Foods-that-can-help-relieve-menopause-symptoms

Foods that can help relieve menopause symptoms

Foods that can help relieve menopause symptoms

March 16th, 2023

During and after menopause many women experience uncomfortable side effects such as bloating, hot flashes, and night sweats. These physical symptoms can be accompanied by emotional changes. While hormonal therapy can help alleviate symptoms, it may also have side effects. Therefore, more attention is being given to changes in diet or the use of natural supplements. This article will explore how certain products like fish, olive leaf extract, yogurt, and flaxseed may be able to provide relief from menopause symptoms.

Foods-that-can-help-relieve-menopause-symptoms

Foods to alleviate menopause symptoms

As women approach menopause a lot of changes occur. Their estrogen levels decrease, leading to various symptoms such as bloating, night sweats, anxiety, or depression.

Menopause can also increase the risk of cardiovascular diseases and bone loss, which are commonly ignored. However, making some dietary changes can be an effective and easy way to alleviate these symptoms. In this article, we’ll discuss five foods that can help ease menopause symptoms.

1. Fish rich in n-3 PUFAs for menopause support

Fish is a great source of healthy and essential fatty acids, including omega-3 polyunsaturated fatty acids (n-3 PUFAs) that have protective effects and anti-inflammatory actions. These fatty acids are found in fatty fish like salmon and some algae species.

Research has shown that consuming fish or fish oil can reduce depression, anxiety (1), hot flashes, and sleeping problems (2) in menopausal women. In addition, fatty fish is rich in vitamin D, which is essential for calcium absorption and maintaining bone health.

If you don’t eat fish, you can still get the benefits of n-3 PUFAs by consuming foods rich in α-linoleic acid (ALA), which our bodies can convert into these beneficial fatty acids. ALA has been shown to improve skin hydration and smoothness and can be found in foods like flaxseeds, almonds, walnuts, and chia seeds (1), as well as soy products that we’ll discuss later.

2. Olive leaf extract for menopausal symptoms

Olives contain (poly)phenolic compounds that have many positive effects, including antioxidant and anti-inflammatory properties, as well as anticancer properties (3).

Interestingly, olive leaves contain significantly higher concentrations of phenolic compounds compared to olives or olive oil (4). As a result, they may have even greater potential for exerting beneficial effects on health. In fact, research has already demonstrated that taking olive leaf extract daily can be an effective alternative treatment for reducing blood pressure in individuals with hypertension (5).

One of the key phenolic compounds found in olive leaf extract is oleuropein, which has been shown to have a significant impact on women’s health during post-menopause. Oleuropein has been proven to reduce cholesterol levels, lower the risk of bone loss, alleviate joint pain, and improve mobility (6,7).

3. Soy products

Soy products, including soy milk, soybeans, and tofu, are rich in isoflavones, which are plant-derived estrogens and selective modulators of estrogen receptors in the body. These properties make soy products a promising alternative to hormonal therapy.

Soybeans contain essential fatty acids, such as ALA (α-linoleic acid), that have anti-inflammatory properties. Additionally, soy protein has been found to reduce bad cholesterol levels, which can lower the risk of cardiovascular diseases (8).

One of the isoflavones found in soybeans is genistein, which is structurally similar to female estrogen and can alleviate menopausal hot flashes. Another isoflavone, daidzein, can inhibit cell proliferation in the gastrointestinal tract, potentially reducing the risk of estrogen-sensitive cancers, such as ovary, prostate, and breast cancer (9).

4. Yogurt to support menopause

Yogurt is a nutrient-rich food that contains calcium and vitamin D, which are important ingredients to improve bone health during menopause. Bifidobacterium bifidum and Lactobacillus acidophilus, which are considered ‘good’ bacteria, are used to make yoghurt and they are also present in the final product, making yogurt a source of probiotics that can benefit gut health.

Research has shown that consuming extra probiotics in yogurt can help to reduce anxiety and stress levels, and improve overall quality of life compared to regular yogurt (10). However, regular yogurt also has similar long-term effects. Additionally, yogurt may have a role in appetite control, making it a helpful food for weight management (11).

Studies have suggested that a well-balanced diet that includes milk and dairy products, like yogurt, may also improve sleep quality (12).

How can foods help with menopause symptoms?

To summarize, consuming fish, soy products, whole grains, olive leaf extract, and yogurt can promote healthy cholesterol levels, maintain bone mass, reduce menopausal symptoms such as hot flashes and mood swings, and help regulate appetite and blood sugar levels. If you’re experiencing menopausal symptoms, these natural products are worth considering.


What-is-perimenopause-and-what-are-the-symptoms

What is (peri)menopause and which changes occur?

What is (peri)menopause and which changes occur?

January 4th, 2023

Menopause leads to changes in women’s bodies and marks the end of the childbearing years. It involves hormonal changes that can lead to both physical and mental symptoms that are better known as menopause symptoms. Because menopause does not occur overnight, a distinction is made between the period called perimenopause and the period that comes after, namely (post)menopause. Each of these periods comes with their own issues and symptoms.

What-is-perimenopause-and-what-are-the-symptoms

What is menopause?

Menopause is marked by the moment that no menstruation has occurred for at least 12 months. This occurs on average when women are between 45 to 55 years of age. However, this varies from woman to woman and depends on multiple factors.

Entering menopause is not an immediate process and does not happen overnight: it is a process that can last for years (1). For this reason we make a distinction between menopause and perimenopause.

What is perimenopause?

The explicit sign that menopause has started is the definitive cessation of menstruation. This does not occur suddenly, but after a long period of irregularity, which begins to manifest itself during perimenopause.

Perimenopause is the phase in which the first bodily changes related to menopause occur. These changes are evident signs of decreasing levels of estrogen and progesterone. (2)

During perimenopause, estrogen deficiency occurs that can no longer be compensated by changes in ovarian hormone production. This decline in ovarian function is a characteristic trigger of natural menopause and because of it circulating estradiol levels will go down. This reduction in estradiol levels will prevent the ovulation from happening, which is thought to be the reason for irregular menstruation.

Postmenopause is the period that begins after 12 consecutive months without menstruation. From this moment on the discomforts related to (peri)menopause will become lighter.

What are the symptoms of perimenopause?

The hormonal changes associated with menopause can affect physical, emotional, mental, and social well-being. The symptoms that are experienced during and after menopause vary greatly from one person to another.

While some women suffer few to no symptoms, others may experience severe symptoms affecting their daily activities and quality of life. In some cases, the symptoms may last for various years (3).

Symptoms of perimenopause

Symptoms that can occur during perimenopause include, but are not limited to:
Irregular menstruation cycle, this is a clear sign that hormones are starting to act up.

Menstruation that is heavier or lighter than normal, which indicates a change in hormonal balance

Weight gain, and a general accentuation of roundness can become a very delicate aspect to manage, also from an emotional point of view.

Changes in hair quality, most women find that their hair loses volume and length around menopause.

Headaches, the hormone changes that happen as women approach menopause mean that all types of headaches, including migraines, become more common.

Muscle aches, estrogen affects your cartilage (which is the connective tissue in joints) as well as the replacement of bone, this plays a part in inflammation and pain.

Bone issues, though it is less noticeable, bone health diminishes during menopause. For this reason, a lot of products exist to improve bone health during (peri)menopause.

Symptoms of (post)menopause

As stated before, after perimenopause starts the actual menopause, which brings its own types of symptoms. These symptoms include:

Night sweats and hot flashes are one of the most typical effects of hormonal imbalance. Many women experience such a sudden rush of feeling hot.

Anxiety or irritability. There are a lot of physical changes during menopause, but emotional changes often occur as well. This happens because the drop in estrogen and progesterone lead to a decrease in expression of several brain chemicals that make you feel calm, happy or energetic. This can cause women to feel anxious or irritable.

Mood swings also occur due to the hormonal changes. Fluctuations in estrogen and progesterone lead to fluctuations in other brain chemicals as well, leading to these mood swings.

Depression is a symptom that can occur during both perimenopause and menopause and is more severe compared to anxiety, irritability or mood swings. Changes in hormones might put women more at risk for depression and this also falls under the emotional changes during menopause.

Insomnia: overall studies show that women in menopause have more trouble with sleeping. These disturbance include difficulty getting to sleep, to stay asleep, early morning wakenings and problems with the overall quality of sleep.

Fatigue, Low energy is one common effects that many women experience before, during, and after this transition time. This often is a result of the sleeping problems described before, but has to do with the previously mentioned ‘energetic’ chemicals in your brain as well.

Dry skin, due to decreasing estrogen levels can become less supple, smooth, and soft. Fine wrinkles, dark spots, and less elasticity are usually not far behind.

Relieving symptoms of perimenopause and (post)menopause

Menopause is a period of hormonal changes marked by physical and emotional changes. A lot of people worry about this and it can be hard to experience these symptoms. For this reason, there are several ways to alleviate these symptoms. Of course, medicinal products are available, but natural ways to relieve symptoms exist as well. Changes in diet and physical activity could be a way to relieve symptoms associated with menopause.


Women's-Health-Webinar

WEBINAR - Women's Health

WEBINAR – Women’s Health

Product concepts with Bonolive® to address post-menopausal-related risks

October 25th, 2022

More than ever, nutrition and supplementation are recognized to be effective strategies to address concerns associated with metabolic changes during menopause. In this webinar we discussed the clinical evidence supporting Bonolive®, and product formulations to target post-menopausal-related risks. Watch it now on demand!

The menopause journey is part of every woman’s life. For some, menopause can be more challenging than for others. With the hormonal changes occurring during this critical period, menopausal women will experience new health challenges.

From short-term complaints, such as hot flashes, mood changes and insomnia, to associated long-term risks such as cardiovascular, bone loss and joint discomfort; nutrition and supplementation are recognised to play an essential role in supporting women during menopause.

Watch our webinar on demand and discover the clinical evidence supporting Bonolive® and how BioActor’s olive polyphenol-based ingredient can be integrated into effective products targeting women’s health.

Watch now on demand!

WATCH NOW ON DEMAND

Meet the Speakers:

Meet-The-Speakers-Maria-Imperatrice-and-Bjarne-Maas

What was discussed during this webinar?

Clinical Research

Presentation by Maria Imperatrice – Clinical researcher, who introduced the science behind Bonolive® and the clinical trials showing the positive effect of Bonolive® on cardiovascular health, bone health and mobility.
Duration: 15 minutes

The Women’s Health trends & consumer insights

Presentation by Bjarne Maas – Marketing & Account Manager, who discussed the consumer insights and product formulation examples related to women’s health.
Duration: 15 minutes

Q&A session

Duration: 10 minutes

WATCH NOW ON DEMAND

Why-is-bone-health-important-and-how-does-it-work-(functions-bone-metabolism-and-influencing-factors)

Why is bone health important and how does it work? (functions, bone metabolism and influencing factors)

Why is bone health important and how does it work? (functions, bone metabolism and influencing factors)

July 4th, 2022

Our bones play various key functions for our bodies, and it is therefore important to maintain their health. To do so, it is essential to understand how our bones work and what factors affect bone health. Bone metabolism is a lifelong occurring process where bone tissue is turned over from mature to new bone tissue. This process keeps your bones healthy and their health is influenced by several aspects, such as age, gender, family history and several risk factors such as tobacco use, physical inactivity and diet.

Why-is-bone-health-important-and-how-does-it-work-(functions-bone-metabolism-and-influencing-factors)

Bone health, menopause, and dietary supplements

Menopause is the permanent cessation of menstruation naturally occurring in females at an average age of 51 [1].

Importantly, menopause leads to a decrease in estrogen levels and consequently increases bone loss. Estrogen is a hormone responsible for menstruation and known to have protective effects on bone loss and reduce inflammation.

Bone tissue in women is generally thinner than in men, and bone density has been reported to markedly decrease after menopause (post-menopause). Women can lose up to 20% of their bone density in just 5-7 years due to these hormonal shifts and experience increased joint pain [2].

The rise in the use of dietary supplements, especially by post-menopausal women, who are at risk of bone loss, is growing tremendously as advances in research are made, and the benefits of multiple natural ingredients are proven [3].

How does bone metabolism work?

Bone metabolism, also known as bone remodelling, is a lifelong occurring process where bone tissue is turned over from mature to new bone tissue. Bone resorption is the process where mature bone tissue is removed by osteoclasts and ossification is the formation of new bone tissue executed by osteoblasts [4]. These processes are responsible for replacing and reshaping bone following injuries such as fractures, but also micro-damage occurring during normal activity.

In the early stages of life, nearly 100% of the skeleton is replaced, due to the bones needing to develop, lengthen and grow. While in adults, bone remodelling proceeds at about 10% yearly [5].

For as long as bone growth is greater than bone breakdown, adults are able to maintain healthy bones. Many living cells within bone originate from the same mesenchymal stem cell. These mesenchymal stem cells can differentiate into the various cell types present in bone, such as osteoblasts (bone-building cells), adipocytes (fat cells) and chondrocytes (cartilage) [6].

However, due to stress, inflammation and ageing, this differentiation shifts towards producing more fat cells and fewer osteoblasts, resulting in more brittle and fatty bones [7]. Usually, bone mass starts to decline at the age of 40 as bone loss overtakes the speed of bone growth [8].

Fortunately, there are factors at play that we have control over to mitigate this bone loss.

What are the factors influencing bone health?

Although both our genes and the environment influence bone health, there is only one we have control over. Our genes, for example, determine whether signalling errors occur and lead to birth defects, while the extrinsic factors, such as lifestyle and diet, are crucial for optimising and maintaining bone health. Bone loss, also referred to as osteoporosis, affects people of all different ages and backgrounds. However, other intrinsic factors that are out of our control include:

Age: naturally as we grow older, our bone mass and strength decreases. This is mainly due to decreased osteoblast activity and an increase in osteoblast apoptosis, while inflammation increases [9,10].

Gender: osteoporosis is four times more common in women than men [11].

Body frame size: people with small body frames tend to have a higher risk of bone loss as they have less bone mass to draw from as they age.

Family history: having a parent or sibling with osteoporosis puts you at greater risk..

 

Fortunately, however, we do have the ability to modify extrinsic factors such as physical activity, diet choices and lifestyle choices. Here is how they can disturb bone health:

Tobacco use: smoking contributes to weak bones by disturbing the balance of bone turnover negatively.

Physical inactivity: just like muscles, bones gets stronger by exercising them. Resistance exercise and weight-bearing exercise help with this.

Alcohol use: alcohol interferes with the calcium balance and affects the production of hormones, linking chronic alcohol intake to an increase in bone fractures and falls.

Diet: foods high in calcium, and vitamin D such as dairy products and green leafy vegetables should be consumed in sufficient quantities to support the maintenance of bone health [12]. Additionally, polyphenols such as oleuropein can help mitigate bone loss, especially with age, through their anti-oxidative effects reducing inflammation [13].

If you want to know more about the crucial nutrients for bone health, click here and read our article on the 8 best ingredients.


Menopausal-bone-health

8 Ingredients proven to improve bone health during (post)menopause

8 Ingredients proven to improve bone health during (post)menopause

June 13th, 2022

Bone health is crucial to maintain, particularly after menopause. Consumption of dietary supplements, especially in post-menopausal women is on the rise, as advances in research are made and proven benefits are elucidated. Here we mention some of the ingredients that have demonstrated the ability to support women during menopause – specifically for the loss and maintenance of bone mineral density! You will also learn about which foods contain these ingredients, how they are beneficial to bone health and their recommended daily intake.

Menopausal-bone-health

Bone health, menopause, and dietary supplements

Menopause is the permanent cessation of menstruation naturally occurring in females at an average age of 51 [1].

Importantly, menopause leads to a decrease in estrogen levels and consequently increases bone loss. Estrogen is a hormone responsible for menstruation and known to have protective effects on bone loss and reduce inflammation.

Bone tissue in women is generally thinner than in men, and bone density has been reported to markedly decrease after menopause (post-menopause). Women can lose up to 20% of their bone density in just 5-7 years due to these hormonal shifts and experience increased joint pain [2].

The rise in the use of dietary supplements, especially by post-menopausal women, who are at risk of bone loss, is growing tremendously as advances in research are made, and the benefits of multiple natural ingredients are proven [3].

8 ingredients to sustain bone health in menopause.

Calcium & Vitamin D

Calcium is a critical component of bone architecture necessary for the deposition of bone minerals. Around 99% of calcium is stored in bones and teeth, making them strong and hard [4].

Vitamin D is vital for regulating intestinal calcium absorption and stimulating bone resorption to maintain serum calcium concentration [5]. There are, however, substances that can interfere with the body’s ability to use calcium, such as oxalate, protein, phytate, and caffeine.

Examples of foods rich in calcium include dairy, soybeans, and green leafy vegetables. While the predominant way of ascertaining vitamin D is through our own body’s synthesis stimulated by sufficient sunlight exposure on our skin. Thus, supplementation of vitamin D3, cholecalciferol, is advocated during autumn and winter due to limited sunlight availability, depending on geography.

Women under the age of 50 should consume a daily dosage of 1000mg of Calcium and 400-800IU Vitamin D, while women above the age of 50 should consume 1200mg of calcium and 800-1000IU of vitamin D daily [6].

Joint-health

Vitamin C, B9 and B12, K

Vitamin C is important in stimulating the differentiation of osteoblasts, cells that synthesize bone matrix and coordinate bone mineralization [7].

Antioxidant effects of vitamin C have also been reported to reduce bones from cell damage and may improve left ventricular diastolic function which menopausal women often experience a dramatic reduction in [8]. Foods rich in vitamin C include citrus fruits, bell peppers, broccoli, and strawberries.

Vitamin B9 (folate) and B12 are major determinants of homocysteine levels. Thus, a deficiency in vitamin B9 and B12 leads to increased homocysteine levels, which have been associated with impaired bone health and osteoporosis, a condition concerning weak and brittle bones [9].

Vitamin B9 and B12 have also been reported to assist with reducing the severity and duration of hot flashes and other menopause symptoms [10]. Therefore, increasing folate and B12 levels through foods such as pulses, legumes, beans, brown rice and, you guessed it, leafy green vegetables, can improve bone health.

Moreover, vitamin K has been reported to assist with reducing hot flashes and other menopause symptoms [11].

The recommended daily amount for adult women according to the National Institutes of Health for vitamin C is 75mg; for vitamin B9 is 400mcg DFE; for vitamin B12 is 2.4mcg and ultimately for vitamin K is 90mcg [12].

Quercetin

Quercetin is the bioactive compound abundantly found in citrus fruits, green leafy vegetables, and onions. Studies show that onions reduce bone loss due to their anti-inflammatory and antioxidant flavonoid, quercetin [13].

Quercetin inhibits the genesis and differentiation of osteoclasts, preserving bone mass and health. Bone mineral density in postmenopausal women has also been reported to improve when supplementing with onion juice [14].

Quercetin at a dose of 150 mg has been shown to improve bone-health metrics, which is around three servings of onion [15]. Note, quercetin is found in the pigment and outer layer of the onion, with red and yellow ones thus having higher concentrations.

Bonolive® (olive leaf extract 40% oleuropein)

Bonolive® is an ingredient derived from olive leaf and rich in the most abundant olive polyphenol, oleuropein, tailored to women to counteract bone loss risk associated with menopause.

Clinical research in post-menopausal women has demonstrated that 12 months of supplementation with 250mg of Bonolive® is able to increase osteocalcin levels by 32%, promote the activity of osteoblasts (the bone-building cells), and decrease osteoclast activity involved in the breakdown and resorption of bone [16,17]. Thus the clinical dosage of 250mg is recommended.

Bonolive-product

Moreover, after 12 months, the Bonolive® treatment group displayed a significant protection against bone loss, compared to the placebo group.

Additionally, chondrocytes, important for cartilage-building, are also increased while cartilage degeneration is inhibited through oleuropein. Further benefits can be ascribed to oleuropein’s anti-oxidant and anti-inflammatory properties.

Oleuropein can be found in olive oil and olive leaf, although in limited quantities and therefore, supplementation with a high-quality, standardized extract such as Bonolive® is a more convenient method of consuming this nutrient in adequate quantities.

Improve bone health during menopause

In conclusion, a well-balanced diet rich in vitamins, minerals and antioxidants, together with the right supplementations may help ameliorate bone health during menopause and promote healthy ageing and active living.


Press release new publication on Bonolive BioActor

New clinical study on patented olive leaf extract Bonolive® shows joint health benefits

New clinical study on patented olive leaf extract Bonolive® shows joint health benefits

Maastricht, Netherlands, February 8th, 2022

Press release
Therapeutic Advances in Musculoskeletal Disease has recently published a new clinical study with Bonolive®, a patented bone and joint health ingredient based on olive polyphenol. The new publication suggests that Bonolive® may improve joint functional capacity and reduce knee pain.

Press release new publication on Bonolive BioActor

New randomized clinical trial published with Bonolive®

Bonolive® is a natural polyphenol extract from olive leaves, developed by BioActor. Bonolive® was already studied for bone protecting effects in post-menopausal women and is covered by a patent on the bone health application of the extract.

A recent randomized, double-blind, placebo-controlled trial including 124 subjects demonstrated a large and significant treatment effect of Bonolive® in improving joint discomfort and reducing pain in subjects with knee pain.

Participants in the study received either a placebo or supplementation with a 125mg capsule containing Bonolive® (40% oleuropein), twice a day for 6 months.

The conclusion indicates that Bonolive® was able to improve the KOOS score (Knee Injury and Osteoarthritis Outcome) and to reduce walking pain in subjects with knee pain.

The researchers from the Liege University Hospital suggested that oleuropein may relieve nociceptive pain triggered by the mechanical strain because of its calcium channel blocker property.

N-type calcium channels are indeed important for neuronal excitability and play a role in pain genesis. As a blocker of these channels, Bonolive® seems to produce an antinociceptive effect, thus reducing pain.

These benefits were not associated with any adverse effect after 6 months of treatment, showing excellent tolerability of the extract. Moreover, the study confirmed yet again the great bioavailability of Bonolive®. The main metabolites of the extract, oleuropein aglycone, hydroxytyrosol and homovanillyl alcool were measured and showed a rapid rise in the urine of all treated subjects.

This study was conducted in the context of a collaboration with Nestlé Health Science, aiming to strengthen the scientific evidence for the benefits of Bonolive®.

“We are proud of the results achieved thanks to this collaboration”, says Hans van der Saag, CEO and founder of BioActor. “Mobility is extremely important for the quality of life and a core indicator of healthy ageing. These new scientific insights on Bonolive® will allow us to expand its applications to mobility targeting products”.

About BioActor

BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.

Feel free to contact BioActor via info@bioactor.com for more information on the possibilities Bonolive® has to offer.

Further information can be found on:  www.bonolive.com and www.bioactor.com


Improving bone health during menopause with Bonolive

Improving Bone Health During Menopause With Bonolive®

Improving Bone Health During Menopause With Bonolive®

February 3rd, 2022

The menopause transition is a critical period for bone health in women. More than ever, to address this key health concern, consumers are shifting away from calcium-only products and seeking out more complex formulas with clinically-backed ingredients.
Bonolive® is a patented ingredient rich in olive polyphenols that offers the possibility of formulating innovative bone health solutions tailored to women to counteract bone loss risk associated with menopause.

Improving bone health during menopause with Bonolive

Menopause transition and bone health

Healthy bones are needed to support our body, providing structure, allowing us to move and protect our organs. They also store essential minerals, such as calcium and phosphorus, and release them into the blood whenever needed.

Bone health depends on a dynamic equilibrium maintained between the constant production of the new bone matrix via osteoblasts – the cells responsible for bone synthesis – and the resorption of old bone by osteoclast activity– the cells responsible for bone breakdown.

There are a lot of symptoms related to menopause, but did you know that the menopause transition is the most critical period for bone health in women? That’s because the fine equilibrium between bone breakdown and synthesis is broken due to hormonal changes.

The onset of the rapid bone loss phase is due to the drastic drop in estrogen levels, which play an important role in maintaining bone strength. This can result in bone resorption exceeding bone formation, leading to thin, fragile bones subject to spontaneous fracture.

Rapid losses in bone mass and strength usually occur in the 3-year window since the date of the final menstrual period [1].

Decreased levels of estrogen cause osteoprotegerin levels to decline. Osteoprotegerin is a protein secreted by osteoblasts, which antagonises the process of bone breakdown mediated by osteoclasts.

Therefore, with the lowered estrogen levels associated with menopausal changes, osteoclast activity increases leading to decreased bone mass and, in many cases, osteoporosis. This results in reduced bone strength and increased risk of fractures.

Although it is essential to build strong and healthy bones during the early stages of our lives, there are also important factors to take care of during adulthood, particularly during menopause, such as sufficient physical activity, proper nutrition and supplementation.

Traditional bone health management

With the world population getting older, bone health issues are increasing. In postmenopausal women, the prevalence of osteoporosis and osteopenia is estimated to be almost 20% and 52%, respectively [2].

Bone health is indeed a key concern for this vulnerable group. This reflects that 25% of women who use dietary supplements are already consuming products to support their bones and there are different ingredients that can be consumed to support bone health.

Over the last decade, supplementation with calcium and vitamin D and exercise has been the most used measure for preventing bone loss during menopause.

It is known that a sufficient calcium intake contributes to an increased bone density and Vitamin D is crucial for bone health because it plays a crucial role in calcium absorption [3].

While this strategy has proven marginal improvements, consumers are becoming more demanding. In fact, the popularity of innovative, nutraceuticals with a clinical back-up addressing bone health is growing.

Scientific evidence has shown that bone physiology can be modulated by phenolic compounds found in olives.

These powerful antioxidant compounds can indeed stimulate markers involved in osteoblast proliferation, differentiation, and maturation, and ultimately lead to a counteracting effect against bone loss risk.

What is Bonolive® and how does it support healthy bones?

Bonolive® is a patented, olive-polyphenol-based ingredient researched and developed by BioActor, with demonstrated efficacy in increasing bone formation in postmenopausal women.

Bonolive® is standardised for highly bioavailable oleuropein, the powerful phytonutrient deemed responsible for the increase in the number and activity of osteoblasts observed during BioActor’s research.

The randomised, double-blind clinical trial demonstrated that an intake of 250mg/day of Bonolive® is sufficient to re-balance the bone turnover [4].

Additionally, after 12 months, a 32% increase in osteocalcin was observed in the treatment group, compared to a 6% decrease in the placebo group.

Osteocalcin is a key component for building new bone, as it forms the scaffold for new bone tissue and binds calcium within a rigid structure.

The increase in osteocalcin is also reflected by the DEXA scan results, which show that subjects taking Bonolive®, displayed protection of bone mineral density at the lumbar spine and a higher gain of bone mineral density at the femur neck, compared to those taking placebo.

Opportunities for new product development with Bonolive®

As consumers are shifting away from calcium-only products and seek out more complex formulas with clinically-backed ingredients, Bonolive® offers the possibility of developing innovative consumer products specifically crafted to help women support healthy bones during menopause.

For a synergistic effect, Bonolive® can be successfully combined with calcium, vitamin D and magnesium, as well as other vitamins, minerals and plant extracts.

This Mediterranean-inspired ingredient can be easily included in various dietary supplements, functional drinks and foods, with a daily dose of only 250mg.

Apart from innovative blends, further product development opportunities in this growing market lie in convenient formats like gummies and ready-to-drink beverages.


Cordiart® and Bonolive®obtained registration by the Malaysian National Pharmaceutical Regulatory Agency

Cordiart® and Bonolive®obtained registration by the Malaysian National Pharmaceutical Regulatory Agency

Maastricht, The Netherlands, September 15th, 2017

Press release

Both Cordiart® and Bonolive® obtained registration by the Malaysian National Pharmaceutical Regulatory Agency. Both finished capsule products of which one containing Cordiart® and the other Bonolive® are now officially registered and can be sold on the Malaysian market.

The Cordiart® and Bonolive® In Malaysia

Cordiart® and Bonolive® containing finished capsule products, named Smoozflo and Bonee Care, have been officially approved and registered in Malaysia by the National Pharmaceutical Regulatory Agency. Cordiart® finished capsule products are registered to be used for improving blood circulation under registration number MAL16110075TC. Bonolive® finished capsule products are registered to be used to strengthen bones and joints under registration number MAL16060038TC.

 

Both Cordiart® and Bonolive® have been clinically evaluated to have significant effects:

Two studies have shown that Cordiart® provides a triple protection of the arteries by improving arterial flexibility, reduces plaque formation, and lower arterial inflammation. The first study targeted patients with metabolic syndrome and impaired endothelial function, whilst the second study was looking at healthy overweight people. In both studies Cordiart® increased flow-mediated dilation compared to placebo. In addition the second study showed a reduction of the levels of adhesion molecules, responsible for plaque formation, and a reduction of the levels of inflammation markers, reflecting the inflammatory status of the arteries.

 

A 12-month double-blind, placebo-controlled study on a group of osteopenic patients consuming 250 mg/daily of Bonolive® showed a 32% significant increase in serum osteocalcin levels. This validates that Bonolive® prevents bone loss by strengthening bone metabolism and stimulating bone-building cell activity.

 

If you are interested in these products please feel free to contact our distributor for the Malaysian market, Membra Health, at info@membra.com.my.

 

About BioActor

BioActor, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. The company focuses on the development of innovative activities that address active living and healthy aging. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

Feel free to contact us via info@bioactor.com for more information on the possibilities Cordiart® and Bonolive® has to offer.
Further information can be found on: www.cordiart.com and www.bonolive.com


Olive leaf extract

New Bonolive® clinical results published in peer reviewed journal. New product launches in USA and Germany

New Bonolive® clinical results published in peer reviewed journal. New product launches in USA and Germany

Maastricht, The Netherlands, November 15th, 2013

Press release
Bonolive® is a clinically proven bone health supplement. The results of a recent bioavailability study in 16 healthy subjects showed excellent uptake and an immediate improvement in antioxidant in the target group of post-menopausal women. The results will be published in the European Journal of Nutrition. Bonolive® has been recently included in 3 major supplement brands in the USA and Germany.

Olive leaf extract

New publication and product launches

Bonolive® is a natural polyphenol extract from olive leaves which supports healthy bones. A recent parallel pharmacokinetics trial in a group of healthy young adults (n=8) and a group of healthy postmenopausal women (n=8) showed that Bonolive® was rapidly absorbed in both groups, whereby the uptake and exposure time was significantly higher in the target group of post-menopausal women (p<0.05). Interestingly, a parallel significant improvement in the plasma antioxidant status (+32%), an important process associated with osteoporosis, was found in the target group of post-menopausal women (p=0.016). This effect was directly correlated with the levels of circulating Bonolive® metabolites.

The results of this study will be published in the European Journal of Nutrition [DOI: 10.1007/s00394013-0604-9]

Bonolive® has recently been incorporated in a nation-wide supplement brands in the USA and Germany, as well as in a leading brand for health practitioners in the USA.

Additional information on Bonolive® and scientific study results can be obtained from www.bonolive.com.

About BioActor

BioActor, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. The company focuses on the development of innovative activities that address active living and healthy aging. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

Feel free to contact us via info@bioactor.com for more information on the possibilities Bonolive® has to offer.
Further information can be found on: www.Bonolive.com


Olive leaf osteoporosis

Bonolive® clinical results will be presented during the 13th European Congress on Osteoporosis and Osteoarthritis in Rome

Bonolive® clinical results will be presented during the 13th European Congress on Osteoporosis and Osteoarthritis in Rome

Maastricht, The Netherlands, March 15th, 2013

Press release
Bonolive® is a clinically proven bone health supplement. A randomized, double-blind, placebo-controlled study proved that Bonolive® has significant benefits on bone mineral density, osteoblast activity and blood lipid profile. The results of this clinical study will be presented by dr. Veronique Coxam during the congress of the International Osteoporosis Foundation in Rome next April 17-20th, 2013.

Olive leaf osteoporosis

The results of the clinical trial

Bonolive® is a natural polyphenol extract from olive leaves which supports healthy bones. A randomized, double-blind, placebo-controlled study showed that Bonolive® has significant benefits on bone mineral density (BMD) (DEXA scan), osteoblast activity (bone formation marker osteocalcin) and blood lipid profile. A 12-month administration of (Bonolive®) resulted in:
•Significantly higher levels of osteocalcin (+32%)
•Significantly lower triglycerides, total and LDL-cholesterol
•A stabilization of lumbar spine BMD in the treatment group

The results of this study will be presented by Dr. Veronique Coxam, Head of the Group Micronutrients at INRA, Centre de Theix. She has done pioneering work on the relationship between micronutrients and bone health. She is co-inventor of the patent covering the use of polyphenolics from olive for the prevention of osteoporosis. The presentation will be held at the 13th European Congress on Osteoporosis and Osteoarthritis.

The International Osteoporosis Foundation (IOF) and ESCEO have worked in partnership for several years to develop a unique European springtime meeting program for healthcare professionals, researchers and young scientists: the 13th European Congress on Osteoporosis and Osteoarthritis in Rome. The presentation of the Bonolive® study results will be held on Saturday April 20 at 11.1011.20 in the Auditorium A (Salone Dei Cavalieri / Level -1). There will also be the opportunity to ask questions. Additional information regarding the Congress on Osteoporosis and Osteoarthritis can be obtained from: www.ecceo13-iof.org. Additional information on Bonolive® and scientific study results can be obtained from www.bonolive.com.

About BioActor

BioActor, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. The company focuses on the development of innovative activities that address active living and healthy aging. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

Feel free to contact us via info@bioactor.com for more information on the possibilities Bonolive® has to offer.
Further information can be found on: www.bonolive.com