hydration sports drinks

How to stay hydrated and increase physical performance?

How to stay hydrated and increase physical performance?

Maastricht, 16th February 2024

Hydration is the key to optimal physical activity. Our bodies work constantly to maintain an internal fluids balance. Effectively managing water loss is crucial for sustaining the body’s health and physical performance. In this blog we explore hydration and sports drinks. How can we stay hydrated and enhance performance?

hydration sports drinks

What is water balance?

When engaging in physical activity, body temperature rises due to increased muscle activity. In response, the body produces sweat to cool down. This process helps regulate body temperature as water and mineral salts evaporate from the skin.

Indeed, water loss during physical activity is a desirable natural process. Its rate varies based on factors such as the intensity and duration of the activity, environmental conditions, and individual differences. On average, an hour of moderate physical activity can cause a person to lose around 0.5 to 1 litre of water (1, 2). Maintaining the water balance in the body is essential to avoid dehydration and optimize overall physical performance.

 

How to maintain a healthy water balance and prevent dehydration?

Dehydration can impact performance of any exercise longer than 15s (3) by affecting endurance, strength, cognitive function, and delaying recovery. Therefore, maintaining a healthy water balance is crucial. Sport drinks are a great choice to solve this issue as they provide plenty of water and supply the electrolytes needed to maintain the body water balance (4).

 

The role of electrolytes

Electrolytes are essential minerals that play a crucial role in maintaining proper hydration and overall bodily function. When we sweat during physical activity or in hot environments, we lose electrolytes along with water. These electrolytes include sodium, potassium, chloride, calcium, and magnesium. Electrolytes help regulate the balance of fluids within the body. Sodium, for example, helps the body retain water, while potassium works to balance sodium levels and regulate fluid distribution within cells (5).

Sports drinks with electrolytes

Depending on their electrolyte concentration, sport drinks can be classified as isotonic, hypertonic, and hypotonic. Each of them serves different purposes. The choice of which type of drink to use depends on individual needs and the type and duration of physical activity.

Hypotonic drinks contain a lower concentration of sugars and electrolytes that the one the body has. Hypotonic drinks are ideal for quick hydration for low duration sports (6).

Isotonic drinks have a concentration of sugars and electrolytes that tries to mimic the body’s concentration and are typically used for electrolytes and water replenishment. They are ideal for endurance events longer than 40 minutes (7).

Lastly, hypertonic drinks contain a higher concentration of electrolytes and sugars than the body does (8). This high dose of electrolytes and sugar is particular useful for long duration sports and is ideal for glycogen stores and fluids replenishment (9).

 

How to improve your standard sports drink beyond electrolytes?

Several beneficial ingredients can be added to a sports drink to enhance its functionality and provide additional benefits to athletes and individuals engaging in physical activity. Here are some examples:

Carbohydrates: Carbohydrates are a primary source of energy for muscles during exercise. Fast absorbed ones like glucose, fructose and maltodextrin are a perfect fit for a sports drink to provide a readily available fuel source (10). On the other hand, adding slow digestible carbohydrates such as isomaltulose or arabinoxylans is also a good strategy to sustain endurance and performance during prolonged activity.

Polyphenols: polyphenols from sources like citrus extracts and Aronia berries can help improve performance by increasing focus, force and endurance.

Caffeine: Caffeine is a stimulant that can enhance mental alertness, focus, and endurance performance. Including caffeine in a sports drink can provide an extra boost of energy and improve exercise performance, particularly during intense workouts or endurance activities.

Vitamins and Minerals: Adding vitamins and minerals such as vitamin C, vitamin E, B-vitamins, and zinc can support overall health, immune function, and recovery from exercise-induced oxidative stress.

Amino Acids: Branched-chain amino acids (BCAAs) such as leucine, isoleucine, and valine may aid in muscle recovery, reduce muscle soreness, and support muscle protein synthesis. Other amino acids like glutamine may help maintain immune function and gut health during intense training.

Adaptogens: Adaptogenic herbs like rhodiola, ginseng, or ashwagandha may help improve resilience to stress, enhance endurance, and support recovery from intense exercise.

Conclusion

Preventing dehydration is crucial for physical performance and subsequent recovery. Choosing the right sports drink with the best quality ingredients according to individual needs is the best strategy to keep hydrated and boost performance.


New Approved Health Claim for Watts'Up®

WATTS’UP® receives an additional approved health claim from Health Canada

Maastricht, 14th February 2024

PRESS RELEASE

Health Canada has issued a new Product Licence for WATTS’UP® and has approved the use of an additional health claim: “Helps to improve average power output during high intensity exercise in moderately trained individuals.

power strength wattsup bioactor solabia

WATTS’UP®, a customized flavonoid extract from sweet orange, has been tested in 2 double-blind placebo-controlled studies. The latest study was conducted in moderately trained men and women and showed a significant improvement in exercise performance with a significant increase in peak force and average 30 seconds power output.

Health Canada has issued a new Product Licence for WATTS’UP® with an enlarged scope. Pursuant to this Product Licence, WATTS’UP® is recommended to be used as “Athletic support” or “Workout/Exercise supplement.”

The following specific claims have been allowed by Health Canada: “Helps to improve average power output during high intensity exercise in moderately trained individuals” ; “Helps improve physical performance during exercise in trained male athletes”; and “Provides antioxidants that help cells to fight against the oxidative effect of free radicals and that helps protect cells and reduce oxidative damage and cell damage caused by free radicals”

The Journal of the International Scoiety of Sports Nutrition has published the results of the latest clinical study with WATTS’UP®. WATTS’UP® is a patent-protected citrus extract with enhanced bioavailability. It was tested in moderately trained athletes (both men and women) and showed a significant increase in power output during the Wingate anaerobic exercise test.

WATTS’UP® can be found on the market in multiple products in the USA, Europe, and Asia. It can be applied in various finished dosage forms, including powders, effervescent tablets, capsules, RTD sachets and beverages.

Feel free to contact us via info@bioactor.com for more information on the possibilities WATTS’UP® has to offer.

Further information can be found on: www.wattsup.eu

 

About Solabia – BioActor

BioActor, a Solabia Nutrition company, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive formulations with clinical studies. The company focuses on the development of innovative bioactives that address healthy living and ageing. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

For further information, see www.bioactor.com


supplement to slow down aging

Actiful®: a key ingredient for healthy aging

Actiful®: a key ingredient for healthy aging

Maastricht, 29th January 2024

Are you looking for an impactful science-based ingredient to add to your energy and vitality supplement? Well, look no further as the research-based evidence is expanded on the key role of Actiful® in supporting energy production, improving mental wellness, and reducing oxidative stress.

supplement to slow down aging

How can we slow down the aging process?

Aging is a complex process (1) characterized by a gradual decline in physiological function and an increased susceptibility to various diseases. It encompasses a range of biological, psychological, and social changes that occur over time. At the cellular level, aging involves factors such as mitochondrial dysfunction and accumulation of damage from oxidative stress. These processes contribute to a decline in the efficiency of cellular repair and maintenance mechanisms.

 

Factors impacting the aging process

Additionally, genetic and environmental factors play significant roles in influencing the rate of aging. While aging is a natural and inevitable part of life, lifestyle choices, such as diet, exercise, and stress management, can impact the rate at which the aging process unfolds. Continuous research is taking place to study aging and better understand potential interventions to promote healthy aging and longevity (2).

 

A combination of diet and supplementation

Slowing down the aging process involves adopting a holistic approach that addresses various aspects of one’s lifestyle. A balanced and nutritious diet rich in antioxidants, vitamins, and minerals is crucial for maintaining cellular health and preventing oxidative stress. Regular exercise, adequate sleep and stress management can positively impact both mental and physical health (3). Avoiding harmful habits such as smoking and excessive alcohol consumption is also vital, as they accelerate the aging process.

 

Combining these lifestyle factors and taking appropriate supplements can create a foundation for a healthier and more vibrant aging experience. Adding supplements to the diet can be beneficial for healthy aging, as they can help address specific nutrient deficiencies and support overall well-being. They are often recommended for digestive health, immune support or cell function optimization. (4, 5)

mitochondria health and energy and healthy aging

Actiful®: clinically proven ingredient for healthy aging

Actiful® is a patent-protected plant-based ingredient for improved energy production, mental wellness and mitochondria support. It is standardized for hesperidin which is a key polyphenol extracted from sweet oranges (Citrus sinensis). Actiful® also contain pomegranate (Punica granatum), known to be rich in nitrate and useful for NO production, leading to vasodilation. Previous clinical data has already shown the beneficial properties that the combination of these polyphenols has in terms of enhanced physical performance (6, 7), mental health support (7), improved energy production by the mitochondria (8) and improved blood flow (9).

Recent clinical data further underlines the benefits that Actiful® brings to the table. The combination of hesperedin and pomegranate in a 350mg supplement capsule was provided to healthy seniors for 4 weeks in a randomised, blinded, placebo-controlled manner. In the end of the intervention period, the concentration of methylglyoxal (MGO) in the blood decreased by ≈ 10% (10). This is a statistically significant and clinically relevant result as MGO accumulation in cells leads to cellular disfunction and shorter cell life. Clearly, you would like to stimulate MGO scavenging, if you are targeting healthy aging. 

 

The role of Actiful® in supporting the mitochondria

The mechanism of action of the polyphenols present in Actiful® is quite complex and apparently linked with benefits and protection for our mitochondria, the so called ‘powerhouse’ of the cells. Hesperidin and pomegranate are known for their antioxidant properties (11, 12), which contributes to the direct MGO scavenging. They also reduce oxidative stress which leads to support of the natural body’s detoxification mechanisms. All of the above mentioned benefits are directly linked with the potential of Actiful® to protect the mitochondria and support its function via the reduction of MGO, observed in the latest clinical data of Actiful® (10).

 

The potential of Actiful® for the supplements market

The latest data allows Actiful® to expand its market possibilities. It can be an active ingredient in vitality supplements for mid-aged adults and active seniors as well as in energy drinks and sports drinks. Actiful® can be marketed for its beneficial effects on vitality, mental wellbeing, energy production and mitochondria support.


Solabia BioACtor Quadram Institute

BioActor & Quadram Institute announce collaboration

Solabia-BioActor announces the start of a collaboration with The Quadram Institute to assess the bioavailability and kinetics of Brainberry®

Maastricht/Norwich, 29th November  2023

Solabia-BioActor announces the start of a collaboration with The Quadram Institute to assess the bioavailability and kinetics of Brainberry®, Solabia-BioActor’s proprietary Aronia melanocarpa extract.

Solabia BioActor Quadram Institute

Solabia-BioActor has expertise and experience in developing innovative active ingredients, extracted from plants (botanicals) with great potential to support human health in terms of cognitive support, healthy aging and gut health enhancement.

 

The Quadram Institute is a premier research organization, based at the Norwich Research Park in the United Kingdom. It is home to researchers and clinicians that work together to develop world-class health, microbiome and food science. 

 

Solabia-BioActor’s Senior Scientist Sanne Ahles takes the lead on this collaboration together with Dr. Paul Kroon, a principal investigator at The Quadram Institute. Dr. Kroon is the leader of the Polyphenols and Health Group and his research focuses on understanding the mechanisms by which dietary polyphenols are absorbed and exert health benefits.

 

The objective of this project is to study the bioavailability and kinetics of Brainberry®, a proprietary aronia melanocarpa extract, in human volunteers. BioActor will carry-out the human intervention study and the Quadram Institute will identify and quantify a broad range of metabolites in a variety of samples obtained in the study.

Sanne Ahles, Senior Scientist at Solabia-BioActor comments:

“The bioavailability of Brainberry® has not been researched until this point. This collaboration with the Quadram Institute will allow us to broaden our knowledge regarding the anthocyanin metabolism and shed light on any possible differences between its steady-state bioavailability in young and older adults.”

About Solabia-BioActor

Solabia-BioActor, based in Maastricht, Netherlands, is a product development company that develops and supplies proprietary bioactive formulations to the health and sports nutrition industry. All Solabia-BioActor’s products are clinically tested, doping-free and from natural origin. The main focus areas are: gut microbiome, brain health, energy & vitality and skin health.


Brainberry®: Winner of Ingredient Idol 2023

Brainberry® is the Winner of Ingredient Idol 2023, Nootropics 

Maastricht, The Netherlands, 2nd November  2023

We are happy to announce that Brainberry® won the Ingredient Idol 2023 award in the Nootropics Category! The contest was organized by Informa Markets and held at SupplySide West on October 26, 2023 in Las Vegas.

Ingredient Idol winner

Out of all ingredients that were submitted for the competition in the Nootropics category, Brainberry® was selected as one of the three finalists that was invited to give a 3-min elevator pitch at the SupplySide West show in Las Vegas. Brainberry® was voted as Winner by the respected jury because of its unique clinically validated benefits on psychomotor control, better focus and mental flexibility.

Judges were three experienced professionals in the field of health and nutrition:

  • David Foreman, also known as “The Herbal Pharmacist” is an established author, and currently on the  editorial advisory board for Nutritional Outlook and on the content advisory board for Vitafoods Europe, Vitafoods Asia and Vitafoods Insights.

 

  • Douglas Lynch, CEO of MarketWell Nutrition Inc., has three decades of experience in the clinical nutrition and wellness industries. He has an award-winning product background in sales and marketing of dietary supplements, medical foods, functional foods, cosmetics, animal nutrition, and proprietary actives.

 

  • Diana Morgan, VP of global regulatory and government affairs for Nutrabolt, makers of the famous C4 Energy, is the founder of What’s Up with Supps. She has numerous years of experience in the natural products industry, having worked for reputable brands in the US nutritional supplement industry.

We are thankful to the jury and all visitors at SupplySide West for voting Brainberry® as the winner in the Nootropics category of Ingredient Idol 2023. Brainberry® was recognized for its advantages such as the low daily dose of 65mg, clinically backed benefits for improving focus and eye-hand coordination, and convenience of formulating in different product formats.

We strongly believe in the importance of clinical research backing up all our ingredients in order to offer true innovation in the health ingredients market. Brainberry® is an extract from Aronia Melanocarpa, standardized for Cyanadin-3-O-glycosides (>25%) and, specifically cyanidin-3-O-galactoside (>15%). It is able to cross the blood-brain barrier and improve neuronal signaling and synaptic plasticity. It is positioned for brain and cognitive support suitable for students, workers, gamers and athletes.

Consumer studies with acute and 7-days intake of 65mg Brainberry® among gamers and professional basketball players demonstrate improved eye-hand coordination, focus and reaction time, without negative impact on sleep or anxiety in self-reported questionnaires.

 

To learn more about Brainberry®, visit www.brainberry.eu, to explore other clinically validated ingredients by Solabia-BioActor, click here.


men health

Top 5 ingredients for men's health

Top 5 ingredients for men’s health

October 30th, 2023

Incorporating health ingredients into daily routines helps to support men’s well-being and health. We will provide you with evidence-based recommendations on five key ingredients supporting men’s health and sexual function, including fenugreek seed extract, zinc, B vitamins, pomegranate extract, and hesperidin.

men health

In today’s fast-paced world, prioritizing our health and well-being is becoming more and more important, also for men. As the increasing expectations and pressures of our lives continue to evolve, it is important for men to develop a proactive approach to maintain their physical, mental, and sexual health.

Health ingredients are designed to meet men’s health needs, ensuring that they stay healthy and full of energy. In this article, we will provide evidence-based recommendations on five key ingredients supporting men’s health and sexual function.

Fenugreek seed extract

As men age, they experience a decrease in testosterone levels. This phenomenon is also known as andropause. Testosterone plays a role in many aspects of health, including sexual function, muscle and bone mass, energy levels, and metabolism. One of the ingredients that may help to combat the problems related to andropause is fenugreek seed extract . Fenugreek (Trigonella foenum-graecum) is a very interesting herb with many potential health benefits.

A study performed on 120 healthy men showed that a 12-week supplementation of fenugreek seed extract (600 mg/day) increased testosterone levels and improved sexual function, compared to placebo [1]. Also, supplementation of fenugreek seed extract in healthy male athletes resulted in increased fat-free mass, lean body mass, and elevated testosterone levels compared to placebo [2]. These findings suggest that fenugreek seed extract is a promising ingredient for men’s health, especially in terms of increasing testosterone levels and improving sexual function.

Zinc

Zinc is an essential mineral, which means that it is not produced by the body itself. It plays an important role in many physiological functions, such as supporting the immune system and healing damaged cells. Zinc is a critical mineral for men’s health as even a small deficiency can impact the immune system, cardiovascular health, reproductive function, and fertility [3].

Sufficient intake of zinc contributes to normal fertility and sexual function in males. Low levels of zinc are related to low levels of testosterone. Besides, it is also important for the normal functioning of the immune system, and the maintenance of bone health [4].

Therefore, we can state that zinc is an important mineral that can help men improve their sexual health and energy levels and maintain a healthy immune system.

B Vitamins

B vitamins play a vital role in the human body. They are involved in many important functions. For example, they are crucial for energy production, oxygen support, and bone health.

The vitamin B complex consists of a total of eight B vitamins, with several of them having beneficial effects on men’s health, for example:

Vitamin B12: Adequate levels of vitamin B12 are important for the production of red blood cells, which are responsible for oxygen transport. Also, studies showed that vitamin B12 is important for bone health [5, 6].

Vitamin B9: Vitamin B9, also known as folate, is not only an important vitamin for women but also for men. Research has shown that folate contributes to the reduction of fatigue, which is a common complaint nowadays [7].

Vitamin B6: Vitamin B6 plays a vital role in energy and vitality. Intake of this vitamin contributes to normal energy metabolism. Studies also showed that it leads to a decrease in fatigue and tiredness [8].

Vitamin B5: Pantothenic acid, also known as vitamin B5 is an essential vitamin, which plays a vital role in various functions in the body. It is mainly known for its important role in the metabolism of food, leading to energy production [9].

All in all, B vitamins are important for energy production. Increased energy levels lead to improved stamina and sexual performance.

Pomegranate extract

Pomegranate (Punicagranatum L.) is a fruit that contains lots of healthy phytochemical compounds, such as polyphenols, flavonoids, and nitrates [10]. These phytochemicals have many antioxidant and anti-inflammatory qualities beneficial for men’s health [11].

The polyphenols within pomegranate fruit are the main bioactive compounds responsible for the various health benefits attributed to this extract. The peel of the pomegranate contains the highest amounts of polyphenols. Two of the primary polyphenols in the peel are ellagitannins (punicalagin and punicalin) and ellagic acid [12].

Studies showed that pomegranate extracts are associated with the treatment and prevention of many diseases and disorders in men , such as cardiovascular diseases, infertility, and erectile dysfunction [13, 14, 15]. For example, pomegranate has a positive effect on blood flow, key for erectile function and sexual performance [16].

Hesperidin 

Hesperidin is a bioflavonoid found in citrus fruits, abundant in sweet oranges (Citrus sinensis). After ingestion, hesperidin is converted to hesperetin by the microbiome. Hesperetin is considered the active metabolite of hesperidin and has been shown to have several beneficial health effects for men.

One of the health effects of hesperidin is that it has antioxidant activity, through neutralizing Reactive Oxygen Species (ROS) [17]. This may eventually lead to enhanced overall well-being and an increase in energy when you need it most. This antioxidant activity also has a positive effect on fertility in men, since free radicals (ROS) decrease sperm motility and increase DNA damage [18].

Additionally, hesperidin is known for its positive effect on blood flow. The active ingredient achieves this by increasing the availability of nitric oxide [19]. Eventually, this leads to an improved supply of nutrients and oxygen during physical and sexual activity, and to an improved erectile function.

Actiful®: An ingredient containing hesperidin and punicalagin

Actiful® is a natural orange and pomegranate complex and is standardized for highly bioavailable hesperidin and punicalagin: the primary polyphenols present in sweet orange (Citrus sinensis) and pomegranate peel (Punica granatum).

The health benefits of this ingredient have been scientifically validated and confirmed through multiple randomized double-blind controlled trials. It is clinically proven that Actiful® results in enhanced physical performance in men [20, 21].

Actiful® not only influences physical performance. It also boosts energy levels by targeting the mitochondria within the cells [22]. Additionally, Actiful® has been demonstrated to positively impact mental health [19].

Lastly, it has been shown that Actiful® positively affects blood flow [21], by increasing the availability of nitric oxide. Hereby it promotes improved erectile function in men, leading to longer-lasting erections.

Overall, Actiful® stands as a promising and scientifically backed choice for men aiming to improve their physical performance, sexual function, and overall health.


gut health or butyrate or short chain fatty acids

New clinical study: MicrobiomeX® improves microbiota composition and SCFA production

New clinical study: MicrobiomeX® improves microbiota composition and SCFA production

Maastricht, The Netherlands, 29th September  2023

Press release

New clinical and pre-clinical data from a study with MicrobiomeX® have been published in a peer-reviewed journal. It is a randomised, double-blind, placebo-controlled parallel study performed by scientists of Maastricht University, the department of Gastro-enterology of Maastricht University Medical Center and BioActor. It shows the potential of MicrobiomeX® to improve short-chain fatty acid (SCFA) profiles in the intestine. After 12 weeks of daily supplementation, there was a significant shift in the SCFA profile (p=0.022) towards butyrate. In addition, a reduction in faecal calprotectin levels was observed, a marker of gut inflammation. Interestingly, a new in-vitro study in the TIM2 model, where faecal samples from volunteers were tested, also showed a strong increase in butyrate production. These new clinical and pre-clinical results highlight MicrobiomeX®’s potential to support intestinal microbiota of subjects with features of metabolic syndrome.

gut health or butyrate or short chain fatty acids

MicrobiomeX®: an an active ingredient supporting the gut microbiome, developed by BioActor

MicrobiomeX® is a clinically validated blend of Citrus sinensis (sweet orange) and Citrus paradisi (grapefruit) extracts. These fruits are naturally rich in flavonoids, known for their anti-inflammatory and antiviral properties (1, 2). MicrobiomeX® already showed promising potential to reduce markers of gut inflammation and increase SCFAs in previous in-vitro and ex-vivo studies conducted with this ingredient (3, 4). Supplement brands all over the world have adopted MicrobiomeX® in their formulations, typically positioned for improving gut microbiome balance and immune system regulation.

The study: Citrus Extract High in Flavonoids Beneficially Alters Intestinal Metabolic Responses in Subjects with Features of Metabolic Syndrome

 

Introduction

This study (5) was published in the international journal “Foods”. The western diet and lifestyle may be the leading causes for the development of various metabolic disorders. An overlooked factor is the gut microbiota composition, which should be considered as a factor determining health status. A healthy gut is related to mental wellbeing and strong immunity. This study aimed to evaluate the benefits of MicrobiomeX® supplementation on the intestinal microbiome of subjects with metabolic disorder traits.

Methods

Fifty adult subjects with features of metabolic syndrome took part in the study. They ingested 500mg MicrobiomeX® or placebo daily for 12 weeks. Additionally, seven volunteers provided faecal samples that were introduced into a TIM-2 system for further analysis. The TIM-2 is a computer-controlled model in an anaerobic environment that replicates the appropriate conditions for microbial growth in the human colon and is able to measure microbiota composition and SCFA production.

Results

A significant shift in the SCFA profile towards more butyrate (p=0.022) was observed in the MicrobiomeX® group after the 12-week supplementation period. An increase in SCFA production was also found in the TIM-2 model, that was mainly due to an increased production of butyrate, acetate and valerate. Additionally, in the MicrobiomeX® group, a trend in calprotectin reduction was observed, which is a marker of gut inflammation. Both in vivo and in vitro data confirm the benefits of MicrobiomeX on gut health, specifically the increased butyrate production and improved SCFA profile. These findings are in line with previous in vitro results and show that MicrobiomeX® can beneficially modulate the gut microbiome.

Conclusion

This study demonstrates the great potential of MicrobiomeX® in playing a role in gut health modulation. This is indicated by the significant increase in SCFAs, mainly butyrate, and a reduction in calprotectin, as found in the present study. By adding MicrobiomeX® to your supplement, you can offer customers a science-based support for gut health. It is an alternative to common prebiotics and an ideal partner for synbiotic formulation targeting gut health and immunity.

Click here to read the complete publication

About BioActor

BioActor, based in Maastricht, Netherlands is part of the Solabia Group and has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. We focus on the development of innovative activities that address active living and healthy ageing. Our goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

Feel free to contact via info@bioactor.com for more information on the possibilities MicrobiomeXl® has to offer. Further information can also be found on: https://bioactor.com/products/microbiomex/ and https://microbiomex.com/


Why are you more easily fatigued as you get older?

Why are you more easily fatigued as you get older? 

September 20th, 2023

Feeling tired all the time? Sleeping or resting is not doing the trick? You might be experiencing more than just regular tiredness – it could be fatigue. As we get older, our energy stores tend to drain more easily, which can contribute to fatigue. Fatigue is a common concern as we age, and it can have a significant impact on our overall well-being. In this article, we’ll explore fatigue in later life, its possible causes, and simple steps you can take to combat it.  

What is fatigue?

As we age, it’s common to notice that our energy levels deplete more easily. We may find ourselves wanting to do the things we used to, but realizing we have less energy to perform these things. This change in energy levels can be attributed to fatigue.

Fatigue is defined as a state of tiredness or exhaustion that comprises a multifaceted combination of mental and physical elements. A crucial aspect of fatigue is that is not solved by simply resting more [1].

Contributing factors to fatigue at later age

One of the potential causes of fatigue at a later age is a loss of function in the mitochondria. Mitochondria are the “powerhouses” of the cell, and they produce energy in the form of adenosine triphosphate (ATP) to sustain all processes in the body.

Loss in function of mitochondria occurs naturally as a result of aging, specifically increased levels of oxidative damage by reactive oxygen species (ROS) cause a decrease in the ability of mitochondria to produce ATP efficiently [2].

Another common cause of fatigue at a later age may be related to the cardiovascular system since aging induces a functional and structural decline in the cardiovascular system [3]. Although the mechanisms are unclear at this moment, it is likely that increased arterial stiffness and reduced cardiac output are related to causing fatigue [4].

Other factors contributing to fatigue at a later age could be:

Hormonal changes: Experiencing hormonal changes as we age is a common symptom. In women, menopause causes decreased production of estrogen and progesterone. These hormonal fluctuations may lead to feeling fatigued [5].

Lack of physical activity: We might become more sedentary as we age, due to several factors. However, this may lead to, for example, mood disturbances, poorer sleep quality, or even changes in your metabolism.

Nutrient deficiencies: As we age, nutrient absorption and intake can be affected by various factors, such as the use of medication, changes in dietary patterns, and changes in gastrointestinal health [6].

Boosting your energy level

Unfortunately, aging is a process that cannot be reversed, so preventing fatigue is not avoidable. However, don’t despair! There are a number of easy lifestyle habits that can help: exercise regularly, participate in social activities you enjoy, and eat a well-balanced diet [6].

A well-balanced diet can be optimized by the implementation of supplements into your diet. Supplements can be a valuable addition to your diet since they address potential nutritional deficiencies and support your overall health and well-being.

Which nutrients help to beat fatigue?

Nutritional deficiencies often contribute to feelings of fatigue, so ensuring adequate nutrient levels is essential. Here are some key nutrients that can help in overcoming fatigue [7,8]:

1. Iron: This vital mineral supports oxygen supply to the muscles and plays a crucial role in energy production. It is also an important part in the structure of the enzymes responsible for ATP production.

2. Magnesium: Another important mineral involved in energy production, magnesium activates ATP synthase, an enzyme responsible for synthesizing ATP. It also serves various functions related to energy production, muscle function, bone health, and protein synthesis.

3. Vitamin C: This essential nutrient aids in fighting fatigue by enhancing iron absorption and safeguarding red blood cells from oxidative stress. By promoting improved oxygen supply to the muscles, vitamin C contributes to combating fatigue.

4. B vitamins: B vitamins play a multifaceted role in energy production. They are integral to the metabolism of macronutrients and also support the production of red blood cells, indirectly contributing to oxygen supply.

5. Bioflavonoids: These polyphenolic compounds offer numerous health benefits, like improved blood flow and increased mitochondrial efficiency. Actiful®, a substance rich in the bioflavonoid hesperidin, is particularly a good option to consider.

3. Actiful®: A natural ingredient for more energy

Actiful® is an orange & pomegranate complex, containing a high amount of micronized hesperidin. The ingredient is developed to boost vitality and optimize energy levels.

A proprietary clinical trial by BioActor showed that Actiful® provides immediate and sustained energy. It does so by improving blood flow to active muscles and optimizing the respiration capacity of mitochondria, in turn increasing ATP production [9].

Actiful®’s positive effect on blood flow is linked to vasodilative capacities of the active metabolites. Micronized hesperidin promotes vasodilation by stimulating the production of nitric oxide [10]. Nitric oxide relaxes the blood vessels, thereby enlarging their diameter and allowing the passage of a greater amount of nutrient-rich blood and oxygen.

As a bonus, Actiful® positively affects mental well-being. In our proprietary clinical trial, we showed a significant improvement in concentration, thinking, memory, and learning [11]. These aspects are vital for overall well-being and quality of life.

Overall, Actiful® is a safe, healthy, and natural ingredient which is perfect to be incorporated into energy-providing supplements.


Actiful: a sweet orange and pomegranate extract suitable for supplements

New publication of clinical data: Actiful® reduces Methylglyoxal, an important marker for healthy aging

New publication of clinical data: Actiful® reduces Methylglyoxal, an important marker for healthy ageing

Maastricht, The Netherlands, 15th September  2023

Press release

A randomized double blinded crossover study performed by Maastricht University, showed the potential of Actiful® as a dietary modulator against advanced glycation end-products (AGEs). AGEs are associated with various age-related chronic diseases. After a 4-week period of Actiful® consumption in healthy elderly subjects, plasma levels of methylglyoxal (MGO) decreased significantly by 9.8% (p = 0.042). These new clinical results highlight Actiful®’s potential to mitigate age-related diseases like diabetes, vascular dysfunction and neurodegeneration. 

Actiful: a sweet orange and pomegranate extract suitable for supplements

Actiful®: an energy-boosting ingredient developed by BioActor

Actiful® is a clinically validated blend of Citrus sinensis (sweet orange) and Punica granatum (pomegranate) extracts. These plants are abundant in bioactive polyphenolic components, mainly flavonoids (1, 2) . Actiful® has a dual mode of action: by increasing synthesis of nitric oxide and by improving ATP production through an increased mitochondrial respiration efficiency (3). In the first clinical study, Actiful® demonstrated to improve energy, mood and antioxidant status in healthy elderly individuals. Actiful® is used globally by leading supplement brands in a vast array of products supporting an active lifestyle and healthy aging.

The study: A Citrus and Pomegranate Complex Reduces Methylglyoxal in Healthy Elderly Subjects: Secondary Analysis of a Double-Blind Randomized Cross-Over Clinical Trial

 

Introduction

This study (4) was published in the International Jouranl of Molecular Sciences . It focuses on the evaluation of additional biomarkers and the effect of Actiful® in reducing the concentrations of reactive α-dicarbonyl compounds (specifically methylglyoxal, glyoxal, and 3-deoxyglucosone) in the blood of healthy elderly participants. These α-dicarbonyls are known to contribute to the formation of advanced glycation end-products (AGEs), which are associated with various chronic diseases, including diabetes and cardiovascular diseases (5).

Methods

Thirty-six healthy elderly subjects were recruited for this double-blind, randomized crossover clinical trial. They received either 700 mg of Actiful® in capsules, or a placebo for four weeks, with a 4-week washout period in between.

Blood samples were collected during the test day to measure α-Dicarbonyls in plasma. This was achieved via ultra-performance liquid chromatography tandem mass spectrometry.

Results

A significant reduction in plasma methylglyoxal concentrations was observed during a 4-week supplementation period. This reduction suggests a potential benefit in terms of reducing the formation of harmful AGEs, which could be attributed to the antioxidant properties of the active compounds in the supplement. The observed reduction in methylglyoxal was around 9.8%, which could be of clinical relevance in preventing or managing age-related conditions related to AGEs formation, like cardiovascular related diseases, diabetes and neurodegeneration. This confirms the importance of exploring promising nutraceuticals like Actiful® as potential healthy ageing strategies to mitigate the impact of reactive α-dicarbonyl compounds on health.

Conclusion

This study demonstrates the great potential of Actiful® for playing a role in healthy ageing. This is indicated by the significant reduction in AGEs, specifically MGO, found in the present study.

Click here to read the complete publication

About BioActor

BioActor, based in Maastricht, Netherlands is part of the Solabia Group and has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. We focus on the development of innovative activities that address active living and healthy ageing. Our goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

Feel free to contact via info@bioactor.com for more information on the possibilities Actiful® has to offer. Further information can also be found on: https://actiful.eu and https://bioactor.com/products/actiful


Enhancing Mitochondrial Health Exploring the Significance of Nutrients

Exploring the significance of nutrients for mitochondrial health

Enhancing mitochondrial health: exploring the significance of nutrients

August 8th, 2023

Discover the influence of nutrients on your mitochondrial health. Dive into our blog to learn how magnesium, hesperidin, vitamin C, omega-3s, and more can enhance your mitochondrial health and boost your overall vitality.

Enhancing Mitochondrial Health Exploring the Significance of Nutrients

Nutrients to support mitochondrial health

Maintaining the optimal performance of our mitochondria is pivotal for our overall well-being. These microscopic organelles act as cellular powerhouses, generating a significant portion of the energy necessary for our cells to function at their best.

Beyond energy production, they also regulate metabolic processes and uphold a delicate balance of nutrients within our cells

Dysfunctional mitochondria can result in notable symptoms like fatigue and muscle weakness. In more serious instances, they have been linked to critical health conditions such as cardiovascular ailments and neurodegenerative diseases.

Consequently, prioritizing the health of our mitochondria is not only essential for general vitality but also plays a preventive role against potential illnesses.

Within this article, we will take a look at specific nutrients that actively contribute to the maintenance and augmentation of mitochondrial health.

Magnesium and mitochondrial vitality

Magnesium plays a vital role in ensuring the well-being of our mitochondria. It serves as a crucial facilitator for enzymes responsible for energy production, while also exhibiting antioxidant properties.

This antioxidative function of magnesium is particularly significant, shielding mitochondria from potential harm induced by harmful molecules. Additionally, magnesium takes on the responsibility of regulating calcium levels within mitochondria, a pivotal function in averting any potential malfunctioning (1).

Sustaining an appropriate intake of magnesium is essential to uphold the health of mitochondria and prevent any disruptions in their functioning. Incorporating magnesium-rich foods into our diet, such as nuts, seeds, whole grains, and leafy green vegetables, provides a natural source of this essential mineral. Additionally, it’s a possible addition for an energy supplement.

Hesperidin: a citrus boost for mitochondria

Hesperidin, a natural compound present in citrus fruits like oranges, lemons, and grapefruits, offers significant potential in maintaining robust mitochondrial health.

By boosting the expression of genes linked to energy production, hesperidin enhances mitochondrial functionality. This augmentation translates to increased energy production within the mitochondria, resulting in elevated energy levels and reduced fatigue (2).

Moreover, hesperidin boasts anti-inflammatory attributes that play a role in curbing inflammation throughout the body. As inflammation can contribute to mitochondrial disturbances, mitigating this inflammation becomes a supportive measure for preserving mitochondrial well-being.

Vitamin C to boost mitochondrial health

Vitamin C holds a crucial role in maintaining the well-being of our mitochondria. Serving as one of the body’s most potent antioxidants, vitamin C offers safeguarding prowess against detrimental molecules known as free radicals, shielding our mitochondria from harm (3).

Free radicals possess the capacity to impair mitochondria, diminishing their capacity to generate energy. However, vitamin C effectively counters these radicals, preventing their damaging effects.

Therefore, ensuring your diet includes a good dose of vitamin C becomes a noteworthy strategy to keep healthy mitochondria.

Omega-3s: helpful for energy

Omega-3 fatty acids are a type of healthy fat found in foods like fatty fish, nuts, and seeds. They play a crucial role in promoting the health of our mitochondria.

These fatty acids are boosters for mitochondria: they help these powerhouses extract more energy from the same amount of nutrients, which means less fatigue and more energy (4). Omega-3s also shield mitochondria from damage caused by harmful molecules. They also improve the mitochondria’s ability to transport nutrients in and out efficiently.

Omega-3 fatty acids also bring anti-inflammatory capabilities, which is good for our overall well-being. Including foods rich in omega-3s in our diet is a smart move to support your mitochondria, boost energy production, and keep inflammation in check.

B-vitamins and their ability to support mitochondrial well-being

B vitamins, including B1, B2, B3, B5, and B7, are fundamental contributors to the maintenance of optimal mitochondrial health. These vitamins play a pivotal role in facilitating energy production within mitochondria by participating in the breakdown of carbohydrates, fats, and proteins.

The main reason for this is that B vitamins can act as co-enzymes and precursors of co-enzymes that help in the breakdown of these nutrients. This is key for mitochondrial health. Inadequate intake of these B vitamins can lead to compromised mitochondrial function, resulting in sensations of fatigue, weakness, and muscular discomfort (5).

Sustaining an adequate dietary supply of B vitamins is imperative to sustain the functional integrity of mitochondria and facilitate efficient energy synthesis.

Intake of nutrients to support mitochondrial health

In summary, looking after the health of our mitochondria is vital for our general well-being. A range of nutrients, such as hesperidin, magnesium, B-vitamins, omega-3 fatty acids, and vitamin C, play key roles in supporting mitochondrial function. They not only help diminish oxidative stress and inflammation but also enhance exercise performance.

By incorporating these essential nutrients in your diet, we can effectively boost our mitochondrial health and ensure our body’s energy production functions at its best.

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