Women's-Health-Webinar

WEBINAR - Women's Health

WEBINAR – Women’s Health

Product concepts with Bonolive® to address post-menopausal-related risks

October 25th, 2022

More than ever, nutrition and supplementation are recognized to be effective strategies to address concerns associated with metabolic changes during menopause. In this webinar we discussed the clinical evidence supporting Bonolive®, and product formulations to target post-menopausal-related risks. Watch it now on demand!

The menopause journey is part of every woman’s life. For some, menopause can be more challenging than for others. With the hormonal changes occurring during this critical period, menopausal women will experience new health challenges.

From short-term complaints, such as hot flashes, mood changes and insomnia, to associated long-term risks such as cardiovascular, bone loss and joint discomfort; nutrition and supplementation are recognised to play an essential role in supporting women during menopause.

Watch our webinar on demand and discover the clinical evidence supporting Bonolive® and how BioActor’s olive polyphenol-based ingredient can be integrated into effective products targeting women’s health.

Watch now on demand!

WATCH NOW ON DEMAND

Meet the Speakers:

Meet-The-Speakers-Maria-Imperatrice-and-Bjarne-Maas

What was discussed during this webinar?

Clinical Research

Presentation by Maria Imperatrice – Clinical researcher, who introduced the science behind Bonolive® and the clinical trials showing the positive effect of Bonolive® on cardiovascular health, bone health and mobility.
Duration: 15 minutes

The Women’s Health trends & consumer insights

Presentation by Bjarne Maas – Marketing & Account Manager, who discussed the consumer insights and product formulation examples related to women’s health.
Duration: 15 minutes

Q&A session

Duration: 10 minutes

WATCH NOW ON DEMAND

Why-is-bone-health-important-and-how-does-it-work-(functions-bone-metabolism-and-influencing-factors)

Why is bone health important and how does it work? (functions, bone metabolism and influencing factors)

Why is bone health important and how does it work? (functions, bone metabolism and influencing factors)

July 4th, 2022

Our bones play various key functions for our bodies, and it is therefore important to maintain their health. To do so, it is essential to understand how our bones work and what factors affect bone health. Bone metabolism is a lifelong occurring process where bone tissue is turned over from mature to new bone tissue. This process keeps your bones healthy and their health is influenced by several aspects, such as age, gender, family history and several risk factors such as tobacco use, physical inactivity and diet.

Why-is-bone-health-important-and-how-does-it-work-(functions-bone-metabolism-and-influencing-factors)

Bone health, menopause, and dietary supplements

Menopause is the permanent cessation of menstruation naturally occurring in females at an average age of 51 [1].

Importantly, menopause leads to a decrease in estrogen levels and consequently increases bone loss. Estrogen is a hormone responsible for menstruation and known to have protective effects on bone loss and reduce inflammation.

Bone tissue in women is generally thinner than in men, and bone density has been reported to markedly decrease after menopause (post-menopause). Women can lose up to 20% of their bone density in just 5-7 years due to these hormonal shifts and experience increased joint pain [2].

The rise in the use of dietary supplements, especially by post-menopausal women, who are at risk of bone loss, is growing tremendously as advances in research are made, and the benefits of multiple natural ingredients are proven [3].

How does bone metabolism work?

Bone metabolism, also known as bone remodelling, is a lifelong occurring process where bone tissue is turned over from mature to new bone tissue. Bone resorption is the process where mature bone tissue is removed by osteoclasts and ossification is the formation of new bone tissue executed by osteoblasts [4]. These processes are responsible for replacing and reshaping bone following injuries such as fractures, but also micro-damage occurring during normal activity.

In the early stages of life, nearly 100% of the skeleton is replaced, due to the bones needing to develop, lengthen and grow. While in adults, bone remodelling proceeds at about 10% yearly [5].

For as long as bone growth is greater than bone breakdown, adults are able to maintain healthy bones. Many living cells within bone originate from the same mesenchymal stem cell. These mesenchymal stem cells can differentiate into the various cell types present in bone, such as osteoblasts (bone-building cells), adipocytes (fat cells) and chondrocytes (cartilage) [6].

However, due to stress, inflammation and ageing, this differentiation shifts towards producing more fat cells and fewer osteoblasts, resulting in more brittle and fatty bones [7]. Usually, bone mass starts to decline at the age of 40 as bone loss overtakes the speed of bone growth [8].

Fortunately, there are factors at play that we have control over to mitigate this bone loss.

What are the factors influencing bone health?

Although both our genes and the environment influence bone health, there is only one we have control over. Our genes, for example, determine whether signalling errors occur and lead to birth defects, while the extrinsic factors, such as lifestyle and diet, are crucial for optimising and maintaining bone health. Bone loss, also referred to as osteoporosis, affects people of all different ages and backgrounds. However, other intrinsic factors that are out of our control include:

Age: naturally as we grow older, our bone mass and strength decreases. This is mainly due to decreased osteoblast activity and an increase in osteoblast apoptosis, while inflammation increases [9,10].

Gender: osteoporosis is four times more common in women than men [11].

Body frame size: people with small body frames tend to have a higher risk of bone loss as they have less bone mass to draw from as they age.

Family history: having a parent or sibling with osteoporosis puts you at greater risk..

 

Fortunately, however, we do have the ability to modify extrinsic factors such as physical activity, diet choices and lifestyle choices. Here is how they can disturb bone health:

Tobacco use: smoking contributes to weak bones by disturbing the balance of bone turnover negatively.

Physical inactivity: just like muscles, bones gets stronger by exercising them. Resistance exercise and weight-bearing exercise help with this.

Alcohol use: alcohol interferes with the calcium balance and affects the production of hormones, linking chronic alcohol intake to an increase in bone fractures and falls.

Diet: foods high in calcium, and vitamin D such as dairy products and green leafy vegetables should be consumed in sufficient quantities to support the maintenance of bone health [12]. Additionally, polyphenols such as oleuropein can help mitigate bone loss, especially with age, through their anti-oxidative effects reducing inflammation [13].

If you want to know more about the crucial nutrients for bone health, click here and read our article on the 8 best ingredients.


Menopausal-bone-health

8 Ingredients proven to improve bone health during (post)menopause

8 Ingredients proven to improve bone health during (post)menopause

June 13th, 2022

Bone health is crucial to maintain, particularly after menopause. Consumption of dietary supplements, especially in post-menopausal women is on the rise, as advances in research are made and proven benefits are elucidated. Here we mention some of the ingredients that have demonstrated the ability to support women during menopause – specifically for the loss and maintenance of bone mineral density! You will also learn about which foods contain these ingredients, how they are beneficial to bone health and their recommended daily intake.

Menopausal-bone-health

Bone health, menopause, and dietary supplements

Menopause is the permanent cessation of menstruation naturally occurring in females at an average age of 51 [1].

Importantly, menopause leads to a decrease in estrogen levels and consequently increases bone loss. Estrogen is a hormone responsible for menstruation and known to have protective effects on bone loss and reduce inflammation.

Bone tissue in women is generally thinner than in men, and bone density has been reported to markedly decrease after menopause (post-menopause). Women can lose up to 20% of their bone density in just 5-7 years due to these hormonal shifts and experience increased joint pain [2].

The rise in the use of dietary supplements, especially by post-menopausal women, who are at risk of bone loss, is growing tremendously as advances in research are made, and the benefits of multiple natural ingredients are proven [3].

8 ingredients to sustain bone health in menopause.

Calcium & Vitamin D

Calcium is a critical component of bone architecture necessary for the deposition of bone minerals. Around 99% of calcium is stored in bones and teeth, making them strong and hard [4].

Vitamin D is vital for regulating intestinal calcium absorption and stimulating bone resorption to maintain serum calcium concentration [5]. There are, however, substances that can interfere with the body’s ability to use calcium, such as oxalate, protein, phytate, and caffeine.

Examples of foods rich in calcium include dairy, soybeans, and green leafy vegetables. While the predominant way of ascertaining vitamin D is through our own body’s synthesis stimulated by sufficient sunlight exposure on our skin. Thus, supplementation of vitamin D3, cholecalciferol, is advocated during autumn and winter due to limited sunlight availability, depending on geography.

Women under the age of 50 should consume a daily dosage of 1000mg of Calcium and 400-800IU Vitamin D, while women above the age of 50 should consume 1200mg of calcium and 800-1000IU of vitamin D daily [6].

Joint-health

Vitamin C, B9 and B12, K

Vitamin C is important in stimulating the differentiation of osteoblasts, cells that synthesize bone matrix and coordinate bone mineralization [7].

Antioxidant effects of vitamin C have also been reported to reduce bones from cell damage and may improve left ventricular diastolic function which menopausal women often experience a dramatic reduction in [8]. Foods rich in vitamin C include citrus fruits, bell peppers, broccoli, and strawberries.

Vitamin B9 (folate) and B12 are major determinants of homocysteine levels. Thus, a deficiency in vitamin B9 and B12 leads to increased homocysteine levels, which have been associated with impaired bone health and osteoporosis, a condition concerning weak and brittle bones [9].

Vitamin B9 and B12 have also been reported to assist with reducing the severity and duration of hot flashes and other menopause symptoms [10]. Therefore, increasing folate and B12 levels through foods such as pulses, legumes, beans, brown rice and, you guessed it, leafy green vegetables, can improve bone health.

Moreover, vitamin K has been reported to assist with reducing hot flashes and other menopause symptoms [11].

The recommended daily amount for adult women according to the National Institutes of Health for vitamin C is 75mg; for vitamin B9 is 400mcg DFE; for vitamin B12 is 2.4mcg and ultimately for vitamin K is 90mcg [12].

Quercetin

Quercetin is the bioactive compound abundantly found in citrus fruits, green leafy vegetables, and onions. Studies show that onions reduce bone loss due to their anti-inflammatory and antioxidant flavonoid, quercetin [13].

Quercetin inhibits the genesis and differentiation of osteoclasts, preserving bone mass and health. Bone mineral density in postmenopausal women has also been reported to improve when supplementing with onion juice [14].

Quercetin at a dose of 150 mg has been shown to improve bone-health metrics, which is around three servings of onion [15]. Note, quercetin is found in the pigment and outer layer of the onion, with red and yellow ones thus having higher concentrations.

Bonolive® (olive leaf extract 40% oleuropein)

Bonolive® is an ingredient derived from olive leaf and rich in the most abundant olive polyphenol, oleuropein, tailored to women to counteract bone loss risk associated with menopause.

Clinical research in post-menopausal women has demonstrated that 12 months of supplementation with 250mg of Bonolive® is able to increase osteocalcin levels by 32%, promote the activity of osteoblasts (the bone-building cells), and decrease osteoclast activity involved in the breakdown and resorption of bone [16,17]. Thus the clinical dosage of 250mg is recommended.

Bonolive-product

Moreover, after 12 months, the Bonolive® treatment group displayed a significant protection against bone loss, compared to the placebo group.

Additionally, chondrocytes, important for cartilage-building, are also increased while cartilage degeneration is inhibited through oleuropein. Further benefits can be ascribed to oleuropein’s anti-oxidant and anti-inflammatory properties.

Oleuropein can be found in olive oil and olive leaf, although in limited quantities and therefore, supplementation with a high-quality, standardized extract such as Bonolive® is a more convenient method of consuming this nutrient in adequate quantities.

Improve bone health during menopause

In conclusion, a well-balanced diet rich in vitamins, minerals and antioxidants, together with the right supplementations may help ameliorate bone health during menopause and promote healthy ageing and active living.


Press release new publication on Bonolive BioActor

New clinical study on patented olive leaf extract Bonolive® shows joint health benefits

New clinical study on patented olive leaf extract Bonolive® shows joint health benefits

Maastricht, Netherlands, February 8th, 2022

Press release
Therapeutic Advances in Musculoskeletal Disease has recently published a new clinical study with Bonolive®, a patented bone and joint health ingredient based on olive polyphenol. The new publication suggests that Bonolive® may improve joint functional capacity and reduce knee pain.

Press release new publication on Bonolive BioActor

New randomized clinical trial published with Bonolive®

Bonolive® is a natural polyphenol extract from olive leaves, developed by BioActor. Bonolive® was already studied for bone protecting effects in post-menopausal women and is covered by a patent on the bone health application of the extract.

A recent randomized, double-blind, placebo-controlled trial including 124 subjects demonstrated a large and significant treatment effect of Bonolive® in improving joint discomfort and reducing pain in subjects with knee pain.

Participants in the study received either a placebo or supplementation with a 125mg capsule containing Bonolive® (40% oleuropein), twice a day for 6 months.

The conclusion indicates that Bonolive® was able to improve the KOOS score (Knee Injury and Osteoarthritis Outcome) and to reduce walking pain in subjects with knee pain.

The researchers from the Liege University Hospital suggested that oleuropein may relieve nociceptive pain triggered by the mechanical strain because of its calcium channel blocker property.

N-type calcium channels are indeed important for neuronal excitability and play a role in pain genesis. As a blocker of these channels, Bonolive® seems to produce an antinociceptive effect, thus reducing pain.

These benefits were not associated with any adverse effect after 6 months of treatment, showing excellent tolerability of the extract. Moreover, the study confirmed yet again the great bioavailability of Bonolive®. The main metabolites of the extract, oleuropein aglycone, hydroxytyrosol and homovanillyl alcool were measured and showed a rapid rise in the urine of all treated subjects.

This study was conducted in the context of a collaboration with Nestlé Health Science, aiming to strengthen the scientific evidence for the benefits of Bonolive®.

“We are proud of the results achieved thanks to this collaboration”, says Hans van der Saag, CEO and founder of BioActor. “Mobility is extremely important for the quality of life and a core indicator of healthy ageing. These new scientific insights on Bonolive® will allow us to expand its applications to mobility targeting products”.

About BioActor

BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.

Feel free to contact BioActor via info@bioactor.com for more information on the possibilities Bonolive® has to offer.

Further information can be found on:  www.bonolive.com and www.bioactor.com


Improving bone health during menopause with Bonolive

Improving Bone Health During Menopause With Bonolive®

Improving Bone Health During Menopause With Bonolive®

February 3rd, 2022

The menopause transition is a critical period for bone health in women. More than ever, to address this key health concern, consumers are shifting away from calcium-only products and seeking out more complex formulas with clinically-backed ingredients.
Bonolive® is a patented ingredient rich in olive polyphenols that offers the possibility of formulating innovative bone health solutions tailored to women to counteract bone loss risk associated with menopause.

Improving bone health during menopause with Bonolive

Menopause transition and bone health

Healthy bones are needed to support our body, providing structure, allowing us to move and protect our organs. They also store essential minerals, such as calcium and phosphorus, and release them into the blood whenever needed.

Bone health depends on a dynamic equilibrium maintained between the constant production of the new bone matrix via osteoblasts – the cells responsible for bone synthesis – and the resorption of old bone by osteoclast activity– the cells responsible for bone breakdown.

The menopause transition is the most critical period for bone health in women because this fine equilibrium is broken due to hormonal changes.

The onset of the rapid bone loss phase is due to the drastic drop in estrogen levels, which play an important role in maintaining bone strength. This can result in bone resorption exceeding bone formation, leading to thin, fragile bones subject to spontaneous fracture.

Rapid losses in bone mass and strength usually occur in the 3-year window since the date of the final menstrual period [1].

Decreased levels of estrogen cause osteoprotegerin levels to decline. Osteoprotegerin is a protein secreted by osteoblasts, which antagonises the process of bone breakdown mediated by osteoclasts.

Therefore, with the lowered estrogen levels associated with menopausal changes, osteoclast activity increases leading to decreased bone mass and, in many cases, osteoporosis. This results in reduced bone strength and increased risk of fractures.

Although it is essential to build strong and healthy bones during the early stages of our lives, there are also important factors to take care of during adulthood, particularly during menopause, such as sufficient physical activity, proper nutrition and supplementation.

Traditional bone health management

With the world population getting older, bone health issues are increasing. In postmenopausal women, the prevalence of osteoporosis and osteopenia is estimated to be almost 20% and 52%, respectively [2].

Bone health is indeed a key concern for this vulnerable group. This reflects that 25% of women who use dietary supplements are already consuming products to support their bones and there are different ingredients that can be consumed to support bone health.

Over the last decade, supplementation with calcium and vitamin D and exercise has been the most used measure for preventing bone loss during menopause.

It is known that a sufficient calcium intake contributes to an increased bone density and Vitamin D is crucial for bone health because it plays a crucial role in calcium absorption [3].

While this strategy has proven marginal improvements, consumers are becoming more demanding. In fact, the popularity of innovative, nutraceuticals with a clinical back-up addressing bone health is growing.

Scientific evidence has shown that bone physiology can be modulated by phenolic compounds found in olives.

These powerful antioxidant compounds can indeed stimulate markers involved in osteoblast proliferation, differentiation, and maturation, and ultimately lead to a counteracting effect against bone loss risk.

What is Bonolive® and how does it support healthy bones?

Bonolive® is a patented, olive-polyphenol-based ingredient researched and developed by BioActor, with demonstrated efficacy in increasing bone formation in postmenopausal women.

Bonolive® is standardised for highly bioavailable oleuropein, the powerful phytonutrient deemed responsible for the increase in the number and activity of osteoblasts observed during BioActor’s research.

The randomised, double-blind clinical trial demonstrated that an intake of 250mg/day of Bonolive® is sufficient to re-balance the bone turnover [4].

Additionally, after 12 months, a 32% increase in osteocalcin was observed in the treatment group, compared to a 6% decrease in the placebo group.

Osteocalcin is a key component for building new bone, as it forms the scaffold for new bone tissue and binds calcium within a rigid structure.

The increase in osteocalcin is also reflected by the DEXA scan results, which show that subjects taking Bonolive®, displayed protection of bone mineral density at the lumbar spine and a higher gain of bone mineral density at the femur neck, compared to those taking placebo.

Opportunities for new product development with Bonolive®

As consumers are shifting away from calcium-only products and seek out more complex formulas with clinically-backed ingredients, Bonolive® offers the possibility of developing innovative consumer products specifically crafted to help women support healthy bones during menopause.

For a synergistic effect, Bonolive® can be successfully combined with calcium, vitamin D and magnesium, as well as other vitamins, minerals and plant extracts.

This Mediterranean-inspired ingredient can be easily included in various dietary supplements, functional drinks and foods, with a daily dose of only 250mg.

Apart from innovative blends, further product development opportunities in this growing market lie in convenient formats like gummies and ready-to-drink beverages.


Woman jogging bone health

Approved new clinical trial with Bonolive®

Approved new clinical trial with Bonolive®

Brussels, Belgium, October 6th, 2008

Press release
BioActor receives approval to start clinical trial with Bonolive®. BioActor’s innovative bone health ingredient Bonolive® will enter the clinic for mitigating ageing-related bone loss.

Woman jogging bone health

New Randomized double-blind placebo-controlled study

BioActor announced today that it has received approval from the regulatory authorities to initiate the combined Phase I/II clinical trial for its innovative bone health ingredient Bonolive®.

Bonolive®, a proprietary olive polyphenols formulation has shown strong inhibition of accelerated bone loss in an animal model for menopause and inflammation-induced bone loss. The first clinical study will be performed in Poland in collaboration with a specialized osteoporosis clinic, which has started recruiting the first subjects.

The trial is a double-blind placebo-controlled study in 60 postmenopausal women who will be treated for a duration of 12 months. The objective is to monitor tolerability, safety and biomarkers for bone metabolism as well as total bone density. BioActor’s scientific partner, INRA is actively involved in the trial design and the analysis of the results.

Hans van der Saag, Managing Director of BioActor comments: “We are very pleased with the progress that has been made with the development of Bonolive® into a first in class health ingredient addressing bone health for an ageing population.”

Osteoporosis is becoming an increasing health burden, affecting an estimated 75 million people in Europe alone. Public health authorities have recognized the need for the prevention of this chronic disease. Functional foods and dietary supplements addressing bone health are seen as excellent solutions for long-term prevention. BioActor is addressing this need by developing a unique product for bone health – Bonolive®. It is now widely known that calcium alone is not sufficient to prevent osteoporosis.

Bonolive® has already been successfully tested in an animal model for osteoporosis and targets the underlying inflammatory processes that lead to osteoporosis.

About BioActor

BioActor, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. The company focuses on the development of innovative activities that address active living and healthy aging. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

 

Feel free to contact us via info@bioactor.com for more information on the possibilities Bonolive® has to offer.
Further information can be found on: www.bonolive.com