Top 5 reasons why Actiful® is a good addition to your energy supplement

May 25th, 2023

The need for healthy ingredients that have undergone extensive clinical testing is increasing as consumers become more interested in dietary supplements that improve energy. The abundance of ingredients available can feel overpowering for supplement formulators who aim to create a product that promotes energy and vitality. But don’t worry – in this article, we’ll cover the top five reasons why Actiful® is a good ingredient for your energy supplement.

Ingredients-for-energy-supplements

Finding ingredients for the rising demand in energy supplements

Low energy levels and a lack of vitality are common complaints in today’s fast-paced world. Many consumers turn to dietary supplements to manage the daily mental and physical stressors they face. Energy-enhancing supplements aim to prevent fatigue, increase physical activity, and promote social engagement.

With the growing demand for energy-enhancing products, it can be challenging to identify scientifically backed ingredients. To simplify the process, we’ve compiled the top 5 reasons why Actiful should be included in your energy supplement as an ingredient.

Actiful®: A combination of sweet orange and pomegranate

Actfiul® is a patent-protected, all-natural ingredient developed by BioActor; a pioneer in clinically substantiating the beneficial impact of citrus flavonoids on energy metabolism. Actiful® is standardized for hesperidin and punicalagin; the main polyphenols found in sweet orange (Citrus sinensis) and the peel of pomegranate (Punica granatum), respectively. Both compounds have been extensively studied for their potential health benefits.

Top 5 reasons to use Actiful® as an ingredient for your energy supplement

1. Enhanced physical performance in both young and old

A double-blind randomized controlled trial conducted on physically fit young males revealed that Actiful® can increase absolute power output by 5% during a 10-minute cycling time-trial without requiring additional oxygen (1). This advantage was observed after just four weeks of daily supplementation with Actiful®.

In addition, a recently published double-blind randomized controlled trial conducted on active seniors found that daily supplementation with Actiful® for four weeks significantly increased their handgrip strength (2). Handgrip strength is a crucial measure of physical fitness in the elderly as it is indicative of overall health and functional status in day-to-day life.

Given that Actiful® has been clinically proven to enhance physical performance in both young and older individuals, it is an ideal ingredient to target a wide population.

2. Mental health benefits

Mental wellbeing plays a significant role in physical fitness, as the way one handles cognitive demanding tasks can affect how energized they feel.

In addition to improved physical performance, the elderly subjects who supplemented with Actiful® also experienced psychological benefits. Compared to the placebo group, the Actiful® group demonstrated significant improvements in cognitive domains such as thinking, memory, learning, and concentration (2). These elements are essential for maintaining one’s quality of life and wellbeing.

Given the critical connection between the mind and body in enhancing vitality, Actiful® is the ideal ingredient to target both.

3. Mitochondria

Boosting your energy can be done by targeting mitochondria, which are the powerhouses of the cell.

A strategy to target the mitochondria is by implementing specific nutrients into your diet. Actiful® enhances energy levels via mitochondria as well. Experiments in muscle cells have demonstrated that Hesperetin, the active metabolite of Hesperidin, can improve energy production by directly targeting the mitochondria (3).

This improvement in energy production has been observed to translate into improved running performance in mice. The mechanism behind this is that Actiful® improves the respiration capacity of the mitochondria.

To produce energy, mitochondria require oxygen to form an electron gradient across the intermembrane, which mechanically produces ATP. When protons leak across the intermembrane, the gradient weakens, resulting in fewer ATP molecules being formed. By inhibiting proton leakage across the mitochondrial intermembrane, Actiful® enhances energy production directly.

4. Antioxidant

During physical activity, there is a heightened production of reactive oxygen species (ROS) due to the increased demand on mitochondria to produce energy. Excessive ROS can lead to damage to the mitochondria and other crucial structures of the cell, which can impair their functionality.

Hesperidin has been demonstrated to not only scavenge ROS directly but also enhance the natural antioxidant systems present in cells (3). In addition, pomegranate has also been found to improve antioxidant status (4).
As a result, Actiful®’s antioxidant capabilities may improve vitality by preserving the functionality of cells and tissues.

5. NO improved bloodflow

Nitric oxide (NO) is a critical component in regulating blood flow. NO relaxes the blood vessels, increasing their diameter, and allowing more oxygen and nutrient-rich blood to pass through.
Endothelial cells that line the blood vessels produce more NO through the enzyme eNOS, which Hesperidin has been found to activate, promoting vasodilation (5).

Furthermore, when oxygen is limited, dietary nitrate can raise NO levels. Pomegranate, which is high in Punicalagin, is a potent source of dietary nitrate that may improve blood flow and increase the efficiency of oxygen and nutrient delivery.

Actiful®: the key ingredient of your energy supplement

All in all, Actiful® is a natural and safe ingredient that has the ideal properties to be incorporated in energy supplements that aim to provide acute and sustained improvements in vitality!