The importance of the mitochondria for health
The importance of the mitochondria for health
Mitochondria are essential organelles that produce cellular energy and play a crucial role in the overall health of the human body. This article explores the structure and function of mitochondria, including their role in exercise, aging, and maintaining cellular health. By understanding the importance of mitochondria, we can work towards maintaining their health and improving overall cellular health.
Mitochondria: structure and function
Mitochondria are tiny organelles that are often referred to as the “powerhouses” of the cell. These structures play a critical role in maintaining the overall health of the human body. In this article, we explore the function and significance of mitochondria in both health and disease.
The endosymbiotic theory suggests that mitochondria originated from free-living bacteria that were engulfed by early eukaryotic cells, leading to the development of a crucial component of the cell’s internal machinery. Today, mitochondria are present in the cells of many living things, including human cells (1).
Mitochondria are responsible for the production of cellular energy through a series of chemical processes that convert glucose into adenosine triphosphate (ATP). In fact, mitochondria generate 90% of the energy required for our bodies to function properly (1). Mitochondria also participate in both cell development and cell death and are essential for the regulation of the cell cycle, cellular differentiation, and other cellular processes.
Mitochondria and exercise
Since mitochondria are responsible for generating energy for the cells, they are essential for exercise and physical activity.
During exercise, the demand for energy in the muscles rises, and the mitochondria produce ATP, the main source of energy for cells. As a result, the muscles may work harder and for longer periods of time (2).
Additionally, the mitochondria aid in the removal of lactic acid from the muscles, which delays the onset of fatigue and discomfort. Overall, mitochondria’s capacity to supply energy to cells is essential for exercise, enabling enhanced physical performance and recovery.
Mitochondria and aging
Reactive oxygen species (ROS), which are created by the mitochondria as a byproduct of energy generation, are theorized to play a role in some aspects of aging (3).
These particles harm proteins, lipids, and DNA, and also harm the mitochondria’s functioning components.
When the mitochondria become dysfunctional, more ROS are produced, which worsens the damage.
Physical activity is thought to be a great approach to support mitochondrial health by controlling mitochondrial quality control (MQC) and allowing damaged mitochondria to be repaired or eliminated and new mitochondria to be synthesized, restoring the metabolic state.
Mitochondrial biogenesis is the process by which new mitochondria are created within cells. This process is essential for maintaining mitochondrial health and function, as it ensures that cells have a sufficient supply of these vital organelles.
Several factors can stimulate mitochondrial biogenesis, including exercise, calorie restriction, and certain dietary supplements. Exercise, in particular, has been shown to have a powerful effect on mitochondrial biogenesis, as it increases the demand for energy in the muscles and stimulates the production of new mitochondria to meet this demand.
Maintaining mitochondrial health
Mitochondria are essential because they serve as the cell’s main energy source. The cell wouldn’t be able to perform its important activities without the energy provided by the mitochondria, which would result in cellular malfunction and ultimately, cell death.
Furthermore, mitochondrial health and function are essential for maintaining tissue and organ function as well as the general health of cells.
To maintain mitochondrial health, it is essential to lead a healthy lifestyle that includes a well-balanced diet, regular exercise, and limiting exposure to contaminants in the environment.
Exercise is particularly important because it promotes mitochondrial quality control and decreases the formation of ROS, boosting the expression of vascular endothelial growth factor (VEGF), and raising the bioavailability of nitric oxide, which favors calcium handling and contractility (4).
The importance of mitochondrial health
Mitochondria play a critical role in maintaining the overall health of the human body. They are essential for the production of cellular energy, the regulation of the cell cycle, and other cellular processes. To maintain mitochondrial health, it is important to lead a healthy lifestyle that includes regular exercise and a well-balanced diet.
Physical activity is a great way to support mitochondrial health by promoting mitochondrial quality control and decreasing the formation of ROS (5). By understanding the function and significance of mitochondria in cells, we can concentrate on keeping these essential organelles active and functional.
WEBINAR - Sports Performance
WEBINAR – Sports Performance
Product concepts with WATTS’UP® to improve performancein both endurance and strength
A critical component of athletic performance is nutrition, and there exists a substantial market for supplementation within this domain. Join us while we dive in the clinical evidence supporting the sports performance boosting citrus extract WATTS’UP®, and product formulations with this ingredient. The webinar will take place at 3PM CEST.
Sports nutrition is a specialized field that focuses on optimizing the diets of athletes and active individuals to enhance performance and promote recovery. Proper nutrition can help athletes achieve their goals by providing the necessary energy, macronutrients, and micronutrients for their bodies to function at their best.
Supplementation of specific macronutrients is an important way to improve sports performance. It can help boost your energy, increase blood flow and enhance your power output.
Join our webinar and discover the clinical evidence supporting WATTS’UP® and how BioActor’s sweet orange extract can be integrated into effective products targeting sports performance.
Sign up now!
Meet the Speakers:
What wil be discussed during this webinar?
Clinical Research
Presentation by Yala Stevens, PhD – Chief Scientific Officer, who will introduce the science behind WATTS’UP® and the clinical trials showing the positive effect of WATTS’UP® on power, peak performance and blood flow.
Duration: 15 minutes
Sports Performance trends & consumer insights
Presentation by Bjarne Maas – Marketing & Account Manager, who will discuss the consumer insights and product formulation examples related to sports performance.
Duration: 15 minutes
Q&A session
Duration: 10 minutes
Actiful® - New Publication Reveals Physical and Mental Health Benefits in Elderly
Actiful® – New Publication Reveals Physical and Mental Health Benefits in Elderly
Press release
A new randomized, double-blind, placebo-controlled clinical trial with Actiful® was recently published in the Journal of Nutrition, Health & Ageing. The study investigated whether Actiful® improves physical fitness and mental well-being in healthy elderly. Additionally, blood biomarkers for oxidative stress and endothelial function were measured. Key findings of the study were an improvement in handgrip strength, a measure of physical fitness, and psychological functioning facets, such as thinking, memory, learning, and concentration.
The study
The new research, published in the Journal of Nutrition Health & Ageing, was conducted by researchers at Maastricht University led by Dr Freddy Troost in collaboration with BioActor, the developer and manufacturer of the branded ingredient, Actiful®.
Actiful® is a citrus flavonoid and pomegranate complex designed to boost vitality and support energy levels for an active lifestyle. The ingredient is standardised for its content in highly bioavailable 2S-hesperidin, an important citrus flavonoid which already showed in previous BioActor studies the efficacy in improving blood flow and sports performances in both highly trained and recreational athletes.
The new study investigated whether daily supplementation with 700mg of Actiful® would affect physical fitness and psychological functioning in a healthy elderly population.
As life expectancy increases rapidly, the elderly population is growing in numbers. Ageing is one of the main risk factors for a wide variety of diseases, such as cardiovascular disease, cognitive decline and reduced physical function. Therefore, strategies to support vitality in senior subjects are becoming increasingly relevant.
The methods
The study included 36 active seniors aged between 60-75 years old. The design of the clinical trial was a randomised, double-blind, placebo-controlled, crossover study. All participants received both treatments and placebo: four weeks of supplementation with Actiful® and four weeks of supplementation with the placebo, separated by a washout period of 4 to 8 weeks.
During the intervention, participants completed the WHOQOL-100 questionnaire, a list of 100 questions created by the World Health Organisation and validated to assess the quality of life. In addition, a senior fitness test and handgrip measurements were performed, which are validated measures of physical performance.
Furthermore, nitrate levels were measured as a marker of endothelial function. Nitrate is considered an important signalling molecule involved in endothelial function by inducing vasodilation, leading to improved blood flow.
Oxidative stress was also evaluated by determining malondialdehyde (MDA) plasma levels. Oxidative stress is an imbalance between free radicals and antioxidants in your body and can damage cells, proteins and DNA, contributing to ageing.
The results
The study results indicate that four weeks of daily Actiful® supplementation significantly improved handgrip strength in healthy elderly. Handgrip strength is an important measure of physical fitness associated with reduced all-cause mortality, as well as increased cognitive function, mobility, and functional status.
According to the researchers, a potential mechanism that might be associated with improving handgrip strength is improved mitochondrial function. In fact, the role of hesperetin – the main metabolite of Actiful®, in mitochondrial functioning, increased intracellular ATP production, and mitochondrial spare capacity was already observed in vitro.
“With age, the number and functionality of mitochondria decreases. Dysfunctional mitochondria have reduced the capacity for producing ATP – our muscles’ principal energy source. Therefore, the next step is to confirm the effect of Actiful® on mitochondrial biogenesis and functionality in humans in vivo”, the researchers commented.
In addition to the handgrip strength, also psychological function improved after the 4 weeks of supplementation with Actiful®.
Specifically, the researchers found a significantly higher score for the treatment group than the placebo in the thinking, memory, learning, and concentration facet. As the quality of life is an important factor in successful ageing, improved psychological functioning is deemed increasingly relevant.
MDA and NO3 were also analysed as a measure of oxidative stress and endothelial functions. After supplementation, plasma MDA decreased compared to the placebo, a sign of improved oxidative stress status.
Finally, higher production of NO3 was observed. NO3 is an important signalling molecule involved in endothelial function by causing vasodilation in smooth muscle cells and can contribute to improving blood flow and exercise capacity, as demonstrated in previous studies.
Overall, the study results suggest that Actiful® consumption results in improved physical performance and better quality of life, which are two crucial factors in successful ageing.
“We are pleased with the results of this clinical trial, which includes improvements both in physical fitness and mental well-being, as well as improved oxidative stress markers. These results have piqued our interest regarding potential underlying mechanisms of action, which are currently being investigated in our new clinical trial.” Commented Sanne Ahles – clinical researcher at BioActor.
Opportunity for innovation
Actiful® has been developed to support vitality and energy levels contributing to healthy ageing. The active ingredient can already be found in various products on the market worldwide. Actiful® is easy to formulate, and it can be added to a wide variety of dietary supplements in several convenient formats, including gummies, effervescent tablets, capsules, ready-to-use sachets and drinks.
About BioActor
BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.
Feel free to contact BioActor via info@bioactor.com for more information on the possibilities that Actiful® has to offer.
Further information can be found on: www.actiful.eu and www.bioactor.com
The effects of Hesperidin on exercise performance - New publication from BioActor in collaboration with Maastricht University
The effects of Hesperidin on exercise performance – New publication from BioActor in collaboration with Maastricht University
Press release
The review recently published in Nutrients was conducted by BioActor in collaboration with Maastricht University and examined the potential mechanisms through which hesperidin can improve exercise performance.
A review on hesperidin and exercise performance
Nutrients, a leading peer-reviewed scientific journal of human nutrition, has recently published a review about hesperidin’s effect on exercise performance. The research was conducted by M. Imperatrice, a clinical researcher at BioActor, in collaboration with the Maastricht University’s Department of Human Biology.
This review collects the results of randomized controlled trials (RTCs), animal studies, and in vitro studies providing more evidence on how hesperidin, a flavanone abundantly present in citrus fruits, could lead to enhancement in exercise performance.
According to the review’s results, hesperidin is able to improve endothelial function (via increased NO availability), inhibit ROS production, decrease production and plasma levels of pro-inflammatory markers, and improve anaerobic exercise outcomes (e.g. power, speed, energy).
“We are really proud to share the results collected in our review about the potential mechanisms linking hesperidin to enhanced anaerobic performance, namely improved endothelial function, reduced exercise-induced oxidative stress, and inflammation. For elite and recreational athletes, hesperidin could be a promising food supplement to optimize the oxygen and nutrient supplies of the muscles, stimulate muscle contraction, and enhance muscle recovery between training sessions. The ergogenic effects that hesperidin can bring to the spectrum of improved exercise performance are promising and should be investigated further. With our “Actiful 2” ongoing Clinical Study, we are going to deepen this knowledge by investigating both the effects of hesperidin supplementation on endurance exercise and on changes in intramuscular markers via skeletal muscle biopsies.” said M. Imperatrice.
BioActor’s interest in hesperidin has resulted in the development of two active ingredients. The first ingredient branded under the name WATTS’UP® and targeting sports performance has already been tested in two randomized placebo-controlled clinical trials, one with highly trained athletes and one with moderately trained subjects. The second ingredient goes under the name Actiful® and targets energy and vitality. This ingredient has already been tested in randomized placebo-controlled clinical trials, in elderly subjects, showing physical and mental benefits.
About BioActor
BioActor, based at the Maastricht Health Campus, Netherlands, is a life science company that has developed a range of proprietary bioactive ingredients for the nutrition & consumer health industries. The company focuses on the development of plant-based health ingredients for active living and healthy ageing. The goal is to provide the nutrition & consumer health industries with clinically tested innovations that confer a real health benefit to the consumer.
Feel free to contact BioActor via info@bioactor.com for more information on the possibilities WATTS’UP® and Actiful® have to offer.
Further information can be found on: www.wattsup.eu, www.actiful.eu and www.bioactor.com
MEET US - BioActor showcasing WATTS’UP® at the 19th Annual ISSN Conference
MEET US – BioActor showcasing WATTS’UP® at the 19th Annual ISSN Conference
Press release
The International Society of Sports Nutrition (ISSN) is organizing their 19th Annual Conference and Expo. BioActor is an active contributor to this conference and Yala Stevens, our chief scientific officer will present the clinical results on our ingredient WATTS’UP®.
BioActor showcasing WATTS’UP® at the 19th Annual ISSN Conference
The International Society of Sports Nutrition (ISSN) is the world’s leader in providing science-based sports nutrition and supplement information. This year they are organizing their 19th Annual Conference and Expo. Anyone interested in sports science/nutrition can attend!
The conference addresses a diverse audience such as researchers, students, dieticians, sports nutritionists, but also the athletes themselves. Therefore, the conference offers a platform to discuss various hot topics related to sports nutrition, such as sports supplements, elucidation of the physiological mechanisms behind nutraceutical interventions, as well as nutritional effects on performance.
The strength of the annual ISSN conference is that top researchers present on novel paradigms in sports nutrition. Besides, it is also an excellent opportunity to make new contacts and reconnect with colleagues from all over the world.
BioActor is an active contributor to this conference, since Yala Stevens, our chief scientific officer will present the clinical results on our ingredient WATTS’UP®. Title of the study: The effect of citrus flavonoid extract supplementation on anaerobic capacity in moderately trained athletes: a randomized controlled trial.
Original research paper presentation by Yala Stevens (CSO)
Previous studies have demonstrated that supplementation with flavonoids from citrus fruits may be an effective strategy to improve exercise performance in male athletes. Repeated intake of 500 mg of a specific citrus fruit extract improved aerobic exercise performance. Also, an increased absolute power output and a decreased oxygen consumption/power ratio were observed.
Yala will be presenting new insights on the beneficial effects of 400 mg and 500 mg citrus fruit extract (WATTS’UP®) supplementation on short-term high-intensity exercise performance. In this study, we used a WinGate protocol, the gold standard for testing high-intensity performance for 92 male and female participants.
Join us on Friday 17th of June at 10:10am for Yala’s presentation in the Westin Fort Lauderdale Beach Resort (Florida).
Business opportunities
BioActor will also be present with a small table top, together with the exclusive distributor for the US market, SEPPIC Inc. Jeremie Feuer (SEPPIC) and Joris Kretzers (BioActor) will be there to represent BioActor’s portfolio, with a specific focus on our sports nutrition ingredients. If you are looking for natural ingredients that benefit athlete’s performance, feel free to pass by at any time on Thursday or Friday for a chat!
We look forward to meeting you in Fort Lauderdale!
The ISSN conference and expo will take place from June, 16-18 2022.
Westin Fort Lauderdale Beach Resort, 321 North Fort Lauderdale Beach Blvd., Fort Lauderdale Florida USA 33304
About BioActor
BioActor, based in Maastricht, Netherlands, is a product development company that supplies proprietary bioactive formulations to the nutrition & healthcare industry. The company focuses on the development of innovative bioactives that address active living and healthy ageing. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.
For further information, see www.bioactor.com or visit www.wattsup.eu
How to increase endurance performance during sport
How to increase endurance performance during sport
Do you experience an overall lack of energy during sports activities? Then it’s time to increase your endurance performance during physical activity. In this article, we will explain what endurance is, why is important for you and which nutrients and supplements can support your diet, boost your energy levels, help you recover faster, and enhance your overall performance during your training.
Endurance Performance in different sports
Endurance is the ability to sustain an activity for extended periods of time and usually relates to aerobic or anaerobic exercise [1].
Aerobic endurance applies to sports like long-distance running or swimming where athletes exercise for extended periods of time. In this type of exercise, the body relies on supplying nutrients and oxygen to working muscles.
On the other hand, anaerobic endurance is related to high-intensity exercises that may last minutes such as weightlifting. In these cases, a different type of endurance (strength) is necessary to achieve the maximum number of sets and reps in a workout plan.
Nowadays, many athletes also focus on activities that include resistance with the body (calisthenics) or equipment such as weight machines and barbell exercises. In these cases, a different type of endurance (strength) is necessary to achieve the maximum number of sets and reps in a workout plan.
The conclusion in each case is that high volume of training puts extreme demands on the body from a physical (strength & power), mental (focus) and energy (endurance) retention standpoint.
Why is endurance performance important?
Endurance can benefit your overall wellness by improving heart health, lowering the levels of cholesterol and blood pressure, preventing injuries and controlling your weight.
As it concerns your performance skills, studies have shown that endurance helps athletes develop skills like agility, speed, power, and strength. More specifically, it is an efficient way of maintaining your energy levels before fatigue sets in.
As an example, you can consider a basketball player who wants to jump for rebounds in the final minutes of an intense game or even a marathon athlete that needs to run the last kilometers of a demanding race.
Thus, endurance can keep your circulatory system healthy and make the difference between winning or losing in different sports.
Ways to boost your endurance during sport
As Paul Krebs, MD, of Premier Orthopedics, part of Premier Physician Network asserted, “body has the ability to get oxygen to the body and to the muscles that are using it during exercise.” A workout program focused on endurance training can lower the level of work-related fatigue [2]. The American Heart Association (AHA) recommends all adults get 150 minutes of aerobic exercise each week.
However, nutrition is also an essential factor that influences the endurance of athletes. More specifically, it has been proved that nutritional supplements in performance endurance and enhancement are essential for athletes, even though there is a lack of knowledge of their use. Thus, athletes need reliable information regarding supplements they can trust and use in their daily demanding life [3]. In the next section, we will focus on the ingredients that a supplement should include for increasing endurance performance.
Ingredients for endurance
L-Glutamine
Even if the body can synthesize glutamine, its levels might not be sufficient for athletes. The body can become depleted of glutamine in case of high intensity training [4] and as a result, athletes seek to increase the dosage intake by supplementation.
L-Glutamine accelerates muscle recovery while it helps athletes to exercise harder. The increased sodium uptake reduces muscle fatigue and breakdown while maintaining muscle growth.
The recommended dosage for L-Glutamine is between 3 to 6 grams [5].
Carbohydrates
As it was mentioned previously, athletes need endurance for different types of training. For example, marathon runners exercise for extended periods of time and require a lot of carbohydrates to sustain their performance.
Any athlete who exercises for more than 60 to 90 minutes requires carbohydrate intake during their performance to sustain sufficient energy levels for fueling muscles since their glycogen stores may only last a limited time.
A combination of carbohydrates with a small amount of protein has been shown to efficiently prevent the amount of muscle damage that occurs during an endurance exercise [6].
The daily recommended dosage for Carbohydrates depends on the type of exercise. The American College of Sports Medicine (ACSM), the Academy of Nutrition and Dietetics (AND), and Dietitians of Canada (DC) recommend:
• Moderate endurance exercise (1 hour per day): 5-7 g/kg of body weight per day.
• Moderate to high-intensity endurance exercise (1-3 hours per day): 6-10 g/kg of body weight per day.
• Moderate to high-intensity endurance exercise (4-5 hours per day). 10-12 g/kg of body weight per day.
Caffeine
Caffeine is a stimulant that athletes can use to temporarily boost their energy [8]. More specifically, it can increase the heart rates when athletes feel fatigued, and it has been proven to improve endurance performance [6].
Even if caffeine reduces athletes’ perception of effort, it is important to be aware of the side effects it might have in higher intakes [9]. Some of the side effects of too much caffeine are anxiety, insomnia, muscle breakdown, rapid heart rate and high blood pressure.
It is also possible that caffeine has the opposite result where the consumption of many caffeinated beverages is followed by fatigue [10].
The recommended clinical dose of caffeine is between 3 and 6 mg/kg.
Citrus flavonoids (hesperidin) – Power and endurance in one ingredient
If you want to increase your endurance, strength, and power during a high intense training, you should bear in mind an extra ingredient with the name of citrus flavonoids (hesperidin). BioActor has developed a proprietary ingredient that is optimized for bioavailability and performance, backed up by two clinical studies: WATTS’UP®.
WATTS’UP® was studied for its beneficial effects on endurance performance and high-intensity performance at a daily dose of 400-500 mg.
The first clinical trial was conducted at the Dutch Olympic training facility. It confirmed that WATTS’UP® is capable of significantly improving aerobic power in endurance athletes in comparison to placebo.
A second clinical trial was tested during the Wingate Anaerobic Test. It confirmed that WATTS’UP® can be very efficient for Peak Force, Anaerobic Power, and Endurance compared to placebo.
In conclusion, proper nutrition in addition to a well-designed training plan, can enhance sporting performance and reduce recovery time.
Which ingredients should a pre-workout formula include?
Which ingredients should a pre-workout formula include?
If you are looking for the ideal pre-workout formula, you came to the right place. In this article, we explore the most relevant ingredients that your pre-workout formula should include to target power, focus and endurance.
Tingles and rashes, this is what the average gym visitor is looking for in a pre-workout formula. However, sometimes it can be difficult to choose the right product due to the endless lists of ingredients.
You may find yourself asking questions like: “Do I really need all these things?”, “What is it that really matters?”. If this is the case, in this article, we explore a few effective ingredients to target the 3 main benefits a high-quality pre-workout should provide: power, focus and endurance.
What is a pre-workout?
Pre-workouts are known to most as cocktails of rash- and tingle-causing formulations. However, these days, formulations are more sophisticated than they used to be. They are consumed by athletes from all disciplines briefly prior to their workout or training.
The goal of consuming these types of formulas is to enhance acute exercise performance [1]. You can find pre-workouts in different forms, like drinks, gels or capsules, yet ready-to-drink powders are by far the most common format.
Getting the most out of your workout
If you are considering consuming a pre-workout for improving your performance, you can pay attention to a few things before buying.
First, you would like to have an effective product that addresses three main benefits: power, focus and endurance.
Further, you would like this product to have a rapid onset of these effects, ideally within 15-30 minutes of intake.
Finally, you can consider choosing a formula that contains natural ingredients and avoid consuming high amounts of stimulants like caffeine.
In the next section, we look at the ingredients that you should be looking for in a pre-workout.
Ingredients for power
These ingredients provide fuel to maximize high-intensity movements within your training or workout [2].
Citrulline malate. Clinical dose: 6 g
This ingredient consists of citrulline, a non-essential amino acid, and malic acid, an intermediate in the citric acid cycle.
Citrulline malate is linked to improved blood flow during exercise by augmenting nitric oxide (NO) levels, as citrulline is a NO precursor [3].
Currently, it is unclear whether the performance improvement is linked to this mechanism, but several studies support an improvement in peak power output after citrulline malate consumption [4,5].
Creatine. Clinical dose: 3 g
Creatine is one of the most well-researched ingredients in sports nutrition. Creatine supplementation increases intramuscular creatine levels. Short-term energy generation in muscle tissue comes virtually 100% from creatine – the phosphorylated isoform, Cr-P.
Daily intake has been demonstrated to promote anaerobic performance in the gold standard Wingate Test [6]. Researchers also found beneficial effects on exercise recovery with creatine intake, reducing exercise-induced muscle damage [7].
Ingredients for focus
These ingredients make sure that you can focus on your movements to execute them with high precision [2]. Focus is more famously referred to as mind-muscle connection.
Brainberry®. Clinical dose: 65 mg
If you are looking for an alternative to caffeine to boost your focus, you might want to learn more about Brainberry®.
Brainberry® is a natural Aronia berry extract developed by BioActor to enhance cognitive performance. Research conducted on Brainberry® revealed that the consumption of Brainberry® can increase focus, psychomotor speed and mental flexibility [8,9].
In particular, a study which was performed on 35 professional basketball players, showed important benefits after one week of supplementation, highlighting the ability of Brainberry® to significantly enhance cognitive performance and improve basketball-specific skills like shooting, rebounding and dribbling.
Brainberry®’s benefits are attributed to the high levels of Cyanidin-3-O-Galactoside contained in the extract, a compound which plays an important role in improving brain health and cognitive functions.
Want to know more about Cy3Gal and how it is involved in brain health? Read this article!
Caffeine. Clinical dose: 200 mg
Similar to creatine, caffeine is one of the most well-researched ingredients in sports nutrition [2], often referred to as the primary ingredient responsible for acute ergogenic effects.
Low doses (3 mg/kg body weight) have been linked to improved alertness, vigilance, mood and cognitive processes during exercise [10].
However, a comparison between non-caffeine and caffeine-containing pre-workout formulas concluded that the caffeine-containing pre-workout reduces calmness. If you are training in the evening, this might be a reason to pass on caffeine [11].
Ingredients for endurance
These ingredients are important to provide nutrients to feel energized until the end of your workout [2].
Beta-alanine. Clinical dose 4-6 g
Beta-alanine is a carnosine precursor, a compound that buffers lactate build-up in the muscle tissue, prolonging the feeling of soreness.
It has been shown that 4-6 g of beta-alanine consumption per day for two weeks improves high-intensity exercise performance. Regular consumption maintains a certain level of intramuscular carnosine levels, as beta-alanine is the limiting factor in carnosine production [12].
Carbohydrates. Dose depending on exercise type [13]
This ingredient depends a lot on the exercise type you are performing. Typical gym sessions last between 45-120 minutes, for which a small amount of rapidly absorbed carbohydrates shortly before exercise can be beneficial.
Carbohydrates are the main energy source during resistance exercise and are mobilized from glycogen stores. A small amount of carbohydrates is able to support glycogen store replenishment [14].
Endurance exercise is typical of a longer duration and would require a larger pre-workout carbohydrate amount to optimize glycogen stores. Slow-release carbohydrates could be a consideration for this type of athlete, as they deliver energy over a longer period of time.
Citrus flavonoids (hesperidin) – Power and endurance in one ingredient
If you want to take your pre-workout to the next level, an additional ingredient you may want to include in your pre-workout formula, are citrus flavonoids (hesperidin).
WATTS’UP® is a natural Citrus sinensis extract researched and developed by BioActor. The recommended daily dose (clinical dose) for this ingredient is 400-500 mg.
Two randomized placebo-controlled clinical trials conducted by BioActor confirmed that WATTS’UP® is able to significantly improve peak force, endurance capacity and anaerobic power in trained subjects.
Further research revealed that WATTS’UP® works by stimulating nitric oxide (NO) synthesis in blood vessels, thus stimulating vasodilation and better blood flow. [15]
Moreover, it was demonstrated that WATTS’UP® boosts mitochondria efficiency and respiration capacity, resulting in 33% higher ATP production – the fuel for our muscle [16].
WATTS’UP® – New Study on Peak Force & Anaerobic Performance Published in Peer-reviewed Journal
WATTS’UP® – New Study on Peak Force & Anaerobic Performance Published in Peer-reviewed Journal
Press release
A new clinical study with WATTS’UP® on Peak Force and Anaerobic Performance was recently published in the Journal of the International Society of Sports Nutrition. WATTS’UP®, a customized flavonoid extract from sweet orange developed by BioActor, was tested in a double-blind, placebo-controlled study in trained male and female athletes and showed a significant peak force and anaerobic exercise performance improvement.
The findings of the new publication
WATTS’UP®, a customized flavonoid extract from sweet orange with enhanced bioavailability, was tested in moderately trained male and female athletes and showed a significant increase in peak power output and anaerobic power during a Wingate Anaerobic Test.
The study was performed at the High-Performance Center of Topsport Limburg in collaboration with Dr. Freddy Troost (Maastricht University).
The purpose of the study, now available in the Journal of the International Society of Sports nutrition, was to assess whether supplementation of WATTS’UP® for 4 weeks improved anaerobic performance in trained male and female athletes.
Participants were given a daily dose of either 400 mg, 500 mg of WATTS’UP®or a placebo for 4 weeks. Exercise performance was tested by means of a 30 second Wingate Anaerobic Test on a WATT BIKE, the gold standard in research.
Peak Force during the first 5 seconds of the exercise significantly increased after 4 weeks of 400mg WATTS’UP® supplementation compared to the placebo, corresponding with a 7.5 % increase.
In addition, the average anaerobic power during the entire Wingate Test significantly increased in the 400mg WATTS’UP® group compared to placebo.
This study is the second RCT-study in trained athletes conclusively showing that WATTS’UP® contributes to exercise performance. WATTS’UP® has been specifically developed to contain a high concentration of the most active isomer hesperidin 2S and an earlier pharmacokinetics study showed that the product is more quickly absorbed.
WATTS’UP® can already be found on the market in several products in the USA and Europe. It can be applied in various finished dosage forms, including effervescent tablets, capsules, RTD sachets and beverages.
Feel free to contact BioActor via info@bioactor.com for more information on the possibilities WATTS’UP® has to offer.
Further information can be found on: www.wattsup.eu and www.bioactor.com
About BioActor
BioActor, based in Maastricht, Netherlands, is a product development company that supplies proprietary bioactive formulations to the nutrition & healthcare industry. The company focuses on the development of innovative bioactives that address active living and healthy ageing. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.
For further information, see www.bioactor.com or visit www.wattsup.eu
Active Pharmaceutica appointed as Exclusive Distributor of WATTS’UP® for the compounding pharmacy market in Brazil
Active Pharmaceutica appointed as Exclusive Distributor of WATTS’UP® for the compounding pharmacy market in Brazil
Press release
Active Pharmaceutica Ltda. and BioActor B.V. entered into an Agreement that appoints Active Pharmaceutica as exclusive distributor of WATTS’UP®, BioActor’s proprietary sports performance ingredient, for the compounding pharmacy market in Brazil.
INSERT HEADER
BioActor and Active Pharmaceutica signed a partnership agreement for the exclusive distribution of WATTS’UP®, BioActor’s science-based sports performance ingredient. Under this partnership agreement, Active Pharmaceutica is appointed as exclusive distributor of WATTS’UP® for the compounding pharmacy market in Brazil. BioActor will actively support Active Pharmaceutica with scientific and formulation input.
Active Pharmaceutica Ltda. is a dynamic Brazilian distribution company with high qualitative standards and know-how to import unique raw materials in Brazil. BioActor is very pleased to start this new partnership with Active Pharmaceutica Ltda. to launch WATTS’UP® in the rapidly growing compound pharmacy market in Brazil.
WATTS’UP®, is a customized flavonoid extract from sweet orange, that can be formulated in a wide range of sports and exercise nutritional products. WATTS’UP® was tested in two placebo-controlled and double-blind studies. The results showed both an aerobic and anaerobic power increase in athletes. WATTS’UP® has a positive effect on the efficiency of the mitochondria and helps to increase ATP production.
The most recent clinical study also showed a significant effect of WATTS’UP® on peak power in a Wingate Test in moderately trained male and female participants. A low daily dose of 400-mg has shown to be sufficient to reach this beneficial effect.
WATTS’UP® can already be found on the market in the USA and Europe. The next step is to expand the footprint of WATTS’UP® in Latin America, starting from the compounding pharmacy market in Brazil.
To know more about WATTS’UP®, visit Active Pharmaceutica at Ação Magistral on the 25th and 26th October, 2019 – Porto Alegre/RS (Brazil)!
About Active Pharmaceutica Ltda.
Active Pharmaceutica, based in Santa Catarina, Brazil, is an importer and distributor of pharmaceutical products that supplies nutraceuticals, botanical extracts, probiotics, among other bioactives to Brazilian compounding pharmacies. The company strives to provide exceptional customer service through the commitment to quality, transparency, and integrity as well as offering innovative solutions to the pharmaceutical compounding market.
For further information, see www.activepharmaceutica.com.br
Are you a compounding pharmacy in Brazil interested in WATTS’UP®?
Please feel free to reach out Active Pharmaceutica at sac@activepharamaceutica.com.br
About BioActor
BioActor, based in Maastricht, Netherlands, is a product development company that has developed a range of proprietary bioactive ingredients for the nutrition & healthcare industry. The company focuses on the development of innovative activities that address active living and healthy aging. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.
Feel free to contact us via info@bioactor.com for more information on the possibilities WATTS’UP® has to offer.
Further information can be found on: www.wattsup.eu
WATTS’UP® receives an approved health claim from Health Canada
WATTS’UP® receives an approved health claim from Health Canada
Press release
Health Canada has issued a Product Licence for WATTS’UP® and has approved the use of the following health claim: “Helps improve physical performance during exercise in trained male athletes”. WATTS’UP®, a customized flavonoid extract from sweet orange, was tested in a double-blind, placebo controlled study in trained male athletes, and showed a significant improvement in exercise performance.
The issued health claim
Health Canada has issued a Product Licence for WATTS’UP®. Pursuant to this Product Licence, WATTS’UP® is recommended to be used as “Athletic support” or “Workout/Exercise supplement”.
The following specific claims have been allowed by Health Canada: “Helps improve physical performance during exercise in trained male athletes”, and “Provides antioxidants that help cells fight against the oxidative effect of free radicals and that helps protect cells and reduce oxidative damage and cell damage caused by free radicals”
The Journal of Sports Science and Medicine has published the results of the latest clinical study with WATTS’UP®. WATTS’UP®, a customized flavonoid extract from sweet orange with enhanced bioavailability, was tested in trained male athletes and showed a significant increase in power output during the exercise test. This study is the first study in athletes conclusively showing that a specific flavonoid extract contributes to exercise performance.
WATTS’UP® can already be found on the market in several products in the USA and Europe. It can be applied in various finished dosage forms, including effervescent tablets, capsules, RTD sachets and beverages.
Feel free to contact us via info@bioactor.com for more information on the possibilities WATTS’UP® has to offer.
Further information can be found on: www.wattsup.eu
About BioActor:
BioActor, based in Maastricht, Netherlands, is a product development company that supplies proprietary Active Nutritional ingredients to the nutrition & healthcare industry. The company focuses on the development of innovative ANI’s that address metabolic syndrome and ageing-related chronic health conditions. The goal is to provide the nutrition & healthcare industry with science-based innovations that confer a real health benefit to the consumer.
For further information, please contact info@bioactor.com