WEBINAR: Women's Health with Bonolive®

WEBINAR: Women’s Health

With Bonolive®

Are you interested in a women’s health ingredient backed-up by science? At this webinar, we will present Bonolive® and the benefits of adding it to your formulation. Find out more about the science behind Bonolive® its formulation possibilities. Dive into the world of women’s health with our exclusive webinar in Spanish . Register here!

REGISTER HERE

Why attend?

 

The awareness about women’s health and especially menopause support is growing. As consumer demand is increasing in this area, brands should be satisfying the need for science-based and clean-produced ingredients. At this webinar, we set the focus on Bonolive®, our premium women’s health ingredient. Deepen your knowledge about the science behind this olive leaf extract as well as the benefits it offers. Find out the opportunities of formulation and product formats available. 

bonolive webinar speakers

Presentation by Marit

10 minutes

EU Market Insights: Explore the latest trends, expected growth, and consumer preferences in the EU women’s health market, with a specific focus on Spain. 

 

Presentation by Valeria

10 minutes 

The Science behind Bonolive®: Discover the clinical data behind Bonolive® and understand the advantages it has to offer for menopausal women.

 

Presentation by Tony

10 minutes

Sales and Formulation possibilities of Bonolive®: Learn about the origin and benefits of formulating with Bonolive®.

REGISTER HERE

oleuropein skin health bonolive

How can oleuropein improve skin health?

How can oleuropein improve skin health?

Maastricht, 16th January 2024

Who doesn’t desire youthful looks and optimal skin health? Unfortunately, the aging process tends to impact our skin negatively. Wouldn’t it be great if we could slow down this natural process and improve skin health? This article delves into the beneficial impact of oleuropein on preserving skin health.

oleuropein skin health bonolive

Why is skin health important?

The skin, our body’s largest organ, acts as the primary barrier between the external environment and our internal world. Beyond its role in protecting against pathogens, toxins, and physical injuries, maintaining skin health is crucial to reduce the risk of infections and diseases (1).

 

Additionally, the skin plays a vital role in regulating body temperature and preventing dehydration, contributing significantly to the overall balance and well-being of the body through the process of homeostasis (2).

 

How does aging affect skin health? 

As we age, the importance of maintaining healthy skin becomes even more apparent. The skin undergoes changes, caused by a combination of genetic and environmental factors. Sun and wind exposure, air pollution, climate conditions, chemical exposure, stress, smoking and alcohol consumption contribute to alterations in the appearance and function of the skin (3).

 

Primarily, visible signs of aging manifest as wrinkles and fine lines. Collagen breakdown and a reduction in elastin fibers results in decreased skin elasticity and firmness. Additionally, aging causes thinning of the skin. The upper layers, the epidermis and dermis, become less thick and lose density, increasing the risk of injury and making blood vessels more visible on the skin surface (4).

 

Maintaining healthy skin becomes paramount to tackle the aging factors, ultimately improving the quality of life as one ages (5). For example, skin dryness and irritation are natural consequences of the decreased oil production with age (6, 7). To remedy this situation, nutritional supplements containing omega-3, collagen or oleuropein are showing some promise. Therefore, supporting skin health from within is a trend, currently popular for investigation among the scientific community.

 

What is oleuropein?

Oleuropein, a natural polyphenol, is abundant in olives, olive leaves and olive oil, giving them a distinctive bitter taste, especially in extra virgin olive oil (8). It is renowned for its antioxidant and anti-inflammatory properties, making it a subject of interest in various studies focused on skin health (8, 9, 10). It holds promise to support the skin’s natural oil production and tackle dryness and irritation.

oleuropein benefits skin

The beneficial effect of oleuropein on skin health

As the skin undergoes the natural aging process, one of the prominent challenges it faces is an escalation in oxidative stress within skin cells. Oxidative stress is characterized by an imbalance between free radicals and the body’s ability to neutralize them. Free radicals are highly reactive molecules that can damage cellular structures including proteins, lipids, and DNA, which contributes significantly to skin damage. By effectively neutralizing free radicals, oleuropein helps to reduce oxidative stress in skin cells and preserves the integrity of cellular structures and functions (9).

 

Furthermore, aging is often accompanied by an increased tendency towards inflammation in skin cells, a phenomenon linked to the emergence of various skin conditions. Oleuropein is suggested to have anti-inflammatory properties. It targets the pathways involved in the inflammatory process, helping to reduce the overall inflammatory burden. By doing so, oleuropein not only addresses the symptoms but also acts preventatively and it’s anti-inflammatory ability emerges as a valuable asset in promoting overall skin wellness and resilience (9).

 

How to use Oleuropein as a supplement? 

Olive leaf extract comprises of 25-40% oleuropein (11). Achieving the clinically studied dose of 100mg oleuropein per day through regular diet alone poses a challenge. Consequently, oleuropein supplementation is the practical consideration. Taking a daily supplement can help you reach the recommended clinical dose and have positive results.

Typical application formats include soft gels, capsules, tablets and powders. Oleuropein is stable and can be combined with collagen, magnesium, selenium and vitamins B, D, E & K.

Oleuropein’s dual action as an antioxidant and anti-inflammatory agent positions it as a valuable component in skincare, offering protective measures against oxidative stress and inflammation associated with the aging process (12, 13, 14)


WEBINAR (french)- Women's Health EU Market

WEBINAR in french – Women’s Health EU market

European Women’s health market, clinical data and product concepts with Bonolive® to support women during menopause.

Webinar: 7th November 2023 – 15:00 CEWT

More than ever, nutrition and supplementation are recognized to be effective strategies to address women’s health. Watch our latest webinar to learn more about the EU market for women’s health supplements, clinical evidence supporting Bonolive®, and product formulations. Watch now on demand!

WATCH ON DEMAND

The European Women’s Health market is growing. Join our webinar to explore evolving trends with a focus on France, address needs across ages, and uncover recent developments. Experts will discuss key factors shaping women’s health, providing insights for global advancement.

Menopause is an important stage of every women’s life. It brings unique challenges due to hormonal changes. From short-term concerns like hot flashes to long-term risks like cardiovascular issues and bone loss , nutrition and supplementation are crucial for support.

Discover Bonolive® and how BioActor’s olive polyphenol-based ingredient supports women during peri- and post-menopause!

What are you going to learn during this webinar?

European Women’s Health Market & Trends in France

Presentation by Aurore de Monclin from the Healthy Marketing Team, who is going to talk about the present state of the European Women’s Health market, the key considerations for women belonging to various age groups, and the trends within the french market.
Duration: 10 minutes

Clinical Research

Presentation provided by Maria Imperatrice – our in house clinical researcher, and presented by Billie Icheva – our Marketing Officer. You will be introduced to the science behind Bonolive® and the clinical trials showing the positive effect of Bonolive® on cardiovascular health, bone health and mobility.
Duration: 10 minutes

Formulating with Bonolive®

Presentation by Tony Payet– Sales Manager Europe, who will dive into Bonolive® mode of action, a new consumer study on its effect and product formulation examples related to women’s health.
Duration: 10 minutes

Q&A session

Duration:  5 minutes

WATCH ON DEMAND

Bonolive for your women's health product

5 reasons to use Bonolive® in your women’s health product

5 reasons to use Bonolive® in your women’s health product

September 5th, 2023

Bonolive® is an extract based on olive polyphenols that contains a high amount of oleuropein, a potent phytonutrient found primarily in olive trees. Numerous studies have demonstrated the beneficial properties of Bonolive®, including mitigation of potential risks associated with menopause. In this blog, we will explore some of the scientific evidence supporting the health benefits of olive polyphenols and why you should use it in your women’s health product.

Bonolive for your women's health product

Bonolive®: Mediterranean support for women’s health

Bonolive® is a natural compound sourced from olive leaves. It’s standardized to contain high levels of olive polyphenols, specifically Oleuropein.

Developed by BioActor, its primary aim is to support women’s health during the post-menopausal phase (1). This period often introduces various health challenges, such as decreased bone density, joint discomfort, and a heightened risk of cardiovascular problems.

Numerous clinical studies consistently highlight the positive effects of supplementing with Bonolive® (1 , 2 , 3). These studies have revealed that Bonolive® plays a role in enhancing bone strength, reducing joint discomfort, balancing lipid profiles, and easing specific menopause-related symptoms.

Consequently, it contributes to lowering the risk of developing conditions like osteoporosis (brittle bones) and heart issues as time progresses.

Oleuropein: the hero compound of Bonolive®

Olive oil holds a pivotal role in the Mediterranean diet (4). The primary polyphenols in olive oil are Oleuropein and its metabolite hydroxytyrosol. These polyphenols have been extensively studied and recognized for their preventive benefits against various disorders.

Researchers have unraveled their mechanisms, showing promise in reducing risks of breast cancer, ovarian cancer, postmenopausal osteoporosis, and other health issues.

Bonolive® is standardized to contain Oleuropein. Because of this, Bonolive® is a perfect match for adding to dietary supplements and functional beverages made to support women’s health during menopause.

5 reasons to use Bonolive® in your women’s health product

1. Bonolive® improves bone health and reduces joint discomfort

Bonolive® has demonstrated its positive influence on bone and joint health (1). An investigation centered on post-menopausal women with reduced bone mass unveiled a notable surge in a foundational protein that serves as the framework for generating new bone. Moreover, an improvement in bone mineral density was seen.

In a recent six-month study involving 124 participants aged 55 and above, the efficacy of Bonolive® came to light. It brought relief to joint discomfort linked to activities like walking, bending, and knee movement (2).

Consequently, a daily dosage of 250 mg of Bonolive® proves sufficient to deliver advantageous outcomes for both bone and joint well-being.

2. Bonolive® reduces menopause related symptoms

BioActor undertook a consumer study aimed at assessing the benefits of Bonolive® among post-menopausal women. This investigation unveiled the favorable influence of Bonolive® on alleviating menopause-related symptoms in this demographic.

The study focused on women who had already gone through menopause, aiming to see how Bonolive® affected their reported symptoms. For 28 days, participants took Bonolive® regularly. After just 14 days, they felt better in terms of bloating, anxiety, mood swings, energy levels, and skin health. This improvement continued even after the full 28 days of using Bonolive®.

This reinforces the potential of Bonolive® in enhancing the well-being of post-menopausal women.

3. Bonolive® has favorable effects on lipid control

Clinical research has shown the favorable impacts of Bonolive® in managing the blood lipid profile among post-menopausal women (1). Notably, supplementation with 250mg of Bonolive® over a 12-month period led to significant improvements. Specifically, a significant reduction in LDL-cholesterol, total cholesterol, and triglycerides was observed.

4. Bonolive® has a superior bioavailability

Another study aimed to assess the bioavailability of Bonolive®. Interestingly, a more substantial increase in the levels of metabolites in the blood of post-menopausal women was observed compared to women who hadn’t gone through menopause yet. This suggests that post-menopausal women experienced higher absorption of Bonolive®.

Additionally, the study revealed that Bonolive® possesses antioxidant effects, as evidenced by its ability to reduce levels of a substance called MDA, which is a marker of oxidative stress.

5. Bonolive® is a sustainable solution

Olive trees hold the distinction of being among the oldest cultivated trees globally. However, the surge in olive oil production has taken a toll on the environment (5).

The primary waste generated during olive growth is the pruned leaves of the olive trees. Yet, these leaves contain valuable compounds of which oleuropein is one. This is why Bonolive® is made from the freshly cut olive leaves, meaning it is a clean, sustainable and natural ingredient for a women’s health product.

Bonolive®: A key ingredient for women’s health

Studies have found that Bonolive® can help women stay healthy after menopause. Using Bonolive® as an olive polyphenol extract can bring big benefits to women’s health products. Bonolive® can be used in many different products and has lots of advantages. It’s a great ingredient to promote a healthier lifestyle and improve women’s well-being.

Curious to read about the clinical studies on Bonolive® in more detail? Download our white paper below!


WEBINAR - Women's Health

WEBINAR – Women’s Health

Women’s health market, clinical data and product concepts with Bonolive® to address post-menopausal-related risks

Webinar: September 26th 2023 at 9AM PDT | 12PM EDT | 6PM CEST.

More than ever, nutrition and supplementation are recognized to be effective strategies to address women’s health. Join us in our next webinar to learn more about the market for women’s health supplements, clinical evidence supporting Bonolive®, and product formulations to target post-menopausal-related risks. Watch now on demand!

WATCH ON DEMAND

The Women’s Health market is a very dynamic one. Join our webinar to explore evolving trends, address needs across ages, and uncover recent developments. Experts will discuss key factors shaping women’s health, providing insights for global advancement.

Menopause is an important women’s health topic. It brings unique challenges due to hormonal changes. From short-term concerns like hot flashes to long-term risks like cardiovascular issues and bone loss, nutrition and supplementation are crucial for support.

Discover Bonolive® and how BioActor’s olive polyphenol-based ingredient enhances women’s health in our upcoming webinar.

Meet the Speakers:

What are you going to learn during this webinar?

Women’s Health Market & Trends

Presentation by Marit Veenstra – Operations Manager & Brand Strategist, who is going to talk about the present state of the Women’s Health market, the key considerations for women belonging to various age groups, and the trends within the market.
Duration: 10 minutes

Clinical Research

Presentation by Maria Imperatrice – Clinical researcher, who will introduce the science behind Bonolive® and the clinical trials showing the positive effect of Bonolive® on cardiovascular health, bone health and mobility.
Duration: 15 minutes

Formulating with Bonolive®

Presentation by Valeria Mastromartino – Account Manager, who will dive into Bonolive® mode of action, a new consumer study on its effect and product formulation examples risks related to women’s health.
Duration: 15 minutes

Q&A session

Duration: 10 minutes

WATCH ON DEMAND

From tree to health support uncovering the benefits of olives, olive leaf and olive oil

From tree to health support: uncovering the benefits of olives, olive leaf and olive oil

From tree to health: uncovering the benefits of olives, olive leaf and olive oil

July 25th, 2023

Delve into the health benefits of the Mediterranean diet, centering on olives and extra virgin olive oil. Uncover the positive effects of oleuropein, particularly for women during and after menopause, providing natural support for overall well-being.

From tree to health support uncovering the benefits of olives, olive leaf and olive oil

The Mediterranean diet has gained widespread recognition as one of the healthiest diets globally, known for its ability to prevent diseases like heart disease and cancer.

Key components of this diet include olives and extra virgin olive oil (EVOO), which are celebrated for their health benefits.

In this article, we will delve into the composition of olives and EVOO, exploring the various health benefits associated with their consumption. Moreover, we will focus on their potential advantages for women facing post-menopausal concerns, shedding light on the natural alternatives available to alleviate their symptoms.

Olives and extra virgin olive oil: Pillars of Mediterranean health

The Mediterranean diet revolves around plant-based foods, whole grains, nuts, herbs, and spices. It encourages moderate consumption of fish, seafood, and poultry, while red meat and sugar are consumed infrequently. The main source of added fat in this diet is EVOO, which stands out for its numerous health benefits (1).

Composition of extra virgin olive oil

EVOO is derived from freshly cold-pressed olives, the fruits of the olive tree (Olea europaea). This process ensures that the beneficial components of EVOO, known as biophenols, are preserved.

The primary fatty acids in EVOO are monounsaturates, particularly oleic acid, which constitutes 55-80% of the total fatty acid content. The remaining portion consists of small amounts of saturated and polyunsaturated fatty acids.

Beyond the fatty acids, EVOO contains various minor components such as antioxidants, including carotenoids, α-tocopherol, and phenol compounds. Among these phenols, the main ones found in EVOO are hydroxytyrosol, tyrosol, and oleuropein. Oleuropein, in particular, is present in olives, olive leaves, and olive oil, making oleuropein a key player in the health benefits associated with these products.

Oleuropein: a compound from olives and olive leaf with remarkable health benefits

Oleuropein, a compound with remarkable health benefits, has been extensively studied for its potential in preventing various disorders. As an antioxidant, it effectively combats harmful compounds in the body, reducing the risk of heart problems, cancer, osteoporosis, Alzheimer’s, and premenstrual syndrome, among others. Studies have demonstrated its ability to protect cells from oxidative damage, reducing the risk of chronic diseases and contributing to the prevention of inflammatory conditions (2, 3).

Furthermore, the cardiovascular benefits of oleuropein are noteworthy, as it supports heart health by reducing LDL (“bad”) cholesterol levels and lowering blood pressure. These effects, in combination with its antioxidant properties, contribute to the prevention of cardiovascular diseases such as atherosclerosis.

Interestingly, while oleuropein is present in olive oil and olives, you might be surprised to learn that olive leaves contain even higher levels of this beneficial compound. This makes olive leaves a great source for obtaining oleuropein and reaping its healthful advantages (4).

Women’s health: how can it benefit from olives?

Postmenopausal women often experience symptoms such as fatigue, anxiety, and mood swings. The global population of postmenopausal women has grown significantly, leading to increased research on natural alternatives to alleviate these symptoms (5).

Oleuropein’s ability to lower blood pressure may be beneficial for women with hypertension during menopause. High blood pressure is a common concern during this stage of life, and the consumption of EVOO as part of the Mediterranean diet could help manage this condition naturally (6).

Oleuropein’s antioxidant properties are also relevant to women’s health. Oxidative stress is a contributing factor to the development of various diseases, and antioxidants like oleuropein help counteract this stress, promoting overall well-being.

Recent studies have also shown that oleuropein has positive effects on bone health, which further enhances its impact on women’s health, especially during and after menopause.

Osteoporosis, a condition characterized by reduced bone density and an increased risk of fractures, is a significant concern for postmenopausal women due to hormonal changes and declining estrogen levels. The anti-inflammatory properties of oleuropein play a crucial role in reducing bone loss and inflammation, helping to maintain bone strength and integrity.

By including the Mediterranean diet with its oleuropein-rich olives and EVOO, women can potentially safeguard their bone health and mitigate the risks associated with osteoporosis, contributing to an overall improvement in their well-being during the post-menopausal stage.

Oleuropein and women’s health: the benefits of olives and olive leaf

The Mediterranean diet, which includes olives and extra virgin olive oil, offers many health benefits, thanks to oleuropein: a compound that helps prevent diseases and promotes overall well-being, especially in women post-menopause.

For those who may have limited olives or olive oil in their regular diet, supplements containing high levels of oleuropein might be beneficial. Bonolive®, an ingredient by BioActor, is high in its oleuropein content and has been extensively studied. To read more about these studies, download our white paper below.


The importance of clinical research: An interview with BioActor's in-house scientists

The importance of clinical research: An interview with BioActor’s in-house scientists

Maastricht, The Netherlands, 29th June 2023

Interview
In the world of clinical research and scientific exploration, BioActor stands out as a leading company dedicated to the development of health ingredients. At the forefront of BioActor’s research and development (R&D) efforts are Sanne Ahles and Maria Imperatrice, two certified clinical research scientists who play vital roles in the BioActor’s R&D initiatives. In this interview, Sanne and Maria provide insights into their responsibilities, experiences, and the challenges they face in their pursuit of scientific advancement.

Could you introduce yourself and your role within BioActor?

Sanne: My name is Sanne Ahles and I am a clinical research scientist at BioActor. In addition, I am a PhD candidate at the Department of Nutrition and Movement Sciences at Maastricht University. I obtained my master’s degree in biomedical sciences after my internship at BioActor, after which I started working as a researcher.

Within BioActor, I am responsible for the research regarding our product Brainberry®, mainly focused on cognitive performance and vascular function. Over the years, I have designed, performed, analyzed, and reported various clinical studies, as well as written a systematic literature review.

Maria: My name is Maria Imperatrice and I also work as a clinical research scientist at BioActor. My research focus is Healthy Ageing and I’m currently performing two studies, Actiful2 and FEMMED, on two of our ingredients (Actiful® and Bonolive®) to evaluate their effect on exercise performance and postmenopausal symptoms, respectively.

I obtained my Bachelor Degree in Biology and my Master in Human Nutrition at the University “Federico II Di Napoli” in Italy, and my second master’s degree in Human Movement Sciences, with a specialisation in Sport and Nutrition, at Maastricht University.

At BioActor, we highly value clinical research because it plays a crucial role in providing evidence-based ingredients. What does clinical research entail and what do you like about it?

Sanne: Clinical research entails many different processes. This includes idea formation and initial literature searches, finding collaborations, obtaining ethics approval, practical work, data analyses, writing reports and papers, and communicating our results at national and international conferences.

Maria: A very interesting part for us is the ideation of the study. At BioActor we highly value innovation, which is why before starting a new clinical trial, we sit in brainstorming sessions with the R&D, marketing and sales teams to try to find white spaces in the current knowledge that can be of interest for the common public and different health domains. Once we find an interesting and never explored topic, the investigation can start.

Could you briefly take us through the process of a clinical trial?

Sanne: First, we initiate the idea formation process by brainstorming ideas that are relevant to customer questions or explore new areas of interest. Next, we perform literature searches to look for relevant papers, available data, and discover white space; topics that have not yet been researched.

Then we reach out to a collaborator, usually a professor at a University, to work with on developing a protocol for ethics review.

Maria: Once we obtain ethics approval, we dive into the practical phase of the clinical trial. This involves engaging with participants through visits where we collect data. This includes not only traditional data that we can extrapolate by collecting blood samples, but also performing tests to evaluate outcomes like reaction time, exercise capacity and mental flexibility.

It’s an interactive and rewarding experience that brings our research to life and allows us to better understand how our ingredients contribute to improving human health and develop evidence-based solutions. Afterwards, we analyze the data, draw conclusions, and share our findings through peer-reviewed publications. It’s a cool journey from start to finish!

Which of the above do you enjoy the most as a scientist?

Sanne: I enjoy collaborating with other companies or academic institutes! It’s such an incredible opportunity for us to broaden our knowledge and take our research to the next level. The energy and creativity that come from working with diverse teams is truly great.

Maria: The practical side of our work is always interesting! Collecting data means we get to perform visits with participants, and trust me, it’s never boring when you’re involved in a human study. The hands-on experience and the constant interaction with people make it such an exciting and fulfilling part of our job.

What is the biggest challenge in designing a study?

Sanne: In my opinion, the biggest challenge in designing a study is obtaining ethics approval, which is a rigorous and time-consuming process. We meticulously prepare documents explaining our research goals, methodology, and participant recruitment.

The ethical committee thoroughly reviews these documents, granting final approval for each aspect of our research.

Maria: I agree! Obtaining ethics approval is a significant challenge. However, this process is crucial for upholding ethical standards and protecting participant rights.

It also adds credibility to our research, fostering trust and allowing our findings to have a greater impact. Despite the challenges, navigating the ethics approval process is vital for conducting valuable and ethically sound research.

What is the best part of working at BioActor as a scientist?

Sanne & Maria: Being a scientist at BioActor is truly rewarding due to the chance to collaborate with a dynamic and passionate team of international colleagues. Within BioActor, we also see other aspects of the company besides R&D.

Our weekly company meetings allow us to really understand the bigger picture of the company and understand what each department entails. Consequently, we explore different facets of the company and gain valuable insights beyond our specific research and development focus.

BioActor: Using clinical science as the key to innovative ingredients

Sanne Ahles and Maria Imperatrice exemplify the passion and dedication that drive BioActor’s pursuit of finding new health effects of ingredients and advancing scientific innovation. From ideation to practical implementation, data analysis, and knowledge dissemination; they are pushing the boundaries of scientific knowledge and embracing the multidisciplinary nature of their work. Sanne and Maria contribute to BioActor’s mission of creating innovative and impactful solutions for a healthier life.


Foods-that-can-help-relieve-menopause-symptoms

Nourishing foods that may help relieve menopause symptoms

Nourishing foods that may help relieve menopause symptoms

March 16th, 2023

During and after menopause many women experience uncomfortable side effects such as bloating, hot flashes, and night sweats. These physical symptoms can be accompanied by emotional changes. While hormonal therapy can help alleviate symptoms, it may also have side effects. Therefore, more attention is being given to changes in diet or the use of natural supplements. This article will explore how certain products like fish, olive leaf extract, yogurt, and flaxseed may be able to provide relief from menopause symptoms.

Foods-that-can-help-relieve-menopause-symptoms

Foods to alleviate menopause symptoms

As women approach menopause a lot of changes occur. Their estrogen levels decrease, leading to various symptoms such as bloating, night sweats, anxiety, or depression.

Menopause can also increase the risk of cardiovascular diseases and bone loss, which are commonly ignored. However, making some dietary changes can be an effective and easy way to alleviate these symptoms. In this article, we’ll discuss five foods that can help ease menopause symptoms.

1. Fish rich in n-3 PUFAs for menopause support

Fish is a great source of healthy and essential fatty acids, including omega-3 polyunsaturated fatty acids (n-3 PUFAs) that have protective effects and anti-inflammatory actions. These fatty acids are found in fatty fish like salmon and some algae species.

Research has shown that consuming fish or fish oil can reduce depression, anxiety (1), hot flashes, and sleeping problems (2) in menopausal women. In addition, fatty fish is rich in vitamin D, which is essential for calcium absorption and maintaining bone health.

If you don’t eat fish, you can still get the benefits of n-3 PUFAs by consuming foods rich in α-linoleic acid (ALA), which our bodies can convert into these beneficial fatty acids. ALA has been shown to improve skin hydration and smoothness and can be found in foods like flaxseeds, almonds, walnuts, and chia seeds (1), as well as soy products that we’ll discuss later.

2. Olive leaf extract for menopausal symptoms

Olives contain (poly)phenolic compounds that have many positive effects, including antioxidant and anti-inflammatory properties, as well as anticancer properties (3).

Interestingly, olive leaves contain significantly higher concentrations of phenolic compounds compared to olives or olive oil (4). As a result, they may have even greater potential for exerting beneficial effects on health. In fact, research has already demonstrated that taking olive leaf extract daily can be an effective alternative treatment for reducing blood pressure in individuals with hypertension (5).

One of the key phenolic compounds found in olive leaf extract is oleuropein, which has been shown to have a significant impact on women’s health during post-menopause. Oleuropein has been proven to reduce cholesterol levels, lower the risk of bone loss, alleviate joint pain, and improve mobility (6,7).

3. Soy products

Soy products, including soy milk, soybeans, and tofu, are rich in isoflavones, which are plant-derived estrogens and selective modulators of estrogen receptors in the body. These properties make soy products a promising alternative to hormonal therapy.

Soybeans contain essential fatty acids, such as ALA (α-linoleic acid), that have anti-inflammatory properties. Additionally, soy protein has been found to reduce bad cholesterol levels, which can lower the risk of cardiovascular diseases (8).

One of the isoflavones found in soybeans is genistein, which is structurally similar to female estrogen and can alleviate menopausal hot flashes. Another isoflavone, daidzein, can inhibit cell proliferation in the gastrointestinal tract, potentially reducing the risk of estrogen-sensitive cancers, such as ovary, prostate, and breast cancer (9).

4. Yogurt to support menopause

Yogurt is a nutrient-rich food that contains calcium and vitamin D, which are important ingredients to improve bone health during menopause. Bifidobacterium bifidum and Lactobacillus acidophilus, which are considered ‘good’ bacteria, are used to make yoghurt and they are also present in the final product, making yogurt a source of probiotics that can benefit gut health.

Research has shown that consuming extra probiotics in yogurt can help to reduce anxiety and stress levels, and improve overall quality of life compared to regular yogurt (10). However, regular yogurt also has similar long-term effects. Additionally, yogurt may have a role in appetite control, making it a helpful food for weight management (11).

Studies have suggested that a well-balanced diet that includes milk and dairy products, like yogurt, may also improve sleep quality (12).

How can foods help with menopause symptoms?

To summarize, consuming fish, soy products, whole grains, olive leaf extract, and yogurt can promote healthy cholesterol levels, maintain bone mass, reduce menopausal symptoms such as hot flashes and mood swings, and help regulate appetite and blood sugar levels. If you’re experiencing menopausal symptoms, these natural products are worth considering.


What-is-perimenopause-and-what-are-the-symptoms

What is (peri)menopause and which changes occur?

What is (peri)menopause and which changes occur?

January 4th, 2023

Menopause leads to changes in women’s bodies and marks the end of the childbearing years. It involves hormonal changes that can lead to both physical and mental symptoms that are better known as menopause symptoms. Because menopause does not occur overnight, a distinction is made between the period called perimenopause and the period that comes after, namely (post)menopause. Each of these periods comes with their own issues and symptoms.

What-is-perimenopause-and-what-are-the-symptoms

What is menopause?

Menopause is marked by the moment that no menstruation has occurred for at least 12 months. This occurs on average when women are between 45 to 55 years of age. However, this varies from woman to woman and depends on multiple factors.

Entering menopause is not an immediate process and does not happen overnight: it is a process that can last for years (1). For this reason we make a distinction between menopause and perimenopause.

What is perimenopause?

The explicit sign that menopause has started is the definitive cessation of menstruation. This does not occur suddenly, but after a long period of irregularity, which begins to manifest itself during perimenopause.

Perimenopause is the phase in which the first bodily changes related to menopause occur. These changes are evident signs of decreasing levels of estrogen and progesterone. (2)

During perimenopause, estrogen deficiency occurs that can no longer be compensated by changes in ovarian hormone production. This decline in ovarian function is a characteristic trigger of natural menopause and because of it circulating estradiol levels will go down. This reduction in estradiol levels will prevent the ovulation from happening, which is thought to be the reason for irregular menstruation.

Postmenopause is the period that begins after 12 consecutive months without menstruation. From this moment on the discomforts related to (peri)menopause will become lighter.

What are the symptoms of perimenopause?

The hormonal changes associated with menopause can affect physical, emotional, mental, and social well-being. The symptoms that are experienced during and after menopause vary greatly from one person to another.

While some women suffer few to no symptoms, others may experience severe symptoms affecting their daily activities and quality of life. In some cases, the symptoms may last for various years (3).

Symptoms of perimenopause

Symptoms that can occur during perimenopause include, but are not limited to:
Irregular menstruation cycle, this is a clear sign that hormones are starting to act up.

Menstruation that is heavier or lighter than normal, which indicates a change in hormonal balance

Weight gain and a general accentuation of roundness can become a very delicate aspect to manage, also from an emotional point of view.

Changes in hair quality, most women find that their hair loses volume and length around menopause.

Headaches, the hormone changes that happen as women approach menopause mean that all types of headaches, including migraines, become more common.

Muscle aches, estrogen affects your cartilage (which is the connective tissue in joints) as well as the replacement of bone, this plays a part in inflammation and pain.

Bone issues, though it is less noticeable, bone health diminishes during menopause. For this reason, a lot of products exist to improve bone health during (peri)menopause.

Symptoms of (post)menopause

As stated before, after perimenopause starts the actual menopause, which brings its own types of symptoms. These symptoms include:

Night sweats and hot flashes are one of the most typical effects of hormonal imbalance. Many women experience such a sudden rush of feeling hot.

Anxiety or irritability. There are a lot of physical changes during menopause, but emotional changes often occur as well. This happens because the drop in estrogen and progesterone lead to a decrease in expression of several brain chemicals that make you feel calm, happy or energetic. This can cause women to feel anxious or irritable.

Mood swings also occur due to the hormonal changes. Fluctuations in estrogen and progesterone lead to fluctuations in other brain chemicals as well, leading to these mood swings.

Depression is a symptom that can occur during both perimenopause and menopause and is more severe compared to anxiety, irritability or mood swings. Changes in hormones might put women more at risk for depression and this also falls under the emotional changes during menopause.

Insomnia: overall studies show that women in menopause have more trouble with sleeping. These disturbance include difficulty getting to sleep, to stay asleep, early morning wakenings and problems with the overall quality of sleep.

Fatigue, Low energy is one common effects that many women experience before, during, and after this transition time. This often is a result of the sleeping problems described before, but has to do with the previously mentioned ‘energetic’ chemicals in your brain as well.

Dry skin, due to decreasing estrogen levels can become less supple, smooth, and soft. Fine wrinkles, dark spots, and less elasticity are usually not far behind.

Relieving symptoms of perimenopause and (post)menopause

Menopause is a period of hormonal changes marked by physical and emotional changes. A lot of people worry about this and it can be hard to experience these symptoms. For this reason, there are several ways to alleviate these symptoms. Of course, medicinal products are available, but natural ways to relieve symptoms exist as well. Changes in diet and physical activity could be a way to relieve symptoms associated with menopause.


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New Open Label Study: Bonolive® shows increase in skin quality and menopause-related quality of life in postmenopausal women

New Open Label Study: Bonolive® shows increase in skin quality and menopause-related quality of life in postmenopausal women

Maastricht, The Netherlands, October 28th, 2022

Press release
BioActor recruited 23 Dutch and Italian postmenopausal women to assess their postmenopausal symptoms after 28 days of supplementation of Bonolive®. Self-assessed improvement of symptoms and skin quality were recorded after 14 days of supplementation. Symptoms such as feeling bloated, feeling anxious or nervous, mood swings and nail strength improved significantly, highlighting the effects of Bonolive® to benefit women’s health.

Postmenopausal symptoms and quality of life

During each woman’s life, many hormonal fluctuations occur, and they have an important impact on their quality of life. During and after menopause, these fluctuations can result in symptoms that can severely influence day-to-day tasks.

For many women, menopause-related symptoms include irregular periods, hot flashes, sweating, trouble sleeping, mood swings, irritability, skin dryness, and more. A lot of solutions are available, but an increasing number of women prefers a natural option to treat these postmenopausal symptoms.

Bonolive® is an olive leaf extract standardized for high oleuropein content, a powerful phytonutrient unique to the olive tree that offers a natural way in the management of menopause in its different phases.

The benefits of Bonolive® have been assessed in several clinical studies, which demonstrated its positive effect on bone, joint and cardiovascular health, as well as its strong antioxidant properties.

Open-label study in Post menopause women

Recently, BioActor has completed an open-label study on 23 postmenopausal women in the Netherlands and Italy, who consumed 250 mg of Bonolive® per day for 28 days.

In this open-label study, we aimed to investigate the short-term (28 days) effects of 250 mg/day Bonolive® supplementation on self-assessed postmenopausal symptoms in healthy post menopausal women (45 – 65 years). Participants were included in the study if they were healthy postmenopausal (i.e. no menstruation for at least 1 year) women with age between 45 and 65 years.

Study design open label study bonolive

The study results

Three times during the study (at baseline and at 14 and 28 days), participants had to complete an online questionnaire to self-assess their postmenopausal symptoms. After they filled in the questionnaire at baseline, they began their Bonolive® supplementation.

The results show that the participants experienced a significant improvement (P≤0.05) after 28 days of supplementation for specific postmenopausal symptoms: feeling bloated, feeling anxious or nervous, mood swings and night sweats. Furthermore, they indicated to notice and improvement in skin elasticity, skin hydration, nail strength and in energy and vitality.

* Sig (P≤0.05) compared to baseline.

 

Our consumer study demonstrates that short-term supplementation with 250 mg/day of Bonolive® results in significant beneficial effects on a wide range of post-menopausal symptoms. Therefore, we think that Bonolive® could be a meaningful addition to any nutritional supplement that aims to improve women’s quality of life during and after menopause.

After finishing her participation in the study one participant said:

“After Bonolive® supplementation, my skin is luminous and plumped too. My hair has fallen out less during this period. I would recommend Bonolive® to all my family and friends “

The participants reported that one of the advantages of Bonolive® is that it improved their skin quality and decreased their bloated feeling.

 

About BioActor

BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.

Feel free to contact BioActor via info@bioactor.com for more information on the possibilities Bonolive® has to offer.
Further information can be found on: www.bonolive.com and www.bioactor.com