play a role in curbing inflammation throughout the body. As inflammation can contribute to mitochondrial disturbances, mitigating this inflammation becomes a supportive measure for preserving mitochondrial well-being.

Vitamin C to boost mitochondrial health

Vitamin C holds a crucial role in maintaining the well-being of our mitochondria. Serving as one of the body’s most potent antioxidants, vitamin C offers safeguarding prowess against detrimental molecules known as free radicals, shielding our mitochondria from harm (3).

Free radicals possess the capacity to impair mitochondria, diminishing their capacity to generate energy. However, vitamin C effectively counters these radicals, preventing their damaging effects.

Therefore, ensuring your diet includes a good dose of vitamin C becomes a noteworthy strategy to keep healthy mitochondria.

Omega-3s: helpful for energy

Omega-3 fatty acids are a type of healthy fat found in foods like fatty fish, nuts, and seeds. They play a crucial role in promoting the health of our mitochondria.

These fatty acids are boosters for mitochondria: they help these powerhouses extract more energy from the same amount of nutrients, which means less fatigue and more energy (4). Omega-3s also shield mitochondria from damage caused by harmful molecules. They also improve the mitochondria’s ability to transport nutrients in and out efficiently.

Omega-3 fatty acids also bring anti-inflammatory capabilities, which is good for our overall well-being. Including foods rich in omega-3s in our diet is a smart move to support your mitochondria, boost energy production, and keep inflammation in check.

B-vitamins and their ability to support mitochondrial well-being

B vitamins, including B1, B2, B3, B5, and B7, are fundamental contributors to the maintenance of optimal mitochondrial health. These vitamins play a pivotal role in facilitating energy production within mitochondria by participating in the breakdown of carbohydrates, fats, and proteins.

The main reason for this is that B vitamins can act as co-enzymes and precursors of co-enzymes that help in the breakdown of these nutrients. This is key for mitochondrial health. Inadequate intake of these B vitamins can lead to compromised mitochondrial function, resulting in sensations of fatigue, weakness, and muscular discomfort (5).

Sustaining an adequate dietary supply of B vitamins is imperative to sustain the functional integrity of mitochondria and facilitate efficient energy synthesis.

Intake of nutrients to support mitochondrial health

In summary, looking after the health of our mitochondria is vital for our general well-being. A range of nutrients, such as hesperidin, magnesium, B-vitamins, omega-3 fatty acids, and vitamin C, play key roles in supporting mitochondrial function. They not only help diminish oxidative stress and inflammation but also enhance exercise performance.

By incorporating these essential nutrients in your diet, we can effectively boost our mitochondrial health and ensure our body’s energy production functions at its best.

Discover YAMAMOTO’s Success Story

Learn how YAMAMOTO integrated WATTS’UP® into their products, driving remarkable success.

Download

The importance of clinical research: An interview with BioActor's in-house scientists

The importance of clinical research: An interview with BioActor’s in-house scientists

Maastricht, The Netherlands, 29th June 2023

Interview
In the world of clinical research and scientific exploration, BioActor stands out as a leading company dedicated to the development of health ingredients. At the forefront of BioActor’s research and development (R&D) efforts are Sanne Ahles and Maria Imperatrice, two certified clinical research scientists who play vital roles in the BioActor’s R&D initiatives. In this interview, Sanne and Maria provide insights into their responsibilities, experiences, and the challenges they face in their pursuit of scientific advancement.

Could you introduce yourself and your role within BioActor?

Sanne: My name is Sanne Ahles and I am a clinical research scientist at BioActor. In addition, I am a PhD candidate at the Department of Nutrition and Movement Sciences at Maastricht University. I obtained my master’s degree in biomedical sciences after my internship at BioActor, after which I started working as a researcher.

Within BioActor, I am responsible for the research regarding our product Brainberry®, mainly focused on cognitive performance and vascular function. Over the years, I have designed, performed, analyzed, and reported various clinical studies, as well as written a systematic literature review.

Maria: My name is Maria Imperatrice and I also work as a clinical research scientist at BioActor. My research focus is Healthy Ageing and I’m currently performing two studies, Actiful2 and FEMMED, on two of our ingredients (Actiful® and Bonolive®) to evaluate their effect on exercise performance and postmenopausal symptoms, respectively.

I obtained my Bachelor Degree in Biology and my Master in Human Nutrition at the University “Federico II Di Napoli” in Italy, and my second master’s degree in Human Movement Sciences, with a specialisation in Sport and Nutrition, at Maastricht University.

At BioActor, we highly value clinical research because it plays a crucial role in providing evidence-based ingredients. What does clinical research entail and what do you like about it?

Sanne: Clinical research entails many different processes. This includes idea formation and initial literature searches, finding collaborations, obtaining ethics approval, practical work, data analyses, writing reports and papers, and communicating our results at national and international conferences.

Maria: A very interesting part for us is the ideation of the study. At BioActor we highly value innovation, which is why before starting a new clinical trial, we sit in brainstorming sessions with the R&D, marketing and sales teams to try to find white spaces in the current knowledge that can be of interest for the common public and different health domains. Once we find an interesting and never explored topic, the investigation can start.

Could you briefly take us through the process of a clinical trial?

Sanne: First, we initiate the idea formation process by brainstorming ideas that are relevant to customer questions or explore new areas of interest. Next, we perform literature searches to look for relevant papers, available data, and discover white space; topics that have not yet been researched.

Then we reach out to a collaborator, usually a professor at a University, to work with on developing a protocol for ethics review.

Maria: Once we obtain ethics approval, we dive into the practical phase of the clinical trial. This involves engaging with participants through visits where we collect data. This includes not only traditional data that we can extrapolate by collecting blood samples, but also performing tests to evaluate outcomes like reaction time, exercise capacity and mental flexibility.

It’s an interactive and rewarding experience that brings our research to life and allows us to better understand how our ingredients contribute to improving human health and develop evidence-based solutions. Afterwards, we analyze the data, draw conclusions, and share our findings through peer-reviewed publications. It’s a cool journey from start to finish!

Which of the above do you enjoy the most as a scientist?

Sanne: I enjoy collaborating with other companies or academic institutes! It’s such an incredible opportunity for us to broaden our knowledge and take our research to the next level. The energy and creativity that come from working with diverse teams is truly great.

Maria: The practical side of our work is always interesting! Collecting data means we get to perform visits with participants, and trust me, it’s never boring when you’re involved in a human study. The hands-on experience and the constant interaction with people make it such an exciting and fulfilling part of our job.

What is the biggest challenge in designing a study?

Sanne: In my opinion, the biggest challenge in designing a study is obtaining ethics approval, which is a rigorous and time-consuming process. We meticulously prepare documents explaining our research goals, methodology, and participant recruitment.

The ethical committee thoroughly reviews these documents, granting final approval for each aspect of our research.

Maria: I agree! Obtaining ethics approval is a significant challenge. However, this process is crucial for upholding ethical standards and protecting participant rights.

It also adds credibility to our research, fostering trust and allowing our findings to have a greater impact. Despite the challenges, navigating the ethics approval process is vital for conducting valuable and ethically sound research.

What is the best part of working at BioActor as a scientist?

Sanne & Maria: Being a scientist at BioActor is truly rewarding due to the chance to collaborate with a dynamic and passionate team of international colleagues. Within BioActor, we also see other aspects of the company besides R&D.

Our weekly company meetings allow us to really understand the bigger picture of the company and understand what each department entails. Consequently, we explore different facets of the company and gain valuable insights beyond our specific research and development focus.

BioActor: Using clinical science as the key to innovative ingredients

Sanne Ahles and Maria Imperatrice exemplify the passion and dedication that drive BioActor’s pursuit of finding new health effects of ingredients and advancing scientific innovation. From ideation to practical implementation, data analysis, and knowledge dissemination; they are pushing the boundaries of scientific knowledge and embracing the multidisciplinary nature of their work. Sanne and Maria contribute to BioActor’s mission of creating innovative and impactful solutions for a healthier life.


making-a-gummy-supplement

Why should you consider making a gummy supplement?

Why should you consider making a gummy supplement?

June 14th, 2023

Gummy supplements are on the rise as people look for a convenient and tasty way to add essential nutrients to their diet. Gummies are a great alternative to capsules and pills for individuals looking for supplements that are not hard to swallow. In this article, we will discuss the advantages of gummy supplements over traditional supplement formats and the factors to consider when choosing a gummy as a supplement.

making-a-gummy-supplement

Tablets as dietary supplements

Recently, there has been a rise in people’s interest in their well-being by using nutritional supplements. This has resulted in a 12% increase in the production of supplements in 2020.

The most common forms of supplements are tablets and capsules, which are convenient, easy to use, and widely available.

Tablets are a solid form of supplement that is typically round or long in shape and can range in size from small and easy to swallow to larger and more difficult to swallow.

Tablets are made by compressing the active ingredients together with other inactive ingredients such as fillers, binders, and lubricants. These ingredients help to give the tablet its shape, size, and consistency and may also affect how the supplement is absorbed and used by the body.

Capsulated supplements

Capsules are another common form of supplement that is made by enclosing the active ingredients in a gelatin or vegetarian shell. Capsules can be filled with powders, liquids, or oils and come in a variety of sizes and shapes.

Both tablets and capsules have advantages and disadvantages depending on the individual and their needs. Tablets are often preferred by people who prefer a solid form of supplement and are more affordable than capsules.

However, what both forms of supplements have in common is that they are generally not liked for their taste. The demand for supplements that are nice to take is growing, which is why gummy supplements are on the rise.

The rise of gummy supplements

Gummies are a type of food supplement that provides essential nutrients that might be lacking in one’s regular diet. They are becoming increasingly popular in the food supplement industry due to their combination of health benefits and sweetness. Gummies are also a great option for individuals looking for vegan, gluten-free, or lactose-free products.

Manufacturers of functional gummies use natural and organic raw materials in their production, making them more appealing to quality-conscious consumers. These gummies typically contain gelatin, corn starch, water, sugar, and added colorings.

Gummies contain active ingredients such as vitamins, minerals, probiotics, antioxidants, and amino acids that can have positive effects on various aspects of health, including digestion, immune system function, cardiovascular health, and mental well-being.

Why choose gummies over pills?

Gummies are a versatile form of supplement that can be used for many different purposes. They can help prevent digestive, sleep, and skin problems, treat vitamin deficiencies, and boost the immune system.

– Studies have shown that gummies are more effective than pills or tablets at delivering nutrients to the body. This is because the nutrients in gummies are dissolved in a liquid gelatin base, which makes them more easily absorbed by the body. As a result, gummies can be a more efficient way of supplying essential nutrients and provide a significant advantage over traditional supplement formats (1).

Gummies are a convenient and tasty way to add vitamins and minerals to your diet. They’re becoming increasingly popular as a simple and easy way to supplement your diet with micronutrients, offering an enjoyable alternative to traditional supplements.

– The soft and chewy textures of gummies make them a great option for people who struggle with swallowing pills or capsules.

– Unlike traditional tablets or pills, gummies come in a variety of delicious flavors that can make taking supplements a more enjoyable experience. By taking vitamin gummies formulated with essential nutrients, individuals can avoid vitamin deficiencies and supplement their diet.

– Incorporating gummies into your brand can help you stand out from traditional supplement companies and offer consumers a unique and enjoyable option for improving their health.

Factors to consider when creating a gummy supplement

Creating high-quality gummy supplements requires careful consideration of the ingredients used. Here are some key points to keep in mind:

– Look for ingredient suppliers that provide options with minimal sugar content or natural sweeteners as alternatives. This ensures that the final gummy product aligns with consumer preferences for reduced sugar intake.

– Prioritize sourcing pure and natural ingredients for your gummy supplements. Consider using natural sources for colors and flavors to enhance the appeal and marketability of the product.

– Incorporate ingredients that offer a significant amount of dietary fiber per serving. Fiber not only adds nutritional value but also promotes digestive health and supports a strong immune system, making your gummies more appealing to health-conscious consumers.

In conclusion, it is important to look for gummies with natural and pure ingredients, as well as sweeteners or with a minimal amount of sugar. Having these factors in mind, consumers can find gummies that not only taste good but also provide essential nutrients and health benefits.

Creating a gummy supplement for focus and brain health

BioActor’s Brainberry® is a great example of an ingredient that can be used in a gummy. It has a low daily dose of only 65mg and has been clinically validated for cognitive performance, focus and hand-eye coordination.

It’s an extract from Aronia berries and if you want to find out more: Here’s everything you need to know about Brainberry® and brain health.

Discover YAMAMOTO’s Success Story

Learn how YAMAMOTO integrated WATTS’UP® into their products, driving remarkable success.

Download

Ingredients-for-energy-supplements

Top 5 reasons why Actiful® is a good ingredient for your energy supplement

Top 5 reasons why Actiful® is a good addition to your energy supplement

May 25th, 2023

The need for healthy ingredients that have undergone extensive clinical testing is increasing as consumers become more interested in dietary supplements that improve energy. The abundance of ingredients available can feel overpowering for supplement formulators who aim to create a product that promotes energy and vitality. But don’t worry – in this article, we’ll cover the top five reasons why Actiful® is a good ingredient for your energy supplement.

Ingredients-for-energy-supplements

Finding ingredients for the rising demand in energy supplements

Low energy levels and a lack of vitality are common complaints in today’s fast-paced world. Many consumers turn to dietary supplements to manage the daily mental and physical stressors they face. Energy-enhancing supplements aim to prevent fatigue, increase physical activity, and promote social engagement.

With the growing demand for energy-enhancing products, it can be challenging to identify scientifically backed ingredients. To simplify the process, we’ve compiled the top 5 reasons why Actiful should be included in your energy supplement as an ingredient.

Actiful®: A combination of sweet orange and pomegranate

Actfiul® is a patent-protected, all-natural ingredient developed by BioActor; a pioneer in clinically substantiating the beneficial impact of citrus flavonoids on energy metabolism. Actiful® is standardized for hesperidin and punicalagin; the main polyphenols found in sweet orange (Citrus sinensis) and the peel of pomegranate (Punica granatum), respectively. Both compounds have been extensively studied for their potential health benefits.

Top 5 reasons to use Actiful® as an ingredient for your energy supplement

1. Enhanced physical performance in both young and old

A double-blind randomized controlled trial conducted on physically fit young males revealed that Actiful® can increase absolute power output by 5% during a 10-minute cycling time-trial without requiring additional oxygen (1). This advantage was observed after just four weeks of daily supplementation with Actiful®.

In addition, a recently published double-blind randomized controlled trial conducted on active seniors found that daily supplementation with Actiful® for four weeks significantly increased their handgrip strength (2). Handgrip strength is a crucial measure of physical fitness in the elderly as it is indicative of overall health and functional status in day-to-day life.

Given that Actiful® has been clinically proven to enhance physical performance in both young and older individuals, it is an ideal ingredient to target a wide population.

2. Mental health benefits

Mental wellbeing plays a significant role in physical fitness, as the way one handles cognitive demanding tasks can affect how energized they feel.

In addition to improved physical performance, the elderly subjects who supplemented with Actiful® also experienced psychological benefits. Compared to the placebo group, the Actiful® group demonstrated significant improvements in cognitive domains such as thinking, memory, learning, and concentration (2). These elements are essential for maintaining one’s quality of life and wellbeing.

Given the critical connection between the mind and body in enhancing vitality, Actiful® is the ideal ingredient to target both.

3. Mitochondria

Boosting your energy can be done by targeting mitochondria, which are the powerhouses of the cell.

A strategy to target the mitochondria is by implementing specific nutrients into your diet. Actiful® enhances energy levels via mitochondria as well. Experiments in muscle cells have demonstrated that Hesperetin, the active metabolite of Hesperidin, can improve energy production by directly targeting the mitochondria (3).

This improvement in energy production has been observed to translate into improved running performance in mice. The mechanism behind this is that Actiful® improves the respiration capacity of the mitochondria.

To produce energy, mitochondria require oxygen to form an electron gradient across the intermembrane, which mechanically produces ATP. When protons leak across the intermembrane, the gradient weakens, resulting in fewer ATP molecules being formed. By inhibiting proton leakage across the mitochondrial intermembrane, Actiful® enhances energy production directly.

4. Antioxidant

During physical activity, there is a heightened production of reactive oxygen species (ROS) due to the increased demand on mitochondria to produce energy. Excessive ROS can lead to damage to the mitochondria and other crucial structures of the cell, which can impair their functionality.

Hesperidin has been demonstrated to not only scavenge ROS directly but also enhance the natural antioxidant systems present in cells (3). In addition, pomegranate has also been found to improve antioxidant status (4).
As a result, Actiful®’s antioxidant capabilities may improve vitality by preserving the functionality of cells and tissues.

5. NO improved bloodflow

Nitric oxide (NO) is a critical component in regulating blood flow. NO relaxes the blood vessels, increasing their diameter, and allowing more oxygen and nutrient-rich blood to pass through.
Endothelial cells that line the blood vessels produce more NO through the enzyme eNOS, which Hesperidin has been found to activate, promoting vasodilation (5).

Furthermore, when oxygen is limited, dietary nitrate can raise NO levels. Pomegranate, which is high in Punicalagin, is a potent source of dietary nitrate that may improve blood flow and increase the efficiency of oxygen and nutrient delivery.

Actiful®: the key ingredient of your energy supplement

All in all, Actiful® is a natural and safe ingredient that has the ideal properties to be incorporated in energy supplements that aim to provide acute and sustained improvements in vitality!


Uncovering the vital role of mitochondria in your overall health

Uncovering the vital role of mitochondria in your overall health

March 24th, 2023

Mitochondria are essential organelles that produce cellular energy and play a crucial role in the overall health of the human body. This article explores the structure and function of mitochondria, including their role in exercise, aging, and maintaining cellular health. By understanding the importance of mitochondria, we can work towards maintaining their health and improving overall cellular health.

Mitochondria: structure and function

Mitochondria are tiny organelles that are often referred to as the “powerhouses” of the cell. These structures play a critical role in maintaining the overall health of the human body. In this article, we explore the function and significance of mitochondria in both health and disease.

The endosymbiotic theory suggests that mitochondria originated from free-living bacteria that were engulfed by early eukaryotic cells, leading to the development of a crucial component of the cell’s internal machinery. Today, mitochondria are present in the cells of many living things, including human cells (1).

Mitochondria are responsible for the production of cellular energy through a series of chemical processes that convert glucose into adenosine triphosphate (ATP). In fact, mitochondria generate 90% of the energy required for our bodies to function properly (1). Mitochondria also participate in both cell development and cell death and are essential for the regulation of the cell cycle, cellular differentiation, and other cellular processes.

Mitochondria and exercise

Since mitochondria are responsible for generating energy for the cells, they are essential for exercise and physical activity.

During exercise, the demand for energy in the muscles rises, and the mitochondria produce ATP, the main source of energy for cells. As a result, the muscles may work harder and for longer periods of time (2).

Additionally, the mitochondria aid in the removal of lactic acid from the muscles, which delays the onset of fatigue and discomfort. Overall, mitochondria’s capacity to supply energy to cells is essential for exercise, enabling enhanced physical performance and recovery.

Mitochondria and aging

Reactive oxygen species (ROS), which are created by the mitochondria as a byproduct of energy generation, are theorized to play a role in some aspects of aging (3).

These particles harm proteins, lipids, and DNA, and also harm the mitochondria’s functioning components.

When the mitochondria become dysfunctional, more ROS are produced, which worsens the damage.

Physical activity is thought to be a great approach to support mitochondrial health by controlling mitochondrial quality control (MQC) and allowing damaged mitochondria to be repaired or eliminated and new mitochondria to be synthesized, restoring the metabolic state.

Mitochondrial biogenesis is the process by which new mitochondria are created within cells. This process is essential for maintaining mitochondrial health and function, as it ensures that cells have a sufficient supply of these vital organelles.

Several factors can stimulate mitochondrial biogenesis, including exercise, calorie restriction, and certain dietary supplements. Exercise, in particular, has been shown to have a powerful effect on mitochondrial biogenesis, as it increases the demand for energy in the muscles and stimulates the production of new mitochondria to meet this demand.

Maintaining mitochondrial health

Mitochondria are essential because they serve as the cell’s main energy source. The cell wouldn’t be able to perform its important activities without the energy provided by the mitochondria, which would result in cellular malfunction and ultimately, cell death.

Furthermore, mitochondrial health and function are essential for maintaining tissue and organ function as well as the general health of cells.

To maintain mitochondrial health, it is essential to lead a healthy lifestyle that includes a well-balanced diet, regular exercise, and limiting exposure to contaminants in the environment.

Exercise is particularly important because it promotes mitochondrial quality control and decreases the formation of ROS, boosting the expression of vascular endothelial growth factor (VEGF), and raising the bioavailability of nitric oxide, which favors calcium handling and contractility (4).

The importance of mitochondrial health

Mitochondria play a critical role in maintaining the overall health of the human body. They are essential for the production of cellular energy, the regulation of the cell cycle, and other cellular processes. To maintain mitochondrial health, it is important to lead a healthy lifestyle that includes regular exercise and a well-balanced diet.

Physical activity is a great way to support mitochondrial health by promoting mitochondrial quality control and decreasing the formation of ROS (5). By understanding the function and significance of mitochondria in cells, we can concentrate on keeping these essential organelles active and functional.

Discover YAMAMOTO’s Success Story

Learn how YAMAMOTO integrated WATTS’UP® into their products, driving remarkable success.

Download

Foods-for-energy

What foods are good for energy?

What foods are good for energy?

February 23rd, 2023

Maintaining high energy levels is crucial to effectively tackle daily tasks. While lifestyle habits like regular physical activity and good sleep patterns play a vital role, different foods might also has an impact on energy levels. Did you know B Vitamins, nitrate, hesperidin and Ashwaganda root are all part of these foods? Read more in this article!

Foods-for-energy

These foods will help you maintain your daily energy

To finish your daily tasks at home or during work it is nice to be fully energized. It allows you to perform well and to get the most out of your day. Spending time full of energy, is time well spent!

Lifestyle habits influence your energy levels. You should take care of your sleep pattern and engage in physical activity frequently, but did you know that your diet also influences your energy status?

And no, we’re not talking about jacking up your caffeine intake, because this might cause some negative side effects that some people are more susceptible to than others. That’s why we wrote this article about alternatives to caffeine to get a mental boost.

In this article, we will dive in the 4 best natural compounds to boost your overall energy!

B Vitamins for energy

B vitamins are water-soluble vitamins that function as coenzymes in many bodily processes. There are eight different B vitamins that you can find in foods such as meat, seafood, and dairy.

Unlike instant energy boosters, B vitamins optimize the pathways which convert ingested food into energy for the body. Furthermore, certain B vitamins help in the formation of red blood cells, which are important to carry oxygen through the body. This oxygen is then used to energize your cells.

Supplements may help to boost energy levels of people who are deficient in vitamin B12. People that follow a varied diet are usually not short on vitamin B, but a deficiency might occur when people follow a vegan or vegetarian diet (1).

Nitrate containing foods to support energy levels

Nitrate is present in high amounts in beetroot and green-leafy vegetables such as arugula, spinach, celery, and lettuce. Dietary nitrate is a precursor of nitric oxide, which is an important signaling molecule in the body.

Nitric oxide induces vasodilation, which increases blood flow. When blood supply is enhanced, more oxygen and nutrients can reach the muscles, which is needed to provide energy to the working muscle.

Dietary nitrate also improves the efficiency of the mitochondria; the powerhouses of the cell. With the use of oxygen, mitochondria convert food into energy in the form of ATP. Dietary nitrate reduces the oxygen cost of ATP production, making it easier to produce energy on a cellular level.

Moreover, dietary nitrate reduces the amount of ATP used to contract your muscles, meaning that it takes a longer time before you are out of energy.

For submaximal endurance type physical activity, and for high-intensity physical activity it is especially beneficial to consume dietary nitrate (2)

Foods that contain hesperidin

Hesperidin is a polyphenol abundantly present in citrus fruits, like oranges. Once ingested, hesperidin is converted into hesperetin by bacteria in the intestines. Hesperetin is then absorbed into the blood and transported to different parts of the body.

The mitochondria are the main providers of energy for the cells, by turning carbohydrates, fats, and proteins into ATP. By increased stress on the mitochondria reactive oxygen species (ROS) is created, which makes you feel less energetic. This happens during exercise for example. Hesperitin is able to boost your energy by inhibiting the production of ROS. (3)

Hesperetin also increases the availability of nitric oxide, leading to increased blood flow to fatigued tissues leading to a higher supply of oxygen and nutrients. Additionally, pro-inflammatory markers are reduced upon hesperetin exposure.

These properties make hesperidin most suitable to enhance recovery after physical activity, optimize the oxygen and nutrient supply to the muscles, and boost your energy! That’s why there are many reasons for including hesperidin in supplements.

Ashwagandha root

Ashwagandha, also known as Withania somnifera, is a traditional herb from India, and its extract is obtained from the root of the plant. Ashwagandha is an apoptogenic herb, meaning that it helps the body’s response to stress.

Due to its diverse composition of phytochemicals, Ashwagandha root extract has many biological implications. It reduces inflammation, and supports the protection mechanisms against infections, and metabolic and neurological illnesses. (4)

Ashwagandha root extract is suggested to enhance endothelial function, improve mitochondrial function, and reduces ROS. As a result, this extract is able to improve aerobic exercise capacity, clearly indicating its energy boosting capacities! (5)

Foods to support your energy levels

In conclusion, there are several natural compounds that can help boost your energy levels without resorting to caffeine or other instant energy boosters. B Vitamins, nitrate, hesperidin, and Ashwagandha root are all natural compounds found in various foods that can help optimize bodily processes, increase blood flow, reduce oxidative stress, and improve mitochondrial function. Incorporating these compounds into your diet, along with maintaining good sleep patterns and engaging in regular physical activity, can help you maintain high energy levels and perform well throughout the day.

Want to know more about nutrients that help your mitochondrial health? Read about it here!


Actiful-physical-and-mental-benefits

Actiful® - New Publication Reveals Physical and Mental Health Benefits in Elderly

Actiful® – New Publication Reveals Physical and Mental Health Benefits in Elderly

Maastricht, The Netherlands, August 29th, 2022

Press release
A new randomized, double-blind, placebo-controlled clinical trial with Actiful® was recently published in the Journal of Nutrition, Health & Ageing. The study investigated whether Actiful® improves physical fitness and mental well-being in healthy elderly. Additionally, blood biomarkers for oxidative stress and endothelial function were measured. Key findings of the study were an improvement in handgrip strength, a measure of physical fitness, and psychological functioning facets, such as thinking, memory, learning, and concentration.

Actiful-physical-and-mental-benefits

The study

The new research, published in the Journal of Nutrition Health & Ageing, was conducted by researchers at Maastricht University led by Dr Freddy Troost in collaboration with BioActor, the developer and manufacturer of the branded ingredient, Actiful®.

Actiful® is a citrus flavonoid and pomegranate complex designed to boost vitality and support energy levels for an active lifestyle. The ingredient is standardised for its content in highly bioavailable 2S-hesperidin, an important citrus flavonoid which already showed in previous BioActor studies the efficacy in improving blood flow and sports performances in both highly trained and recreational athletes.

The new study investigated whether daily supplementation with 700mg of Actiful® would affect physical fitness and psychological functioning in a healthy elderly population.

As life expectancy increases rapidly, the elderly population is growing in numbers. Ageing is one of the main risk factors for a wide variety of diseases, such as cardiovascular disease, cognitive decline and reduced physical function. Therefore, strategies to support vitality in senior subjects are becoming increasingly relevant.

 

The methods

The study included 36 active seniors aged between 60-75 years old. The design of the clinical trial was a randomised, double-blind, placebo-controlled, crossover study. All participants received both treatments and placebo: four weeks of supplementation with Actiful® and four weeks of supplementation with the placebo, separated by a washout period of 4 to 8 weeks.

During the intervention, participants completed the WHOQOL-100 questionnaire, a list of 100 questions created by the World Health Organisation and validated to assess the quality of life. In addition, a senior fitness test and handgrip measurements were performed, which are validated measures of physical performance.

Furthermore, nitrate levels were measured as a marker of endothelial function. Nitrate is considered an important signalling molecule involved in endothelial function by inducing vasodilation, leading to improved blood flow.

Oxidative stress was also evaluated by determining malondialdehyde (MDA) plasma levels. Oxidative stress is an imbalance between free radicals and antioxidants in your body and can damage cells, proteins and DNA, contributing to ageing.

 

The results

The study results indicate that four weeks of daily Actiful® supplementation significantly improved handgrip strength in healthy elderly. Handgrip strength is an important measure of physical fitness associated with reduced all-cause mortality, as well as increased cognitive function, mobility, and functional status.

According to the researchers, a potential mechanism that might be associated with improving handgrip strength is improved mitochondrial function. In fact, the role of hesperetin – the main metabolite of Actiful®, in mitochondrial functioning, increased intracellular ATP production, and mitochondrial spare capacity was already observed in vitro.

“With age, the number and functionality of mitochondria decreases. Dysfunctional mitochondria have reduced the capacity for producing ATP – our muscles’ principal energy source. Therefore, the next step is to confirm the effect of Actiful® on mitochondrial biogenesis and functionality in humans in vivo”, the researchers commented.

In addition to the handgrip strength, also psychological function improved after the 4 weeks of supplementation with Actiful®.

Specifically, the researchers found a significantly higher score for the treatment group than the placebo in the thinking, memory, learning, and concentration facet. As the quality of life is an important factor in successful ageing, improved psychological functioning is deemed increasingly relevant.

MDA and NO3 were also analysed as a measure of oxidative stress and endothelial functions. After supplementation, plasma MDA decreased compared to the placebo, a sign of improved oxidative stress status.

Finally, higher production of NO3 was observed. NO3 is an important signalling molecule involved in endothelial function by causing vasodilation in smooth muscle cells and can contribute to improving blood flow and exercise capacity, as demonstrated in previous studies.

Overall, the study results suggest that Actiful® consumption results in improved physical performance and better quality of life, which are two crucial factors in successful ageing.

We are pleased with the results of this clinical trial, which includes improvements both in physical fitness and mental well-being, as well as improved oxidative stress markers. These results have piqued our interest regarding potential underlying mechanisms of action, which are currently being investigated in our new clinical trial.” Commented Sanne Ahles – clinical researcher at BioActor.

 

Opportunity for innovation

Actiful® has been developed to support vitality and energy levels contributing to healthy ageing. The active ingredient can already be found in various products on the market worldwide. Actiful® is easy to formulate, and it can be added to a wide variety of dietary supplements in several convenient formats, including gummies, effervescent tablets, capsules, ready-to-use sachets and drinks.

 

About BioActor

BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.

Feel free to contact BioActor via info@bioactor.com for more information on the possibilities that Actiful® has to offer.
Further information can be found on: www.actiful.eu and www.bioactor.com


man-training

The effects of Hesperidin on exercise performance - New publication from BioActor in collaboration with Maastricht University

The effects of Hesperidin on exercise performance – New publication from BioActor in collaboration with Maastricht University

Maastricht, The Netherlands, July 22nd, 2022

Press release
The review recently published in Nutrients was conducted by BioActor in collaboration with Maastricht University and examined the potential mechanisms through which hesperidin can improve exercise performance.

man-training

A review on hesperidin and exercise performance

Nutrients, a leading peer-reviewed scientific journal of human nutrition, has recently published a review about hesperidin’s effect on exercise performance. The research was conducted by M. Imperatrice, a clinical researcher at BioActor, in collaboration with the Maastricht University’s Department of Human Biology.

 

This review collects the results of randomized controlled trials (RTCs), animal studies, and in vitro studies providing more evidence on how hesperidin, a flavanone abundantly present in citrus fruits, could lead to enhancement in exercise performance.

 

According to the review’s results, hesperidin is able to improve endothelial function (via increased NO availability), inhibit ROS production, decrease production and plasma levels of pro-inflammatory markers, and improve anaerobic exercise outcomes (e.g. power, speed, energy).

 

We are really proud to share the results collected in our review about the potential mechanisms linking hesperidin to enhanced anaerobic performance, namely improved endothelial function, reduced exercise-induced oxidative stress, and inflammation. For elite and recreational athletes, hesperidin could be a promising food supplement to optimize the oxygen and nutrient supplies of the muscles, stimulate muscle contraction, and enhance muscle recovery between training sessions. The ergogenic effects that hesperidin can bring to the spectrum of improved exercise performance are promising and should be investigated further. With our “Actiful 2” ongoing Clinical Study, we are going to deepen this knowledge by investigating both the effects of hesperidin supplementation on endurance exercise and on changes in intramuscular markers via skeletal muscle biopsies.” said M. Imperatrice.

 

BioActor’s interest in hesperidin has resulted in the development of two active ingredients. The first ingredient branded under the name WATTS’UP® and targeting sports performance has already been tested in two randomized placebo-controlled clinical trials, one with highly trained athletes and one with moderately trained subjects. The second ingredient goes under the name Actiful® and targets energy and vitality. This ingredient has already been tested in randomized placebo-controlled clinical trials, in elderly subjects, showing physical and mental benefits.

 

About BioActor

BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.

Feel free to contact BioActor via info@bioactor.com for more information on the possibilities WATTS’UP® and Actiful® have to offer.
Further information can be found on: www.wattsup.eu, www.actiful.eu and www.bioactor.com