What are the health benefits of arabinoxylans from wheat?

December 10th, 2021

Arabinoxylans are soluble prebiotic fibres extracted from cereal grains, such as the wheat endosperm. Arabinoxylans can be used as dietary supplements or functional food ingredients due to their researched beneficial effects on gut health, glycaemic control and immune health.

What are arabinoxylans?

Arabinoxylans are soluble fibres extracted from cereal grains. Arabinoxylans have been identified in all major cereal grains, including wheat, barley, oats, rye, rice, sorghum, maize, and millet.

In cereal grains, arabinoxylans are localized mainly in the cell walls of starchy endosperm and the aleurone layer, in the bran tissues, and in the husk of some cereals.

Depending on the genus and species, the amount and structure of arabinoxylans in a particular tissue may vary. For instance, in wheat, there is more arabinoxylan in the walls surrounding the cells of starchy endosperm than in those of aleurone.

Not all arabinoxylans are the same. They vary on the degree of polymerization, which represents the length of the arabinoxylan chains, and on the soluble arabinoxylan content.

As with all fibres, their physicochemical characteristics affect the degree to which they are utilised by the gut microbiota. Higher degrees of polymerization and concentrations of soluble fibre are related to greater bifidogenic effects. [1]

Arabinoxylans can be used as a dietary supplement due to their beneficial effects on gut health, glycaemic control and immune health.

Moreover, due to the physicochemical and technological properties of these molecules (e.g. water-binding capacity, gelation), arabinoxylans can also be used as a baking additive to improve dough consistency, increase loaf volumes and improve crumb structure.

The health benefits of arabinoxylans

Research around arabinoxylans has suggested that these compounds, as part of dietary fibre, have many beneficial physiological effects along the entire human gastrointestinal tract.

These effects are dependent on a complex mixture of molecular and physical properties of arabinoxylan preparations, as well as on the site, rate and extent of their digestion and fermentation in the gut.

• Arabinoxylans have strong prebiotic properties

Arabinoxylans have demonstrated to have prebiotic properties, by selectively stimulating the growth of beneficial bacteria in the colon, such as Bifidobacterium and Bacteroides species. [2,3]

This change in the microbiota is associated with positive health outcomes, such as improved overall health, decreased gut infections and enhanced mineral absorption.

Additionally, the fermentation of prebiotics by intestinal bacteria results in the production of short-chain fatty acids (SCFAs), which have numerous favourable effects.

These effects include the inhibition of harmful bacteria, colon cancer prevention or improvement of glucose tolerance, among others. [4]

• Arabinoxylans improve glycaemic control and insulin sensitivity

Evidence suggests that arabinoxylans from wheat may improve metabolic control in people with impaired glucose tolerance and with Diabetes type 2, by improving blood glucose and insulin levels.

The short-chain fatty acids (SCFAs) formed from the metabolization of arabinoxylans by the gut microbiota are mainly butyrate, acetate and propionate. Acetate and propionate can bind to a specific protein called GPCR43 in the colon.

After binding, the secretion of two peptides (PYY and GLP-1) is increased. This leads to a lowered intestinal motility and a decrease in the levels of a hunger hormone called ghrelin. These processes are key to improving glucose handling. [5,6]

The European Food Safety Authority (EFSA) concluded that there is sufficient scientific evidence to substantiate the health claim that the consumption of arabinoxylans produced from wheat endosperm contributes to a reduction of the glucose rise after a meal. [7]

Some other soluble fibres have also been associated with this health benefit; however, one of the advantages of arabinoxylans lies in their higher palatability.

• Arabinoxylans boost immune health

Arabinoxylans have shown to boost the immune system. Specifically, they may enhance adaptive immunity, innate immunity and gut barrier integrity:

1. Adaptive immunity. Arabinoxylans may enhance vaccination efficacy against influenza, resulting in fewer adverse events, fewer respiratory tract infections and an improved seroprotection rate. [8]

2. Innate immunity. As mentioned, arabinoxylans may promote a beneficial short-chain fatty acid (SCFA) profile. This leads to increased cytokine production, improved monocytes recruitment capacity, and activation of regulatory T-cells, resulting in an increased immune system vigilance. All these cells are involved in keeping the immune system in check by making sure that it returns to a stable state after invaders have been successfully cleaned up. [9,10]

3. Gut barrier integrity. The short-chain fatty acid (SCFA) butyrate provides additional energy to the gut cells and strengthens the mucus layer. Arabinoxylans further induce the upregulation of tight junction proteins, protecting the human body against foreign invaders and strengthening the immune system. [11,12]

How can you add arabinoxylans to your diet?

Arabinoxylans can be found in cereal grains. Arabinoxylan supplements can also be purchased in health food stores and online. They can be found in capsule form, in powder blends or even in bars.

Generally, 1 to 5 grams of arabinoxylans daily are enough to benefit from their prebiotic effect. Regarding EFSA’s health claim on glycaemic control, at least 8% of arabinoxylan-rich fibre produced from wheat endosperm per unit of available carbohydrates should be consumed.

Arabinoxylans are generally considered safe and well tolerated by the gut, meaning that they do not cause intestinal discomfort. [13,14]