Exploring the significance of nutrients for mitochondrial health
Enhancing mitochondrial health: exploring the significance of nutrients
Discover the influence of nutrients on your mitochondrial health. Dive into our blog to learn how magnesium, hesperidin, vitamin C, omega-3s, and more can enhance your mitochondrial health and boost your overall vitality.
Nutrients to support mitochondrial health
Maintaining the optimal performance of our mitochondria is pivotal for our overall well-being. These microscopic organelles act as cellular powerhouses, generating a significant portion of the energy necessary for our cells to function at their best.
Beyond energy production, they also regulate metabolic processes and uphold a delicate balance of nutrients within our cells
Dysfunctional mitochondria can result in notable symptoms like fatigue and muscle weakness. In more serious instances, they have been linked to critical health conditions such as cardiovascular ailments and neurodegenerative diseases.
Consequently, prioritizing the health of our mitochondria is not only essential for general vitality but also plays a preventive role against potential illnesses.
Within this article, we will take a look at specific nutrients that actively contribute to the maintenance and augmentation of mitochondrial health.
Magnesium and mitochondrial vitality
Magnesium plays a vital role in ensuring the well-being of our mitochondria. It serves as a crucial facilitator for enzymes responsible for energy production, while also exhibiting antioxidant properties.
This antioxidative function of magnesium is particularly significant, shielding mitochondria from potential harm induced by harmful molecules. Additionally, magnesium takes on the responsibility of regulating calcium levels within mitochondria, a pivotal function in averting any potential malfunctioning (1).
Sustaining an appropriate intake of magnesium is essential to uphold the health of mitochondria and prevent any disruptions in their functioning. Incorporating magnesium-rich foods into our diet, such as nuts, seeds, whole grains, and leafy green vegetables, provides a natural source of this essential mineral. Additionally, it’s a possible addition for an energy supplement.
Hesperidin: a citrus boost for mitochondria
Hesperidin, a natural compound present in citrus fruits like oranges, lemons, and grapefruits, offers significant potential in maintaining robust mitochondrial health.
By boosting the expression of genes linked to energy production, hesperidin enhances mitochondrial functionality. This augmentation translates to increased energy production within the mitochondria, resulting in elevated energy levels and reduced fatigue (2).
Moreover, hesperidin boasts anti-inflammatory attributes that play a role in curbing inflammation throughout the body. As inflammation can contribute to mitochondrial disturbances, mitigating this inflammation becomes a supportive measure for preserving mitochondrial well-being.
Vitamin C to boost mitochondrial health
Vitamin C holds a crucial role in maintaining the well-being of our mitochondria. Serving as one of the body’s most potent antioxidants, vitamin C offers safeguarding prowess against detrimental molecules known as free radicals, shielding our mitochondria from harm (3).
Free radicals possess the capacity to impair mitochondria, diminishing their capacity to generate energy. However, vitamin C effectively counters these radicals, preventing their damaging effects.
Therefore, ensuring your diet includes a good dose of vitamin C becomes a noteworthy strategy to keep healthy mitochondria.
Omega-3s: helpful for energy
Omega-3 fatty acids are a type of healthy fat found in foods like fatty fish, nuts, and seeds. They play a crucial role in promoting the health of our mitochondria.
These fatty acids are boosters for mitochondria: they help these powerhouses extract more energy from the same amount of nutrients, which means less fatigue and more energy (4). Omega-3s also shield mitochondria from damage caused by harmful molecules. They also improve the mitochondria’s ability to transport nutrients in and out efficiently.
Omega-3 fatty acids also bring anti-inflammatory capabilities, which is good for our overall well-being. Including foods rich in omega-3s in our diet is a smart move to support your mitochondria, boost energy production, and keep inflammation in check.
B-vitamins and their ability to support mitochondrial well-being
B vitamins, including B1, B2, B3, B5, and B7, are fundamental contributors to the maintenance of optimal mitochondrial health. These vitamins play a pivotal role in facilitating energy production within mitochondria by participating in the breakdown of carbohydrates, fats, and proteins.
The main reason for this is that B vitamins can act as co-enzymes and precursors of co-enzymes that help in the breakdown of these nutrients. This is key for mitochondrial health. Inadequate intake of these B vitamins can lead to compromised mitochondrial function, resulting in sensations of fatigue, weakness, and muscular discomfort (5).
Sustaining an adequate dietary supply of B vitamins is imperative to sustain the functional integrity of mitochondria and facilitate efficient energy synthesis.
Intake of nutrients to support mitochondrial health
In summary, looking after the health of our mitochondria is vital for our general well-being. A range of nutrients, such as hesperidin, magnesium, B-vitamins, omega-3 fatty acids, and vitamin C, play key roles in supporting mitochondrial function. They not only help diminish oxidative stress and inflammation but also enhance exercise performance.
By incorporating these essential nutrients in your diet, we can effectively boost our mitochondrial health and ensure our body’s energy production functions at its best.
Discover YAMAMOTO’s Success Story
Learn how YAMAMOTO integrated WATTS’UP® into their products, driving remarkable success.
6 reasons to use WATTS’UP® in your sports nutrition supplement to go that extra mile
6 reasons to use WATTS’UP® in your sports nutrition supplement
Over the past years, consumption of dietary supplements has become more widespread amongst both athletes and non-athletes. Athletes, in particular, have taken to these supplements to boost their athletic performance, speed up recovery, and prevent injuries. For product developers it can be hard to decide which ingredients to include in their sports nutrition supplements. In this article you will get to know more about the health benefits of our citrus extract WATTS’UP® and 6 reasons to include it in your sports nutrition supplement.
Beneficial effects of antioxidants for sports nutrition
Polyphenols are molecules that are present in many fruits. They have attracted attention for their ability to act as antioxidants and reduce inflammation (1). Studies have shown that polyphenols from citrus, pomegranates, and blueberries can alleviate muscle pain after exercise and enhance muscle strength.
Additionally, flavonoid supplementation has been found to enhance endurance exercise performance in humans.
Therefore, BioActor researched and developed a unique sports nutrition ingredient called WATTS’UP®, which is a natural ingredient, extracted from Citrus sinensis and standardized for highly bioavailable hesperidin.
WATTS’UP® has been designed to improve performance in both endurance and strength disciplines, making it a high-quality ingredient for supplements in the sport nutrition market. For this reason, we would like to delve into 6 reason to use it in your sports nutrition supplement.
1. WATTS’UP® increases production of nitric oxide for optimal blood flow
Hesperidin can boost the cells that form the lining of our blood vessels by promoting the production of nitric oxide (1). This substance is capable to induce the muscles in our blood vessels to relax and expand, facilitating blood flow.
This increase in blood circulation leads to a decrease in blood pressure, as well as an increase in the supply of oxygen and nutrients to the muscles during physical activity, thereby reducing fatigue.
2. WATTS’UP® has a direct effect on the mitochondria
The mitochondria play a vital role in providing energy obtained from food into ATP (Adenosine Triphosphate), which is the energy source that the muscles need for physical activity (2).
Inside the muscle cells, WATTS’UP® increases the efficiency of mitochondria, allowing these organelles to produce much needed energy in a more efficient way (1). Simply put, WATTS’UP® makes sure that the mitochondria do not lose any of their potential to create energy, meaning that less energy is lost without production of ATP.
3. WATTS’UP® increases sports performance in trained athletes and recreational gym-goers
Performance booster for trained athletes
A placebo-controlled double-blind study investigated the long-term effect of a daily dose of 500mg of WATTS’UP® supplementation on highly trained athletes.
After 4 weeks of supplementation with 500mg of WATTS’UP® a strong increase in anaerobic power (p=0.03) was observed, as well as a sustained superior aerobic-derived power throughout the whole exercise. The tested individuals spent 10 hours per week biking, meaning that even in highly trained individuals, WATTS’UP® can give you the power to go that extra mile.
Performance booster for moderately trained individuals
Another placebo-controlled and double-blind study investigated the effect of a daily dose of 400mg of WATTS’UP® on peak power in moderately trained subjects.
The results showed an increase in average peak power (p<0.001) as well as a significant increase in peak power within the first five seconds (p=0.020) after 4 weeks of supplementation. This means that WATTS’UP® is not only able to help highly trained individuals, but also gym-goers.
Read more about these studies in our white paper for WATTS’UP®.
4. Higher bioavailable
WATTS’UP ® was specifically developed and has been micronized for an improved bioavailability and rapid uptake (4).
A bioavailability study in human volunteers showed that metabolites of WATTS’UP® reached the bloodstream after only 15 minutes of consumption to boost performance right from the start, enhancing the power during the exercise.
5. Natural powder and easy to formulate
WATTS’UP® is a clean and natural ergogenic sports performance ingredient, which is why it is a great addition to boost any sports nutrition formula. It has a neutral taste and is easily combined with electrolytes, BCAAs, creatine or caffeine in powder blends, capsules, effervescent tablets, beverages, and gummies.
Curious about which ingredients a pre-workout formula should include? Find out more!
6. WATTS’UP® is sustainably sourced
WATTS’UP® is made from immature oranges that are sustainably sourced. During the growth of an orange tree, the tree has to decide which fruits are the most promising ones. To sustain these high quality oranges, the tree has to allocate its resources to them. This means that the less promising oranges are dropped from the tree in a process that’s literally called ‘Fruit drop’.
That these immature oranges are dropped, does not mean that they are not full of valuable nutrients! For this reason, we collect this byproduct of orange trees to create our citrus extracts. Read more about this process here!
WATTS’UP®, the key ingredient for your sports nutrition supplement
WATTS’UP® increases aerobic and anaerobic power through a direct effect on the mitochondria showing positive effects on peak force, anaerobic power, and endurance, making it the ideal sports supplement for both trained athletes and active people that want to get nutritional support for their physical exercise.
Due to the fact that it is an innovative and science-based ingredient it will add the differentiation and help your supplement of getting a defined and solid positioning on the market therefore creating a successful product.
Discover YAMAMOTO’s Success Story
Learn how YAMAMOTO integrated WATTS’UP® into their products, driving remarkable success.
The importance of clinical research: An interview with BioActor's in-house scientists
The importance of clinical research: An interview with BioActor’s in-house scientists
Interview
In the world of clinical research and scientific exploration, BioActor stands out as a leading company dedicated to the development of health ingredients. At the forefront of BioActor’s research and development (R&D) efforts are Sanne Ahles and Maria Imperatrice, two certified clinical research scientists who play vital roles in the BioActor’s R&D initiatives. In this interview, Sanne and Maria provide insights into their responsibilities, experiences, and the challenges they face in their pursuit of scientific advancement.
Could you introduce yourself and your role within BioActor?
Sanne: My name is Sanne Ahles and I am a clinical research scientist at BioActor. In addition, I am a PhD candidate at the Department of Nutrition and Movement Sciences at Maastricht University. I obtained my master’s degree in biomedical sciences after my internship at BioActor, after which I started working as a researcher.
Within BioActor, I am responsible for the research regarding our product Brainberry®, mainly focused on cognitive performance and vascular function. Over the years, I have designed, performed, analyzed, and reported various clinical studies, as well as written a systematic literature review.
Maria: My name is Maria Imperatrice and I also work as a clinical research scientist at BioActor. My research focus is Healthy Ageing and I’m currently performing two studies, Actiful2 and FEMMED, on two of our ingredients (Actiful® and Bonolive®) to evaluate their effect on exercise performance and postmenopausal symptoms, respectively.
I obtained my Bachelor Degree in Biology and my Master in Human Nutrition at the University “Federico II Di Napoli” in Italy, and my second master’s degree in Human Movement Sciences, with a specialisation in Sport and Nutrition, at Maastricht University.
At BioActor, we highly value clinical research because it plays a crucial role in providing evidence-based ingredients. What does clinical research entail and what do you like about it?
Sanne: Clinical research entails many different processes. This includes idea formation and initial literature searches, finding collaborations, obtaining ethics approval, practical work, data analyses, writing reports and papers, and communicating our results at national and international conferences.
Maria: A very interesting part for us is the ideation of the study. At BioActor we highly value innovation, which is why before starting a new clinical trial, we sit in brainstorming sessions with the R&D, marketing and sales teams to try to find white spaces in the current knowledge that can be of interest for the common public and different health domains. Once we find an interesting and never explored topic, the investigation can start.
Could you briefly take us through the process of a clinical trial?
Sanne: First, we initiate the idea formation process by brainstorming ideas that are relevant to customer questions or explore new areas of interest. Next, we perform literature searches to look for relevant papers, available data, and discover white space; topics that have not yet been researched.
Then we reach out to a collaborator, usually a professor at a University, to work with on developing a protocol for ethics review.
Maria: Once we obtain ethics approval, we dive into the practical phase of the clinical trial. This involves engaging with participants through visits where we collect data. This includes not only traditional data that we can extrapolate by collecting blood samples, but also performing tests to evaluate outcomes like reaction time, exercise capacity and mental flexibility.
It’s an interactive and rewarding experience that brings our research to life and allows us to better understand how our ingredients contribute to improving human health and develop evidence-based solutions. Afterwards, we analyze the data, draw conclusions, and share our findings through peer-reviewed publications. It’s a cool journey from start to finish!
Which of the above do you enjoy the most as a scientist?
Sanne: I enjoy collaborating with other companies or academic institutes! It’s such an incredible opportunity for us to broaden our knowledge and take our research to the next level. The energy and creativity that come from working with diverse teams is truly great.
Maria: The practical side of our work is always interesting! Collecting data means we get to perform visits with participants, and trust me, it’s never boring when you’re involved in a human study. The hands-on experience and the constant interaction with people make it such an exciting and fulfilling part of our job.
What is the biggest challenge in designing a study?
Sanne: In my opinion, the biggest challenge in designing a study is obtaining ethics approval, which is a rigorous and time-consuming process. We meticulously prepare documents explaining our research goals, methodology, and participant recruitment.
The ethical committee thoroughly reviews these documents, granting final approval for each aspect of our research.
Maria: I agree! Obtaining ethics approval is a significant challenge. However, this process is crucial for upholding ethical standards and protecting participant rights.
It also adds credibility to our research, fostering trust and allowing our findings to have a greater impact. Despite the challenges, navigating the ethics approval process is vital for conducting valuable and ethically sound research.
What is the best part of working at BioActor as a scientist?
Sanne & Maria: Being a scientist at BioActor is truly rewarding due to the chance to collaborate with a dynamic and passionate team of international colleagues. Within BioActor, we also see other aspects of the company besides R&D.
Our weekly company meetings allow us to really understand the bigger picture of the company and understand what each department entails. Consequently, we explore different facets of the company and gain valuable insights beyond our specific research and development focus.
BioActor: Using clinical science as the key to innovative ingredients
Sanne Ahles and Maria Imperatrice exemplify the passion and dedication that drive BioActor’s pursuit of finding new health effects of ingredients and advancing scientific innovation. From ideation to practical implementation, data analysis, and knowledge dissemination; they are pushing the boundaries of scientific knowledge and embracing the multidisciplinary nature of their work. Sanne and Maria contribute to BioActor’s mission of creating innovative and impactful solutions for a healthier life.
Why should you consider making a gummy supplement?
Why should you consider making a gummy supplement?
Gummy supplements are on the rise as people look for a convenient and tasty way to add essential nutrients to their diet. Gummies are a great alternative to capsules and pills for individuals looking for supplements that are not hard to swallow. In this article, we will discuss the advantages of gummy supplements over traditional supplement formats and the factors to consider when choosing a gummy as a supplement.
Tablets as dietary supplements
Recently, there has been a rise in people’s interest in their well-being by using nutritional supplements. This has resulted in a 12% increase in the production of supplements in 2020.
The most common forms of supplements are tablets and capsules, which are convenient, easy to use, and widely available.
Tablets are a solid form of supplement that is typically round or long in shape and can range in size from small and easy to swallow to larger and more difficult to swallow.
Tablets are made by compressing the active ingredients together with other inactive ingredients such as fillers, binders, and lubricants. These ingredients help to give the tablet its shape, size, and consistency and may also affect how the supplement is absorbed and used by the body.
Capsulated supplements
Capsules are another common form of supplement that is made by enclosing the active ingredients in a gelatin or vegetarian shell. Capsules can be filled with powders, liquids, or oils and come in a variety of sizes and shapes.
Both tablets and capsules have advantages and disadvantages depending on the individual and their needs. Tablets are often preferred by people who prefer a solid form of supplement and are more affordable than capsules.
However, what both forms of supplements have in common is that they are generally not liked for their taste. The demand for supplements that are nice to take is growing, which is why gummy supplements are on the rise.
The rise of gummy supplements
Gummies are a type of food supplement that provides essential nutrients that might be lacking in one’s regular diet. They are becoming increasingly popular in the food supplement industry due to their combination of health benefits and sweetness. Gummies are also a great option for individuals looking for vegan, gluten-free, or lactose-free products.
Manufacturers of functional gummies use natural and organic raw materials in their production, making them more appealing to quality-conscious consumers. These gummies typically contain gelatin, corn starch, water, sugar, and added colorings.
Gummies contain active ingredients such as vitamins, minerals, probiotics, antioxidants, and amino acids that can have positive effects on various aspects of health, including digestion, immune system function, cardiovascular health, and mental well-being.
Why choose gummies over pills?
– Gummies are a versatile form of supplement that can be used for many different purposes. They can help prevent digestive, sleep, and skin problems, treat vitamin deficiencies, and boost the immune system.
– Studies have shown that gummies are more effective than pills or tablets at delivering nutrients to the body. This is because the nutrients in gummies are dissolved in a liquid gelatin base, which makes them more easily absorbed by the body. As a result, gummies can be a more efficient way of supplying essential nutrients and provide a significant advantage over traditional supplement formats (1).
– Gummies are a convenient and tasty way to add vitamins and minerals to your diet. They’re becoming increasingly popular as a simple and easy way to supplement your diet with micronutrients, offering an enjoyable alternative to traditional supplements.
– The soft and chewy textures of gummies make them a great option for people who struggle with swallowing pills or capsules.
– Unlike traditional tablets or pills, gummies come in a variety of delicious flavors that can make taking supplements a more enjoyable experience. By taking vitamin gummies formulated with essential nutrients, individuals can avoid vitamin deficiencies and supplement their diet.
– Incorporating gummies into your brand can help you stand out from traditional supplement companies and offer consumers a unique and enjoyable option for improving their health.
Factors to consider when creating a gummy supplement
Creating high-quality gummy supplements requires careful consideration of the ingredients used. Here are some key points to keep in mind:
– Look for ingredient suppliers that provide options with minimal sugar content or natural sweeteners as alternatives. This ensures that the final gummy product aligns with consumer preferences for reduced sugar intake.
– Prioritize sourcing pure and natural ingredients for your gummy supplements. Consider using natural sources for colors and flavors to enhance the appeal and marketability of the product.
– Incorporate ingredients that offer a significant amount of dietary fiber per serving. Fiber not only adds nutritional value but also promotes digestive health and supports a strong immune system, making your gummies more appealing to health-conscious consumers.
In conclusion, it is important to look for gummies with natural and pure ingredients, as well as sweeteners or with a minimal amount of sugar. Having these factors in mind, consumers can find gummies that not only taste good but also provide essential nutrients and health benefits.
Creating a gummy supplement for focus and brain health
BioActor’s Brainberry® is a great example of an ingredient that can be used in a gummy. It has a low daily dose of only 65mg and has been clinically validated for cognitive performance, focus and hand-eye coordination.
It’s an extract from Aronia berries and if you want to find out more: Here’s everything you need to know about Brainberry® and brain health.
Discover YAMAMOTO’s Success Story
Learn how YAMAMOTO integrated WATTS’UP® into their products, driving remarkable success.
Uncovering the vital role of mitochondria in your overall health
Uncovering the vital role of mitochondria in your overall health
Mitochondria are essential organelles that produce cellular energy and play a crucial role in the overall health of the human body. This article explores the structure and function of mitochondria, including their role in exercise, aging, and maintaining cellular health. By understanding the importance of mitochondria, we can work towards maintaining their health and improving overall cellular health.
Mitochondria: structure and function
Mitochondria are tiny organelles that are often referred to as the “powerhouses” of the cell. These structures play a critical role in maintaining the overall health of the human body. In this article, we explore the function and significance of mitochondria in both health and disease.
The endosymbiotic theory suggests that mitochondria originated from free-living bacteria that were engulfed by early eukaryotic cells, leading to the development of a crucial component of the cell’s internal machinery. Today, mitochondria are present in the cells of many living things, including human cells (1).
Mitochondria are responsible for the production of cellular energy through a series of chemical processes that convert glucose into adenosine triphosphate (ATP). In fact, mitochondria generate 90% of the energy required for our bodies to function properly (1). Mitochondria also participate in both cell development and cell death and are essential for the regulation of the cell cycle, cellular differentiation, and other cellular processes.
Mitochondria and exercise
Since mitochondria are responsible for generating energy for the cells, they are essential for exercise and physical activity.
During exercise, the demand for energy in the muscles rises, and the mitochondria produce ATP, the main source of energy for cells. As a result, the muscles may work harder and for longer periods of time (2).
Additionally, the mitochondria aid in the removal of lactic acid from the muscles, which delays the onset of fatigue and discomfort. Overall, mitochondria’s capacity to supply energy to cells is essential for exercise, enabling enhanced physical performance and recovery.
Mitochondria and aging
Reactive oxygen species (ROS), which are created by the mitochondria as a byproduct of energy generation, are theorized to play a role in some aspects of aging (3).
These particles harm proteins, lipids, and DNA, and also harm the mitochondria’s functioning components.
When the mitochondria become dysfunctional, more ROS are produced, which worsens the damage.
Physical activity is thought to be a great approach to support mitochondrial health by controlling mitochondrial quality control (MQC) and allowing damaged mitochondria to be repaired or eliminated and new mitochondria to be synthesized, restoring the metabolic state.
Mitochondrial biogenesis is the process by which new mitochondria are created within cells. This process is essential for maintaining mitochondrial health and function, as it ensures that cells have a sufficient supply of these vital organelles.
Several factors can stimulate mitochondrial biogenesis, including exercise, calorie restriction, and certain dietary supplements. Exercise, in particular, has been shown to have a powerful effect on mitochondrial biogenesis, as it increases the demand for energy in the muscles and stimulates the production of new mitochondria to meet this demand.
Maintaining mitochondrial health
Mitochondria are essential because they serve as the cell’s main energy source. The cell wouldn’t be able to perform its important activities without the energy provided by the mitochondria, which would result in cellular malfunction and ultimately, cell death.
Furthermore, mitochondrial health and function are essential for maintaining tissue and organ function as well as the general health of cells.
To maintain mitochondrial health, it is essential to lead a healthy lifestyle that includes a well-balanced diet, regular exercise, and limiting exposure to contaminants in the environment.
Exercise is particularly important because it promotes mitochondrial quality control and decreases the formation of ROS, boosting the expression of vascular endothelial growth factor (VEGF), and raising the bioavailability of nitric oxide, which favors calcium handling and contractility (4).
The importance of mitochondrial health
Mitochondria play a critical role in maintaining the overall health of the human body. They are essential for the production of cellular energy, the regulation of the cell cycle, and other cellular processes. To maintain mitochondrial health, it is important to lead a healthy lifestyle that includes regular exercise and a well-balanced diet.
Physical activity is a great way to support mitochondrial health by promoting mitochondrial quality control and decreasing the formation of ROS (5). By understanding the function and significance of mitochondria in cells, we can concentrate on keeping these essential organelles active and functional.
Discover YAMAMOTO’s Success Story
Learn how YAMAMOTO integrated WATTS’UP® into their products, driving remarkable success.
WEBINAR - Sports Performance
WEBINAR – Sports Performance
Product concepts with WATTS’UP® to improve performancein both endurance and strength
A critical component of athletic performance is nutrition, and there exists a substantial market for supplementation within this domain. Join us while we dive in the clinical evidence supporting the sports performance boosting citrus extract WATTS’UP®, and product formulations with this ingredient. Watch it now on demand!
Sports nutrition is a specialized field that focuses on optimizing the diets of athletes and active individuals to enhance performance and promote recovery. Proper nutrition can help athletes achieve their goals by providing the necessary energy, macronutrients, and micronutrients for their bodies to function at their best.
Supplementation of specific macronutrients is an important way to improve sports performance. It can help boost your energy, increase blood flow and enhance your power output.
Join our webinar and discover the clinical evidence supporting WATTS’UP® and how BioActor’s sweet orange extract can be integrated into effective products targeting sports performance.
Watch now on demand!
Meet the Speakers:
What was discussed during this webinar?
Clinical Research
Presentation by Yala Stevens, PhD – Chief Scientific Officer, who introduced the science behind WATTS’UP® and the clinical trials showing the positive effect of WATTS’UP® on power, peak performance and blood flow.
Duration: 15 minutes
Sports Performance trends & consumer insights
Presentation by Bjarne Maas – Marketing & Account Manager, who discussed the consumer insights and product formulation examples related to sports performance.
Duration: 15 minutes
Q&A session
Duration: 10 minutes
Actiful® - New Publication Reveals Physical and Mental Health Benefits in Elderly
Actiful® – New Publication Reveals Physical and Mental Health Benefits in Elderly
Press release
A new randomized, double-blind, placebo-controlled clinical trial with Actiful® was recently published in the Journal of Nutrition, Health & Ageing. The study investigated whether Actiful® improves physical fitness and mental well-being in healthy elderly. Additionally, blood biomarkers for oxidative stress and endothelial function were measured. Key findings of the study were an improvement in handgrip strength, a measure of physical fitness, and psychological functioning facets, such as thinking, memory, learning, and concentration.
The study
The new research, published in the Journal of Nutrition Health & Ageing, was conducted by researchers at Maastricht University led by Dr Freddy Troost in collaboration with BioActor, the developer and manufacturer of the branded ingredient, Actiful®.
Actiful® is a citrus flavonoid and pomegranate complex designed to boost vitality and support energy levels for an active lifestyle. The ingredient is standardised for its content in highly bioavailable 2S-hesperidin, an important citrus flavonoid which already showed in previous BioActor studies the efficacy in improving blood flow and sports performances in both highly trained and recreational athletes.
The new study investigated whether daily supplementation with 700mg of Actiful® would affect physical fitness and psychological functioning in a healthy elderly population.
As life expectancy increases rapidly, the elderly population is growing in numbers. Ageing is one of the main risk factors for a wide variety of diseases, such as cardiovascular disease, cognitive decline and reduced physical function. Therefore, strategies to support vitality in senior subjects are becoming increasingly relevant.
The methods
The study included 36 active seniors aged between 60-75 years old. The design of the clinical trial was a randomised, double-blind, placebo-controlled, crossover study. All participants received both treatments and placebo: four weeks of supplementation with Actiful® and four weeks of supplementation with the placebo, separated by a washout period of 4 to 8 weeks.
During the intervention, participants completed the WHOQOL-100 questionnaire, a list of 100 questions created by the World Health Organisation and validated to assess the quality of life. In addition, a senior fitness test and handgrip measurements were performed, which are validated measures of physical performance.
Furthermore, nitrate levels were measured as a marker of endothelial function. Nitrate is considered an important signalling molecule involved in endothelial function by inducing vasodilation, leading to improved blood flow.
Oxidative stress was also evaluated by determining malondialdehyde (MDA) plasma levels. Oxidative stress is an imbalance between free radicals and antioxidants in your body and can damage cells, proteins and DNA, contributing to ageing.
The results
The study results indicate that four weeks of daily Actiful® supplementation significantly improved handgrip strength in healthy elderly. Handgrip strength is an important measure of physical fitness associated with reduced all-cause mortality, as well as increased cognitive function, mobility, and functional status.
According to the researchers, a potential mechanism that might be associated with improving handgrip strength is improved mitochondrial function. In fact, the role of hesperetin – the main metabolite of Actiful®, in mitochondrial functioning, increased intracellular ATP production, and mitochondrial spare capacity was already observed in vitro.
“With age, the number and functionality of mitochondria decreases. Dysfunctional mitochondria have reduced the capacity for producing ATP – our muscles’ principal energy source. Therefore, the next step is to confirm the effect of Actiful® on mitochondrial biogenesis and functionality in humans in vivo”, the researchers commented.
In addition to the handgrip strength, also psychological function improved after the 4 weeks of supplementation with Actiful®.
Specifically, the researchers found a significantly higher score for the treatment group than the placebo in the thinking, memory, learning, and concentration facet. As the quality of life is an important factor in successful ageing, improved psychological functioning is deemed increasingly relevant.
MDA and NO3 were also analysed as a measure of oxidative stress and endothelial functions. After supplementation, plasma MDA decreased compared to the placebo, a sign of improved oxidative stress status.
Finally, higher production of NO3 was observed. NO3 is an important signalling molecule involved in endothelial function by causing vasodilation in smooth muscle cells and can contribute to improving blood flow and exercise capacity, as demonstrated in previous studies.
Overall, the study results suggest that Actiful® consumption results in improved physical performance and better quality of life, which are two crucial factors in successful ageing.
“We are pleased with the results of this clinical trial, which includes improvements both in physical fitness and mental well-being, as well as improved oxidative stress markers. These results have piqued our interest regarding potential underlying mechanisms of action, which are currently being investigated in our new clinical trial.” Commented Sanne Ahles – clinical researcher at BioActor.
Opportunity for innovation
Actiful® has been developed to support vitality and energy levels contributing to healthy ageing. The active ingredient can already be found in various products on the market worldwide. Actiful® is easy to formulate, and it can be added to a wide variety of dietary supplements in several convenient formats, including gummies, effervescent tablets, capsules, ready-to-use sachets and drinks.
About BioActor
BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.
Feel free to contact BioActor via info@bioactor.com for more information on the possibilities that Actiful® has to offer.
Further information can be found on: www.actiful.eu and www.bioactor.com
The effects of Hesperidin on exercise performance - New publication from BioActor in collaboration with Maastricht University
The effects of Hesperidin on exercise performance – New publication from BioActor in collaboration with Maastricht University
Press release
The review recently published in Nutrients was conducted by BioActor in collaboration with Maastricht University and examined the potential mechanisms through which hesperidin can improve exercise performance.
A review on hesperidin and exercise performance
Nutrients, a leading peer-reviewed scientific journal of human nutrition, has recently published a review about hesperidin’s effect on exercise performance. The research was conducted by M. Imperatrice, a clinical researcher at BioActor, in collaboration with the Maastricht University’s Department of Human Biology.
This review collects the results of randomized controlled trials (RTCs), animal studies, and in vitro studies providing more evidence on how hesperidin, a flavanone abundantly present in citrus fruits, could lead to enhancement in exercise performance.
According to the review’s results, hesperidin is able to improve endothelial function (via increased NO availability), inhibit ROS production, decrease production and plasma levels of pro-inflammatory markers, and improve anaerobic exercise outcomes (e.g. power, speed, energy).
“We are really proud to share the results collected in our review about the potential mechanisms linking hesperidin to enhanced anaerobic performance, namely improved endothelial function, reduced exercise-induced oxidative stress, and inflammation. For elite and recreational athletes, hesperidin could be a promising food supplement to optimize the oxygen and nutrient supplies of the muscles, stimulate muscle contraction, and enhance muscle recovery between training sessions. The ergogenic effects that hesperidin can bring to the spectrum of improved exercise performance are promising and should be investigated further. With our “Actiful 2” ongoing Clinical Study, we are going to deepen this knowledge by investigating both the effects of hesperidin supplementation on endurance exercise and on changes in intramuscular markers via skeletal muscle biopsies.” said M. Imperatrice.
BioActor’s interest in hesperidin has resulted in the development of two active ingredients. The first ingredient branded under the name WATTS’UP® and targeting sports performance has already been tested in two randomized placebo-controlled clinical trials, one with highly trained athletes and one with moderately trained subjects. The second ingredient goes under the name Actiful® and targets energy and vitality. This ingredient has already been tested in randomized placebo-controlled clinical trials, in elderly subjects, showing physical and mental benefits.
About BioActor
BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.
Feel free to contact BioActor via info@bioactor.com for more information on the possibilities WATTS’UP® and Actiful® have to offer.
Further information can be found on: www.wattsup.eu, www.actiful.eu and www.bioactor.com
MEET US - BioActor showcasing WATTS’UP® at the 19th Annual ISSN Conference
MEET US – BioActor showcasing WATTS’UP® at the 19th Annual ISSN Conference
Press release
The International Society of Sports Nutrition (ISSN) is organizing their 19th Annual Conference and Expo. BioActor is an active contributor to this conference and Yala Stevens, our chief scientific officer will present the clinical results on our ingredient WATTS’UP®.
BioActor showcasing WATTS’UP® at the 19th Annual ISSN Conference
The International Society of Sports Nutrition (ISSN) is the world’s leader in providing science-based sports nutrition and supplement information. This year they are organizing their 19th Annual Conference and Expo. Anyone interested in sports science/nutrition can attend!
The conference addresses a diverse audience such as researchers, students, dieticians, sports nutritionists, but also the athletes themselves. Therefore, the conference offers a platform to discuss various hot topics related to sports nutrition, such as sports supplements, elucidation of the physiological mechanisms behind nutraceutical interventions, as well as nutritional effects on performance.
The strength of the annual ISSN conference is that top researchers present on novel paradigms in sports nutrition. Besides, it is also an excellent opportunity to make new contacts and reconnect with colleagues from all over the world.
BioActor is an active contributor to this conference, since Yala Stevens, our chief scientific officer will present the clinical results on our ingredient WATTS’UP®. Title of the study: The effect of citrus flavonoid extract supplementation on anaerobic capacity in moderately trained athletes: a randomized controlled trial.
Original research paper presentation by Yala Stevens (CSO)
Previous studies have demonstrated that supplementation with flavonoids from citrus fruits may be an effective strategy to improve exercise performance in male athletes. Repeated intake of 500 mg of a specific citrus fruit extract improved aerobic exercise performance. Also, an increased absolute power output and a decreased oxygen consumption/power ratio were observed.
Yala will be presenting new insights on the beneficial effects of 400 mg and 500 mg citrus fruit extract (WATTS’UP®) supplementation on short-term high-intensity exercise performance. In this study, we used a WinGate protocol, the gold standard for testing high-intensity performance for 92 male and female participants.
Join us on Friday 17th of June at 10:10am for Yala’s presentation in the Westin Fort Lauderdale Beach Resort (Florida).
Business opportunities
BioActor will also be present with a small table top, together with the exclusive distributor for the US market, SEPPIC Inc. Jeremie Feuer (SEPPIC) and Joris Kretzers (BioActor) will be there to represent BioActor’s portfolio, with a specific focus on our sports nutrition ingredients. If you are looking for natural ingredients that benefit athlete’s performance, feel free to pass by at any time on Thursday or Friday for a chat!
We look forward to meeting you in Fort Lauderdale!
The ISSN conference and expo will take place from June, 16-18 2022.
Westin Fort Lauderdale Beach Resort, 321 North Fort Lauderdale Beach Blvd., Fort Lauderdale Florida USA 33304
About BioActor
BioActor, based in Maastricht, Netherlands, is a product development company that supplies proprietary bioactive formulations to the nutrition & healthcare industry. The company focuses on the development of innovative bioactives that address active living and healthy ageing. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.
For further information, see www.bioactor.com or visit www.wattsup.eu
How to increase endurance performance during sport
How to increase endurance performance during sport
Do you experience an overall lack of energy during sports activities? Then it’s time to increase your endurance performance during physical activity. In this article, we will explain what endurance is, why is important for you and which nutrients and supplements can support your diet, boost your energy levels, help you recover faster, and enhance your overall performance during your training.
Endurance Performance in different sports
Endurance is the ability to sustain an activity for extended periods of time and usually relates to aerobic or anaerobic exercise [1].
Aerobic endurance applies to sports like long-distance running or swimming where athletes exercise for extended periods of time. In this type of exercise, the body relies on supplying nutrients and oxygen to working muscles.
On the other hand, anaerobic endurance is related to high-intensity exercises that may last minutes such as weightlifting. In these cases, a different type of endurance (strength) is necessary to achieve the maximum number of sets and reps in a workout plan.
Nowadays, many athletes also focus on activities that include resistance with the body (calisthenics) or equipment such as weight machines and barbell exercises. In these cases, a different type of endurance (strength) is necessary to achieve the maximum number of sets and reps in a workout plan.
The conclusion in each case is that high volume of training puts extreme demands on the body from a physical (strength & power), mental (focus) and energy (endurance) retention standpoint.
Why is endurance performance important?
Endurance can benefit your overall wellness by improving heart health, lowering the levels of cholesterol and blood pressure, preventing injuries and controlling your weight.
As it concerns your performance skills, studies have shown that endurance helps athletes develop skills like agility, speed, power, and strength. More specifically, it is an efficient way of maintaining your energy levels before fatigue sets in.
As an example, you can consider a basketball player who wants to jump for rebounds in the final minutes of an intense game or even a marathon athlete that needs to run the last kilometers of a demanding race.
Thus, endurance can keep your circulatory system healthy and make the difference between winning or losing in different sports.
Ways to boost your endurance during sport
As Paul Krebs, MD, of Premier Orthopedics, part of Premier Physician Network asserted, “body has the ability to get oxygen to the body and to the muscles that are using it during exercise.” A workout program focused on endurance training can lower the level of work-related fatigue [2]. The American Heart Association (AHA) recommends all adults get 150 minutes of aerobic exercise each week.
However, nutrition is also an essential factor that influences the endurance of athletes. More specifically, it has been proved that nutritional supplements in performance endurance and enhancement are essential for athletes, even though there is a lack of knowledge of their use. Thus, athletes need reliable information regarding supplements they can trust and use in their daily demanding life [3]. In the next section, we will focus on the ingredients that a supplement should include for increasing endurance performance.
Ingredients for endurance
L-Glutamine
Even if the body can synthesize glutamine, its levels might not be sufficient for athletes. The body can become depleted of glutamine in case of high intensity training [4] and as a result, athletes seek to increase the dosage intake by supplementation.
L-Glutamine accelerates muscle recovery while it helps athletes to exercise harder. The increased sodium uptake reduces muscle fatigue and breakdown while maintaining muscle growth.
The recommended dosage for L-Glutamine is between 3 to 6 grams [5].
Carbohydrates
As it was mentioned previously, athletes need endurance for different types of training. For example, marathon runners exercise for extended periods of time and require a lot of carbohydrates to sustain their performance.
Any athlete who exercises for more than 60 to 90 minutes requires carbohydrate intake during their performance to sustain sufficient energy levels for fueling muscles since their glycogen stores may only last a limited time.
A combination of carbohydrates with a small amount of protein has been shown to efficiently prevent the amount of muscle damage that occurs during an endurance exercise [6].
The daily recommended dosage for Carbohydrates depends on the type of exercise. The American College of Sports Medicine (ACSM), the Academy of Nutrition and Dietetics (AND), and Dietitians of Canada (DC) recommend:
• Moderate endurance exercise (1 hour per day): 5-7 g/kg of body weight per day.
• Moderate to high-intensity endurance exercise (1-3 hours per day): 6-10 g/kg of body weight per day.
• Moderate to high-intensity endurance exercise (4-5 hours per day). 10-12 g/kg of body weight per day.
Caffeine
Caffeine is a stimulant that athletes can use to temporarily boost their energy [8]. More specifically, it can increase the heart rates when athletes feel fatigued, and it has been proven to improve endurance performance [6].
Even if caffeine reduces athletes’ perception of effort, it is important to be aware of the side effects it might have in higher intakes [9]. Some of the side effects of too much caffeine are anxiety, insomnia, muscle breakdown, rapid heart rate and high blood pressure.
It is also possible that caffeine has the opposite result where the consumption of many caffeinated beverages is followed by fatigue [10].
The recommended clinical dose of caffeine is between 3 and 6 mg/kg.
Citrus flavonoids (hesperidin) – Power and endurance in one ingredient
If you want to increase your endurance, strength, and power during a high intense training, you should bear in mind an extra ingredient with the name of citrus flavonoids (hesperidin). BioActor has developed a proprietary ingredient that is optimized for bioavailability and performance, backed up by two clinical studies: WATTS’UP®.
WATTS’UP® was studied for its beneficial effects on endurance performance and high-intensity performance at a daily dose of 400-500 mg.
The first clinical trial was conducted at the Dutch Olympic training facility. It confirmed that WATTS’UP® is capable of significantly improving aerobic power in endurance athletes in comparison to placebo.
A second clinical trial was tested during the Wingate Anaerobic Test. It confirmed that WATTS’UP® can be very efficient for Peak Force, Anaerobic Power, and Endurance compared to placebo.
In conclusion, proper nutrition in addition to a well-designed training plan, can enhance sporting performance and reduce recovery time.
Discover YAMAMOTO’s Success Story
Learn how YAMAMOTO integrated WATTS’UP® into their products, driving remarkable success.
