Baltic Brainfuel: Discover the health and sustainability behind the Nero Eggert variety of Aronia berries
Baltic Brainfuel: Discover the health and sustainability behind the Nero Eggert variety of Aronia berries
Discover the world of Aronia berries, where health and sustainability intertwine in the extraordinary Nero Eggert variety. With its exceptional nutritional profile and eco-conscious characteristics, this superfruit is a beacon of wellness for both individuals and the planet. Learn more about the reasons Aronia berries are superfruits and about the ever more special Nero Eggert variety.
Aronia berries: Sustainable health-enhancers
Aronia berries are small dark fruits that are becoming increasingly popular amongst health-conscious consumers as they have excellent content in micronutrients and strong antioxidant properties. Moreover, they have many health benefits.
Apart from providing numerous health benefits, Aronia berries are also interesting from an environmental perspective, thanks to some unique characteristics of this plant.
This is particularly true for the variety called Nero Eggert, selected by BioActor to produce the active ingredient for brain health, namely Brainberry®.
Join us, while we dive into the reasons why Aronia berries are considered superfruit and why the Nero Eggert variety is especially great.
We visited Mr. Eggert, who spent more than 30 years on creating the Nero Eggert variety. Watch the video below:
Aronia Berries: Reason they are excellent for health and sustainability reasons
1. Full of nutrients and anthocyanins:
Aronia berries are more than just berries – they’re nutritional powerhouses. Packed with vital vitamins, minerals, and dietary fibers, these berries contribute significantly to your overall well-being. However, their true power lies in their antioxidant content, particularly the anthocyanins. These antioxidants play a pivotal role in combating oxidative stress and supporting cellular health.
2. Multifaceted health benefits:
Aronia berries have diverse health benefits. From bolstering cardiovascular health to enhancing cognitive function, these berries offer a holistic approach to health.
3. Embracing sustainability:
What truly sets Aronia berries apart is their minimal impact on the environment. Unlike resource-intensive crops, Aronia plants thrive on modest water consumption and natural pest resistance, making them a responsible and sustainable choice for environmentally-conscious consumers.
Nero Eggert variety: What sets it apart from other Aronia berries?
1. Sustainable harvesting methods:
Meet the Nero Eggert Aronia variety – a game-changer in sustainable agriculture. With unique low-reaching branches, this breed helps with harvesting practices. Not only does it yield more fruit per land area, but it also provides reduced land usage, striking a balance between productivity and ecological responsibility.
2. Flourishing amidst harsh climates:
Witness nature’s resilience through the Nero Eggert variety. Flourishing even in freezing temperatures as low as minus 20 degrees Celsius, these berries naturally rejuvenate during harsh winters, eliminating the need for chemical interventions. This adaptation showcases the variety’s capacity to coexist harmoniously with the environment.
3. Abundant in anthocyanins:
The Nero Eggert variety’s high anthocyanin content is a testament to its ability to thrive under stress. The challenging climate it thrives in stimulates the production of these antioxidants, making every berry a valuable source of natural health support.
4. Bee-friendly:
Beyond its health and sustainability attributes, the Nero Eggert Aronia berry plays a vital role in the ecosystem. Its extended flowering period provides nourishment for bees during their lifecycle, promoting biodiversity and exemplifying the variety’s contribution to preserving nature’s balance.
Nero Eggert Aronia Berries: A blend of health and sustainability
The Nero Eggert Aronia berry seamlessly intertwines health benefits and sustainable practices. For this reason, we have chosen this unique fruit as the base for our Brainberry® extract, which has been clinically validated to boost your cognitive performance.
Feel free to contact BioActor via info@bioactor.com and visit www.brainberry.eu and www.bioactor.com to learn more about Brainberry® or click here to learn everything you need to know about Brainberry® and brain health.
Ways to increase focus in students
Ways to increase focus in students
Studying can become an overwhelming task due to focus loss. However, the good news is that there are plenty of productive ways to improve your focus. Planning tasks beforehand, practicing meditation, exercising and also changing your eating habits are just a few things you could do as a student to gain that extra kick of focus.
Focus loss in students
The process of studying can become a quite challenging task for students these days. A lot of effort is needed to concentrate on study materials for various reasons such as information load, distractions, lack of focus and other external factors.
Students however tend to overlook the obstacles they face and therefore get used to bad studying habits. These lead to physical and mental fatigue making studying an unattainable goal.
Why do students lose their focus?
Even if the end of the pandemic has alleviated students from isolation, online courses, and reinstated interaction with their peers; it has also distorted their focus when following courses on academic grounds.
Distractions caused by social media are an important reason for focus loss. This is because the use of mobile phones and the internet is an integral part of their daily life, especially since it has become the primary communication tool these days.
Bad eating habits and unstable sleeping patterns can also lead to the loss of focus. Most students tend to “make their lives easier” by avoiding nutritious meal preparations and thus consuming unhealthy snacks and food options.
Also, studies have shown that students have an overall poor sleep quality consisting of disrupted and short sleep patterns (1). These factors can all affect mental health and the ability to concentrate leading to nonproductive behaviors (2).
How to increase your focus as a student
The good news is that there are plenty of productive ways to improve your focus as a student.
First of all, a planner might narrow the overwhelming feeling and help reach achievement when starting a new task by maintaining effective schedules. This will also reduce anxiety and stress and will eventually improve concentration and productivity.
Practicing mindfulness and meditation can also help with building focus. Taking short breaks in between study sessions will aid with clearing your mind. This is vital to mental health and concentration.
Another way to enhance focus is brain training. The brain benefits from regular exercise and there are ways to specifically train your brain. Memory games, sudoku and word searchers are a successful way to stay off your phone while activating different parts of the brain and boost your concentration.
These are all exciting tips, but did you know nutrition and eating patterns also have an influence on your ability to focus?
Foods that can improve your focus
Nutrition affects your brain performance. There are foods known for improving attentiveness when incorporated in one’s daily diet. Berries, fatty fish, nuts, and eggs are just some options which have shown to have great effects on brain health (3).
While diet is key to a healthier lifestyle, students often find it difficult to retain a nutritious diet due to preparation time and costs. While keeping in mind that healthy balanced diet is essential, adding supplements is a way to boost your nutrient intake!
Essential vitamins and minerals
Supplements are an effective way to get the vitamins and minerals you need. Omega-3, vitamin D, C & B12 and magnesium are good options for memory and concentration and have been found to contribute to overall enhanced concentration and focus.
In fact, studies have shown that people with a low Vitamin B12 and D intake show a poor learning ability (4).
Anthocyanins
Fruits containing antioxidants are highly necessary to be included in your diet, especially when willing to boost your focus. More specifically, a category of antioxidants shown to have beneficial effects related to focus are anthocyanins. These anthocyanins have been associated with increasing cognitive performance in several studies.
Anthocyanins are antioxidants better known for giving fruits and vegetables a distinctive blue, purple or red color. (5)
Examples of antocyanin-containing fruits are blueberries, cherries, red grapes, and black plums. However, one of the highest concentrations of anthocyanins has been found in Aronia Melanocarpa, also known as the black chokeberry.
Aronia Melanocarpa contains high levels of the anthocyanin Cyanidin-3-0-Galactoside which has been shown to have effects on brain health and cognition. (6)
Curious to know more about the anthocyanin Cyanidin-3-O-galactoside? Click here!
Boost your focus with these tips
Studying properly is a skill that is learnt over time. Being able to concentrate on studying is an integral part of this skill. However, by integrating the above-mentioned techniques in your daily lives, you can certainly get an extra boost of focus and allow yourself to come close to your ideal studying practice.
Everything you need to know about Brainberry® and brain health
Everything you need to know about Brainberry® and brain health
We constantly use the brain to make decisions, to coordinate our movements, to focus and to memorize thousands of things. For this reason it is of utmost importance to make sure our brain is healthy. Every day we learn more about the brain and about how important it is to support our brain’s health. In this article, we will discuss what brain health is, why it is important, and how an ingredient like Brainberry® can help you support it.
What is brain health and why is it important?
The brain is a massive network of neurons, that accounts for 2% of our body weight. It is a very active organ that makes a ton of decisions on a daily basis, and despite its weight, it uses up to 20% of our total oxygen per day!
Other than oxygen, the brain needs a lot of nutrients to keep processes running, even when we are not awake. These nutrients are important to keep the brain healthy, meaning that it can function across cognitive, sensory, social, and motor domains. A healthy brain allows a person to live life to its fullest potential, which is why it’s important to keep your brain healthy.
How can you support brain health?
There are plenty of ways to keep your brain healthy. It has been shown that regular exercise is beneficial, but also that enough sleep is good to keep a healthy brain. Both staying socially involved and staying mentally active are also good for brain health and have been shown to ward off depression and stress.
Another way to support your brain health is by improving your gut health. The bidirectional communication system between your gut and brain is called the gut-brain axis and research has shown that gut bacteria and their metabolites affect brain health.
Moreover, your diet plays an enormous role in brain health. The Mediterranean diet is seen as supportive to a well-functioning brain because it includes a wide variation of nutrient-providing foods. Examples of these are seafood, fruits, vegetables, and olives.
Also supplementing with specific compounds can be a useful approach to support brain health. Berry anthocyanins are an example of specific compounds that can exhibit a beneficial effect on brain health and function.
More specifically, Aronia Melanocarpa berries, rich in anthocyanins, have been shown to provide health benefits on immune health, cardiovascular function, and brain health due to their antioxidant properties.
What are Aronia Melanocarpa berries?
Aronia berries are little dark fruits that belong to the Rosaceae Family. They are native to north America but are mostly grown in the Baltic region of Europe, where it was introduced in the first half of the 20th century.
As the locations where the plant is cultivated suggests, the Aronia plant is a low-demanding plant and thrives in harsher and colder regions.
What are the health benefits of Aronia berries?
Aronia berries have a lot of health benefits. They contain high levels of vitamin C, but the main reason they are healthy is due their high level of polyphenols, anthocyanins and proanthocyanins, which are all types of antioxidants. In fact, they contain one of the highest levels of antioxidants among all berries.
The main reason antioxidants are considered to be healthy, is because they can help to prevent free radicals from damaging the body’s cells. The health benefits of Aronia berries include strengthening the immune system, improving cardiovascular health, and improving brain health. For this function, they are considered a superfruit (1, 2).
Among the anthocyanins in Aronia berries is the phytocompound cyanidin-3-O-galactoside, which is a key molecule for brain health.
What is Cyanidin-3-O-Galactoside?
Several health benefits of Cy3Gal, also known as Idaein, in humans have been researched due to its excellent antioxidant capacity as well as anti-inflammatory and anti-diabetic properties (3). However, the brain health benefits might be the most interesting aspect of Cy3Gal.
Cy3Gal is a water-soluble molecule, which can cross the blood-brain barrier. Consequently, it can exert a health benefit on several brain regions, including the cortex, cerebellum, and hippocampus.
What brain health benefits are associated with Cyanidin-3-O-galatoside?
Cy3Gal can cross the blood-brain barrier, which allows it to impact brain health in multiple regions of the brain. Firstly, in the hippocampus, Cy3Gal can lower the activity of acetylcholine esterase. As a result, acetylcholine is broken down at a slower rate, resulting in higher levels of this neurotransmitter. This leads to improved neuronal signaling.
In mice, Cy3Gal has been shown to relieve neuronal damage in the hippocampus and cortex and there is evidence that Cy3Gal may improve cognitive function (3, 4).
One of the most interesting effects of Cy3Gal is that it can increase the activity of brain-derived neurotrophic factor (BDNF), which has many beneficial effects.
What is brain-derived neurotrophic factor?
Brain-derived neurotrophic factor (BDNF) is a protein highly expressed in the central nervous system and especially in the brain. It promotes the growth of neurons, more specifically the dendrites and dendritic spines. This supports the hippocampus, a brain region good for learning and long-term memory. BDNF is also involved in repairing brain damage.
An ideal ingredient to target brain health is the Aronia Melanocarpa extract Brainberry®.
What is Brainberry®?
Brainberry® is an Aronia Melanocarpa extract that is standardized for high levels of Cy3Gal. It is designed to enhance cognitive performance and brain fitness and it has been clinically tested in multiple studies.
Brainberry® contains high levels of Cy3Gal, which makes it an interesting ingredient for brain health formulations to target benefits mentioned before. Even more so, because Brainberry® has been clinically tested in several studies that are further described in its White Paper.
It has been shown that Brainberry® has beneficial effects on cognitive performance, such as attention and psychomotor speed, executive function, and memory. Moreover, effects on vascular function and cardiometabolic risk markers were investigated.
Provided its health benefits, Brainberry® is an interesting ingredient for a wide variety of consumers, such as athletes, gamers and students.
How can Brainberry® support athletes?
Power, endurance and focus are important during sports. Increasing psychomotor speed and hand-eye coordination is an important goal for many athletes. For this reason, there is a diverse collection of products focused on increasing these parameters.
Pre-workout formulas are an example of this. These products are consumed by athletes from all disciplines briefly prior to their workout or training. The goal of consuming these types of formulas is to enhance acute exercise performance (5). Brainberry® can increase focus, psychomotor speed and mental flexibility, which is why it is a good ingredient for a pre-workout formula.
Additionally, Brainberry® has been demonstrated to significantly enhance cognitive performance in 35 professional basketball players. It also improved basketball-specific skills like shooting, rebounding, and dribbling.
How can Brainberry® help gamers?
Gaming requires many skills, such as visual-spatial skills that allow you to analyze, recognize, and rapidly respond to changes on the screen. Besides, gaming sessions can last for hours, which means enhanced attention and focus are crucial.
Brainberry®’s high levels of Cy3Gal, which improves focus and psychomotor control, make it a relevant ingredient for gaming supplements.
This is further supported by a consumer study done with Brainberry® in young, healthy e-gamers. In this study, Brainberry® significantly improved relevant measures for gaming performance, such as hand-eye coordination, focus, reaction time and energy.
How could students benefit from Brainberry®?
There is a lot of pressure on students to perform well during their studies while also being involved in a social environment. They study for entire days, especially during exam periods.
Coffee seems to be a common good for students in these periods, but did you know there are quite some substitutes for coffee that don’t have the downsides of causing stress, anxiety and sometimes sleeping problems?
Brainberry® could be an interesting solution for students that want to stay focused on their studies, but don’t want the well-known caffeine-rush later followed by a crash in energy levels.
That’s because Cy3Gal, the hero-component of Brainberry®, is a powerful antioxidant that supports brain function and focus, without the sometimes-troublesome side-effects of caffeine.
Other benefits of Brainberry®
Except for being clinically proven to enhance psychomotor speed, focus and attention, Brainberry® has other benefits as well. It is 100% natural as it is extracted from high-quality Aronia berries from the Baltics.
The dosage of Brainberry® is very low at 65 mg and it does not contain any stimulants that are usually associated with undesired side effects. This makes Brainberry® a healthier option compared to many stimulants.
The bioavailability of Cy3Gal is very high, which means it is rapidly absorbed by the body. Also, Brainberry® is easy to formulate thanks to its excellent solubility and pleasant taste.
Lastly, there are many environmental benefits of Aronia Melanocarpa. The Aronia plant helps keeping bees healthy and happy, consumes little water and it is naturally organic.
Learn more about Brainberry®
If you are curious to know more about Brainberry®, you can check out the product page of Brainberry® or its website.
Aronia Extract Brainberry® gains US patent for cognitive performance support
Aronia Extract Brainberry® gains US patent for cognitive performance support
Press release
BioActor’s Aronia Extract, Brainberry®, has been granted a US patent for supporting cognitive function. The patent protects the composition and dosage of the ingredient and serves as official recognition of its ability to boost brain fitness and performance, which was demonstrated in two clinical trials.
US Patent for Aronia Extract Brainberry®
BioActor’s Aronia Extract, Brainberry®, has been granted a US patent for supporting cognitive function and, specifically, for improving reaction time and attention.
The patent protects the composition and dosage of the ingredient and serves as official recognition of its ability to boost brain fitness and performance.
Brainberry® is an all-natural ingredient derived from Aronia Melanocarpa berries from the Baltics and standardized for 15% Cyanidin-3-O-galactoside content: a powerful bioactive able to cross the blood-brain barrier and exerts multiple brain fitness benefits.
The supporting research
The ingredient is supported by two randomized, double-blind clinical trials carried out by BioActor, one in mid-age and one in younger subjects.
The two studies demonstrated Brainberry®’s beneficial effect on cognitive functioning after low-dose long-term (6 weeks and 12 weeks) and short-term acute (7 days) consumption.
Researchers found that Brainberry® increases attention/concentration, reaction time, psychomotor function, and visual-motor coordination.
Moreover, it was demonstrated that a beneficial effect in maintaining optimal levels of BDNF, an essential protein for brain health that is involved in neuronal plasticity and neuroprotection mechanisms.
The clinical research so far conducted, revealed that both middle-aged individuals, young students and professionals can benefit from the daily consumption of a low dose of Brainberry®.
Two additional studies to further investigate the benefits and elucidate the mode of action of Brainberry® are ongoing, thanks to the Public Private Partnership established between BioActor and Maastricht University.
About BioActor
BioActor is a life science company based on the Maastricht Health Campus and dedicated to researching, developing and commercialising health ingredients addressing healthy ageing and active living. BioActor has a targeted portfolio of patented and branded health ingredients that are all based on food crops, clinically researched and produced in Europe.
For more info: www.bioactor.com or www.brainberry.eu
New Open Label Study: Brainberry® shows cognitive and performance benefits in professional basketball players.
New open-label study: Brainberry® shows cognitive and performance benefits in professional basketball players.
Press release
BioActor recruited 35 professional Greek male and female basketball players to assess their cognitive and basketball-specific skills after an acute and one-week intake of Brainberry®. Notably, cognitive performance linked to focus, reaction time and hand-eye coordination improved acutely and following a one-week intake. Also, basketball-specific skills like shooting, rebounding and dribbling improved significantly, underlining the ability of Brainberry® to benefit sports performance.
Open-label study in professional basketball players
According to the F.I.B.A. (Fédération Internationale de Basketball), more than 450 million people play basketball worldwide, and about 70.000 of them are professionals. In the US, basketball is one of the most followed sports, and according to Statista, the National Basketball Association (NBA) generates about $6 to $8 billion in revenue per season.
Especially at the top level, nutritional strategies to improve cognition are key to succeeding in this sport. A professional basketball player needs to combine cognitive and physical skills and react to different situations during the game. Moreover, since players need to communicate with each other and their coach while performing, the cognitive load involved in this sport is massive.
Brainberry® is a nootropic ingredient developed by BioActor to help consumers improve their brain fitness in a natural and safe way. More specifically, Brainberry® is an Aronia berry extract from the Baltics, standardized for high levels of cyanidin-3-O-galactoside.
BioActor already conducted 2 double-blind placebo-controlled clinical studies which demonstrated cognitive benefits in middle-aged healthy individuals and in young healthy individuals.
Moreover, in a previous open-label study, Brainberry® improved cognitive performance of amateur gamers. The study revealed that gamers can benefit from the consumption of Brainberry® and improve their gaming skills such as eye-hand coordination and focus.
In follow up to these studies, BioActor now completed another open-label study on 35 professional basketball players in Greece, who consumed 65 mg of Brainberry® for seven days. Basketball is characterized by highly intermittent actions with changes in movement type every 1-2 seconds. Particularly at the highest level, the combination of gross and fine motor skills along with cognitive functions and psychomotor control is key to success. Female and male professional basketball players were selected from teams that participate in the first Greek basketball league.
The objective of the study was to investigate the effect of a daily intake of a capsule containing 65mg of Brainberry® on overall cognitive and basketball-specific skills.
The study results
During the three time points, Baseline (Time 0), Acute (Time 1) and 7 days (Time 2), the participants had to fill out a questionnaire with specific questions aiming at assessing cognitive skills, basketball-specific skills, mood, and sleep quality. At Time 0, the participants did not consume Brainberry®, in order to generate a baseline measurement for their self-reported skills during a basketball session.
The results show that the basketball players who participated in the study experienced a significant improvement (P < 0.05) from day one, in terms of cognitive: focus, reaction time and eye-hand coordination; and basketball-specific skills: shooting, rebounding, and dribbling. At the same time, no significant differences were found in their speed and quality of sleep was not affected.
*Sig (P < 0.05) baseline vs acute; **Sig (P < 0.05) baseline vs after 7 days and ***Sig (P < 0.05) acute vs 7 days
With this additional study, which highlights the ability to enhance cognitive and basketball-specific skills, Brainberry® taps into the sports nutrition segment, where already some sports nutrition brands have adopted the ingredient and formulated products targeting brain fitness for athletes.
Vasiliki Louka, a professional basketball player that belongs to the women’s national Greek team stated:
“Brainberry® surprised me in a good way. This month was really tiring and stressful, especially for the athletes competing for the national team. I felt more focused during my training and considering that Brainberry® contains only natural ingredients, it makes it an interesting choice.”
Furthermore, the participants reported that one of the advantages of Brainberry®, compared to the most common caffeine-based supplements that they have been using, is that Brainberry® did not affect their quality of sleep and, at the same time, helped them decrease their stress level.
About BioActor
BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.
Feel free to contact BioActor via info@bioactor.com for more information on the possibilities Brainberry® has to offer.
Further information can be found on: www.brainberry.eu and www.bioactor.com
What are the best substitutes for caffeine?
What are the best substitutes for caffeine?
A wide variety of caffeine-containing products are available, ranging from coffee and tea to dietary supplements, sodas and energy drinks. However, consuming too much caffeine often leads to side effects such as stress, anxiety, and even sleeping problems. If you are looking for alternative products to boost energy levels and increase focus, Brainberry®, maca root, ginseng, Rhodiola, and Lion’s Mane are natural ingredients that can help you get through the day without side effects.
Why should you substitute caffeine with another ingredient?
Most people drink coffee regularly. It is consumed because people like the taste or because of the social aspects to drinking coffee. Even though there are many ways to improve your focus, coffee is often consumed because it makes people feel more awake, alert, and energetic.
Of course, coffee is a source of caffeine, which is the ingredient that gives coffee its effects. There are other drinks that contain caffeine, and some people even take dietary supplements containing caffeine to boost their energy levels during the day or for their workout. [1].
Besides positive effects, consumption of caffeine may also have some downsides. These include giving people feelings of stress and anxiety. Besides increasing these feelings, caffeine consumption could also lead to insomnia [2].
Caffeine is unique in its function, but these adverse effects are a reason for people to reduce the intake of caffeine and look for alternative ingredients. Here are some suggestions of natural substitutes that make you feel awake and help you focus, without leaving you feeling stressed.
The best substitutes for caffeine
1. Maca root
Maca is a plant that grows in Peru (also called Peruvian ginseng). It’s a plant that belongs to the brassica (mustard) family. It is traditionally used for nutritional and medicinal purposes. The plant is made into a powder that is often added to smoothies, juices, and shakes.
It has been used for centuries as a fertility enhancer in humans and animals, but now more benefits of consuming maca are being discovered. The benefits of maca root vary, and evidence shows it may help increase energy levels and improve mood.
Additionally, other findings show that maca can help against feelings of anxiety and stress. This makes Maca a good alternative to caffeine, which can have the opposite effect.
2. Ginseng
Like maca, ginseng is a herb made from the root of its plant. It has been one of the most important products for health care in Asia. There, it has been used to make traditional medicine for centuries.
There are different types of ginseng, which vary in the way they are grown and processed. White ginseng is dried naturally, while red ginseng is steamed before it is dried, which increases its efficacy. The most important compounds in ginseng are ginsenosides and gintonin [3].
Ginseng is one of the most popular caffeine substitutes. Various research demonstrated that this plant is able to improve brain functions, boost mood and memory, help against fatigue, and increase energy levels.
3. Brainberry® (Aronia berry extract)
Aronia berries are becoming increasingly popular among consumers because of their many demonstrated health benefits. Aronia plants are native to North America but are also commonly found in the Baltic region of Europe.
Brainberry® is an Aronia berry extract researched and developed by BioActor. It was demonstrated that the daily consumption of Brainberry® is able to boost mental energy and focus without side effects. An ideal alternative if you want to get rid of caffeine!
The main constituent of Brainberry is an anthocyanin called Cyanidin 3-O-galactoside, a powerful antioxidant that can improve brain health and support brain function.
If this sparked your interest, you can find out everything you need to know about Brainberry®, brain health and improving your focus here.
4. Rhodiola
Rhodiola is a plant that can be found in Europe and Asia. Like ginseng and maca its root is consumed for health benefits. Rosavin and salidroside are believed to be its most profitable compounds.
Rhodiola has been used for many years and has been mostly recommended to treat headaches, hernias and has also been used as an astringent. Nowadays, rhodiola is often consumed by people during stressful times.
If you’re looking for a natural alternative to caffeine that reduces fatigue, rhodiola is a good option because it has been shown to improve symptoms in participants that suffered from chronic fatigue. The stress-lowering and energizing effects of rhodiola make it a great natural replacement for coffee.
5. Lion’s Mane
Lion’s Mane is a mushroom that can grow long hair-like strings that resemble a lion’s mane. It is often found in North America, Europe, and Asia. It consists for roughly 20% out of protein.
Lion’s Mane is increasingly studied. It has properties that are believed to be neuroprotective. That is because two novel nerve growth factors have been discovered in this mushroom [4].
Lion’s Mane has thus been said to have positive effects on the brain. It can improve memory and helps to lower feelings of stress and anxiety. This makes it an ingredient that can help consumers cut down on their caffeine consumption.
The bottom line
We all love a good cup of coffee in the morning. However, there are several reasons to reduce caffeine intake and look for a substitute. The aforementioned ingredients are good natural alternatives to caffeine as they can boost energy levels and brain functions, without having any anxiety or stress inducing effects.
BDNF: A key molecule for cognition and eye health
BDNF: A key molecule for cognition and eye health
Brain-derived neurotrophic factor (BDNF) is a protein highly expressed in the central nervous system, especially in the brain. BDNF promotes the growth of dendrites and dendritic spines, contributing to synaptic strength and plasticity in the hippocampus, thus important for learning and long-term memory. Research shows that increased levels of BDNF in serum are correlated with improved cognitive functions while decrease in BDNF is associated with neurodegenerative and mental illnesses. Moreover, new scientific evidence suggests that BDNF is also an important factor in eye health.
What is BDNF and why is it so important?
BDNF belongs to the neurotrophin family of growth factors and plays an important role in brain development, mainly growth and maturation of neurons and synapses.
Highest levels of BDNF can be found in hippocampus, amygdala, cerebellum and cerebral cortex in both rodents and humans [1]. As well as in the brain, BDNF has been detected in other tissues such as the eye, lung, liver and skeletal muscle.
Today we know that BDNF is also crucial for the adult brain, where it regulates synaptic changes and efficacy.
BDNF is believed to be involved in the cellular mechanisms underlying memory formation and consolidation, learning and other complex behaviors by promoting long term potentiation in hippocampus [2].
BDNF in disease and the ageing brain
BDNF also seems to play a significant role in brain damage repair. Studies have shown that following traumatic brain injury, the mRNA expression level of BDNF is temporarily significantly upregulated in the injured cortex and in the hippocampus. These findings suggest that BDNF acts as an endogenous neuroprotective mechanism attenuating cell damage [3].
In addition, emerging scientific data suggest that BDNF could be involved in the pathophysiology of brain-associated diseases. Impaired BDNF signaling has been observed in several diseases, such as Huntington’s disease, Alzheimer’s disease, depression, schizophrenia, and bipolar and anxiety disorders.
Finally, part of the natural process of ageing is reduction of hippocampal volume and decrease in BDNF expression, which is associated with age-related cognitive decline [4].
What is the role of BDNF in eye health?
BDNF is produced by neurons and glial cells in the retina. Similarly to the brain, research indicates that BDNF could be involved in retinal development by modifying neuronal cell number or synapse formation [5].
Nowadays, our eyes are constantly being overworked as a consequence of increased usage of visual display terminal (VDT) devices, such as smartphones, computers or tablets. This can negatively affect blink frequency, which can induce dry eye and associated symptoms including pain, burning and visual disturbances.
Interestingly, BDNF knockdown mice showed decreased basal tear secretion, pointing at the role of BDNF in tear secretion and to the pathology of dry eye disease [6].
Moreover, recent studies show that BDNF plays a vital role in other eye diseases, such as age-related macular degeneration (AMD) or diabetic retinopathy (DR). In AMD patients, serum BDNF levels are decreased and the same trend is observed in DR patients.
These findings suggest that optimal BDNF levels may be necessary to exert protective effects on the eye and that decreased levels of BDNF signal eye disease [7, 8].
How can you increase BDNF naturally?
Control your stress levels
Acute stress down-regulates hippocampal BDNF mRNA expression and interestingly, antidepressants up-regulate BDNF expression [9]. Practicing yoga or other stress management techniques therefore seem to be an efficient way how to boost your BDNF [10].
Exercise
Some studies have shown that exercise enhances the expression of BDNF. The reasoning is not fully understood but one possible explanation is that exercise leads to the release of the ketone body β-hydroxybutyrate, which in turn induces the activity of BDNF promoters [11].
Practice occasional fasting
Not every stress is bad for your brain: it appears that mild metabolic stress associated with dietary restriction leads to significantly enhanced expression of various neurotrophic factors, BDNF included. A study showed that following 48-hour fasting, BDNF was significantly upregulated in human skeletal muscle [12].
Eat anthocyanin rich foods
Apart from the above mentioned, dietary interventions have been also gaining on attention as a potential strategy to elevate BDNF levels. There is extensive scientific evidence that foods high in anthocyanins, such as edible berries, are good for your brain health [13]. A recent study showed that 6-week supplementation of pure anthocyanins increased BDNF expression and improved spatial and psychomotor performances in aged rats [14].
Aronia melanocarpa anthocyanins and BDNF
Aronia melanocarpa is a berry native to North America, which is higher in anthocyanins than any other berries. Aronia-specific anthocyanin, cyanidin-3-O-galactoside (Cy3Gal), crosses the blood brain barrier and interacts with BDNF sinaling pathway, thereby contributing to a better neuronal signalling.
In a double-blind placebo-controlled crossover study, we recently demonstrated that short-term supplementation of Brainberry®, aronia melanocarpa extract with a standardized content of Cy3Gal, significantly increased BDNF levels in healthy young adults.
Curious to know more about brain health and how Cy3Gal can increase BDNF? Find out more!
The bottom line
Given all the scientific evidence, BDNF plays a huge role in brain fitness, brain disease and eye health.
Manipulating BDNF levels through dietary factors might be a promising strategy to not only treat various neurological and psychiatric disorders, but also to naturally boost memory and learning.
To level-up BDNF is desirable for everyone: not only for the ageing population but also for young professionals seeking ways to enhance their cognition.
Cyanidin-3-O-Galactoside: A Natural Compound for Brain Health
Cyanidin-3-O-Galactoside:
A Natural Compound for Brain Health
Cyanidin 3-O-Galactoside is a powerful anthocyanidin naturally present in some foods and found in particularly high concentrations in Aronia melanocarpa berries (chokeberries). Research has demonstrated that this active compound is able to cross the blood-brain barrier and play a beneficial role in brain health and cognition. Cyanidin 3-O-Galactoside is believed to stimulate neurogenesis, improve neuron plasticity and reduce neuronal damage.
What is Cyanidin 3-O-Galactoside?
Cyanidin 3-O-galactoside (Cy3Gal), also known as ‘Idaein’, belongs to the class of organic compounds called anthocyanins and, more specifically, to the anthocyanidin-3-O-glycosides.
Cy3Gal is a water-soluble molecule found in high concentrations in some fruits –red-skinned apples and berries in particular– and it is responsible for their characteristic pigmentation.
Aronia melanocarpa berries, also known as chokeberries, contain the highest Cy3Gal content of all fruits, and are the most practical and efficient natural source to use for mechanical, water-based extraction of Cy3Gal in a high concentration.
Several health benefits of Cy3Gal in humans have been researched due to its excellent antioxidant capacity as well as anti-inflammatory and anti-diabetic properties [1].
However, brain health benefits and improved cognition are perhaps the most interesting when it comes to the health benefits provided by this active compound.
Cyanidin 3-O-Galactoside and brain health benefits
One of the most interesting properties associated with Cy3gal is the potential effect on brain health and cognition.
Cy3Gal is able to cross the blood-brain barrier and enter a wide range of brain regions, including the cortex, cerebellum and hippocampus.
In the hippocampus, Cy3Gal lowers the activity of acetylcholine esterase, triggering an increase in acetylcholine, which results in improved neuronal signalling.
At the same time, Cy3Gal increases the activity of brain-derived neurotrophic factor (BDNF), resulting in increased neuron plasticity and neuronal functions. [2]
Moreover, according to a recently published study in the Journal of Agricultural and Food Chemistry administration of Cy3Gal for 8 weeks in ageing mice relieved neuronal damage in the hippocampus and cortex [3].
The researchers determined that protein kinase B (AKT) may be the target of Cy3Gal, which played a beneficial role in controlling the brain’s energy metabolism, suggesting that early intervention with Cy3Gal could promote neuroprotection.
All in all, scientific evidence shows that Cy3Gal may produce neuroprotective activity and improve cognitive function [1, 4, 5].
Cyanidin 3-O-Galactoside: Brainberry®’s hero compound
Cy3Gal is one of the main focuses of BioActor’s research program, which together with Maastricht University (“UM”) established a Public-Private Partnership (“PPP”) to study the effects of Brainberry® on brain fitness and cognition.
Brainberry® is an Aronia melanocarpa extract standardized for high levels of Cy3Gal, developed by BioActor.
Brainberry® was investigated in the first-ever study to link Aronia berry extract to improved cognitive performance.
A 12-week double-blind placebo-controlled clinical study that included 101 subjects linked Aronia berry extract (Brainberry®) to a significant increase in psychomotor speed, eye-hand coordination and focus [6].
Sounds interesting? Here’s everything you need to know about Brainberry® and brain health.
The Link between Gut and Brain Health
The Link between Gut and Brain Health
The bidirectional communication system between your gut and brain is called the gut-brain axis. These two organs are connected through the vagus nerve, neurotransmitters, production of short-chain fatty acids (SCFAs) by gut microbiota and the immune system. This gut-brain link works in both directions. Gut bacteria affect brain health and, therefore, altering your gut bacteria through compounds such as probiotics and prebiotics may improve your brain health.
The Gut-Brain Connection
Did you ever “go with the gut” to make a decision? Have you ever felt “butterflies in your stomach” when nervous? This is because the brain and the gastrointestinal system are closely connected.
The bidirectional communication system between your gut and brain is called the gut-brain axis. These two organs are connected both physically through the vagus nerve and biochemically through hormones and neurotransmitters.
Gut microbiota has an important impact on the gut-brain axis, interacting not only locally with intestinal cells and enteric nervous system (ENS), but also directly with the central nervous system (CNS).
The Vagus Nerve
Your gut contains 500 million neurons, connected to your brain through the nervous system [1].
One of the biggest nerves connecting your gut and brain is the vagus nerve, which sends signals both ways. Gut microbiota communication with the brain, therefore, involves the vagus nerve [2].
Conditions such as Chron’s disease and irritable bowel syndrome (IBS) involve brain-gut dysfunctions where the vagus nerve is an important component.
People suffering from these conditions actually have a reduced vagal tone, which indicates a decreased function of the vagus nerve [3].
Neurotransmitters
Your gut and brain are also connected through neurotransmitters. Neurotransmitters produced in the brain have an impact on our feelings and emotions.
Many of these neurotransmitters are produced by our gut cells and microbiota as well.
Around 90% of serotonin, a neurotransmitter that contributes to feelings of happiness, is produced by enterochromaffin cells, a group of gut mucosal cells [4].
Gamma-aminobutyric acid (GABA), a neurotransmitter that helps control feelings of fear and anxiety, is also produced by many species of Lactobacillus and Bifidobacterium in the gut microbiota [5].
Production of SCFAs by gut microbiota
Gut microbiota produces short-chain fatty acids (SCFAs), such as butyrate, propionate and acetate.
These SCFAs have a lot of health benefits in the gut, including maintaining the intestinal barrier, increasing mucus production and reducing gut inflammation. On top of that, they also play a role in the gut-brain interaction.
SCFAs can affect brain function in different ways. They are able to stimulate the sympathetic nervous system, mucosal serotonin release and influence the memory and learning process in the brain [6].
Immune system
Your gut and brain are also linked through the immune system. The microbiota provides essential signals for the development and function of the immune system.
The microbiota, its metabolites and components are not only necessary for immune homeostasis, but they also influence your susceptibility to many immune-mediated diseases and disorders [7].
If the gut barrier becomes leaky, bacteria and lipopolysaccharide (LPS) –an inflammatory toxin produced by some bacteria– can enter the blood, causing inflammation.
Inflammation and high LPS content in the blood are associated with brain disorders, such as depression and dementia [8].
The Role of Probiotics and Prebiotics in the Link between Gut and Brain
The gut-brain connection works in both directions. Gut bacteria affect brain health and, therefore, altering your gut bacteria may improve or worsen your brain health.
Probiotics are beneficial live bacteria. Psychobiotics are a class of probiotics that are able to produce and deliver neuroactive substances such as GABA and serotonin, which act on the brain-gut axis [9].
Studies have found that some psychobiotics have antidepressant or anxiolytic activity. These effects may be mediated via the vagus nerve, spinal cord, or neuroendocrine systems [10].
Prebiotics are compounds derived from non-digestible carbohydrates, mostly fibre. Prebiotics may also affect brain health by lowering cortisol levels, the stress hormone [11].
Beneficial Foods for the Gut-Brain Axis
Some foods can be beneficial for the gut-brain axis. These include the following:
• Probiotic foods. Probiotics can be found in fermented foods and drinks, such as yoghurt, kefir, tempeh or kombucha.
• Prebiotic foods. Prebiotics can be found in high fibre foods, such as vegetables, fruits, nuts, seeds and whole-grain products.
• Omega-3 fats. Omega-3 fatty acids can improve microbiota diversity [12]. These fats can be found in fatty fish, such as salmon, mackerel, tuna, herring and sardines.
• Polyphenol-rich foods. Polyphenols are found in foods such as cocoa, citrus, green tea, olive leaf and coffee. These compounds, digested by gut bacteria, increase healthy bacteria strains and may improve cognition [13].
• Tryptophan-rich foods. The amino acid tryptophan is the precursor of serotonin. Tryptophan is found in milk, cheese, oats, turkey and chicken, among others.
Curious to know more about brain health?
Did this article spark your interest in brain health and how you can improve it? Here you can find out everything you need to know about brain health and what ingredients are best to keep a healthy brain!
Brainberry® – A promising ingredient for gaming supplements
Brainberry® – A promising ingredient for gaming supplements
Brainberry® is an Aronia melanocarpa extract that provides an innovative and natural way to boost gaming performance in a safe and effective way. If you plan to get rid of typical sugar- and stimulant-loaded supplements and energy drinks, Brainberry® may be the healthier alternative you are looking for. Thanks to its high content in functional anthocyanins, it promises to enhance gamers’ experience by providing sustained crash-free energy, as well as clinically proven brain benefits.
Why are supplements relevant for gaming?
Gaming has grown exponentially over the last few years, not only in amateur gamers but also in professional ones– eSports.
If you are a gamer yourself, you may have already noticed that gaming requires an incredible number of mental skills. Indeed, gaming is continuous and with very few breaks. Therefore, you need to manage a high cognitive workload, especially if your session will last for an extended period of time.
Visual-spatial skills are essential. These skills allow you to analyse, recognize and rapidly respond to changes on the screen. In addition, as gaming sessions can last for hours, enhanced attention and focus are crucial too. You need to have the skills to stay focused and alert, without getting sleepy and distracted.
Lastly, when gaming, it is important that you manage emotions, such as anger, anxiety and stress, as these can negatively impact your performance.
Even though nutrition has been often overlooked by most gamers, the supplement industry for this segment is growing exponentially, showing that more and more attention is being paid to this important aspect.
Over the last year, in fact, several brands have launched gaming formulas on the market and supplement use is continuously increasing amongst gamers looking to up their gaming performance. There is a wide range of products tailored to gamers, ranging from powders to capsules, functional drinks and even gummies.
Whether you are a competitive gamer or not, taking care of your body and mind through proper nutrition, supplements, and rest can yield the best results.
What is the main problem with most gaming supplements and energy drinks?
Supplements have the potential to enhance your cognitive performance when gaming. As mentioned, together with the increased number of gamers, gaming supplement and energy drink interest and consumption has significantly grown in the last years.
However, as you may have experienced, many of these products contain high amounts of caffeine and sugars. High intakes of these two compounds are generally associated with negative health effects.
After a high caffeine intake, you may experience tachycardia, jitters, headaches or disrupted sleep [1, 2, 3]. In fact, excessive caffeine consumption can have a negative impact on your brain performance. On top of this, a high caffeine consumption during the teenage years is associated with an increased risk of suffering from anxiety disorders in adulthood [4].
On the other hand, a high sugar intake may lead you to unhealthy weight gain and dental caries, both undesired health effects. Moreover, high sugar spikes in the blood are often followed by an energy crash, which is not ideal when you need to be focused.
If you plan to get rid of typical sugar- and stimulant-loaded supplements and energy drinks, Brainberry® may be the healthier alternative you are looking for.
What is Brainberry®?
Brainberry® is an Aronia melanocarpa extract, standardized for high levels of the anthocyanin cyanidin-3-O-galactoside. This ingredient is clinically validated to improve focus and psychomotor control.
The consumption of anthocyanins has been associated with an improvement in cognition skills, such as memory, attention and psychomotor speed [5, 6, 7].
The active cyanidins present in Aronia berry extract in the form of cyaniding-3-O-galactoside are able to cross the blood-brain barrier and contribute to brain perfusion.
In the hippocampus, cyanidin-3-O-galactoside lowers the activity of acetylcholine esterase, triggering an increase in acetylcholine, which results in improved neuronal signalling. This leads to faster and more accurate reactions due to improved visual processing speed and psychomotor control.
Brainberry® is water-soluble, easy to formulate and has a pleasant taste. Its possible applications include liquid forms (e.g. ready-to-drink formulas), chewable tablets, gummies, effervescent tablets, stick packs and capsules.
What makes Brainberry® an ideal ingredient for gaming supplements?
Brainberry® is the ideal ingredient for gaming supplements for several reasons:
• 100% natural. Extracted from high-quality Aronia berries from the Baltics, it is a completely natural ingredient.
• Clinically proven. It has been validated in a randomized, double-blind, placebo-controlled trial.
• Increased visual processing speed. Its hero compound, cyanidin-3-O-galactoside, significantly improves psychomotor control, resulting in better eye-hand coordination.
• Tested in gamers. It has been successfully tested in a consumer study with active gamers.
• Low dosage and stimulant-free. The recommended daily dose is 65 mg. It does not contain stimulants, which are usually accompanied by undesired side effects. This makes it a healthier option compared to other solutions high stimulants.
• High bioavailability. The bioavailability of the active compound present in Brainberry®, cyanidin-3-O-galactoside, has been evaluated and it has demonstrated a rapid absorption.
• Easy to formulate. Thanks to its excellent solubility and pleasant taste, it is possible to include it in a wide range of forms (e.g. drinks, gummies, capsules…).
What type of research has been conducted with Brainberry®?
Double-blind placebo-controlled trial
Brainberry® has been investigated in the first-ever study to link Aronia berry extract to improved cognitive performance. A 12-week double-blind placebo-controlled clinical study that included 101 subjects linked Aronia berry extract (Brainberry®) to a significant increase in psychomotor speed, eye-hand coordination, and focus.
After only 6 weeks of supplementation with 65 mg of Brainberry® daily, a significant improvement in psychomotor speed was observed, with even a further increase for the rest of the trial (12 weeks).
After 12 weeks, concentration was increased by 43% in the group supplemented with 65 mg of Brainberry®. [8]
Consumer study with active gamers
More recently, a consumer study was conducted in active gamers using Brainberry®. Twenty-one healthy young recreational active gamers consumed 65 mg of Brainberry® daily for 7 days.
After just one dose of Brainberry®, participants successfully reported a significant improvement in the most relevant measures for gaming performance, such as eye-hand coordination, focus, reaction time and energy.
As gamers need fast-acting noticeable effects, the significant improvements in eye-hand coordination, focus, energy and reaction after a single dose, confirmed the effectiveness of Brainberry®.
What’s perhaps even more important, is that these improvements were sustained after one week of supplementation.
As mentioned before, mood is also key during a gaming session. In fact, not being able to deal with difficult emotions (i.e. anger, stress, anxiety) that are likely to arise while competing, negatively impact performance. Interestingly, the participants in the study reported an improvement in mood parameters after one week of supplementation with Brainberry®.
It is important to point out that supplementation with Brainberry® after the seven days, did not have any negative effects on fatigue, sleep quality and anxiety levels. It is well-known that these types of complaints are frequently reported by subjects (often gamers) who consume large quantities of sugar- and stimulant-loaded energy drinks.
The bottom line
Brainberry® is an Aronia melanocarpa extract that provides an innovative and healthy solution to boost gaming performance in a natural and safe way. Thanks to its high content in functional anthocyanins, it promises to enhance gamers’ experience by providing sustained, crash-free energy and clinically proven brain benefits.
Brainberry® is the perfect alternative to supplements and energy drinks that are high in sugar and caffeine. It allows limiting these compounds in your diet while offering sustained crash-free energy, as well as clinically proven brain benefits.