supplement to slow down aging

Actiful®: a key ingredient for healthy aging

Actiful®: a key ingredient for healthy aging

Maastricht, 29th January 2024

Are you looking for an impactful science-based ingredient to add to your energy and vitality supplement? Well, look no further as the research-based evidence is expanded on the key role of Actiful® in supporting energy production, improving mental wellness, and reducing oxidative stress.

supplement to slow down aging

How can we slow down the aging process?

Aging is a complex process (1) characterized by a gradual decline in physiological function and an increased susceptibility to various diseases. It encompasses a range of biological, psychological, and social changes that occur over time. At the cellular level, aging involves factors such as mitochondrial dysfunction and accumulation of damage from oxidative stress. These processes contribute to a decline in the efficiency of cellular repair and maintenance mechanisms.

 

Factors impacting the aging process

Additionally, genetic and environmental factors play significant roles in influencing the rate of aging. While aging is a natural and inevitable part of life, lifestyle choices, such as diet, exercise, and stress management, can impact the rate at which the aging process unfolds. Continuous research is taking place to study aging and better understand potential interventions to promote healthy aging and longevity (2).

 

A combination of diet and supplementation

Slowing down the aging process involves adopting a holistic approach that addresses various aspects of one’s lifestyle. A balanced and nutritious diet rich in antioxidants, vitamins, and minerals is crucial for maintaining cellular health and preventing oxidative stress. Regular exercise, adequate sleep and stress management can positively impact both mental and physical health (3). Avoiding harmful habits such as smoking and excessive alcohol consumption is also vital, as they accelerate the aging process.

 

Combining these lifestyle factors and taking appropriate supplements can create a foundation for a healthier and more vibrant aging experience. Adding supplements to the diet can be beneficial for healthy aging, as they can help address specific nutrient deficiencies and support overall well-being. They are often recommended for digestive health, immune support or cell function optimization. (4, 5)

mitochondria health and energy and healthy aging

Actiful®: clinically proven ingredient for healthy aging

Actiful® is a patent-protected plant-based ingredient for improved energy production, mental wellness and mitochondria support. It is standardized for hesperidin which is a key polyphenol extracted from sweet oranges (Citrus sinensis). Actiful® also contain pomegranate (Punica granatum), known to be rich in nitrate and useful for NO production, leading to vasodilation. Previous clinical data has already shown the beneficial properties that the combination of these polyphenols has in terms of enhanced physical performance (6, 7), mental health support (7), improved energy production by the mitochondria (8) and improved blood flow (9).

Recent clinical data further underlines the benefits that Actiful® brings to the table. The combination of hesperedin and pomegranate in a 350mg supplement capsule was provided to healthy seniors for 4 weeks in a randomised, blinded, placebo-controlled manner. In the end of the intervention period, the concentration of methylglyoxal (MGO) in the blood decreased by ≈ 10% (10). This is a statistically significant and clinically relevant result as MGO accumulation in cells leads to cellular disfunction and shorter cell life. Clearly, you would like to stimulate MGO scavenging, if you are targeting healthy aging. 

 

The role of Actiful® in supporting the mitochondria

The mechanism of action of the polyphenols present in Actiful® is quite complex and apparently linked with benefits and protection for our mitochondria, the so called ‘powerhouse’ of the cells. Hesperidin and pomegranate are known for their antioxidant properties (11, 12), which contributes to the direct MGO scavenging. They also reduce oxidative stress which leads to support of the natural body’s detoxification mechanisms. All of the above mentioned benefits are directly linked with the potential of Actiful® to protect the mitochondria and support its function via the reduction of MGO, observed in the latest clinical data of Actiful® (10).

 

The potential of Actiful® for the supplements market

The latest data allows Actiful® to expand its market possibilities. It can be an active ingredient in vitality supplements for mid-aged adults and active seniors as well as in energy drinks and sports drinks. Actiful® can be marketed for its beneficial effects on vitality, mental wellbeing, energy production and mitochondria support.


men health

Top 5 ingredients for men's health

Top 5 ingredients for men’s health

October 30th, 2023

Incorporating health ingredients into daily routines helps to support men’s well-being and health. We will provide you with evidence-based recommendations on five key ingredients supporting men’s health and sexual function, including fenugreek seed extract, zinc, B vitamins, pomegranate extract, and hesperidin.

men health

In today’s fast-paced world, prioritizing our health and well-being is becoming more and more important, also for men. As the increasing expectations and pressures of our lives continue to evolve, it is important for men to develop a proactive approach to maintain their physical, mental, and sexual health.

Health ingredients are designed to meet men’s health needs, ensuring that they stay healthy and full of energy. In this article, we will provide evidence-based recommendations on five key ingredients supporting men’s health and sexual function.

Fenugreek seed extract

As men age, they experience a decrease in testosterone levels. This phenomenon is also known as andropause. Testosterone plays a role in many aspects of health, including sexual function, muscle and bone mass, energy levels, and metabolism. One of the ingredients that may help to combat the problems related to andropause is fenugreek seed extract . Fenugreek (Trigonella foenum-graecum) is a very interesting herb with many potential health benefits.

A study performed on 120 healthy men showed that a 12-week supplementation of fenugreek seed extract (600 mg/day) increased testosterone levels and improved sexual function, compared to placebo [1]. Also, supplementation of fenugreek seed extract in healthy male athletes resulted in increased fat-free mass, lean body mass, and elevated testosterone levels compared to placebo [2]. These findings suggest that fenugreek seed extract is a promising ingredient for men’s health, especially in terms of increasing testosterone levels and improving sexual function.

Zinc

Zinc is an essential mineral, which means that it is not produced by the body itself. It plays an important role in many physiological functions, such as supporting the immune system and healing damaged cells. Zinc is a critical mineral for men’s health as even a small deficiency can impact the immune system, cardiovascular health, reproductive function, and fertility [3].

Sufficient intake of zinc contributes to normal fertility and sexual function in males. Low levels of zinc are related to low levels of testosterone. Besides, it is also important for the normal functioning of the immune system, and the maintenance of bone health [4].

Therefore, we can state that zinc is an important mineral that can help men improve their sexual health and energy levels and maintain a healthy immune system.

B Vitamins

B vitamins play a vital role in the human body. They are involved in many important functions. For example, they are crucial for energy production, oxygen support, and bone health.

The vitamin B complex consists of a total of eight B vitamins, with several of them having beneficial effects on men’s health, for example:

Vitamin B12: Adequate levels of vitamin B12 are important for the production of red blood cells, which are responsible for oxygen transport. Also, studies showed that vitamin B12 is important for bone health [5, 6].

Vitamin B9: Vitamin B9, also known as folate, is not only an important vitamin for women but also for men. Research has shown that folate contributes to the reduction of fatigue, which is a common complaint nowadays [7].

Vitamin B6: Vitamin B6 plays a vital role in energy and vitality. Intake of this vitamin contributes to normal energy metabolism. Studies also showed that it leads to a decrease in fatigue and tiredness [8].

Vitamin B5: Pantothenic acid, also known as vitamin B5 is an essential vitamin, which plays a vital role in various functions in the body. It is mainly known for its important role in the metabolism of food, leading to energy production [9].

All in all, B vitamins are important for energy production. Increased energy levels lead to improved stamina and sexual performance.

Pomegranate extract

Pomegranate (Punicagranatum L.) is a fruit that contains lots of healthy phytochemical compounds, such as polyphenols, flavonoids, and nitrates [10]. These phytochemicals have many antioxidant and anti-inflammatory qualities beneficial for men’s health [11].

The polyphenols within pomegranate fruit are the main bioactive compounds responsible for the various health benefits attributed to this extract. The peel of the pomegranate contains the highest amounts of polyphenols. Two of the primary polyphenols in the peel are ellagitannins (punicalagin and punicalin) and ellagic acid [12].

Studies showed that pomegranate extracts are associated with the treatment and prevention of many diseases and disorders in men , such as cardiovascular diseases, infertility, and erectile dysfunction [13, 14, 15]. For example, pomegranate has a positive effect on blood flow, key for erectile function and sexual performance [16].

Hesperidin 

Hesperidin is a bioflavonoid found in citrus fruits, abundant in sweet oranges (Citrus sinensis). After ingestion, hesperidin is converted to hesperetin by the microbiome. Hesperetin is considered the active metabolite of hesperidin and has been shown to have several beneficial health effects for men.

One of the health effects of hesperidin is that it has antioxidant activity, through neutralizing Reactive Oxygen Species (ROS) [17]. This may eventually lead to enhanced overall well-being and an increase in energy when you need it most. This antioxidant activity also has a positive effect on fertility in men, since free radicals (ROS) decrease sperm motility and increase DNA damage [18].

Additionally, hesperidin is known for its positive effect on blood flow. The active ingredient achieves this by increasing the availability of nitric oxide [19]. Eventually, this leads to an improved supply of nutrients and oxygen during physical and sexual activity, and to an improved erectile function.

Actiful®: An ingredient containing hesperidin and punicalagin

Actiful® is a natural orange and pomegranate complex and is standardized for highly bioavailable hesperidin and punicalagin: the primary polyphenols present in sweet orange (Citrus sinensis) and pomegranate peel (Punica granatum).

The health benefits of this ingredient have been scientifically validated and confirmed through multiple randomized double-blind controlled trials. It is clinically proven that Actiful® results in enhanced physical performance in men [20, 21].

Actiful® not only influences physical performance. It also boosts energy levels by targeting the mitochondria within the cells [22]. Additionally, Actiful® has been demonstrated to positively impact mental health [19].

Lastly, it has been shown that Actiful® positively affects blood flow [21], by increasing the availability of nitric oxide. Hereby it promotes improved erectile function in men, leading to longer-lasting erections.

Overall, Actiful® stands as a promising and scientifically backed choice for men aiming to improve their physical performance, sexual function, and overall health.


gut health or butyrate or short chain fatty acids

New clinical study: MicrobiomeX® improves microbiota composition and SCFA production

New clinical study: MicrobiomeX® improves microbiota composition and SCFA production

Maastricht, The Netherlands, 29th September  2023

Press release

New clinical and pre-clinical data from a study with MicrobiomeX® have been published in a peer-reviewed journal. It is a randomised, double-blind, placebo-controlled parallel study performed by scientists of Maastricht University, the department of Gastro-enterology of Maastricht University Medical Center and BioActor. It shows the potential of MicrobiomeX® to improve short-chain fatty acid (SCFA) profiles in the intestine. After 12 weeks of daily supplementation, there was a significant shift in the SCFA profile (p=0.022) towards butyrate. In addition, a reduction in faecal calprotectin levels was observed, a marker of gut inflammation. Interestingly, a new in-vitro study in the TIM2 model, where faecal samples from volunteers were tested, also showed a strong increase in butyrate production. These new clinical and pre-clinical results highlight MicrobiomeX®’s potential to support intestinal microbiota of subjects with features of metabolic syndrome.

gut health or butyrate or short chain fatty acids

MicrobiomeX®: an an active ingredient supporting the gut microbiome, developed by BioActor

MicrobiomeX® is a clinically validated blend of Citrus sinensis (sweet orange) and Citrus paradisi (grapefruit) extracts. These fruits are naturally rich in flavonoids, known for their anti-inflammatory and antiviral properties (1, 2). MicrobiomeX® already showed promising potential to reduce markers of gut inflammation and increase SCFAs in previous in-vitro and ex-vivo studies conducted with this ingredient (3, 4). Supplement brands all over the world have adopted MicrobiomeX® in their formulations, typically positioned for improving gut microbiome balance and immune system regulation.

The study: Citrus Extract High in Flavonoids Beneficially Alters Intestinal Metabolic Responses in Subjects with Features of Metabolic Syndrome

 

Introduction

This study (5) was published in the international journal “Foods”. The western diet and lifestyle may be the leading causes for the development of various metabolic disorders. An overlooked factor is the gut microbiota composition, which should be considered as a factor determining health status. A healthy gut is related to mental wellbeing and strong immunity. This study aimed to evaluate the benefits of MicrobiomeX® supplementation on the intestinal microbiome of subjects with metabolic disorder traits.

Methods

Fifty adult subjects with features of metabolic syndrome took part in the study. They ingested 500mg MicrobiomeX® or placebo daily for 12 weeks. Additionally, seven volunteers provided faecal samples that were introduced into a TIM-2 system for further analysis. The TIM-2 is a computer-controlled model in an anaerobic environment that replicates the appropriate conditions for microbial growth in the human colon and is able to measure microbiota composition and SCFA production.

Results

A significant shift in the SCFA profile towards more butyrate (p=0.022) was observed in the MicrobiomeX® group after the 12-week supplementation period. An increase in SCFA production was also found in the TIM-2 model, that was mainly due to an increased production of butyrate, acetate and valerate. Additionally, in the MicrobiomeX® group, a trend in calprotectin reduction was observed, which is a marker of gut inflammation. Both in vivo and in vitro data confirm the benefits of MicrobiomeX on gut health, specifically the increased butyrate production and improved SCFA profile. These findings are in line with previous in vitro results and show that MicrobiomeX® can beneficially modulate the gut microbiome.

Conclusion

This study demonstrates the great potential of MicrobiomeX® in playing a role in gut health modulation. This is indicated by the significant increase in SCFAs, mainly butyrate, and a reduction in calprotectin, as found in the present study. By adding MicrobiomeX® to your supplement, you can offer customers a science-based support for gut health. It is an alternative to common prebiotics and an ideal partner for synbiotic formulation targeting gut health and immunity.

Click here to read the complete publication

About BioActor

BioActor, based in Maastricht, Netherlands is part of the Solabia Group and has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. We focus on the development of innovative activities that address active living and healthy ageing. Our goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

Feel free to contact via info@bioactor.com for more information on the possibilities MicrobiomeXl® has to offer. Further information can also be found on: https://bioactor.com/products/microbiomex/ and https://microbiomex.com/


Why are you more easily fatigued as you get older?

Why are you more easily fatigued as you get older? 

September 20th, 2023

Feeling tired all the time? Sleeping or resting is not doing the trick? You might be experiencing more than just regular tiredness – it could be fatigue. As we get older, our energy stores tend to drain more easily, which can contribute to fatigue. Fatigue is a common concern as we age, and it can have a significant impact on our overall well-being. In this article, we’ll explore fatigue in later life, its possible causes, and simple steps you can take to combat it.  

What is fatigue?

As we age, it’s common to notice that our energy levels deplete more easily. We may find ourselves wanting to do the things we used to, but realizing we have less energy to perform these things. This change in energy levels can be attributed to fatigue.

Fatigue is defined as a state of tiredness or exhaustion that comprises a multifaceted combination of mental and physical elements. A crucial aspect of fatigue is that is not solved by simply resting more [1].

Contributing factors to fatigue at later age

One of the potential causes of fatigue at a later age is a loss of function in the mitochondria. Mitochondria are the “powerhouses” of the cell, and they produce energy in the form of adenosine triphosphate (ATP) to sustain all processes in the body.

Loss in function of mitochondria occurs naturally as a result of aging, specifically increased levels of oxidative damage by reactive oxygen species (ROS) cause a decrease in the ability of mitochondria to produce ATP efficiently [2].

Another common cause of fatigue at a later age may be related to the cardiovascular system since aging induces a functional and structural decline in the cardiovascular system [3]. Although the mechanisms are unclear at this moment, it is likely that increased arterial stiffness and reduced cardiac output are related to causing fatigue [4].

Other factors contributing to fatigue at a later age could be:

Hormonal changes: Experiencing hormonal changes as we age is a common symptom. In women, menopause causes decreased production of estrogen and progesterone. These hormonal fluctuations may lead to feeling fatigued [5].

Lack of physical activity: We might become more sedentary as we age, due to several factors. However, this may lead to, for example, mood disturbances, poorer sleep quality, or even changes in your metabolism.

Nutrient deficiencies: As we age, nutrient absorption and intake can be affected by various factors, such as the use of medication, changes in dietary patterns, and changes in gastrointestinal health [6].

Boosting your energy level

Unfortunately, aging is a process that cannot be reversed, so preventing fatigue is not avoidable. However, don’t despair! There are a number of easy lifestyle habits that can help: exercise regularly, participate in social activities you enjoy, and eat a well-balanced diet [6].

A well-balanced diet can be optimized by the implementation of supplements into your diet. Supplements can be a valuable addition to your diet since they address potential nutritional deficiencies and support your overall health and well-being.

Which nutrients help to beat fatigue?

Nutritional deficiencies often contribute to feelings of fatigue, so ensuring adequate nutrient levels is essential. Here are some key nutrients that can help in overcoming fatigue [7,8]:

1. Iron: This vital mineral supports oxygen supply to the muscles and plays a crucial role in energy production. It is also an important part in the structure of the enzymes responsible for ATP production.

2. Magnesium: Another important mineral involved in energy production, magnesium activates ATP synthase, an enzyme responsible for synthesizing ATP. It also serves various functions related to energy production, muscle function, bone health, and protein synthesis.

3. Vitamin C: This essential nutrient aids in fighting fatigue by enhancing iron absorption and safeguarding red blood cells from oxidative stress. By promoting improved oxygen supply to the muscles, vitamin C contributes to combating fatigue.

4. B vitamins: B vitamins play a multifaceted role in energy production. They are integral to the metabolism of macronutrients and also support the production of red blood cells, indirectly contributing to oxygen supply.

5. Bioflavonoids: These polyphenolic compounds offer numerous health benefits, like improved blood flow and increased mitochondrial efficiency. Actiful®, a substance rich in the bioflavonoid hesperidin, is particularly a good option to consider.

3. Actiful®: A natural ingredient for more energy

Actiful® is an orange & pomegranate complex, containing a high amount of micronized hesperidin. The ingredient is developed to boost vitality and optimize energy levels.

A proprietary clinical trial by BioActor showed that Actiful® provides immediate and sustained energy. It does so by improving blood flow to active muscles and optimizing the respiration capacity of mitochondria, in turn increasing ATP production [9].

Actiful®’s positive effect on blood flow is linked to vasodilative capacities of the active metabolites. Micronized hesperidin promotes vasodilation by stimulating the production of nitric oxide [10]. Nitric oxide relaxes the blood vessels, thereby enlarging their diameter and allowing the passage of a greater amount of nutrient-rich blood and oxygen.

As a bonus, Actiful® positively affects mental well-being. In our proprietary clinical trial, we showed a significant improvement in concentration, thinking, memory, and learning [11]. These aspects are vital for overall well-being and quality of life.

Overall, Actiful® is a safe, healthy, and natural ingredient which is perfect to be incorporated into energy-providing supplements.


Actiful: a sweet orange and pomegranate extract suitable for supplements

New publication of clinical data: Actiful® reduces Methylglyoxal, an important marker for healthy aging

New publication of clinical data: Actiful® reduces Methylglyoxal, an important marker for healthy ageing

Maastricht, The Netherlands, 15th September  2023

Press release

A randomized double blinded crossover study performed by Maastricht University, showed the potential of Actiful® as a dietary modulator against advanced glycation end-products (AGEs). AGEs are associated with various age-related chronic diseases. After a 4-week period of Actiful® consumption in healthy elderly subjects, plasma levels of methylglyoxal (MGO) decreased significantly by 9.8% (p = 0.042). These new clinical results highlight Actiful®’s potential to mitigate age-related diseases like diabetes, vascular dysfunction and neurodegeneration. 

Actiful: a sweet orange and pomegranate extract suitable for supplements

Actiful®: an energy-boosting ingredient developed by BioActor

Actiful® is a clinically validated blend of Citrus sinensis (sweet orange) and Punica granatum (pomegranate) extracts. These plants are abundant in bioactive polyphenolic components, mainly flavonoids (1, 2) . Actiful® has a dual mode of action: by increasing synthesis of nitric oxide and by improving ATP production through an increased mitochondrial respiration efficiency (3). In the first clinical study, Actiful® demonstrated to improve energy, mood and antioxidant status in healthy elderly individuals. Actiful® is used globally by leading supplement brands in a vast array of products supporting an active lifestyle and healthy aging.

The study: A Citrus and Pomegranate Complex Reduces Methylglyoxal in Healthy Elderly Subjects: Secondary Analysis of a Double-Blind Randomized Cross-Over Clinical Trial

 

Introduction

This study (4) was published in the International Jouranl of Molecular Sciences . It focuses on the evaluation of additional biomarkers and the effect of Actiful® in reducing the concentrations of reactive α-dicarbonyl compounds (specifically methylglyoxal, glyoxal, and 3-deoxyglucosone) in the blood of healthy elderly participants. These α-dicarbonyls are known to contribute to the formation of advanced glycation end-products (AGEs), which are associated with various chronic diseases, including diabetes and cardiovascular diseases (5).

Methods

Thirty-six healthy elderly subjects were recruited for this double-blind, randomized crossover clinical trial. They received either 700 mg of Actiful® in capsules, or a placebo for four weeks, with a 4-week washout period in between.

Blood samples were collected during the test day to measure α-Dicarbonyls in plasma. This was achieved via ultra-performance liquid chromatography tandem mass spectrometry.

Results

A significant reduction in plasma methylglyoxal concentrations was observed during a 4-week supplementation period. This reduction suggests a potential benefit in terms of reducing the formation of harmful AGEs, which could be attributed to the antioxidant properties of the active compounds in the supplement. The observed reduction in methylglyoxal was around 9.8%, which could be of clinical relevance in preventing or managing age-related conditions related to AGEs formation, like cardiovascular related diseases, diabetes and neurodegeneration. This confirms the importance of exploring promising nutraceuticals like Actiful® as potential healthy ageing strategies to mitigate the impact of reactive α-dicarbonyl compounds on health.

Conclusion

This study demonstrates the great potential of Actiful® for playing a role in healthy ageing. This is indicated by the significant reduction in AGEs, specifically MGO, found in the present study.

Click here to read the complete publication

About BioActor

BioActor, based in Maastricht, Netherlands is part of the Solabia Group and has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. We focus on the development of innovative activities that address active living and healthy ageing. Our goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.

Feel free to contact via info@bioactor.com for more information on the possibilities Actiful® has to offer. Further information can also be found on: https://actiful.eu and https://bioactor.com/products/actiful


Enhancing Mitochondrial Health Exploring the Significance of Nutrients

Exploring the significance of nutrients for mitochondrial health

Enhancing mitochondrial health: exploring the significance of nutrients

August 8th, 2023

Discover the influence of nutrients on your mitochondrial health. Dive into our blog to learn how magnesium, hesperidin, vitamin C, omega-3s, and more can enhance your mitochondrial health and boost your overall vitality.

Enhancing Mitochondrial Health Exploring the Significance of Nutrients

Nutrients to support mitochondrial health

Maintaining the optimal performance of our mitochondria is pivotal for our overall well-being. These microscopic organelles act as cellular powerhouses, generating a significant portion of the energy necessary for our cells to function at their best.

Beyond energy production, they also regulate metabolic processes and uphold a delicate balance of nutrients within our cells

Dysfunctional mitochondria can result in notable symptoms like fatigue and muscle weakness. In more serious instances, they have been linked to critical health conditions such as cardiovascular ailments and neurodegenerative diseases.

Consequently, prioritizing the health of our mitochondria is not only essential for general vitality but also plays a preventive role against potential illnesses.

Within this article, we will take a look at specific nutrients that actively contribute to the maintenance and augmentation of mitochondrial health.

Magnesium and mitochondrial vitality

Magnesium plays a vital role in ensuring the well-being of our mitochondria. It serves as a crucial facilitator for enzymes responsible for energy production, while also exhibiting antioxidant properties.

This antioxidative function of magnesium is particularly significant, shielding mitochondria from potential harm induced by harmful molecules. Additionally, magnesium takes on the responsibility of regulating calcium levels within mitochondria, a pivotal function in averting any potential malfunctioning (1).

Sustaining an appropriate intake of magnesium is essential to uphold the health of mitochondria and prevent any disruptions in their functioning. Incorporating magnesium-rich foods into our diet, such as nuts, seeds, whole grains, and leafy green vegetables, provides a natural source of this essential mineral. Additionally, it’s a possible addition for an energy supplement.

Hesperidin: a citrus boost for mitochondria

Hesperidin, a natural compound present in citrus fruits like oranges, lemons, and grapefruits, offers significant potential in maintaining robust mitochondrial health.

By boosting the expression of genes linked to energy production, hesperidin enhances mitochondrial functionality. This augmentation translates to increased energy production within the mitochondria, resulting in elevated energy levels and reduced fatigue (2).

Moreover, hesperidin boasts anti-inflammatory attributes that play a role in curbing inflammation throughout the body. As inflammation can contribute to mitochondrial disturbances, mitigating this inflammation becomes a supportive measure for preserving mitochondrial well-being.

Vitamin C to boost mitochondrial health

Vitamin C holds a crucial role in maintaining the well-being of our mitochondria. Serving as one of the body’s most potent antioxidants, vitamin C offers safeguarding prowess against detrimental molecules known as free radicals, shielding our mitochondria from harm (3).

Free radicals possess the capacity to impair mitochondria, diminishing their capacity to generate energy. However, vitamin C effectively counters these radicals, preventing their damaging effects.

Therefore, ensuring your diet includes a good dose of vitamin C becomes a noteworthy strategy to keep healthy mitochondria.

Omega-3s: helpful for energy

Omega-3 fatty acids are a type of healthy fat found in foods like fatty fish, nuts, and seeds. They play a crucial role in promoting the health of our mitochondria.

These fatty acids are boosters for mitochondria: they help these powerhouses extract more energy from the same amount of nutrients, which means less fatigue and more energy (4). Omega-3s also shield mitochondria from damage caused by harmful molecules. They also improve the mitochondria’s ability to transport nutrients in and out efficiently.

Omega-3 fatty acids also bring anti-inflammatory capabilities, which is good for our overall well-being. Including foods rich in omega-3s in our diet is a smart move to support your mitochondria, boost energy production, and keep inflammation in check.

B-vitamins and their ability to support mitochondrial well-being

B vitamins, including B1, B2, B3, B5, and B7, are fundamental contributors to the maintenance of optimal mitochondrial health. These vitamins play a pivotal role in facilitating energy production within mitochondria by participating in the breakdown of carbohydrates, fats, and proteins.

The main reason for this is that B vitamins can act as co-enzymes and precursors of co-enzymes that help in the breakdown of these nutrients. This is key for mitochondrial health. Inadequate intake of these B vitamins can lead to compromised mitochondrial function, resulting in sensations of fatigue, weakness, and muscular discomfort (5).

Sustaining an adequate dietary supply of B vitamins is imperative to sustain the functional integrity of mitochondria and facilitate efficient energy synthesis.

Intake of nutrients to support mitochondrial health

In summary, looking after the health of our mitochondria is vital for our general well-being. A range of nutrients, such as hesperidin, magnesium, B-vitamins, omega-3 fatty acids, and vitamin C, play key roles in supporting mitochondrial function. They not only help diminish oxidative stress and inflammation but also enhance exercise performance.

By incorporating these essential nutrients in your diet, we can effectively boost our mitochondrial health and ensure our body’s energy production functions at its best.

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Learn how YAMAMOTO integrated WATTS’UP® into their products, driving remarkable success.

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Cyclists going that extra mile

6 reasons to use WATTS’UP® in your sports nutrition supplement to go that extra mile

6 reasons to use WATTS’UP® in your sports nutrition supplement

July 14th, 2023

Over the past years, consumption of dietary supplements has become more widespread amongst both athletes and non-athletes. Athletes, in particular, have taken to these supplements to boost their athletic performance, speed up recovery, and prevent injuries. For product developers it can be hard to decide which ingredients to include in their sports nutrition supplements. In this article you will get to know more about the health benefits of our citrus extract WATTS’UP® and 6 reasons to include it in your sports nutrition supplement.

Cyclists going that extra mile

Beneficial effects of antioxidants for sports nutrition

Polyphenols are molecules that are present in many fruits. They have attracted attention for their ability to act as antioxidants and reduce inflammation (1). Studies have shown that polyphenols from citrus, pomegranates, and blueberries can alleviate muscle pain after exercise and enhance muscle strength.

Additionally, flavonoid supplementation has been found to enhance endurance exercise performance in humans.

Therefore, BioActor researched and developed a unique sports nutrition ingredient called WATTS’UP®, which is a natural ingredient, extracted from Citrus sinensis and standardized for highly bioavailable hesperidin.

WATTS’UP® has been designed to improve performance in both endurance and strength disciplines, making it a high-quality ingredient for supplements in the sport nutrition market. For this reason, we would like to delve into 6 reason to use it in your sports nutrition supplement.

1. WATTS’UP® increases production of nitric oxide for optimal blood flow

Hesperidin can boost the cells that form the lining of our blood vessels by promoting the production of nitric oxide (1). This substance is capable to induce the muscles in our blood vessels to relax and expand, facilitating blood flow.

This increase in blood circulation leads to a decrease in blood pressure, as well as an increase in the supply of oxygen and nutrients to the muscles during physical activity, thereby reducing fatigue.

2. WATTS’UP® has a direct effect on the mitochondria

The mitochondria play a vital role in providing energy obtained from food into ATP (Adenosine Triphosphate), which is the energy source that the muscles need for physical activity (2).

Inside the muscle cells, WATTS’UP® increases the efficiency of mitochondria, allowing these organelles to produce much needed energy in a more efficient way (1). Simply put, WATTS’UP® makes sure that the mitochondria do not lose any of their potential to create energy, meaning that less energy is lost without production of ATP.

3. WATTS’UP® increases sports performance in trained athletes and recreational gym-goers

Performance booster for trained athletes

A placebo-controlled double-blind study investigated the long-term effect of a daily dose of 500mg of WATTS’UP® supplementation on highly trained athletes.

After 4 weeks of supplementation with 500mg of WATTS’UP® a strong increase in anaerobic power (p=0.03) was observed, as well as a sustained superior aerobic-derived power throughout the whole exercise. The tested individuals spent 10 hours per week biking, meaning that even in highly trained individuals, WATTS’UP® can give you the power to go that extra mile.

Performance booster for moderately trained individuals

Another placebo-controlled and double-blind study investigated the effect of a daily dose of 400mg of WATTS’UP® on peak power in moderately trained subjects.

The results showed an increase in average peak power (p<0.001) as well as a significant increase in peak power within the first five seconds (p=0.020) after 4 weeks of supplementation. This means that WATTS’UP® is not only able to help highly trained individuals, but also gym-goers.

Read more about these studies in our white paper for WATTS’UP®.

4. Higher bioavailable

WATTS’UP ® was specifically developed and has been micronized for an improved bioavailability and rapid uptake (4).

A bioavailability study in human volunteers showed that metabolites of WATTS’UP® reached the bloodstream after only 15 minutes of consumption to boost performance right from the start, enhancing the power during the exercise.

5. Natural powder and easy to formulate

WATTS’UP® is a clean and natural ergogenic sports performance ingredient, which is why it is a great addition to boost any sports nutrition formula. It has a neutral taste and is easily combined with electrolytes, BCAAs, creatine or caffeine in powder blends, capsules, effervescent tablets, beverages, and gummies.

Curious about which ingredients a pre-workout formula should include? Find out more!

6. WATTS’UP® is sustainably sourced

WATTS’UP® is made from immature oranges that are sustainably sourced. During the growth of an orange tree, the tree has to decide which fruits are the most promising ones. To sustain these high quality oranges, the tree has to allocate its resources to them. This means that the less promising oranges are dropped from the tree in a process that’s literally called ‘Fruit drop’.

That these immature oranges are dropped, does not mean that they are not full of valuable nutrients! For this reason, we collect this byproduct of orange trees to create our citrus extracts. Read more about this process here!

WATTS’UP®, the key ingredient for your sports nutrition supplement

WATTS’UP® increases aerobic and anaerobic power through a direct effect on the mitochondria showing positive effects on peak force, anaerobic power, and endurance, making it the ideal sports supplement for both trained athletes and active people that want to get nutritional support for their physical exercise.

Due to the fact that it is an innovative and science-based ingredient it will add the differentiation and help your supplement of getting a defined and solid positioning on the market therefore creating a successful product.

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Ingredients-for-energy-supplements

Top 5 reasons why Actiful® is a good ingredient for your energy supplement

Top 5 reasons why Actiful® is a good addition to your energy supplement

May 25th, 2023

The need for healthy ingredients that have undergone extensive clinical testing is increasing as consumers become more interested in dietary supplements that improve energy. The abundance of ingredients available can feel overpowering for supplement formulators who aim to create a product that promotes energy and vitality. But don’t worry – in this article, we’ll cover the top five reasons why Actiful® is a good ingredient for your energy supplement.

Ingredients-for-energy-supplements

Finding ingredients for the rising demand in energy supplements

Low energy levels and a lack of vitality are common complaints in today’s fast-paced world. Many consumers turn to dietary supplements to manage the daily mental and physical stressors they face. Energy-enhancing supplements aim to prevent fatigue, increase physical activity, and promote social engagement.

With the growing demand for energy-enhancing products, it can be challenging to identify scientifically backed ingredients. To simplify the process, we’ve compiled the top 5 reasons why Actiful should be included in your energy supplement as an ingredient.

Actiful®: A combination of sweet orange and pomegranate

Actfiul® is a patent-protected, all-natural ingredient developed by BioActor; a pioneer in clinically substantiating the beneficial impact of citrus flavonoids on energy metabolism. Actiful® is standardized for hesperidin and punicalagin; the main polyphenols found in sweet orange (Citrus sinensis) and the peel of pomegranate (Punica granatum), respectively. Both compounds have been extensively studied for their potential health benefits.

Top 5 reasons to use Actiful® as an ingredient for your energy supplement

1. Enhanced physical performance in both young and old

A double-blind randomized controlled trial conducted on physically fit young males revealed that Actiful® can increase absolute power output by 5% during a 10-minute cycling time-trial without requiring additional oxygen (1). This advantage was observed after just four weeks of daily supplementation with Actiful®.

In addition, a recently published double-blind randomized controlled trial conducted on active seniors found that daily supplementation with Actiful® for four weeks significantly increased their handgrip strength (2). Handgrip strength is a crucial measure of physical fitness in the elderly as it is indicative of overall health and functional status in day-to-day life.

Given that Actiful® has been clinically proven to enhance physical performance in both young and older individuals, it is an ideal ingredient to target a wide population.

2. Mental health benefits

Mental wellbeing plays a significant role in physical fitness, as the way one handles cognitive demanding tasks can affect how energized they feel.

In addition to improved physical performance, the elderly subjects who supplemented with Actiful® also experienced psychological benefits. Compared to the placebo group, the Actiful® group demonstrated significant improvements in cognitive domains such as thinking, memory, learning, and concentration (2). These elements are essential for maintaining one’s quality of life and wellbeing.

Given the critical connection between the mind and body in enhancing vitality, Actiful® is the ideal ingredient to target both.

3. Mitochondria

Boosting your energy can be done by targeting mitochondria, which are the powerhouses of the cell.

A strategy to target the mitochondria is by implementing specific nutrients into your diet. Actiful® enhances energy levels via mitochondria as well. Experiments in muscle cells have demonstrated that Hesperetin, the active metabolite of Hesperidin, can improve energy production by directly targeting the mitochondria (3).

This improvement in energy production has been observed to translate into improved running performance in mice. The mechanism behind this is that Actiful® improves the respiration capacity of the mitochondria.

To produce energy, mitochondria require oxygen to form an electron gradient across the intermembrane, which mechanically produces ATP. When protons leak across the intermembrane, the gradient weakens, resulting in fewer ATP molecules being formed. By inhibiting proton leakage across the mitochondrial intermembrane, Actiful® enhances energy production directly.

4. Antioxidant

During physical activity, there is a heightened production of reactive oxygen species (ROS) due to the increased demand on mitochondria to produce energy. Excessive ROS can lead to damage to the mitochondria and other crucial structures of the cell, which can impair their functionality.

Hesperidin has been demonstrated to not only scavenge ROS directly but also enhance the natural antioxidant systems present in cells (3). In addition, pomegranate has also been found to improve antioxidant status (4).
As a result, Actiful®’s antioxidant capabilities may improve vitality by preserving the functionality of cells and tissues.

5. NO improved bloodflow

Nitric oxide (NO) is a critical component in regulating blood flow. NO relaxes the blood vessels, increasing their diameter, and allowing more oxygen and nutrient-rich blood to pass through.
Endothelial cells that line the blood vessels produce more NO through the enzyme eNOS, which Hesperidin has been found to activate, promoting vasodilation (5).

Furthermore, when oxygen is limited, dietary nitrate can raise NO levels. Pomegranate, which is high in Punicalagin, is a potent source of dietary nitrate that may improve blood flow and increase the efficiency of oxygen and nutrient delivery.

Actiful®: the key ingredient of your energy supplement

All in all, Actiful® is a natural and safe ingredient that has the ideal properties to be incorporated in energy supplements that aim to provide acute and sustained improvements in vitality!


improving-cardiovascular-health

Simple ways to boost your cardiovascular health

Simple ways to boost your cardiovascular health

May 10th, 2023

Cardiovascular health refers to the health of the cardiovascular system. Its definition is based on all the behaviors and health factors that, when optimal, are associated with better cardiovascular disease-free survival and quality of life. Choosing a healthy diet, being more active, and maintaining normal blood lipid and glucose levels are some of the strategies that help to maintain great cardiovascular health throughout our lives.

improving-cardiovascular-health

How to define cardiovascular health?

The American Heart Association has provided a number of metric definitions that can be used to classify poor, intermediate, or ideal cardiovascular health. These include diet, physical activity, smoking, sleep, weight, blood and glucose levels, and blood pressure.

Pursuing a healthier lifestyle from a young age is a great strategy for maintaining ideal cardiovascular health throughout our lives. This will result in a lower risk of developing cardiovascular diseases such as hypertension, strokes, atherosclerosis, peripheral artery disease, and vein diseases (1).
In this article, we will dive into the 7 ways to improve your cardiovascular health!

Healthy eating behaviors

Creating a healthy eating pattern represents an easy way to improve your cardiovascular health. This means preferring certain foods such as vegetables, fruits, whole grains, plant-based proteins, fish and limiting sweetened drinks, alcohol, full-fat dairy products, and highly processed foods.

Avoiding trans-fat and partially hydrogenated oils that are contained in many commercial baked goods represents another good and easy strategy to improve your eating habits (1).

Polyphenols derived from olive leaves also have many beneficial effects and represent a promising, natural ingredient for supporting cardiovascular health (2).

Giving up smoking

Smoking is deleterious for your circulatory system as it increases the risk of stroke in both men and women. Cigarettes, e-cigarettes, and tobacco products contain many toxic chemicals, as do their smoke, and liquids. Several beneficial changes occur after quitting smoking and within one year after quitting, your risk of heart disease goes down with 50% (1).

Physical activity

Regular exercise and physical activity are associated with remarkable health benefits. Adults should do at least 150 minutes of moderate-intensity aerobic activity a week or 75 minutes of vigorous aerobic activity or a combination of both, throughout the week. Parking further away from your work place or taking the stairs instead of the elevator contributes to physical activity levels and improves health outcomes (1).

Sleep quality

Sleep plays a crucial role for overall health and well-being. Short sleep duration or poor sleep quality is associated with high blood pressure, elevated cholesterol levels, and atherosclerosis. These conditions can be prevented by aiming for an average of 7-9 hours of quality sleep a day (1).

Body weight management

Maintaining a healthy weight, defined as a body mass index between 18.5 and 24.9 for adults, can help reduce the risk of many heart problems such as cardiovascular disease, stroke, and high blood pressure.
A few strategies that can help to manage body weight include choosing a healthy diet, increasing physical activity levels, limiting alcohol, avoiding stress, and improving your sleep quality (1).

Stable blood lipid and glucose levels

Cholesterol is a fat-like substance that your body needs, in the right amounts, for good health. Unhealthy levels of cholesterol can lead to a higher risk of cardiovascular disease, such as heart disease and stroke. Checking your cholesterol levels regularly can help you understand whether you have normal blood lipid levels.

Over time, high blood glucose levels can damage your health too. Blood glucose levels rise because of the glucose that enters the bloodstream and insulin, a hormone that helps the cells take up the glucose they can use for energy production.

A healthy diet that includes vegetables, fruits, whole grains, beans, legumes, nuts, plant-based proteins, and lean animal proteins, may help you manage cholesterol and glucose levels. Other strategies include being more active, quitting smoking, and maintaining a healthy weight (3).

Blood pressure control

Blood pressure is defined as the pressure of your blood on the walls of the arteries as your heart pumps it throughout your body. When your blood pressure is permanently higher than normal, the risk of heart attacks and strokes increases.

There are no signs or symptoms of high blood pressure, which means it is crucial to have regular check-ups to measure it. Simple changes to your lifestyle, such as eating healthy and being more active can help manage your blood pressure over time (4).

How to improve your cardiovascular health?

To summarize, choosing a healthy diet, quitting smoking, being more active, improving sleep health, maintaining normal blood lipid, and glucose levels, and managing your blood pressure are great strategies to lower the risk of developing cardiovascular disease thus, improving your cardiovascular health.


Uncovering the vital role of mitochondria in your overall health

Uncovering the vital role of mitochondria in your overall health

March 24th, 2023

Mitochondria are essential organelles that produce cellular energy and play a crucial role in the overall health of the human body. This article explores the structure and function of mitochondria, including their role in exercise, aging, and maintaining cellular health. By understanding the importance of mitochondria, we can work towards maintaining their health and improving overall cellular health.

Mitochondria: structure and function

Mitochondria are tiny organelles that are often referred to as the “powerhouses” of the cell. These structures play a critical role in maintaining the overall health of the human body. In this article, we explore the function and significance of mitochondria in both health and disease.

The endosymbiotic theory suggests that mitochondria originated from free-living bacteria that were engulfed by early eukaryotic cells, leading to the development of a crucial component of the cell’s internal machinery. Today, mitochondria are present in the cells of many living things, including human cells (1).

Mitochondria are responsible for the production of cellular energy through a series of chemical processes that convert glucose into adenosine triphosphate (ATP). In fact, mitochondria generate 90% of the energy required for our bodies to function properly (1). Mitochondria also participate in both cell development and cell death and are essential for the regulation of the cell cycle, cellular differentiation, and other cellular processes.

Mitochondria and exercise

Since mitochondria are responsible for generating energy for the cells, they are essential for exercise and physical activity.

During exercise, the demand for energy in the muscles rises, and the mitochondria produce ATP, the main source of energy for cells. As a result, the muscles may work harder and for longer periods of time (2).

Additionally, the mitochondria aid in the removal of lactic acid from the muscles, which delays the onset of fatigue and discomfort. Overall, mitochondria’s capacity to supply energy to cells is essential for exercise, enabling enhanced physical performance and recovery.

Mitochondria and aging

Reactive oxygen species (ROS), which are created by the mitochondria as a byproduct of energy generation, are theorized to play a role in some aspects of aging (3).

These particles harm proteins, lipids, and DNA, and also harm the mitochondria’s functioning components.

When the mitochondria become dysfunctional, more ROS are produced, which worsens the damage.

Physical activity is thought to be a great approach to support mitochondrial health by controlling mitochondrial quality control (MQC) and allowing damaged mitochondria to be repaired or eliminated and new mitochondria to be synthesized, restoring the metabolic state.

Mitochondrial biogenesis is the process by which new mitochondria are created within cells. This process is essential for maintaining mitochondrial health and function, as it ensures that cells have a sufficient supply of these vital organelles.

Several factors can stimulate mitochondrial biogenesis, including exercise, calorie restriction, and certain dietary supplements. Exercise, in particular, has been shown to have a powerful effect on mitochondrial biogenesis, as it increases the demand for energy in the muscles and stimulates the production of new mitochondria to meet this demand.

Maintaining mitochondrial health

Mitochondria are essential because they serve as the cell’s main energy source. The cell wouldn’t be able to perform its important activities without the energy provided by the mitochondria, which would result in cellular malfunction and ultimately, cell death.

Furthermore, mitochondrial health and function are essential for maintaining tissue and organ function as well as the general health of cells.

To maintain mitochondrial health, it is essential to lead a healthy lifestyle that includes a well-balanced diet, regular exercise, and limiting exposure to contaminants in the environment.

Exercise is particularly important because it promotes mitochondrial quality control and decreases the formation of ROS, boosting the expression of vascular endothelial growth factor (VEGF), and raising the bioavailability of nitric oxide, which favors calcium handling and contractility (4).

The importance of mitochondrial health

Mitochondria play a critical role in maintaining the overall health of the human body. They are essential for the production of cellular energy, the regulation of the cell cycle, and other cellular processes. To maintain mitochondrial health, it is important to lead a healthy lifestyle that includes regular exercise and a well-balanced diet.

Physical activity is a great way to support mitochondrial health by promoting mitochondrial quality control and decreasing the formation of ROS (5). By understanding the function and significance of mitochondria in cells, we can concentrate on keeping these essential organelles active and functional.

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Learn how YAMAMOTO integrated WATTS’UP® into their products, driving remarkable success.

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